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<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3F4</accession>
    <name>A0A133V3F4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_03065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000060">
        <property type="protein sequence ID" value="KXB00972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00972">
        <property type="protein sequence ID" value="KXB00972"/>
        <property type="gene ID" value="AKJ44_03065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.636"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="48"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="539" mass="61282" checksum="384F1CDF16D7C671" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3H7</accession>
    <name>A0A133V3H7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_03060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000059">
        <property type="protein sequence ID" value="KXB00990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00990">
        <property type="protein sequence ID" value="KXB00990"/>
        <property type="gene ID" value="AKJ44_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="233" mass="27091" checksum="C2A89EDF41EFD36B" modified="2016-07-06" version="1">MLEETMTDHEKELSVKSKSGLRVSDGRREIVVCDTNILVYKAFDEIGISPSHSSRKIDSAIKKFGQLASKGNRMLMPKSVEKELKPVCERKLEEEDLDEEEKNRVRDGIKKYTKKYSPEDLPVGTPIEGEEDYLKQVRSFYRSYPDKLSEITQKKINNKPEKKHEILLERGEIFPTRGPTPSEGDIRLLAECIRMNRLPIPRIWHISLLSNDSDFLWFTTEIEREFGIKIHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3I0</accession>
    <name>A0A133V3I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_03055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000059">
        <property type="protein sequence ID" value="KXB00989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00989">
        <property type="protein sequence ID" value="KXB00989"/>
        <property type="gene ID" value="AKJ44_03055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="167" mass="19094" checksum="F2AF2DBDEF0510B5" modified="2016-07-06" version="1">MEAISNSTPLIYLAKVSNLNLLKKLFNEIIVPEEVYEEVVVKGEERGEPEVSLISDLFEEGFIRKEKARRPKRGLRGLHEAEGKAIDLCEEEGIDHILVDDKEAFKLAKLLGLEPWRTSSIILKFFELGEIDYRKLRRALQDLSNAGYFMTAEVYELILGKARELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3K4</accession>
    <name>A0A133V3K4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bmp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_03030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000057">
        <property type="protein sequence ID" value="KXB01019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01019">
        <property type="protein sequence ID" value="KXB01019"/>
        <property type="gene ID" value="AKJ44_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="56"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="429" mass="47022" checksum="15B502C0B28FD096" modified="2016-07-06" version="1">MGEKLGKKGIAVSTAVIITVIVTAIIVGSGVYVLKPAAGEKEVTKSCTLAIEHFSPIAGTTWSGAHDRAAKRLMEKYPTLEYVYREEIGPDLTNSTAEELIASEGADIVVGNAEFMGLPLADIADDYPDVYFSSIIASDLTTKRNFIRYFPGQYQALYLEGLIAGALTETNNIGIVSAFPCVQVNRRQNAFYLGIMDAAEILDENINLYVKYAGDWYLPTDEAEIARTLIDTYNCDVITQQTDSGAPLDVAGEKGVWFVGKDMDIVGEYGWSSTDTVAVSFDTRWEVGYEKMIKSWMAGDNNPDTILYPRMDDKIILPEPPWPGGPTVLPTVDIQNNHEVGIDAISPAARPLIESEIISLVENRRTQMMSGVWDPFFAHEFVSNGTGLELESVSIPTAGTVVKSANETPTDEWLLSKFNFDLEGINILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3U7</accession>
    <name>A0A133V3U7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ORF">AKJ44_02920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000052">
        <property type="protein sequence ID" value="KXB01112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01112">
        <property type="protein sequence ID" value="KXB01112"/>
        <property type="gene ID" value="AKJ44_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="199" mass="22531" checksum="22288E951B2BD85B" modified="2016-07-06" version="1">MPRKKYGPHEVIEYRRKREGRTDYQRRIKLLRSGKPRLVVRPSLKHVRVQVIQAELDGDQTLASAFSKELSNFGWKGQTSNTPSAYLVGLLGGFRAKKTGVEECILDIDRHVPVPEAKIFAALKGTLDAGVTISHEEDVIPSEERIQGRHIAQYAESLKSDDEAYQNQFSKYLENDLAPEDLPEHFNQVKQAIITKYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3V3</accession>
    <name>A0A133V3V3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="8" type="ORF">AKJ44_02935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000052">
        <property type="protein sequence ID" value="KXB01115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01115">
        <property type="protein sequence ID" value="KXB01115"/>
        <property type="gene ID" value="AKJ44_02935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.583"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="30"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="148" mass="16292" checksum="83117F8FC8116281" modified="2016-07-06" version="1">MVVRKTRKTKKKRGSRTVGGGTVKKRRHSGHKGGKGLAGSHKHRWMKLTKKAPKHFGKHGFTRPPKLQKSVSTINVGELDERIDELLETEAAEQKEGKTIVDVTKIGIDKVLGRGKISRSMKVIAKNFSKSAKEKLEEAGGEVTTGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3V9</accession>
    <name>A0A133V3V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000053">
        <property type="protein sequence ID" value="KXB01096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01096">
        <property type="protein sequence ID" value="KXB01096"/>
        <property type="gene ID" value="AKJ44_02960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="60" mass="6681" checksum="8A1D59D6EF3CFCFC" modified="2016-07-06" version="1">MTVCDECGEAKDTVQIGDKNYCLDCLRKQEDSLKSAIEAGADKNSELEEVQDAIWILEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V433</accession>
    <name>A0A133V433_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000047">
        <property type="protein sequence ID" value="KXB01202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01202">
        <property type="protein sequence ID" value="KXB01202"/>
        <property type="gene ID" value="AKJ44_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="64" mass="7718" checksum="76A91C414D85DE04" modified="2016-07-06" version="1">MNFRELRKLICKVDRIEGEEREGLLRKLIKEIPKLDPLERHSEFAVMAAKTLARVKWFSYHKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V446</accession>
    <name>A0A133V446_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000047">
        <property type="protein sequence ID" value="KXB01201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01201">
        <property type="protein sequence ID" value="KXB01201"/>
        <property type="gene ID" value="AKJ44_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="222" mass="26742" checksum="593E48E2B5C74FDD" modified="2016-07-06" version="1">MIDPEKFEQRWNSFSSNYMRDFNSFWNWKLEIEKSNGHILDDSNLGSTHRRLCGILPGWQTYRPYGLNEQILREALEEISWAYDKIRNHSLLEFKDIPRETLRLIWTELGRVKTKNRSDYQYVMSVCKPLMMLWGQTLAFDKNVRKKIPFAAKTKSKWNFETWKSIMNGFSHKLNQSPETVEFLKEWSRKEFGTDTPAPYGRFLDIYYFTDSSKRFQQTRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V452</accession>
    <name>A0A133V452_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000048">
        <property type="protein sequence ID" value="KXB01186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01186">
        <property type="protein sequence ID" value="KXB01186"/>
        <property type="gene ID" value="AKJ44_02845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="103" mass="11400" checksum="1184C48810501C2C" modified="2016-07-06" version="1" fragment="single">KTVDKVQEKVSETGDKVSKTDVKILALALQLSEEGKNPVIVSDDYAIQNLSRLFDLPYSRIAKPGISVVFKWVKECPACGRVYSVDAEKCEACGSKLVRKPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V470</accession>
    <name>A0A133V470_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps7</name>
        <name evidence="7" type="ORF">AKJ44_02815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000047">
        <property type="protein sequence ID" value="KXB01206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01206">
        <property type="protein sequence ID" value="KXB01206"/>
        <property type="gene ID" value="AKJ44_02815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="6">
        <location>
            <begin position="46"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="201" mass="22380" checksum="6748B990662D562A" modified="2016-07-06" version="1">MSPKYFDKWPTDDVKVTDRGLKRYISLDPKLVPHISGRHAEKQFGKSNVFIVERLLNKLMRSGPGKGKIGGKLIRGSKNCGKKHKAYRIVRQALEKIEDETGENSIQVLVNAIQNSAPREETTKISYGGITYHVAVDSAPQRRLDTALKNLVDGAYSSSFRSNQSMPDALAEELILASKSDMDSYAVSKKEETERIAKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V488</accession>
    <name>A0A133V488_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMC_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000044">
        <property type="protein sequence ID" value="KXB01265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01265">
        <property type="protein sequence ID" value="KXB01265"/>
        <property type="gene ID" value="AKJ44_02705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.506"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="2">
        <location>
            <begin position="74"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="354" mass="40885" checksum="C0D90329983B95F0" modified="2016-07-06" version="1" fragment="single">FMEIASETGEIKKAGSKLQKLRSKFTALKTRRSEFKKRIDDLKQKIRESEEELEEAEARAKQVKESIRELREEIDELSEKAKNQENKSKKNQEKIDSLKEAREDLRVKEAEIKTELKEAEKKREKYDIKIKRTPRTPIKKLRGQIKKLEREIEKLKPINERAIESYKKVKKRYDSQRGHYDKLMDEKQALLDFMEEIDQKKAEVFMETFKEIAENFSEIFSELSPGGSGRLFLENPEDPFEGGLEIEARPAGKKLLNINSLSGGEKALTALSFIFAIQRTKPSALYVLDEIGAHLDPENEKRVAKMLKKSSEESQIVVITLKDAMMAVADRLFGVHMDKSNISHLVSVDLEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V490</accession>
    <name>A0A133V490_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000046">
        <property type="protein sequence ID" value="KXB01226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01226">
        <property type="protein sequence ID" value="KXB01226"/>
        <property type="gene ID" value="AKJ44_02785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="121" mass="13782" checksum="40DD9258236EA897" modified="2016-07-06" version="1">MESSITISPRDIYKNGIDEIDSHLGRKNTCDVCGENNPAEFHLYRGPKKTLSFCGECDKTDNSGILKYLLHGSQVYGSKIAKISEETGLLQKDVESTPRKLLSNNLVRRDKRKHPTRWFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V498</accession>
    <name>A0A133V498_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000044">
        <property type="protein sequence ID" value="KXB01269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01269">
        <property type="protein sequence ID" value="KXB01269"/>
        <property type="gene ID" value="AKJ44_02735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003831">
        <property type="entry name" value="DUF211"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023129">
        <property type="entry name" value="MTH889-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02680">
        <property type="entry name" value="DUF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160363">
        <property type="entry name" value="SSF160363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="68" mass="7456" checksum="42AA93149C8DB917" modified="2016-07-06" version="1">MEIASETGEIKKAGSKLQKLRSKFTALKTLKITVDGELDYPKIKSTIEEWGGVIHSVDEVVAGRKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4B7</accession>
    <name>A0A133V4B7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000043">
        <property type="protein sequence ID" value="KXB01289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01289">
        <property type="protein sequence ID" value="KXB01289"/>
        <property type="gene ID" value="AKJ44_02675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="323" mass="37048" checksum="4F47265942E2A59B" modified="2016-07-06" version="1">MRLGRDFTNCLLPDYLKEEQRTALLNEELDLPSANAMVLEDYKKDVVGQLKIINKMGMNHLELDSDPPNPYLDFTEKQRKEIRETAESMDITLSLHLPYTYIGASLCCFQESDRKIAAAHSLECAEFAADIGAKHVVTHPGKIPFYQAKGRYYEQAKNAIVKSLSEIYEVCESGGVNLHMENNVAFDNFMTEVNECIEVIRKARDRGTEVYFLFDIGHWFTRADAGKEIPDDPVKVVEDVPKELIKELHLNDYVPEKIIFHPPLHLQWGPLKREALERYAKIAKGKGVETIVLETALKNINQFRDRDKLLEDEAKYVREVFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4E1</accession>
    <name>A0A133V4E1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000043">
        <property type="protein sequence ID" value="KXB01291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01291">
        <property type="protein sequence ID" value="KXB01291"/>
        <property type="gene ID" value="AKJ44_02695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="308" mass="32870" checksum="822C51E09AD67717" modified="2016-07-06" version="1">MERLVKATLIGSSAHEALECESGEVHSIFERTFNILLGDKLVGIARSGVTPSPINIITDIPSDENMSALGIDEQMTVRREDNRLSVNDVLKISLESAEIWRPKTGAEGYIDFELTGRNLELAKRLAADKSRSGGLGQLLPSIGDVALGKTPQISDLNQVARKALPQIVGLVKSSRARDVTRVREYGQNLIGLGQGLSPSADDMLSGSMVARWWVANSLSGNLSRVKAENEAIIDSAEKTTLMSQQLLRHAAKGEVNEAVESLLGAILTGTAADVGAGVERVFAIGETSGIDMMVGLLLGLEVGLEKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4K7</accession>
    <name>A0A133V4K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000040">
        <property type="protein sequence ID" value="KXB01379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01379">
        <property type="protein sequence ID" value="KXB01379"/>
        <property type="gene ID" value="AKJ44_02610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="401" mass="43862" checksum="A2ED35268855899F" modified="2016-07-06" version="1">MMIVVGLESCVDVWVTFPNLNGFEGFAREYDGPLTSHVKDAYSAVREGVGGEVPIDGKANEARELIEAASDRGAKVKQALGGNGAQETAAFKALGSDVAFIGGFSPSQVTQLPSKSREFFEGADLSFAYSSGEYRPISVILQARGTNRYILCEGQGRRIEQLRPYVRKLPEVIGRVLDRYGKPDMMNLVGWHVLFANGISDRDLRLVKKVIREIRGVVDSPLFTDAGGLGAFGEGEKHRLCQIYSLFDILSVNEDEVMEVSRTLGSEAEDEFRAMHDILESSEKPSTIWLHSTDYQASLSTQYGRELLERAQTAAATAGVHRVENGAYPTIEELRGRVRVENYSEEGLKVVERAEREYGSKIGSAELVVTPCYKARSFKSTVGAGDTAAAAYAYVIAGGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4L0</accession>
    <name>A0A133V4L0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000040">
        <property type="protein sequence ID" value="KXB01380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01380">
        <property type="protein sequence ID" value="KXB01380"/>
        <property type="gene ID" value="AKJ44_02615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.484"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="105"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="404" mass="44838" checksum="7A054A9B997D2072" modified="2016-07-06" version="1">MDLIIRDARIFGESKIKDIGIKDGKIAKIGKITEDADEEIKADGRLTSPSFVDPHIHLDKVLIADDLPPNKSGTLQEAIELIGERKREYTIEGIKARARKVVQSATRNGTMKMRTHVDVDTIGELTPLKGLLATRREVEEDIDLQIVAFPQEGVVRDPGTEELLRKAMSEGADVIGGMPHHEKSPEEMREHVDVIFEIAKEFDADIDMHVDETDDPNSRSLEYVAKKTIEEEYEGRVTAGHTCALAAYPDDYARKVIEEVKKAEINVITNPATNLAIQGREDDQPVRRGITRVKELLEAGVNVTFGQDCVSDAFYPFGKADMLEVALITAHAAHLTMPEEIKTVFRMMTHNAAQTLGVEKEYGIKVGGPADLVITNAPNHKEAIRLQPDRWVIKRGTILASPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4N0</accession>
    <name>A0A133V4N0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000041">
        <property type="protein sequence ID" value="KXB01356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01356">
        <property type="protein sequence ID" value="KXB01356"/>
        <property type="gene ID" value="AKJ44_02635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.489"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="429" mass="46411" checksum="6FB9F1047425E234" modified="2016-07-06" version="1">MSWKDSKSCTVLGGENLGKIDDANENAITRYKEAGAVLTGLDKAKNVIPGMNEKTLLHAGPPIEWERMSGPTRGAVMGALIFEGLANDEEEAEELAASGEIEFDPCHDHDSVGPMAGVISPSMSVYIIENPEHGNKAYSNLNEGLGEVLRYGAYSEKVLDKLKWMEDVEAPILKATLEQSEPIDCKEIIAQALHMGDDGHCRDVAMSLMFLRELAPYIMETDFDVEDKEKVLKFMGENQLTFLNPLMASGKAMIDAAHGIDYSTMITALTRNGTDFGIRVSGLPGQWFTAPAPKPNTLFFPGFKEGDQGRDIGDSAICETIGLGGFASATAPSIVQVVGGTPSDAADRTREMREITIDEHPSFTIPFMNFQGVPIGIDIRKVVDTGIEPFINTGVAHKDPGVGGVGFGLVRAPMDCFKKALKAFAEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4N5</accession>
    <name>A0A133V4N5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000040">
        <property type="protein sequence ID" value="KXB01381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01381">
        <property type="protein sequence ID" value="KXB01381"/>
        <property type="gene ID" value="AKJ44_02620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025707">
        <property type="entry name" value="DNA_bp_PD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016702">
        <property type="entry name" value="DNA_bp_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="142" mass="15913" checksum="28D5B08386AA3FDF" modified="2016-07-06" version="1">MTAAELDLGRNFVIRAEHDSDIIQYIIKFAEDNEIEIGTFTAIGALKNAKLGFYNQKEHEYQEMEIASPHEIASCLGNISLKDKKPFVHAHAVLADESGETRAGHLIGGTVFAAEIHLRELKGPKLERKHDDVTDLSLWKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4Q8</accession>
    <name>A0A133V4Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000038">
        <property type="protein sequence ID" value="KXB01432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01432">
        <property type="protein sequence ID" value="KXB01432"/>
        <property type="gene ID" value="AKJ44_02540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.443"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="201" mass="22419" checksum="6BA5DC4F803907DE" modified="2016-07-06" version="1">MGKRTVSKHDIIELGVLFATLAIVTIMAFYTPLKIEWVWRAPQLLVPFAILLVHHKSVKSIGLDVRNFPQNMGLGILAAILLTVGLAPIYLWLWSPTMPTSLYLDVWAWVTIFVIANALVIEIFYRGGLQSRLTKLTGFMPALIITSLLCGIDFFEFMIFGPITAVIAAAVSGFLYYKTETLVAPITAHILWPLLIMMLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4R4</accession>
    <name>A0A133V4R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01407">
        <property type="protein sequence ID" value="KXB01407"/>
        <property type="gene ID" value="AKJ44_02575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.454"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="81" mass="9261" checksum="04F37A620280DDE5" modified="2016-07-06" version="1">MWKGSEAWVAKDVRTGVASQGETRREALENLDEAISLHEGEGGESIESWEEEREFLKELGIDPEEVKRARKSGRELPEFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4T7</accession>
    <name>A0A133V4T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000037">
        <property type="protein sequence ID" value="KXB01459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01459">
        <property type="protein sequence ID" value="KXB01459"/>
        <property type="gene ID" value="AKJ44_02490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="78" mass="9197" checksum="456C6DC8E5CAF5A3" modified="2016-07-06" version="1">MEEYSGKLIALDDRMTATIERAKESYEKEDWIGFLEVLREYKSLLVEAQNIMPELFKGASELADRQRENSTYLFSRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4T9</accession>
    <name>A0A133V4T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000037">
        <property type="protein sequence ID" value="KXB01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01463">
        <property type="protein sequence ID" value="KXB01463"/>
        <property type="gene ID" value="AKJ44_02510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="364" mass="42269" checksum="B81D8D3A5456EC2E" modified="2016-07-06" version="1">MRGRCLNLHQIPNRLLQRSVITPILIHLPSELKTIMIELWFESEEDAEKAADELSEFGRPTLGKRVDTRFSISKFLETNYEEAVKELEEVSEELDLDDEENPIKHLKKSLTITRSLLEDGNYKKIAEAPDRMKAENVLYKTVNELESYRELKERVNQHIRKLVEETEESGEEERELTAEPEVSEEAADDLARYSLAMEFLINPVLSIVKKHASEENPLKSFNRNVHLDVTPISNSFDDLKQRIDLEARMTYTVKLGIEHVLRMEDVVQRLRDAKFLNSAEDVLYRFLTLHFIASEVLSSVRGKKKMPYEEFVRGVKERINTSIRELGEESDALPYTTDEAVRWIVQKLKRVGLVRKKGNKISEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4W5</accession>
    <name>A0A133V4W5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HELICc2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000036">
        <property type="protein sequence ID" value="KXB01489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01489">
        <property type="protein sequence ID" value="KXB01489"/>
        <property type="gene ID" value="AKJ44_02475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="1">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="239" mass="28234" checksum="8B95D3D80D3544F7" modified="2016-07-06" version="1">MKILDFEEEVVSEEREGKVTYFIPDPKPVLSSLRKKIGGKWLMMSATVQDREVLNQIYGIDPAFVEGEVKFPGKLIQRKLGPEVRVNNANWKNSSFKREYSRARDEVFRRAARPGFVPVHATKYLPEGMDELTKTDRMERDGITFSTKMDRGADLKEMRSVILLKYPYPDLGDPLLRATRNRLGDKKFWIYYRDRSRREFIQQIGRTLRSPDDEVEFWSPDQICHENLQRDWRGEITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4W7</accession>
    <name>A0A133V4W7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000036">
        <property type="protein sequence ID" value="KXB01488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01488">
        <property type="protein sequence ID" value="KXB01488"/>
        <property type="gene ID" value="AKJ44_02470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="301" mass="33727" checksum="3D163468B471E59D" modified="2016-07-06" version="1">MKLNLYEGSEELEPLSYSTGKNQGELVGEILESFESSDTVFLKGVVGSGKSVIGIRTALEFGGGTISVPTKVLSRQYQDDYEAGKYFLKDSGEKARIGVLRGGGNFTCPHLKDDHPDWPPWRLSCQNRALPCTRPLGKTVRVKEGKEVETRESRMDAVKECPYWGFIFLHSLGLEKLEEHVGAYQGLSGKYSLLLKKGGECPYWSQYQSYLTADVNVMNSSKWRIEAQIGRLPLTRVTVVDEADAWLDGLCTKVSVTDQRIEKLADNLREEGLDEEAGRVEGIWNDYKEGFIEPLVLARFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4Z6</accession>
    <name>A0A133V4Z6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_02440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000035">
        <property type="protein sequence ID" value="KXB01520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01520">
        <property type="protein sequence ID" value="KXB01520"/>
        <property type="gene ID" value="AKJ44_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="381" mass="40857" checksum="8DB487A4F81D039D" modified="2016-07-06" version="1">MKIGKHELRLERRLAPLAGGDAAKISLVAILVGLALFSIIFILADVNPLSAYKTLFSYAFTSPYGLSATANRFVYLLLCTLAFIIPFRAGLWNIGMTGQLYFGALGAFGVLYAFTGAWAPPTPDPGVSSGLVILLMILVAALCGAGFAAIAGFLKGRFNVNEIVTTIMLNFIALWFVRYMIFGGGPFMNPGGRSESFNVPPSARLSSISVGDVSIPLTIFLAIGIAVLLYFLFTKTKLGYQIKAFGHNPTAARYSGVSPLKITLLVFIIGGMIAGLAGYHYFGGPGGSGYNKIQRNFYLIGDLAFYGIVCGLISLGNPLSAIPVSLFFGGLTTGTRYIQGQFHMAFGLDYALLGVLMILLVAFQFFSRYRIVWTKKLKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V509</accession>
    <name>A0A133V509_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000036">
        <property type="protein sequence ID" value="KXB01486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01486">
        <property type="protein sequence ID" value="KXB01486"/>
        <property type="gene ID" value="AKJ44_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="181" mass="19723" checksum="742A8751455FFB12" modified="2016-07-06" version="1">MPTLSIYGDEIAVAFSYTRDPDTSKKKILLSLPHLESLSHWIVEEEEDFSVVPSRNPIVFDGSIAETLGAVNTGSGVVIKSLDEYGTVREYPLDLGAGEEAVRIVNVMDQYGDSEFYDESFLLVTKGQSGDEGKIRRATWALQTETSGETKAPFLNPLTLMAISGILILGGIILLILGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V526</accession>
    <name>A0A133V526_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000034">
        <property type="protein sequence ID" value="KXB01550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01550">
        <property type="protein sequence ID" value="KXB01550"/>
        <property type="gene ID" value="AKJ44_02425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.416"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="403" mass="46076" checksum="0ED3A37FAEB22D70" modified="2016-07-06" version="1">MIRRLSDYREVVDEAKISEIYRKGNKIADNHILHINSTYYGGGVAEILMHMMPLLDDIGIDVGWRSLVGSPDFFRVTKKFHNALQGEEITLTDMKKRVYEQTNLSFAKFTHIDHDLVIIHDPQPLPLSKFYKRKQPWIWRCHIDLSEPQGEIWEYLRGFILPYNLVVYQMDEFAAQGVSGDYTIMRPSIDPLSVKNKDLPDGTIEKYTQKAGIDRERPLITQVSRFDKWKDPQGVIKVFDLIREEIDCQLLLVGAMATDDPEGQQVYEEVHSLIKDRNDIIVRIGAHDIMVNAIQKSSDVVLQKSIREGFGLSATEALWKKTPVVASNVGGLPAQVKDGETGFLVEPDDYEGAAKKVMDLLTDEDLREEMGENAKQHVKENFLITRHVEDWIDLWTKLLAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V565</accession>
    <name>A0A133V565_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000033">
        <property type="protein sequence ID" value="KXB01583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01583">
        <property type="protein sequence ID" value="KXB01583"/>
        <property type="gene ID" value="AKJ44_02375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.406"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="PTHR40695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="253" mass="27528" checksum="EC35C20F2792CCD7" modified="2016-07-06" version="1">MTEIESDHPRAESLRVREKLVNGFEKGLVVPEGLSAHGRGEAFDYILGEETSNLARKAIETATATLLEAENPVISVNGNTAALVPGEVVELAGEVGAKIEVNLFHRSPEREKLIAEHLISHGASEVLGVEEEFAARIPEIHSDRRKVDERGIKAADVVLVPLEDGDRTEALKELGKTVIAIDLNPMSRTAQAADVTIVDNIVRSLPLMIKEARDLSEVSSNKREGAVWGFDNEQNLGSTINLMLGRLEELSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5F3</accession>
    <name>A0A133V5F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01678">
        <property type="protein sequence ID" value="KXB01678"/>
        <property type="gene ID" value="AKJ44_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="97" mass="11421" checksum="79F1AD0A2A6E30F9" modified="2016-07-06" version="1">MSLEDVAELISPKKPVKIVRLLESFRSGRKPTIQDLMDASQESEKMVRYYLTKMRDHYLIESFQDPKGETRYSLNPMAFKARIESQWVDPLKRLVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5F7</accession>
    <name>A0A133V5F7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01672">
        <property type="protein sequence ID" value="KXB01672"/>
        <property type="gene ID" value="AKJ44_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="123" mass="14105" checksum="1369E6B1566916BD" modified="2016-07-06" version="1">MMEDLDELIWGKKEKRKKKGTRRGSGKRGKKKTKRKSVPQRLQREIAMRSKGRCEFCGTPFEGNAILGTRKVGFHLHHIDGNRANNRKSNLILLCPNCHDMADRGEITKRELKNRISGFGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5K4</accession>
    <name>A0A133V5K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01721">
        <property type="protein sequence ID" value="KXB01721"/>
        <property type="gene ID" value="AKJ44_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="124" mass="14529" checksum="16CEAFF4E1C591EE" modified="2016-07-06" version="1" fragment="single">SQLEFNPTLLRKCTVLDSLTVEGLWFHELKLDRVFNQVSMDTNLANLLTRDSRRSTDFSKVKENAIEFCEEIQVNLTPSEIQAIEQFYDKGEFNPDLITTKNEFHEEIQEYPAITWALQKTRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5S7</accession>
    <name>A0A133V5S7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000027">
        <property type="protein sequence ID" value="KXB01794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01794">
        <property type="protein sequence ID" value="KXB01794"/>
        <property type="gene ID" value="AKJ44_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="424" mass="48383" checksum="D6A084AB52EC1A15" modified="2016-07-06" version="1">MELEIADLDRLSKSKRVYLSQEVFRELVEDLQEKYGSQRKAASTLNIFQSFLSRASNGKRHSTTVGVLLKILRALDRGKASVKRIESPNGYRRRSIAKANAKKRPPDVQFEDVTSKSSVGIILDVLGWLGKCVYVKRLSRLRGVVQLTNVEVDRNVITLKYRVFKRTSSAFLTSTSVLPRFINLDTPTMYFLGLWCGDNAGGGRVGIVNQNLNILKKSAELLVKCFNQPQHHLIGNVMFSSKLDKADKDGYEAALREIGIEKITYTMNEGLRGFPVFTVSVHNSVLRRLLDFLKENLSQIFLDASAEDRGAFYGGLFDAEGNVNFNLHNRELNFRWSVKDEEFASWLVERFQEDGFLPHYDGANVKVGQRKKRRKKEFQCFEKLILPHIIHPKKQSKAQQMLDHVFSLSENIGFNRGTNERNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5X6</accession>
    <name>A0A133V5X6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase</fullName>
            <ecNumber evidence="7">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eno</name>
        <name evidence="12" type="ORF">AKJ44_02140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell surface</location>
        </subcellularLocation>
        <text evidence="7">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000027">
        <property type="protein sequence ID" value="KXB01796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01796">
        <property type="protein sequence ID" value="KXB01796"/>
        <property type="gene ID" value="AKJ44_02140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.325"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="132"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB01796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="416" mass="44680" checksum="E32EDB588E32C69A" modified="2016-07-06" version="1">MGSIRGRKILNSRGDPTIETEVSILGKSGAVTGFGVAAAPSGASTGVHEVIAFPKGGVDKSLESLEDVAQELEGMTFEDLASFDEKCRELDGTKDLSKIGGNTIVALSMAMAKAMASISGGPLYKYLLIGESPRIPYPLGNVLGGGEHAGPTAPDIQEFLALPLGAESFHQAAFGNAKVHKKVKELILKKSKTFTGGKGDEGAWAPNLENQEALEIVAKACEEISEELGFKIKPGLDVAASSLYDEESEKYEYSREEESRDAGEQIDFILELINTYNLTYVEDPIWEEDFKSFAEITKKVGQECLICGDDLFVTNVERIQKGIENNSANAVLIKPNQIGTLTDTRKAVELTKKNVGIPVMSHRSGETPDTTIAHLAVGYGCPIIKTGVVGGERIAKLNELIRVEDELGEEAQMGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5X8</accession>
    <name>A0A133V5X8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N6_Mtase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000026">
        <property type="protein sequence ID" value="KXB01845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01845">
        <property type="protein sequence ID" value="KXB01845"/>
        <property type="gene ID" value="AKJ44_02100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.317"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="347"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="441" mass="51460" checksum="9EDC9AF015AD2EAF" modified="2016-07-06" version="1">MSSEYENIDKSQIEGLVDKYRKVLKNQDQDKFNEEDVKAKFINPLLEALGWDVRGLDQVKFEQTTLTGRTDFGLRLNEEEDPVLFVEAKSFSESLDGYRVKRGKKITYPQQAIDDAWSMKVDWAILTNFKKLRIYYSHVKKPEDGLQFELKFKDFLSDKGLEKLSSLSKESVEAGSLERYEARRTREDVNTEFVNDLYTLRKDLAGAISEKNDLSADEIRESVQRILDRLVVIRVAEDREIIHRESLHKMIEAWETTSIDPSVRTLMKDLKNLFRDFDSVYNSELFDEHMCEDLNIENDTIKETIDTLYNYNFDLIDADVLGSMYENYIGHILEEKEEGVDIKEDYQTRKKSGIYYTPTFVVDFLVDHTLGRMIRDSSGPEEVSKINVLDPACGSGSFLIKAFDYFKDYYESYNRKIQSKAEKSGKLTDYDMITNQQENTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Y3</accession>
    <name>A0A133V5Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01858">
        <property type="protein sequence ID" value="KXB01858"/>
        <property type="gene ID" value="AKJ44_02065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="100" mass="11782" checksum="E68BD78451C457ED" modified="2016-07-06" version="1">MSRYEELKEKTHKLGELSPGTIQERWLTCGNPDCRCARGERHGPYYYFAYPDRKTGKTAQISIPEDVVAGLKARIKNYEKFREELWELVEIEAERMRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V630</accession>
    <name>A0A133V630_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01890">
        <property type="protein sequence ID" value="KXB01890"/>
        <property type="gene ID" value="AKJ44_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="72" mass="8153" checksum="A8F5B6AB1A673B03" modified="2016-07-06" version="1">MLTYTSYLRPLLLVLAPLMIGILARRTKKLDPIFKGIYALVLWAVLPVLVFGSVAIQRPDQMYNLGVQLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V641</accession>
    <name>A0A133V641_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_01935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01903">
        <property type="protein sequence ID" value="KXB01903"/>
        <property type="gene ID" value="AKJ44_01935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="121"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="447" mass="50124" checksum="E7D1CB09F0CCEF10" modified="2016-07-06" version="1">MMGIRLTGDGSKGKGDQGSCRETVGDVVARQENFGGIVFDQRNGLMLELDREAFFFLLNYDKTSNYSEMLRLLEREFRRSFSLGELWRLSKKLFGLGIMSTSLSSQSKEFSESNWPKTEYLSAPETVHLAVTYRCNLECSCCYVEGGDCSEDEMSLGQIRRLVDKLSELRVFQIAIGGGEPFLRSDLPEIVDVIRRRGIIPNITTNGTLLTRTTLEEIADEIGRLKISFESGDISKKIEPVNSAGVPFGINLILTRENIARIEDILSLCSRLGAKDVTLLRPKPSSRDLEWWRAHRPQPAEYVRLGEKLVKLANKFGDIQITVDCALSFLMKGVSLTVLTYHGVYGCSAGERFLFIAPNADVYPCSQFTDTDHLIGNALKEDFADLWNESPVLTKFRKFRENDAFSKTSCGKCRNVINCGGCRVITRENQGDFYGRDPACSQGVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V645</accession>
    <name>A0A133V645_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000024">
        <property type="protein sequence ID" value="KXB01866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01866">
        <property type="protein sequence ID" value="KXB01866"/>
        <property type="gene ID" value="AKJ44_01995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.291"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="159" mass="17747" checksum="11EB27A3FCD4310D" modified="2016-07-06" version="1" fragment="single">EELCQKFNKDQGLDTVCLRYFNVHGPRQTFGPYAGVILKFLKRAKKGKPPIIFGDGKQTRDFVYVQDIVRGTLLALRQKDVGGQIFNIGSGTAISINKLCETILNVTNSTELEPIYKEAKPGDIRHSHADLSKAKEILGFEPKVSLNEGLARLVKKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V665</accession>
    <name>A0A133V665_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Mevalonate kinase</fullName>
            <shortName evidence="11">MK</shortName>
            <shortName evidence="11">MVK</shortName>
            <ecNumber evidence="2 11">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mvk</name>
        <name evidence="14" type="ORF">AKJ44_01795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2 11"/>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01935">
        <property type="protein sequence ID" value="KXB01935"/>
        <property type="gene ID" value="AKJ44_01795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.227"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="99"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="229"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB01935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="322" mass="33306" checksum="D9A08CB2B971DC17" modified="2016-07-06" version="1">MIASAPGQIFLFGEHAVVYSQPALAAPIDLRTRVKSESRDDMRVLVDSEGVGKLEGVVRGKGGQWTIEKKSGDVRELEHVVKAVESTFSHLGDGGGLELEILSDIPVGSGLGSSSAVTTATIAATSAVMGEVLDGEDVSELAFSAEKAVQGPASRTGVSVATQGGFARIQGREMENLEELPPLDIVIGYTGIYGSTAETVRRVKQLRESNPMITNPILETIGAITQAGIQAVKEGDFKKVGALMNANQNLLEGLRVSSEDLDRLITAARGSGALGAKLTGGGGGGSMIALSESDPQGIVEAIKEVGGQPIATEIGVEGLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V683</accession>
    <name>A0A133V683_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_01835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01943">
        <property type="protein sequence ID" value="KXB01943"/>
        <property type="gene ID" value="AKJ44_01835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.235"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="456" mass="48969" checksum="27FF9C33DE698308" modified="2016-07-06" version="1">MFIPVPATLIFHETTLAPLFIIPGAIALTIGILLWRKFEEEKVSLGDAMVLVALAWILISLLGSIPFIFGNGMSFLNAWFESMSGFTATGLTVLQGQSGWIGGVPAQTIMFWRSLSQWIGGLGVIVLFLIVYPGTGKIARKLFKSEAREGRIMPSLKGTTGTILKIYLLFTALGAIGLFLAGMGPFAAINHSMTGIATGGYTTTPNSFAGYTIPIFGIALTIMIFGAISFRTHHKAISNGWHEFFKSIEVKAMLVLIGLATLALAWKVGLVDALFESTSALTGTGFSSTGLIPQTWGSFQKGILTVLMISGGGYGSTSSAIKLIRTIIILGTIYWLIKRAFLPERAVVPLKIGGNVYSEKDVMETATYAFLYFIVLIVGSLIVMLAMPGQGTANVLFESASAQGNVGLSTGITSIAPPIVKIVFIIQMIAGRLEILPVLAFLGFFIKKRPRRRKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V690</accession>
    <name>A0A133V690_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01957">
        <property type="protein sequence ID" value="KXB01957"/>
        <property type="gene ID" value="AKJ44_01765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.219"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="134" mass="15103" checksum="E0F89C386C2A7066" modified="2016-07-06" version="1">MAKASSSTDKSPEEVEELVGELAREGNSPSEIGLILRDQYGVPSVKEATGKKMSEILKSIGESPEVPEDLMSLLRKAVDLHDHLERNPRDSRTSRSLEELESRIHELTKYYKKKGRLPEAWRYSPAAAELLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6B4</accession>
    <name>A0A133V6B4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meth_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01936">
        <property type="protein sequence ID" value="KXB01936"/>
        <property type="gene ID" value="AKJ44_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="327" mass="37303" checksum="84399BDDBB3AC2F9" modified="2016-07-06" version="1">MKILTTNNGSYPRVGDKPGQQKLRQKYRQWEVDEISDEELEETYQEATREVIDEQVQAGLDIVTDGQLRWYDPISHFARKIKGCKINGLLRFFDTNFYFRQPVIKDKISWKEPIVKKEFTTAKEYSPVPVKPVVTGPYTMAKLSINEQYEEFSKLVRDFAKAISKEIDTLAKAGAEEIQVDEPAILKNPGEFKIFQEGVSKIIEEKNGARIALYTYFGDAAPLYGKLARLPIDILGLDFTYSPELPAKIARLGCEKGLGLGLIDGRNTKREDNQEILDTMRTILPNVGSERVYLNPSCGLDYLPRKVALEKLKHMVKIAEKAKEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6D1</accession>
    <name>A0A133V6D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01993">
        <property type="protein sequence ID" value="KXB01993"/>
        <property type="gene ID" value="AKJ44_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="101" mass="11785" checksum="146CECA78E3E3BD2" modified="2016-07-06" version="1">MTTKTQIATRVDKDLLAQIKEIEREMKADRAEVIRRLLDEGIKKRQLDKAVTMLRDGKVTVSKAAEIAGVSIWEMMEVMREKQIPVPYDEEDLRKSLKWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6D3</accession>
    <name>A0A133V6D3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01956">
        <property type="protein sequence ID" value="KXB01956"/>
        <property type="gene ID" value="AKJ44_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="363"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="470" mass="51812" checksum="D81CA2AAA099A02D" modified="2016-07-06" version="1">MVRAEVRRFQRAAEEIAADLKSQLVADVRVKILTHTDTDGISAGNILARCLNYYDIPFHITFTPPLSSSELEELAKEDYDLFFFLDQGTGQISGIEEHLLNTDHKVVILDHHPGEFPDNPGLFHLNPHTHDLNGAKDVSASGVVYSVVKELDERFTPLSEIALIGALGDRQEFFSGFTSVNQEICKQSIDEEILNVKQGLKLVPRTSKISETLLRSIKPYLSGISGGEEAAQKLVENTGLDPNKVLAELDLESEEKLKDAILNQVKVEPTGDFKHALWGTIYTSTVEQTAGPKNAHEYVAMLDACEKLGRPELGFATLFGDEDARDEALEMLREYQEKMVKVLDWFASKRKNFKANPQMRYIDTGNEVESKMIGEALSLAIESSLINPDLPIFGLADFGEDGLKVSARATPDYVMRGPNIGNILGKVSRELGGSGGGHDTAAAARLPRERKDEFITKVSQSLEKAVAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6E6</accession>
    <name>A0A133V6E6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RPOL9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02018">
        <property type="protein sequence ID" value="KXB02018"/>
        <property type="gene ID" value="AKJ44_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPOL9" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="84" mass="9954" checksum="F1D02918C4695AC1" modified="2016-07-06" version="1">MKFCPKCGTVMMPKMKGKSIKLVCSDCGTWRKIKKEEDYKFGEKRQKKAEKIAVVEEGEEKKKRRKEEEFDIDTDAYAELYESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6F4</accession>
    <name>A0A133V6F4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_01595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02021">
        <property type="protein sequence ID" value="KXB02021"/>
        <property type="gene ID" value="AKJ44_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="156"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="3">
        <location>
            <begin position="350"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="473" mass="51908" checksum="C0087820CE5BE850" modified="2016-07-06" version="1">MYLILGCGDVGFTLAKKLREKGEAIRIIEKNPQKVSQLTELGFDTAEGDFTKPETLRDSGIERAEVVLIMASNSEVTERGLGAINQVKLDLGIDPIIIARSTDTLEITDMKEYGAAEVVASSEVLADFTHQKFQEFRERIKERQLRKVLERIEGKMAIILQDNPDPDSISSGLALSIYASAFGVGSDMVYGGQIGHQQNRALVNALNLNLRGAKEVDLENYDAYALVDVSTRGNCALPEKIKPNIIIDHHSVVSEEIEADHKNIVKVGATATLLANYLRYGGIEYDESLATALAFGILTDTLNFTRNASHLDFITFEQLLPLISEDLLKELQSPPVSADTLEVIRKAIRSSRVKGGYLISNVGEVKDHDAITQAADYLLRREGALTTLIYGIEGEKIYVSGRTKDVRLHIGKLMKDIYSKIGSAGGHPTAGGATIPLDAFDETKENMQALRGAMDRAIGRKFWETVGALKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6H3</accession>
    <name>A0A133V6H3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02050">
        <property type="protein sequence ID" value="KXB02050"/>
        <property type="gene ID" value="AKJ44_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="63" mass="7593" checksum="DB269E0FF6812CCF" modified="2016-07-06" version="1">MEEERKLPRPHPSPYFYWMKYSKFVKGGFTQFRNPLMDKDTGFSENPVEIQDGLDFEWGNLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6H4</accession>
    <name>A0A133V6H4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02041">
        <property type="protein sequence ID" value="KXB02041"/>
        <property type="gene ID" value="AKJ44_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="174" mass="19212" checksum="9D66ED0BF9E52AB1" modified="2016-07-06" version="1">MEPLIHFAIPFAILTMLGIRPKVAIPVSLLALVPDMDVFFGIHKWFLHSIIILIPLGIGLSIVFLLRRTGLRNYAPLGLLAMLSHPVLDVFWNYTPILWPVYGESIWINLGINLQAGSSLGIGHNVGVLTQPTSFEAFTTLDAPLVTGAGLIIFVLLVILPVLLMEIRGRRSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6I3</accession>
    <name>A0A133V6I3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5678 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02043">
        <property type="protein sequence ID" value="KXB02043"/>
        <property type="gene ID" value="AKJ44_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043734">
        <property type="entry name" value="DUF5678"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18929">
        <property type="entry name" value="DUF5678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5678" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="73" mass="8344" checksum="1FB8E9F8D2AC1F12" modified="2016-07-06" version="1">MSETKGMLSQYLETERKFEGKWFALKGGELIALADTNGELWGKLRELDARDVLIGYAPTKAEREADCLYVIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6I5</accession>
    <name>A0A133V6I5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS</name>
        <name evidence="3" type="ORF">AKJ44_01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02016">
        <property type="protein sequence ID" value="KXB02016"/>
        <property type="gene ID" value="AKJ44_01570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.173"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="269" mass="31130" checksum="CC053F3EFFE92AC1" modified="2016-07-06" version="1">MDLQRIPVERLPGIRELRKLARDYYEKRLLAKVKNNGNLPQHVAVILDGNRRYAEEVGIPRKDGHILGAEKLDEVLEWCQELGIRHMTVYAFSKDNFNRSSQEVGELMKLFKQKFMKVAKDDRIHRKKIRIRAIGDLKSLPEEVRSAIREAEESTKDYDDYSLNIAVGYGGRAELAKAVQKICERVKDGDIEPREVNENIIGDHLYTAGLPDPDLIIRTSGEERLSGFLLWQAAYSELYFCEANWPGFDKINFLRAISTYQSRERRFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6J4</accession>
    <name>A0A133V6J4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02026">
        <property type="protein sequence ID" value="KXB02026"/>
        <property type="gene ID" value="AKJ44_01625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.183"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="190" mass="21547" checksum="1DCB3BFDB3322F76" modified="2016-07-06" version="1">MMLDQDFYERDTATVARELLGKTLTHKTPEGVTSGRIVETEAYYGKGDPASRASKKKTKLNELMWERGGLAFVYVVHGHELFNVTTEREDVPGAVLIRALDPIKGIKQMQKRRPVPKLQLTSGPGKLTQAMGIKRKHHKLNLTDPKSKLTIVASKHSPEFEIGKSHRIGVTEDLKRDLRFFIRKNPYVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6K8</accession>
    <name>A0A133V6K8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02074">
        <property type="protein sequence ID" value="KXB02074"/>
        <property type="gene ID" value="AKJ44_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="163"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="334" mass="39119" checksum="8C6F2FCDB3351D90" modified="2016-07-06" version="1">MGKYKVTCLEKDEYERWNEFVDKSPQGTIFHKTYWLETLGNNFEVYKCLKGQETVGGVPVNYTQLKSLKIAHPPKFTPYGGPIFRKEMGKYVSKISTRKKANKALIKKLKENFSVVYNWNTSPNTEDLQPFIWEGFSTELKYTYVLPLNDLDIIWENMDRGRRKDIRKGLENEELYVEIGNDFEELYTLVEKAYSRKEKNPIDRGIARNIDEIVRERNRCKTFIVKNKESLPLAGIYIIWDEKRAYQLLSGFDPENSPREANPLAIWKAIEFTNNEISPTEYDFEGSMIPGIEQYFRSFGGKLIPIFQLNWAVSSILLKLLGNDFLRKIIKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6R6</accession>
    <name>A0A133V6R6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02127">
        <property type="protein sequence ID" value="KXB02127"/>
        <property type="gene ID" value="AKJ44_01355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="81" mass="9397" checksum="044C7FD0F75E3CE7" modified="2016-07-06" version="1">MMASEYNGMDIYSDRGNYVGEVREVVLDIDQGKVAGLSIERRGEKHRMIPYENVMAVSDIILVESREHVFHRPEKTKERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6U9</accession>
    <name>A0A133V6U9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0216 protein AKJ44_01190</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0216 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02168">
        <property type="protein sequence ID" value="KXB02168"/>
        <property type="gene ID" value="AKJ44_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00585">
        <property type="entry name" value="UPF0216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002746">
        <property type="entry name" value="UPF0216"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01886">
        <property type="entry name" value="DUF61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005264">
        <property type="entry name" value="UCP005264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="138" mass="16220" checksum="2A7674EBCC64C6A0" modified="2016-07-06" version="1">MKEDRFLRKQIQTLNRHLPKRRASLAKLLKEEKPQVTARDKTTHRFKKQELKYLAELLPKDLHKRLRLPIIIRISPQLGRGAAKISGKIERTVIEKILEKEKSEEDELVIYRPEVRIVRKKLPTTTQYAFMISTGAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6W0</accession>
    <name>A0A133V6W0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02179">
        <property type="protein sequence ID" value="KXB02179"/>
        <property type="gene ID" value="AKJ44_01245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="118" mass="13301" checksum="F1EDC13A9F6B1CBC" modified="2016-07-06" version="1">MDWLAVLMPGEFLARRYDPSYLKFAMKAKNRGTIAKIAAIMEYAFVVMVGLISGIFSFYWPILVLLAAYPFVVIGEPWVWRKYYGEIAEGVGVTGAFLANLDMLYLFTIGYLVGVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6W1</accession>
    <name>A0A133V6W1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02146">
        <property type="protein sequence ID" value="KXB02146"/>
        <property type="gene ID" value="AKJ44_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="78" mass="8950" checksum="DECED67EDE26E59F" modified="2016-07-06" version="1">MIASKYYGMDIYSDGGNYVGEVREVVLDIDEGKVAGLSFERRGEKQRMIPYENVMAVGDVILVESREQVFQRAEKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6W2</accession>
    <name>A0A133V6W2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpF</name>
        <name evidence="7" type="ORF">AKJ44_01210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02172">
        <property type="protein sequence ID" value="KXB02172"/>
        <property type="gene ID" value="AKJ44_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="106" mass="12003" checksum="5C1B10444CA8B5D3" modified="2016-07-06" version="1">MEIASITDPTTAIGLRLAGVREAHEVEDWREAEEIFEEMLEEREVGIIILTERLAQKMGEKVLELKEERGITPIIVEIPDKEGALPERAEAVREIVKRAVGVEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6X5</accession>
    <name>A0A133V6X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02199">
        <property type="protein sequence ID" value="KXB02199"/>
        <property type="gene ID" value="AKJ44_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="126" mass="14082" checksum="775E78C8976361DD" modified="2016-07-06" version="1" fragment="single">SSLVIEKLEDALKEWGARLVVVTGLAFIFMNSDIPQREAVKLFEPVAEELENFSRRDPVFFLASGFLSGVEESEILSKLISVADVVLEARDRGQNIRVKLEKHPSKSPQKTILAPPNTWSCSTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V700</accession>
    <name>A0A133V700_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02203">
        <property type="protein sequence ID" value="KXB02203"/>
        <property type="gene ID" value="AKJ44_01100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="209" mass="23430" checksum="8EFD5A70AFAD591A" modified="2016-07-06" version="1">MVKLDEESVRDLLEEIGGALRKKITLYLLGGGVMVLRGLKEDTVDLDFIAKLNTDREAVVEVLKKLGFRSRLAGARFERQQAGALERVEIDVGRFMNVPLTDGARSRAEPEKYGDLEVKLLSNEDVFLFKSVTGRGKDLSDLSSLKSARPNWDIIRNESTKMERMGVSKVSPRIVAITLQHLDVEESVIKKFKDVSEVERTPNPTSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V719</accession>
    <name>A0A133V719_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02240">
        <property type="protein sequence ID" value="KXB02240"/>
        <property type="gene ID" value="AKJ44_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="127" mass="15002" checksum="FD27EA58391A61A7" modified="2016-07-06" version="1">MDKKQVKKDFEFLKGDERVLGVLVFGSQITGRTHERSDIDVCIVAPDTDPWGVLKQVFSKIDTEKKNYDVHVFEEFTLRLKHYVMENYETLWTRDKSELETYFYFYRKLWSDQAKARGVAASPTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V743</accession>
    <name>A0A133V743_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MgtE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_00895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02260">
        <property type="protein sequence ID" value="KXB02260"/>
        <property type="gene ID" value="AKJ44_00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="48"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="185" mass="19426" checksum="0C140BBC0C0AFB5A" modified="2016-07-06" version="1">MADVTARNIVGQALPILLLCVLIEVGAGLVLGGMEENFKLLPGLIVLVPPLLGLRGNISGALASRLGTALHQGVLDPRFLWGPEMRVNVFSSFFLTLLVSASAGILAWLVTLLVGIESVSLFTFLAIAIIAGILSSFILIGLTIGIAFMSYAKGFDPDNVTSPLMASIGDIFTIICIYISVLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V745</accession>
    <name>A0A133V745_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02262">
        <property type="protein sequence ID" value="KXB02262"/>
        <property type="gene ID" value="AKJ44_00905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.614"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="300"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="395" mass="44632" checksum="BEA0C82893B0219C" modified="2016-07-06" version="1">MSEEYESRNVRELLTEMKDVSDITIDLAYASLQLENEELAEQVIELEELMDELMYQIRTLVSLSVRSVDDAERTTGILQVADAAEEISNATGDLADIVLRDIEVHPVIKSALKKANEKLSQVKARKDSEIDGKTFHELKLPSRLGVWVLAIQRGEKWKIAPTQEAKVKAGDLLIIRGPQEGIDTFCEMASAPERDWRIGKRYRRLKETLARMRDTGCLMVDMAYSSALFKSVEVAEEVREVEEQYDELNYAVWREVLKAAKREKDVTKLNSVLQVVKCIERLTDAADSIVDVVLRGVELHPVFEQALEEADERISRVKISKKSPLADRTLGKLDLWSRIGAYVLVIKRGKDYKFNPTKGVTVRAGDFLIIRGSTLGVEELERVAAGKTKLPLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V750</accession>
    <name>A0A133V750_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02275">
        <property type="protein sequence ID" value="KXB02275"/>
        <property type="gene ID" value="AKJ44_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="77"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="391" mass="44220" checksum="50E06DE82185F71C" modified="2016-07-06" version="1">MISTMKGPIAMSDHENLEYKLVEIAEKIKSQGKKRRALAKILRRVKDELELPIDEENQEVTETKLVTRTGLDPLNDDTIAGVDGGVLARPLHGLDLILVRAIATIFHYEDESLKQAEYHPSEMPWPELMSIHEPLDSREFELLVGMYRQLTELKRAKEAIENWSIDTLLLDGSIVPQYTSHASKSRTRELYRELVDSFTNLYQTCVKKNVLLLGVVKDSRSARLIDIFQGKILSDIDAGTNLSSNEIASLEDNRSVLLDSRDTVFLDHLLDPGERSFVFRYADAPANLLRDIGDWRNQIHAFYVKTVPYDRPLRIEFVSTPENVSQTADGASSLIRALSAHHDACALPSVLIEADACARLAQEEISMIRDSITDRLEPSTLLDLRRERGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V752</accession>
    <name>A0A133V752_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02264">
        <property type="protein sequence ID" value="KXB02264"/>
        <property type="gene ID" value="AKJ44_00915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="181" mass="19948" checksum="9C668E3D8DA2BD4B" modified="2016-07-06" version="1">MLELNGPFGRRVLAITGAHAHVEDVESVIRKVRKISRANEVVSQIFNAKHIAGRQHLIHAARLALIAQEEGRNFADSQSIELTCWTAGLRQINQALERVGLRKGSAEVAILTIGGKVEKVKKAREEILHELGAKQGEGVLDLTPEKEPTLIRDFGISESELEVANLQSLVLERVALLSLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V765</accession>
    <name>A0A133V765_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02263">
        <property type="protein sequence ID" value="KXB02263"/>
        <property type="gene ID" value="AKJ44_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="170" mass="18926" checksum="82C7EC36D8F32D68" modified="2016-07-06" version="1">MAKLIVTSRGLEAAPQTLRVIKDAFPDAEVGRTGFRGVITMDAEGDALKLAEHVYQECFVDIGRAVAIFSEVESTREEVEEAAVRIGEENIERGESFCFRLYKRGSHQFEKDTPELEEKIGGAIWEVLEEKRGEEPEVDLETPSVTIDAEVLGSKTAVGVLRREWEVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V775</accession>
    <name>A0A133V775_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02305">
        <property type="protein sequence ID" value="KXB02305"/>
        <property type="gene ID" value="AKJ44_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="230" mass="26362" checksum="B199FFF5F9C65969" modified="2016-07-06" version="1">MVTVEEAVIARLSTHGEDFEVLVDPELVLDYRAGEEVDLREILASEKVFKDSKKGKKASEERMEELFETSDPIKVAEKIIKKGKIQVTTEQRHQMRDQRRKQIISLIARRSIDPQSDRPHPPNRIENALDQTSVQIDPFKSAEEQLSEVVEALRPIIPLKFETRRIAIKIPPKYAGKAYRIVDESAEIKKDEWLDDGSWAVVVEIPAGTQPEFFEKLNNFTQGEVETKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V779</accession>
    <name>A0A133V779_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosomal protein S1e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="5" type="ORF">AKJ44_00860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02315">
        <property type="protein sequence ID" value="KXB02315"/>
        <property type="gene ID" value="AKJ44_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="30S_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_S3Ae_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="190" mass="21919" checksum="C3B4329005D8A772" modified="2016-07-06" version="1">MARAKGRDSWRLKKWYEIVASPMFGSQKIGETIAADPEQLKGRVLEVTLRDLIDDYSKSHVKLYFKVTRVEGERAITEFVSHDMARGYIRSQVRRRATKVDCRTDVTTANGKKLRITAMVISLRRVQSSHIDSIHSKMEETIQERAKKLEFDQLVQEIALGKLASDIYKRVKEICPIRRVEVKKSKVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V786</accession>
    <name>A0A133V786_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02276">
        <property type="protein sequence ID" value="KXB02276"/>
        <property type="gene ID" value="AKJ44_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="115" mass="13070" checksum="7F4B205F99EADDAC" modified="2016-07-06" version="1" fragment="single">GEVEDVRFGGGVDAPELHPQEPGGEEAKNLVSELCPTGMQVYLDLDDLADENPGSAGPFRDKYERLVAVIYVQKDNSWINVNAKVLKWGQQEYPNHDWLKYSYIIRSLTRMWMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V789</accession>
    <name>A0A133V789_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_00830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02311">
        <property type="protein sequence ID" value="KXB02311"/>
        <property type="gene ID" value="AKJ44_00830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.556"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="185" mass="21428" checksum="793FB89E031E8AF7" modified="2016-07-06" version="1">MRKSTRKLKSEKSEEILKRRMREWRKGPAIERVKKPSKIERARKLGYKEKEGVVVARARVRSGGRRKSRPSLGRRPKRMGVRKITPKKSIQRIAEERTARKFPNLEVLNSYPIGKDGKYHYFESILIDPNHPAITSDPDLSWVSNSSQRGRAYRGLTSEGKKTRGLRKKGKGSEKNRPSQRSARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7A3</accession>
    <name>A0A133V7A3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp41</name>
        <name evidence="9" type="ORF">AKJ44_00790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02320">
        <property type="protein sequence ID" value="KXB02320"/>
        <property type="gene ID" value="AKJ44_00790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.548"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="7">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="8">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="240" mass="26609" checksum="2A33BA474246194F" modified="2016-07-06" version="1">MEEPEQLITDGKRIDDRKPEEMRPLKIEAGVLKKADGSAYLELGKNKVLAAVYGPRELHPRHLQRPDRAVLTCRYDMAPFSVEERARPGPSRRSREISKVSREALEPALFLQKYPRAGIEVSMEILQAGAGTRTAGISAASVALADAGIPMRDLVASLAAGKADDTIVLDLGKEEDQLGEADMPIAYMPQKEQITLLQMDGNFSPDEFDEALELAIEGCKQVYEKQREALSKKYAKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7B5</accession>
    <name>A0A133V7B5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02349">
        <property type="protein sequence ID" value="KXB02349"/>
        <property type="gene ID" value="AKJ44_00735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="262" mass="30210" checksum="C84CA357C204BF93" modified="2016-07-06" version="1">MVKLFDLSQPLNQDAPFWPYYPPFEVKYIKRKPEHGVNAQYIMTSNHIGTHLDAPRHFKTNGMTIDEIPLDWLYRDGVIVDLTDEMDDLAAYTPGMIEERADVQKGDILILHTGWHKYAQFGDEADEERYIHLHPGAHPDMVDWLIEKEIQIWGVDAVSTDHPMDLPIGRFLGKGTFGHCDRVRAKAIEKFGEEKVEELFPEEDYQLTHNKLFPHDIMHVENLGGEISAPEIQNKRMKIGVFPWKFKGGEAAFARVVAFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7B9</accession>
    <name>A0A133V7B9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02341">
        <property type="protein sequence ID" value="KXB02341"/>
        <property type="gene ID" value="AKJ44_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="190" mass="21474" checksum="0E39410A7CADEA65" modified="2016-07-06" version="1">MIGTVILAAGESKRMGRPKLLLEVKGERVIDRVVNSFKDVADEVVVVLGHEPENLIPILGELEVRWEINEEYQEGMVSSIKTGVKTLKDCEALFLALGDQSIIKQDFLNAAIGAWKNGAKLVSPIHEDKKGHPVLFDQSLFEEILSLKREETLRKVIHEHDEDHELIDAGKWAIMDFDTPEDYQAVKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7E9</accession>
    <name>A0A133V7E9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="6" type="ORF">AKJ44_00570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribosomal protein L31e family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02378">
        <property type="protein sequence ID" value="KXB02378"/>
        <property type="gene ID" value="AKJ44_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="83" mass="9486" checksum="4D0D558070BB33C6" modified="2016-07-06" version="1">MPEEQVYTIPLKDARKTQKQKRAARAAKLVKEFLKRHMKSEIVNLDQELNNQLWKHSAGNPPPKIRVKAIRQDDGAVLASLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7F4</accession>
    <name>A0A133V7F4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02346">
        <property type="protein sequence ID" value="KXB02346"/>
        <property type="gene ID" value="AKJ44_00720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.474"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="776" mass="85228" checksum="37BE1F9333E342A3" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G1</accession>
    <name>A0A133V7G1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02385">
        <property type="protein sequence ID" value="KXB02385"/>
        <property type="gene ID" value="AKJ44_00620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="328"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="442" mass="46709" checksum="4E1B2CD5F0949772" modified="2016-07-06" version="1">MDHIVIIGFESAGITAASAARTTNQDVKITAVERQPYAIYHPCAIPSAIEGTIKDMEDLIEPAPKMPNVEVRTSTEATGINPDDQTVELKTDGGTEELEYDSLIISTGSNAIKPPITGRDLDGVHVLKTIEDGQAIINEIGKAENAVVVGGGCIGIEAAAALNERGLNVSIVEMLPSLLPGLLDSDMVKTVSERLEDMGIKVYRGTRVEEILGDDRVKSVSIGEEELPAELVILAVGVEPEVELAKNAGIEIGETGGIKTDQHTCTSIDEIYAAGDCAESFSPITNRPILSQFATTAIRMGKVAGTNAAGGSASYLGSLNTAVTWAYGLEIAATGVTTKAAEEAGFQPVSARTRVSSKPHYYPGAKPITTKITVEPEQHKIISGQIIGTEGASERANLLALAIQKETTIEELAKSDYCYSPPINDCIGPLVVTAETLIRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G7</accession>
    <name>A0A133V7G7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02347">
        <property type="protein sequence ID" value="KXB02347"/>
        <property type="gene ID" value="AKJ44_00725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.475"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="287" mass="30665" checksum="248B3164E9DCFC62" modified="2016-07-06" version="1">MPLPEFDYLKPKLVDEVADILAEHGGNAKILAGGTDLMPDLRARISSPKLIVDIKGIQEMNGLSYDKENGLKIGAGVTLKELVESEVVREKFGVLWSALSQLADPIVRNRATLTGNICTASPAGDSSPALLVLDAEVEAVSKGTERTIPIHDFFTGVKRTSLGENEFVKAIRIPTPPEDAVGEYMKWTRTRGEDLAVVGVAALVTGDRNGDLRIALSSVAPIPLYVEGAENVLKQGGSLKEKIEKAVSIVKGGISPITDVRCCKGYRLHMAGVLTKRVLTKLLAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7I7</accession>
    <name>A0A133V7I7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="2">6.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_00455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02419">
        <property type="protein sequence ID" value="KXB02419"/>
        <property type="gene ID" value="AKJ44_00455"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="7">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="224" mass="25366" checksum="7F0D38667A91069C" modified="2016-07-06" version="1">MEVVYEGKTKIVLKSNDEWFLEFKDSVTGDDSGNIDSGGNRVVDELEGKAEATAKTATHFFQMVNEEDVSTHFVELSSPTRIQIIPTERIPLEVIYRKSAYGSFLSRYGDYVDPMEELNLIEFNLKDDELGDPLLTEESVIRLKIASTEDIQQMKRITREVANLIQSDLGEHGLDLIDMKLEFGRSDGGLRVVDEISGDTMRVRDLETGQMLNQIELAERLELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7I9</accession>
    <name>A0A133V7I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02386">
        <property type="protein sequence ID" value="KXB02386"/>
        <property type="gene ID" value="AKJ44_00625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.376"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="6">
        <location>
            <begin position="146"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="304" mass="33521" checksum="DB875E0C7E4D502A" modified="2016-07-06" version="1">MIKIGIVGGAGKLGAMIGHNIAAERLADEIVLIDLLEEKAEAQAHDISHSIAWEQDVEVYQGDYENAEDADLFIITAGEPREPGMSRLDLIDANKGIMKDIAEKISEVAPETITITTTNPTDMMNFALYHYGNRSRQKTIGEAGMLDSARFRYALSQKFDVGMTNVEAYIIGEHGDSQVPLFSQVKVQGEEKTIKSEKEREEILNSLRKSAMSVIEDKGATIFGPARGVTLMIDSILNDKKKVYPCSVIPDGEYGLTDGSIGLPTKLGSNGVEEIVEWKISEEEKKMLTDSHEKILEICQEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7J8</accession>
    <name>A0A133V7J8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02396">
        <property type="protein sequence ID" value="KXB02396"/>
        <property type="gene ID" value="AKJ44_00605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="79" mass="9345" checksum="812AEB0499D5494B" modified="2016-07-06" version="1">MKEIRESAEEIVDSFKEVTKDLPKEEETYYGQDTLNVMRQDQSPSPKEEREEFERGFKKIMPESDEDGNLKVEVGEWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7K9</accession>
    <name>A0A133V7K9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ade</name>
        <name evidence="8" type="ORF">AKJ44_00465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02421">
        <property type="protein sequence ID" value="KXB02421"/>
        <property type="gene ID" value="AKJ44_00465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.240"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="78"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="423"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="597" mass="64694" checksum="3DE772D7B18D7387" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7L8</accession>
    <name>A0A133V7L8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02426">
        <property type="protein sequence ID" value="KXB02426"/>
        <property type="gene ID" value="AKJ44_00515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="152" mass="17730" checksum="72D0709AF1D4DC6E" modified="2016-07-06" version="1">MPALRFRVKSAWNPRGLWRDIVIGENRTLEDLHRGINHGFGLDFDHLWFFARGQKYWGSGARFVHPVELEEAYYDEWPGVRGEARDAGETPLSDLNLKVRDRLSYLFDYGGEWRFYMILKGEIEDEPSDKEPEVVKGEGEKIENQYGPGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7N2</accession>
    <name>A0A133V7N2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02432">
        <property type="protein sequence ID" value="KXB02432"/>
        <property type="gene ID" value="AKJ44_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="358" mass="37935" checksum="AE6345186E506DD5" modified="2016-07-06" version="1">MKLRKRRVASIWTKLGIAALSICLAILITSIMLILMGFNPANVYWKLFVGAFGTASGLLRTVTKTIPLLLVSLGLAIAFRAKAWNIGAPGQMAIGAIAGGGVALFLLPNLPSYLLIPLIFIAGFLSGAGLAAICAILNDKIGLDMVISTLLLNYVMFKLLNYLLYGPWQTEAAFPYTETIPTSAQLPTLAGTDFHYPTLILGIATMVALYVFLTRSSWGYEIRVFGENPQASNYAGISSFKVLVLVMMISGGLAGLAGAGEVMGVHHMLRRGITGAGAVYAASYGYTAIFIAWLGRNHPIGAGLASFFVAGILVGGQNLQAEVAGLPYAMVSVILGLMLLLLMAGEFLIRHRIEFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7N3</accession>
    <name>A0A133V7N3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="4">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="4">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">folD</name>
        <name evidence="7" type="ORF">AKJ44_00270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="4"/>
    <dbReference type="EC" id="3.5.4.9" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02459">
        <property type="protein sequence ID" value="KXB02459"/>
        <property type="gene ID" value="AKJ44_00270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.57"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="6">
        <location>
            <begin position="120"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="282" mass="30839" checksum="0DD2A4DA2A84154D" modified="2016-07-06" version="1">MMAVVMDGKELAQVIKKNIMGQVESSDITPCAASVLVGDEPSSKKYVELKGKDCRSVGINFQTHQLPKGVSEEELLGLIDELNEDSEIHGIIIQLPLPQKLSAEKAIMRVDPAKDVDGLHPYNVGKLWLGDYELERDLVPSTPKGIMEFLEHYDVEIQGKEAVIINRSNLVGKPLAKLLLDKNATVTTCHSKTKNIEEHTKRADILVSAVGSRPEFQITEDMVKEGAVVVDVGMSYINDKLYGDVDFEEVKGKTSHITPMPGGVGPMTRVALLQNILIAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P0</accession>
    <name>A0A133V7P0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02468">
        <property type="protein sequence ID" value="KXB02468"/>
        <property type="gene ID" value="AKJ44_00315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="78" mass="8940" checksum="D3C11F5167BE43B7" modified="2016-07-06" version="1">MAKKRKKRGKFTSVSIPVELFDKVKEHVEKTGFPSVSSYVGYLLREVLVEAHETGEMPFAREDAEKIRERLRALGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P2</accession>
    <name>A0A133V7P2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02470">
        <property type="protein sequence ID" value="KXB02470"/>
        <property type="gene ID" value="AKJ44_00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="242" mass="28468" checksum="7BBE32D335D7A7B4" modified="2016-07-06" version="1">MVVVFAIDALEHELVEEFDCKNLKGVTYGKTDISEFNQPRTMVLWSSFMTGENKEEEILAKGDEEMWKTKIPLEETFFSNFENPKIIDLPGFSYDRKQHDKERELLKKFFEEAEDQEEKKEIRKEYNQHGLKHHRKIKDEFLNSLEKDHDFVLGYFSAADVIGHLNFCNKTLMKMIYNDLDEIAGKIKEIRDDHLLVLSDHGMEGVGMFGDHNEYGFWSFDEECDLENPKITDFADFLTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q1</accession>
    <name>A0A133V7Q1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LAGLIDADG_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02478">
        <property type="protein sequence ID" value="KXB02478"/>
        <property type="gene ID" value="AKJ44_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAGLIDADG_2" evidence="1">
        <location>
            <begin position="176"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="278" mass="31754" checksum="458B127450749FF8" modified="2016-07-06" version="1">MKAISHRLASRVKHLRRNGFSYKEIAEKLPVSVGTSYNYAKDVKVMPAGMKRLKSRQGNGRPPKEVSIVKELTVEKTRIISHCLFDVSVIINNGDYVVKYTNASHGLIRQFVSGMRKIYGMSPGDIRLYQGKNHPWWEVMYRSKRVVEDLLRYSPTYSTSNSVGLPKGIARKRKFIQTFLRAFWDDEGCIAQSGALTLYSNSRRLILDAKQLHEKLGIRCSVYRKKSCFVLRVKGGLENLRRFQRKVGFTESIIVRGKAIGSKKRAVLANFLASYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q5</accession>
    <name>A0A133V7Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02481">
        <property type="protein sequence ID" value="KXB02481"/>
        <property type="gene ID" value="AKJ44_00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026453">
        <property type="entry name" value="PGF_pre_PGF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04213">
        <property type="entry name" value="PGF_pre_PGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="253" mass="27428" checksum="F4BD837D1D4B49F6" modified="2016-07-06" version="1">MRLKTLKYRITRGQKLECGCAPMKDPATIPGEGILLPTPRILFKKASGTQDAFSWPTPASKFMALLITFSLVVGMMLVFTPSASAAPGDTSENIGATMKSGENQHGYSLILLGSTITRVQFFVSHKTPRAEINVRELEGPPIGVENLPPAAQSFFEITTNLEENYEILSATIEFKVPKSWVEQNGASENSVKLLRLNGKWQELPTTLVDESPSYLYYEAQSPGFSIFAISAEGVPPPSPGLPLALYATVAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7R8</accession>
    <name>A0A133V7R8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <ecNumber evidence="4">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02489">
        <property type="protein sequence ID" value="KXB02489"/>
        <property type="gene ID" value="AKJ44_00365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.75"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="119" mass="12941" checksum="3B49ABC4B618D9F4" modified="2016-07-06" version="1">MLDYAKRHADFLEAEVVEELVVPGAFELPIAAKKLASNENIDAVIALGAVIEGDTQHDEIVMMHASRKLMDLSIESGKPIALGVSGPGETRLQALERVNEYARRAVEAAVKTVKRTSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7S2</accession>
    <name>A0A133V7S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_00345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02472">
        <property type="protein sequence ID" value="KXB02472"/>
        <property type="gene ID" value="AKJ44_00345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.71"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="340" mass="38573" checksum="446AF84AD319EF62" modified="2016-07-06" version="1">MKKPAKYWEEMPDNNVRCTLCPRKCVITPGKIGYCQARKNENGELFTMVYGEATSLTPDPIEKKPLYHFYPGTRVFSMSTAGCNFECKHCQNWTISQSSVEEIGTEQVTPEQVVEYTQRSDSQGVAYTYGEPAIWFEFCLDAAKLVHKAGLYNVYVANGYMELDAWKEIKPYLDAMNVDVKAFDDEFYQKVCGAPSVQPVLDTCEWAVENGVHLEVTNLVIPGENDDPEQIRELCQWVANDLNPSVPIHFSRFHPMYKMMDKSSTPVETLEKALKIAKEEGLKHVYIGNVPSHEADNTYCPKCGELLIRRRGFSVSEYKLEDHNCPKCGAEINIVGEYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7U2</accession>
    <name>A0A133V7U2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02530">
        <property type="protein sequence ID" value="KXB02530"/>
        <property type="gene ID" value="AKJ44_00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rho_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="126" mass="14234" checksum="457E80C0324D01C7" modified="2016-07-06" version="1">MPTKRELLEEKTVKELKQMAKDKDLSGYSTKRKSGLIDMIEKNYTKSEIESWPWVERKARPKEVELGELELEGKLAEWPPSAEAAGETGEATGKASEEEEALKRIIIGTIIGLILVMIIIVVFYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7U4</accession>
    <name>A0A133V7U4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02518">
        <property type="protein sequence ID" value="KXB02518"/>
        <property type="gene ID" value="AKJ44_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029291">
        <property type="entry name" value="Tfx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004645">
        <property type="entry name" value="Tfx_DNA-bd_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018384">
        <property type="entry name" value="Tfx_DNA-bd_euryarc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036657">
        <property type="entry name" value="Tfx_DNA-bd_sf_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14601">
        <property type="entry name" value="TFX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004932">
        <property type="entry name" value="DNA_bind_Tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89915">
        <property type="entry name" value="SSF89915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00721">
        <property type="entry name" value="tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="141" mass="15241" checksum="22EFA2FE39825493" modified="2016-07-06" version="1">MRLNTMTGENTFLTETQVKILKLRNSGLTQAEIARKLGTSRANICSIEQRAKRNIKRAKETLALAEKIKAPASIMIEAGEDILDAAKRLFKAADGADLKVSLDTPGLVSEIKTQAGEKLDGRIASEKISLVLTSDGDVMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V1</accession>
    <name>A0A133V7V1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc-hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02528">
        <property type="protein sequence ID" value="KXB02528"/>
        <property type="gene ID" value="AKJ44_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="6">
        <location>
            <begin position="360"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="796" mass="92503" checksum="CC6AF428FDCEAF15" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7X1</accession>
    <name>A0A133V7X1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02526">
        <property type="protein sequence ID" value="KXB02526"/>
        <property type="gene ID" value="AKJ44_00130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.28"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018716">
        <property type="entry name" value="DUF2240"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09999">
        <property type="entry name" value="DUF2240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OB" evidence="3">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="3">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="3">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="3">
        <location>
            <begin position="428"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Rep_fac-A_C" evidence="4">
        <location>
            <begin position="547"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="691" mass="76986" checksum="6E04CB2DE29365B6" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7X2</accession>
    <name>A0A133V7X2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02533">
        <property type="protein sequence ID" value="KXB02533"/>
        <property type="gene ID" value="AKJ44_00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="362" mass="37836" checksum="2496A9D0162A7AB5" modified="2016-07-06" version="1">MVDLSVNLCGLELRNPILPAAGPTSRDGDTLLTAANNGAGGLVSKTVSLEPAEVPRPNMAKVKNGLLNCETWSEIPLKKWLSEEYPKAKKSGLSLIASIGYTAEEIGEIAPQVMEAGADALELSTHYLGHDPSPVVESVKAAKSKVDAPVLVKLSPHVLDITEFASAAEEAGADGIVAINTVGPCLSIDVNTGHPVLGSENGYGWLSGPAIKPLALRCVADIARTVDIPVVGVGGISKERDVVEFLMAGATAVELCTAAITRGPKIYGLIADGLSKFMRSKKYNSVADFQGEALKHMPEEPLRTKSKPPEILTSRCTGCGLCAKHCTFGAVKIVGGKAKIDPTKCTGCGLCVSVCPPRALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Y5</accession>
    <name>A0A133V7Y5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Replication factor C small subunit</fullName>
            <shortName evidence="6">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfcS</name>
        <name evidence="8" type="ORF">AKJ44_00220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02546">
        <property type="protein sequence ID" value="KXB02546"/>
        <property type="gene ID" value="AKJ44_00220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.47"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="35"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="320" mass="36331" checksum="6EC19A2E9C50FF26" modified="2016-07-06" version="1">MEEIWVEKYRPIELSKIEGQDNITERLETFVEKKSLPHLLFAGPPGNGKTTAALCIARELFGENWQRNFLELNASDERGIDTIRTRVKDYARTRPIGDFPYKIIYLDESDALTSQAQHALRRTMEMYAETCRFILACNYSSKIIEPIQSRCAVFRFKRLADEDIEKVLETIAKSEDIKLTKGGIKAIIYVSRGDMRRAINVLQAASALGEKISKKVVYDVSAEASPDEVKDMVELALDGKFEDARDKLLDLLIDRGLAGDDILQQMHREAFNLDIPEPVKIKLVDRIGEFEFRLVEGANERIQLEAALAHVALIGNRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Y8</accession>
    <name>A0A133V7Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02532">
        <property type="protein sequence ID" value="KXB02532"/>
        <property type="gene ID" value="AKJ44_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="192" mass="21431" checksum="28F356D6A0E8D3D4" modified="2016-07-06" version="1">MWAEVSVILLAIIILLLAWIYFSGGGTPHTLKLKREINSLQEEVENLRETNKVLRSGMDSSKKEYQHPVVRASALVENLERLKDSLKGSKAAKDALKEKFEEEPNPDLVDRILSSEPNISSPLKRRLAHEVLVGDSGRDILRRLEEGATIEDAVAEAGIPLNTGRQKIVILQRLGYLDSKLNLTETGREALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Z5</accession>
    <name>A0A133V7Z5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="7">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">top6A</name>
        <name evidence="9" type="ORF">AKJ44_00050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02517">
        <property type="protein sequence ID" value="KXB02517"/>
        <property type="gene ID" value="AKJ44_00050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.12"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="8">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="356" mass="40011" checksum="C609154629C50917" modified="2016-07-06" version="1">MPKKKKTKDPRKEAKKKLVEFGSEVLESIKKTEPPRMKVPSRSTSNILYDDKNRFYTLGEKAGTRTAANMRQVKKFAQTMCAAEFCRSLIDADKTATLREMYYTSEGWETGGFSDQGRSDKVVEDLESAFGVKREDLGLLPEEDGASIFGELVVDEGGMEVNATEAGRAGYTIPPTMNDVEFLECGAKKVLAVETMGMYHRLVQEEAWDQFDALVVALKGQPARATRRFLKRANEELGLPIHLFTDGDPFGFHIAMVVISGSAKLAYINHELAVPDAKFIGVTASDIEDYDLPTDKLRETDVKRLKQLLDDPRYSDDTWQSEIKKMLKIGRKAEQQAFSKYGLDYVVNEYLPSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Z7</accession>
    <name>A0A133V7Z7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxT</name>
        <name evidence="7" type="ORF">AKJ44_00100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02542">
        <property type="protein sequence ID" value="KXB02542"/>
        <property type="gene ID" value="AKJ44_00100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.22"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="201" mass="22120" checksum="01708E326259E70B" modified="2016-07-06" version="1">MKIGVIGLQGAVSEHTEIINKAMRELDLEGKAFWLQEASQLSEVNGIIIPGGESTTIGRLMSTSGIFEKVKEMGRRGMPILGTCAGLILLAKEGDEEVEKTGQPLLNLMDMRITRNAFGRQRESFEVNLDIPAFGERPFRCVFIRAPAIEEVWSTVGVLAGYRGKIVAAKQENLVALAFHPELTDDTRAHKYFLNLCAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3J5</accession>
    <name>A0A133V3J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_03025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000057">
        <property type="protein sequence ID" value="KXB01018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01018">
        <property type="protein sequence ID" value="KXB01018"/>
        <property type="gene ID" value="AKJ44_03025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.607"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="61" mass="6817" checksum="0842B0CB0A48BEF2" modified="2016-07-06" version="1" fragment="single">VAVIGDIVFVDKLPKTRSGKIMRRTIKDIMLDNPLGDISTMEDQSAVKEIKSACKEIEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3Q0</accession>
    <name>A0A133V3Q0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">AKJ44_03020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000056">
        <property type="protein sequence ID" value="KXB01036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01036">
        <property type="protein sequence ID" value="KXB01036"/>
        <property type="gene ID" value="AKJ44_03020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="135" mass="15472" checksum="BB6E4B86A1F2F3BC" modified="2016-07-06" version="1">MHEWALAEGVVSTALKIADERNARKILEIRIKVGKLQQIDSEIFEFALKELAKNTKAEESKIRLEPEEVVLICNLCNHEWSFDEVSERLSPEESELIHFFPEVVHTYARCPECGSPDFRIEGGRGAWIDSIEMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3Z0</accession>
    <name>A0A133V3Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_02875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000050">
        <property type="protein sequence ID" value="KXB01155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01155">
        <property type="protein sequence ID" value="KXB01155"/>
        <property type="gene ID" value="AKJ44_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="288" mass="32897" checksum="9B0C52DEAB04C8D2" modified="2016-07-06" version="1">MNDFSKLALGITIVILLTSTFAGTVNAQGSERENYKNLLNTIDGAIRTFRLRGENSASMALKVAENQYGHFKSLYENTIRYDSRLSNLDNDINAKFDSLQQSPSVDGIRDLRGMVSEMANGLGVELSFLYKYAFIIILFVSLVLAFSVNMVSRTIVDWEKVNKVKRKSEELKNKLKKARREGKSKKVHKLMKEQQEFTKKHMGVLFSPMKTMLIIIIPFIIIFQLLSSTYGGWVVAWMPVNLPWPNLNIPLLSRFFPGTVASLSFFGWYLLSYFGFSMTLRRFLIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3Z7</accession>
    <name>A0A133V3Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000051">
        <property type="protein sequence ID" value="KXB01136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01136">
        <property type="protein sequence ID" value="KXB01136"/>
        <property type="gene ID" value="AKJ44_02895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.576"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="364" mass="41126" checksum="CD9FB0443AF22BC0" modified="2016-07-06" version="1">MKIALVTDTYHPQVNGVVSSVDTIAEELEKEHEVHIFAPTRSERAYSFNSFPFYLWPDYRIAYVRAKTLAKIFEEKDIEIIHVHTPFSLGVSGVGAARHLTLPAVGTFHTLLPEYTHYISETLGLLLRRFGWRYVNWFYGRFNAVTVPSTPIKESLVKRGLKNVHVIPNAVNVDLFHPGKEPPSSDPCILFVGRLGKEKRLEVLIDAASSVLEEYPKAKFQIIGRGIHEDWYKKIVKEKGLSNNFVFEGYVSSPDLIKAYQECDIFAIPSDTETQGLVTLEAMACEKPVIGANALGLKDVITHEVDGYLFQPGNSSELSDYLLQLLEDDKQRREMGKKAREKAKEFSAERIGGQWVNFYSSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V449</accession>
    <name>A0A133V449_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongation factor 1-alpha</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf</name>
        <name evidence="2" type="ORF">AKJ44_02820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000047">
        <property type="protein sequence ID" value="KXB01207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01207">
        <property type="protein sequence ID" value="KXB01207"/>
        <property type="gene ID" value="AKJ44_02820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.535"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="93" mass="10733" checksum="4AD70BC890574015" modified="2016-07-06" version="1" fragment="single">MAKKPHLNLAMIGHVDHGKSTLVGRTFYDTGEIDDTVIKKFEEMGDKGKTFKFAWVMDSVKEERERGLTIDLAHRKFETDKYYFTIIDAPGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V474</accession>
    <name>A0A133V474_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000045">
        <property type="protein sequence ID" value="KXB01248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01248">
        <property type="protein sequence ID" value="KXB01248"/>
        <property type="gene ID" value="AKJ44_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="228" mass="25894" checksum="8AFD66CEC179DB16" modified="2016-07-06" version="1">MLNASAAIFDTDGTLIDTTKRFYTVFCSMIKERGQEPLEWSEFFKHYSEDTLDEIISREAENREEELRDFWLEFLKRYRSIPIPDDSLIEDADVILEKISDAGVKIAVTTSCILPPPKLEEELEDYGLMKHVDVVVTGENVIEDLVETHHFSKREIFEVALSELEVKPEDSVIIGDYWNDMKAGKELGAKTIAVLTGDIKPEILEDLEPDAILESVGDLFSVVKFSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V478</accession>
    <name>A0A133V478_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="11" type="ORF">AKJ44_02755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="LHXY01000045">
        <property type="protein sequence ID" value="KXB01249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01249">
        <property type="protein sequence ID" value="KXB01249"/>
        <property type="gene ID" value="AKJ44_02755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.516"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB01249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="462" mass="52589" checksum="FDC9F0BFAEBF2D8E" modified="2016-07-06" version="1">MMEKLLDKVLKKVKPKKDDQEELREVAEELLEKAGEIIDDKGLDVTPMLVGSAARGTWLKGEKDIDIFLLFPEESPRNKLEERGLELAREIAEGRGTEQFAEHPYLTANIEGFDVDIVPCYDIKDPSKLRSAVDRSPHHQEYVKGQLTPELTDQVLLLKGFLRGIGVYGAELRIHGFSGYLAELLIIHFESFQDLIQNAKEWEEGQIIDFTQEYSTPEDVYRMFPDQPLIVIDPVDPSRNVAAAVSEKNFATFVRACEDLDRNPNEKFFFLKPPDLSKKEIHEFMKKRGTKIFTIVFDTPSDLVPDIIYPQLRKTERTLIQRLDRCDFKVLRSGVHSTPKKSVIVLELSVSELPKAYKHQGPPLGVESDSFIQKHIESDQKLAGPFIDSSGNLAFELSREYYNAEEVIRDSLESCNGFGKHVAEAIGEGYELAEGATVTKLIDDELKGFFSRYLTHCLPWYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V479</accession>
    <name>A0A133V479_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000045">
        <property type="protein sequence ID" value="KXB01250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01250">
        <property type="protein sequence ID" value="KXB01250"/>
        <property type="gene ID" value="AKJ44_02760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.517"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="186" mass="20806" checksum="8A08E38B1C32E445" modified="2016-07-06" version="1">MPRAFVSIEITDDIRNQLVQVQEKLGETGADLKLVEPQNIHLTLRFLGDVPEKRLSKIKNAIRDAKDIADPFNLHVSGLGVFPNPNYMRVVWAGVSDGSNPTTALRQKLDKNLAKINLPSDNKEFTPHLTIARVKSGKAKEKLREKLTRMSAKDFGTCRVDAIELKESKLTPEGPIYSTLEKFELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V497</accession>
    <name>A0A133V497_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hist_deacetyl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000045">
        <property type="protein sequence ID" value="KXB01247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01247">
        <property type="protein sequence ID" value="KXB01247"/>
        <property type="gene ID" value="AKJ44_02745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="115" mass="12743" checksum="74F3569DE0D2FE6F" modified="2016-07-06" version="1">MQEIFMPLTEQFKPQVIAVSAGFDAHQKDPLTRLGLSTSAYGWITKFVKNQSEELCGGRTVFMLEGGYNLDVIGDSNVEVVKALTGKESTSPPSRAPTPRVVEEVKDTLSDYWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4F5</accession>
    <name>A0A133V4F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-viologen-reducing hydrogenase subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000042">
        <property type="protein sequence ID" value="KXB01330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01330">
        <property type="protein sequence ID" value="KXB01330"/>
        <property type="gene ID" value="AKJ44_02655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlpD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="139" mass="15770" checksum="0D2AACA1904B3788" modified="2016-07-06" version="1">MGGFKPKIVGLLCRWCTYQAADTAGTSRMKYPPNLIPVRVQCSGRIDPTFVIKAFESGADGVFIGGCHPGDCHYEDGNYNTMRRIPILKRLLGQFGIEEDRLRLEWISAAEPNKFVKTVTEFTERIYELGPLEWEKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4N8</accession>
    <name>A0A133V4N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01404">
        <property type="protein sequence ID" value="KXB01404"/>
        <property type="gene ID" value="AKJ44_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="72" mass="8128" checksum="F26789CA45270EFE" modified="2016-07-06" version="1">MKILLVTEYFPENGITGGVEARSYYLSKHLAENPEGSAKDILTDYSKVRKTTIANGIRISSNLLRWKRVNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4S8</accession>
    <name>A0A133V4S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01406">
        <property type="protein sequence ID" value="KXB01406"/>
        <property type="gene ID" value="AKJ44_02600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="137" mass="15251" checksum="DD601B185E8327B9" modified="2016-07-06" version="1" fragment="single">EEVKREAVDRGKELKKGDALVIEKAIEDGWLKVSKAEPIESPIELEPGETAAISLAKKLGGQEVLIDEVSARTAARLLGLKPKGTVLVLLKTLEEGEMNLDEFLETMNDLVEHGFRLREEVYIEAIRKAREIEEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4T5</accession>
    <name>A0A133V4T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000038">
        <property type="protein sequence ID" value="KXB01431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01431">
        <property type="protein sequence ID" value="KXB01431"/>
        <property type="gene ID" value="AKJ44_02535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="424" mass="48231" checksum="FC55C7EE57C6CDEF" modified="2016-07-06" version="1">MTRAGYAKLLLAIGIMITVNIMPMSWGTASSSDVTVSIYPEEPYNKFYLGNEINVTIEISNIGEATERIKLHLSEYPENMLVIGRDGLALPFERDIAGGEDFYYGVVAIPHDNVDNDLIGFKATTPNDNLLDAKQISLEIIRPQLDNENLAVKASEYGLSEIVRVFSIPRYRRYWHPDRDEKSTNAQLGYVWLIIGTEGNILIDDNTGELIATNVRIPNQADAPEQGTARVWNGNRFENLQVPTVKTVGDLSFTLRRFELYYAEQNGKPVWVTRQILYWQIGEDPIIQAGGPLSETPDTERVELWVSAEDGTELSTISDYHFYSYKYDPTDSYTIAGDVHSPLPSEVGWQMWFSAIANYKNIYPASSIPHDRIGFTKYAHPLTRTFFEEYWLVVRRNLVGLTLVILVFITPIMWKFFKSRTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4U9</accession>
    <name>A0A133V4U9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000037">
        <property type="protein sequence ID" value="KXB01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01464">
        <property type="protein sequence ID" value="KXB01464"/>
        <property type="gene ID" value="AKJ44_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="199" mass="23461" checksum="7B0E69C98117CBDE" modified="2016-07-06" version="1">MGLKEFFVKEVGVPEEYWEYNKSRLRELSSEAVYRYVNWLYGYTKYGRGSLEVTVGISDRLERKDECLGFLSKEVLESELPEKPMIIEKLTGLAFESFGACRYSIMDVLNYLSHQDRIMELEHAEWFVWRDTLSEPENYGEMFGRIMNGNIADSRKIAVFVIMVASLKERKREDLSRRLTTRFFESSEIPHPIRRGLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4W2</accession>
    <name>A0A133V4W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000037">
        <property type="protein sequence ID" value="KXB01461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01461">
        <property type="protein sequence ID" value="KXB01461"/>
        <property type="gene ID" value="AKJ44_02500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.436"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="234" mass="26751" checksum="B1BAD5A551E7E124" modified="2016-07-06" version="1">MMELSSVIDDYMAKTTGLKKFCDRCLKSERWSGNVVLMVVDAAFDSIGLNYFNSIVPKVVEFEEAFVENGEVNNLKDLSQLPHEQVKNIWANKRSWSVAKSVASYLHESGRNGGLNDRKALREWARNTSLEGWKQDPIGKIGGVGLTTYQYLRMMGGVDTAMPDKIVKRVIEEILDKAEVKMPTNKDLEFIKTIDQIATISGYRPIEICWMTWLVQSEGDKIRMEKYRDTLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4W3</accession>
    <name>A0A133V4W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000036">
        <property type="protein sequence ID" value="KXB01490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01490">
        <property type="protein sequence ID" value="KXB01490"/>
        <property type="gene ID" value="AKJ44_02480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="261" mass="30714" checksum="719CF26D98669ACE" modified="2016-07-06" version="1">MEHAFFISYLEDRLNYSRELGYIEEDVGKTAPLENSLEIGDDITFDDIESLLEKREALSKKDRKALVIEKINQLGGKPLAREIENLLKCNTSPSKVTAKIRRLSPKIQGRILEWIYAERCPSIRWNFDWEGYVVVGVPEGITDEFVYEFKTTRKESYLKTARPPAIAQADLYGHFFKRKKKRVQFMIRETEEILTWKEKVDRKNALNTLKNFEEVERGLKEPFPPADWKCRVCKYRNKCKKCDMKLSPRIKRLSTGLVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4Z9</accession>
    <name>A0A133V4Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000035">
        <property type="protein sequence ID" value="KXB01523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01523">
        <property type="protein sequence ID" value="KXB01523"/>
        <property type="gene ID" value="AKJ44_02455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="352" mass="40644" checksum="1AD4CE7F137359BF" modified="2016-07-06" version="1">MGRTNPHQKILDEYIEALKNKEIEYVPKGENERSINWSKYDEAQVNELKDMLAFIGDVVDGAVLRLGLDEANKVGRGRPPYPAEDLAKGILLQQYFEVSNRVAVGFVDIFKEKLRIERTYSYKTLERAYENPKVLMILREVFRMIQQPIRDKEYSFAPDGTGIPTSLKVNWSRDSVDDGYQYEFLKMIPIIGTTYHLISAVEFPDNPAAHESPYFKPLLEETAANYSSIEGVSGDAAYLSRDNCDLVASVGGKPRFYPKEGITLKMRGSLGAWTDMLLDFIDDPQQWLRDYYSRSNAESVFSAFKRKFLAPLRKFLHFRRKAEAFTRVCDYNLRRVSRLRRMEGLKVPWILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V523</accession>
    <name>A0A133V523_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000034">
        <property type="protein sequence ID" value="KXB01549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01549">
        <property type="protein sequence ID" value="KXB01549"/>
        <property type="gene ID" value="AKJ44_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="77" mass="8381" checksum="EE653D68AA85DF68" modified="2016-07-06" version="1">MAEEGEGPVCAVPGCERELSEEQVESGMVVCEKCEAAKMHLCEACGKKLSPEQIQAGAVLCENCEERLEMGIDYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V550</accession>
    <name>A0A133V550_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000034">
        <property type="protein sequence ID" value="KXB01551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01551">
        <property type="protein sequence ID" value="KXB01551"/>
        <property type="gene ID" value="AKJ44_02415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="11349" checksum="A2D19CB80E558750" modified="2016-07-06" version="1">MPEYPESVLTESRKGKTEVRALASKGEFVMCEYLDPESLERTEKKKKLILKREDGETEEYFIIPMKQKGRDLLITPKEKSGEYTFWNKTEEKIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V590</accession>
    <name>A0A133V590_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01614">
        <property type="protein sequence ID" value="KXB01614"/>
        <property type="gene ID" value="AKJ44_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="67" mass="7777" checksum="8DDA176B2454AEA8" modified="2016-07-06" version="1">MMGSIARERMRSLGYGKEAYERLADERISFFMKWANSVAEKSRPTTNACELLSEHLMECFRELADDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V595</accession>
    <name>A0A133V595_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01619">
        <property type="protein sequence ID" value="KXB01619"/>
        <property type="gene ID" value="AKJ44_02360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="245" mass="29403" checksum="1A9DEFF43AFBA52C" modified="2016-07-06" version="1">MDYSDWNLCNGIFITIYSKKQVNLLEKRLGLVEKESMKPIIIELVKNLYSLYEDIIKNMKSLEKKEFSWGHESSNISTLKEIDTGFLSFYKSYLPPDDTISLIESKPYLNGLRKKLKELAGSIYSEEFRKECEKRIEEFLEEHENTPLEDKDLSRISSTLLAYTINNYDSLPYRNTYYEFWKENKEHFLKFRERDEVKEKIEKVEQKVKTLHDSHAELTNQLDKILSYYQRKFDIPLKEFVRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V599</accession>
    <name>A0A133V599_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01620">
        <property type="protein sequence ID" value="KXB01620"/>
        <property type="gene ID" value="AKJ44_02365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="129" mass="14503" checksum="31DEE4CD3527DCCB" modified="2016-07-06" version="1" fragment="single">SSLVIEKLEDALKEWGARLVVVTGLAFIFMHSDIPQREAVKLFEPVAEELENLSKRDQVFFLASGFSSGVEESEILSKLISVADVVLEARDREQSIGVKLEKHPSNPPSKDCSSSPNTWSCSTRRVWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5D9</accession>
    <name>A0A133V5D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01616">
        <property type="protein sequence ID" value="KXB01616"/>
        <property type="gene ID" value="AKJ44_02345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10983" checksum="3210AE1198443ED2" modified="2016-07-06" version="1">MGKGGKVSYSFFPEFGSQPPNPPQVRHDRRRAVSGKIGILHPSMVGICPLWIETPDSGKYDLHVKWRVWTLNIKEGLEIPIKDLEKVFRIVVREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5E4</accession>
    <name>A0A133V5E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01668">
        <property type="protein sequence ID" value="KXB01668"/>
        <property type="gene ID" value="AKJ44_02245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="93" mass="10946" checksum="55BA4618034E65C1" modified="2016-07-06" version="1">MRNQGGTDILDVPHAVKKWADWSEEGWRNESPERRRRIREMWESVEEVVTALQKLGWEMVAENYYQGTQYVDFKKGDYAVRLEIGDITDGLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5E9</accession>
    <name>A0A133V5E9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DpnI_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01669">
        <property type="protein sequence ID" value="KXB01669"/>
        <property type="gene ID" value="AKJ44_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010324">
        <property type="entry name" value="DRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041368">
        <property type="entry name" value="DRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043025">
        <property type="entry name" value="DRP_PD-(D/E)XK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06044">
        <property type="entry name" value="DpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17726">
        <property type="entry name" value="DpnI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DpnI_C" evidence="1">
        <location>
            <begin position="187"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="264" mass="30518" checksum="3D27C19FCDF35C3C" modified="2016-07-06" version="1">MNLKMDPTIASEKNIEHPPQVIRITTETWADENLYCPACLHGSLDKARTGKPVLDFMCPECSERYQLKSKKHSFGNKVSNSAYQPKIKAILDGTIPNFAFLQYDPSDWVVRELFVVPSHFMTESIIEKRKPLPPSARRAGWVGSNILLGNLARDAKIHIVRNGGALPRKIVKRWWDQFSFMRKQPVESRGWLSDVLMCVRRIDQDAFTLSQVYEFEEELSELHPKNKHIQEKIRQQLQVLRDKGVINFLGDGWYQVKDLEALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5F6</accession>
    <name>A0A133V5F6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01671">
        <property type="protein sequence ID" value="KXB01671"/>
        <property type="gene ID" value="AKJ44_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.91.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011338">
        <property type="entry name" value="BamHI/BglII/BstY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015278">
        <property type="entry name" value="BglII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09195">
        <property type="entry name" value="Endonuc-BglII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="166" mass="19842" checksum="F0B713ACA13E2970" modified="2016-07-06" version="1">MRFRSWSYRFAEEVMNSKFSLKQEIEEIIRAVDLDLSELSRPRLNKEFEKEFLERDWEKEPQVFEGPADPQAKIDFLKDRVGVEVAFTHSSFIGIDLLKFQTLSYSYLDRIDVGVYIMVTKDYRRKLIKEYDQPWSGSLTYEKVQDYLPHFRSAIQVPIWIIGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5I5</accession>
    <name>A0A133V5I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01677">
        <property type="protein sequence ID" value="KXB01677"/>
        <property type="gene ID" value="AKJ44_02290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="212" mass="24028" checksum="754DA2495DF00703" modified="2016-07-06" version="1">MKLEEKISEAAGILNSTPNMEVVLHIINGDDYASAIARQLDHSVPTVTEQLSKLEESNIIKVSEIGKAKRYEVNWDTITEVFYHITDIVCDLRGEFVSGRDEKVKGMDKSKIVPPELVKVFLNEYVATREAVGGKRKDFSEIVLSFFGALEDLKNGDPGEDYWKRLIDRFSMDEKDLASLTWMVGREHWLVEQTAITGYLELTGGRDNVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5J6</accession>
    <name>A0A133V5J6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fumerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_02195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01715">
        <property type="protein sequence ID" value="KXB01715"/>
        <property type="gene ID" value="AKJ44_02195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.336"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="290" mass="31440" checksum="D8646DB6625E0986" modified="2016-07-06" version="1">MIAKENFLDNVEEMLKLAATRLPSDVVKALEECKKSEDNPIAIQQFESILENLEIAEREERPICQDTGIPIFFVKLGSEINLDFDLNSVLKEAVRNATESVPLRPNVVDPLTRENPGDNTGENQPIIHLEIVPGEDLEIGLMLKGAGSENWSKLFTLKPTSTSEDVKEIILKTIEEAGGQPCPPTIVGVGIGGSANAASLLAKRALLRPLDEENEDEALAKLEKKITENANKLGVGPMGLGGKNTVLGVKIAKAGCHIASLPLAVNLQCWAARRSQARLVDDELEIEVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5J9</accession>
    <name>A0A133V5J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01676">
        <property type="protein sequence ID" value="KXB01676"/>
        <property type="gene ID" value="AKJ44_02285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="254" mass="28151" checksum="4A761A577F29A627" modified="2016-07-06" version="1">MSSRTSDGPLVILKGETHSSLEDLEEEKDLMNQDIDVLVLEGSKTDKMNTTLANSWHVTTFRLFLWIFDNIWLSKEALTELASLQSAEIEFTRESNIEIFENSPLYMKATASISSYILFVFGIGLGIGVPIISSSFIGGFGIFCLSILTPVLVLRIVNMRIVSGDKNRDQIMAGKINEFIDGNARKILAIVGQGHLAGVKKRIRGGTKVKVRKAKSSAVRSTVKFFPQLIKSLLALFSLYILFIIFVTSVTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5K0</accession>
    <name>A0A133V5K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01718">
        <property type="protein sequence ID" value="KXB01718"/>
        <property type="gene ID" value="AKJ44_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="312" mass="35109" checksum="EA35D14D86C24A89" modified="2016-07-06" version="1">MTLAYSPGGELGGENKEIIVGEWEEFRVSLTNDSPSTASPWENILIRVKFYGVENEEISLGYKHDGVWENSQVYDLRSLEQGMIGVVADLGPARGWTVKPQTTENFDLRVKIDKVVKDVKVEMLAITNESTLGAGGEKVENLESKNILDPLQDTYIHQGNPSTNYSSEDYLELTTQEDGNAHALLEFDRQDIPNQVGSAELNLYQYWGSGFSDLRDSGITVQAFPIAENLNLNSVTWKTTPAHNATNPIAEEEIQGTNKSYNFNMTNYLNSLENEKIVTVLLKFSQDNFDNKERRIRFDSLEGENPPYLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5M2</accession>
    <name>A0A133V5M2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01717">
        <property type="protein sequence ID" value="KXB01717"/>
        <property type="gene ID" value="AKJ44_02205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="68" mass="7789" checksum="0DF44B178F541079" modified="2016-07-06" version="1">MLTEKYCEAGTLLAKNEDKNTITATFLRPNSGKFTVIPPSLWRKEIYKEKIDGFARLTNNIRAIKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5N5</accession>
    <name>A0A133V5N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000028">
        <property type="protein sequence ID" value="KXB01753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01753">
        <property type="protein sequence ID" value="KXB01753"/>
        <property type="gene ID" value="AKJ44_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="131" mass="14962" checksum="53071FCB7CF264E4" modified="2016-07-06" version="1">MAKKKSSEKPPESIEDVKHRLGVVERELGNLVKFQWKYAKRMLKFGTAAWIFGLAVFVATLTIYQDPGLLFGAPSISLSLLVIAAAAPVLITVIMLQRHRRKIKRLERIRQGLLTQYEKTLLKKMEENITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5N6</accession>
    <name>A0A133V5N6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000028">
        <property type="protein sequence ID" value="KXB01758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01758">
        <property type="protein sequence ID" value="KXB01758"/>
        <property type="gene ID" value="AKJ44_02170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.331"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="226" mass="25003" checksum="737BAF4A53AF07FD" modified="2016-07-06" version="1">MGVIADPHSNLPALKAVLGHMPKVDQIICVGDLVGYGAEPNEVVETVKSKDISSVIGNHDHAAVTGKVSSFNPYSAKAALWTGEALTNENREFLENLPREAKFKKGKWGIYMVHGSPRRPLTEYILPGISNQDLVRLTKEINADVVILGHTHVPLERRIMGKLIINPGAVGQPRDRDPRASYMVLKLGRKLDVEHKRVSYNVEEATQKIMEAGLPEELATRLNFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5N7</accession>
    <name>A0A133V5N7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM_MT_TRM5_TYW2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_02160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000028">
        <property type="protein sequence ID" value="KXB01754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01754">
        <property type="protein sequence ID" value="KXB01754"/>
        <property type="gene ID" value="AKJ44_02160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="280" mass="31611" checksum="EEF29E59533E8D8E" modified="2016-07-06" version="1">MQPRNLREALEGELNEKELGELGRSFDIVGDIAILKIPDSLSSKKRVIGEALMNVHHNLKTVLRQTSPVRGEYRTRDLEVIAGKPTTITEHRESDCTFKVDLAKTYFSPRLAHERMRIAKKVESGEVVTNMFAGVGCYSVIIARHANSSKVYSIDKNPDAVEFMRHNIRVNKVGETVVPIEGDAREIIDSQLKERANRVLMPLPELGRDFLDVALRALKPEGGIIHFYDFGEEPNPFKSSLKFVQEAVSPKKVELLESRKVRSYAPNLYHVVLDLHIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Z0</accession>
    <name>A0A133V5Z0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetolactate synthase small subunit</fullName>
            <shortName evidence="1">AHAS</shortName>
            <shortName evidence="1">ALS</shortName>
            <ecNumber evidence="1">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01853">
        <property type="protein sequence ID" value="KXB01853"/>
        <property type="gene ID" value="AKJ44_02035"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ALS_ss_C" evidence="2">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="130" mass="14606" checksum="DC85F28330EA7F87" modified="2016-07-06" version="1">MDSITVGIEPSGGARIIILFKADERMANFLQRVLNRLTQVIRVEPLEGETSIVREIALVKTKPLKGEKRGEVLHQIEEVGGRVLEVKEDAIIAEIHGHHERIERVLNSLGSEVLDEVARSGQVYISREFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Z8</accession>
    <name>A0A133V5Z8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="4">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcm</name>
        <name evidence="5" type="ORF">AKJ44_02015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000024">
        <property type="protein sequence ID" value="KXB01869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01869">
        <property type="protein sequence ID" value="KXB01869"/>
        <property type="gene ID" value="AKJ44_02015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.297"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="221" mass="24225" checksum="1FAB11C49FB14C8F" modified="2016-07-06" version="1">MSNDRAEEMANRLKQIGYLRTPRIIDAFRKVPRHEFLPEKMRGDAYLDHPLPIGHGQTISAPSMIAIMLEVLQPEEGDKVLEIGTGSGYNAALIAEIIGKTGGIYTIERLKEIAELGEENLRKAGYEWVNVVVGDGTQGYEEEAPWDKILVTACAPKIPEPLVNQLKIGGKMAAPVGQNYMAQTLTLLEKTGENETSIQKHGGCAFVPLIGEDGWSEEQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V625</accession>
    <name>A0A133V625_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01891">
        <property type="protein sequence ID" value="KXB01891"/>
        <property type="gene ID" value="AKJ44_01990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.290"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="444" mass="48872" checksum="DD3C319F031CC41B" modified="2016-07-06" version="1">MKGPKIVATPPGPKAREFMERDKKVMSPSLTRTAPLVGVEAEGVWVKDIDDNIFLDFSSGIAVTNIGHRDPRVMSAIREQAEKAIHINSCDFYTLPQVDLAEKLFEVTPGDFKKRIFFGNSGTEAVEAALKIAQWHTQNYYVISFIGGFHGRTMGSLQLTTPGVTARRHFKGMMPGAYHTPYPYCYRCPFKLEYPDCGLRCLEYIEDTVLDKLCPPEDASCLIVEPIQGAAGYIVPPDEFMPRLAKLCKEHGIILVADEVQTGFGRSGEWFACNHWDVKPDIITVSKAIASGLPCGAAIARAEIMDWESGAHENTLGGNPVVCSAALSVVDAIRSDDLVENSAKIGSYLLERFEEMAEDHPIIGDVRGKGLMIGLELVKDRESKEPAKKQRDELMRKAFKRGLILLGADVSSLRLAPPLILTKEQADAGLRVFEDALSEVEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V651</accession>
    <name>A0A133V651_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01917">
        <property type="protein sequence ID" value="KXB01917"/>
        <property type="gene ID" value="AKJ44_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="228" mass="25641" checksum="31B8BA2BE91B1930" modified="2016-07-06" version="1">MKKIIGRAPFKADLIDPFGRPSDVASFSGPSYGFRKRKDGKVEVIFLPWHRRNGHSITMGAFFAALVYILTSLLNTPVPPYVFAMAVFFPWLLHVIIDQFGHMGNNLFWPFTGHRNSGLGLVSASDPYWNFFVVYSSVALIFWDMNHAAQSWLSAEAVAWSGVPLWYYALLVIVIPLAIIGGLTLIYKTYFEGKGEGEPPVKSAAARIIEELPEDQQMEIEERPVPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V656</accession>
    <name>A0A133V656_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01920">
        <property type="protein sequence ID" value="KXB01920"/>
        <property type="gene ID" value="AKJ44_01865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="228" mass="25622" checksum="FBEF18255EF72B46" modified="2016-07-06" version="1">MGGLALAVLGTLAIYVYALEFQGPPPQLKIWDIEPTMNWGVARFQGVVTGARYETDTGWLSIFLDDNTGSIFIRAYDSKTQALIERNNVPGVGQHISVVGKIRTRPGFNMLILSVAGGLDILPEDVPRENISTITSNPENYVYERVQIEGKVIKKTKDDPFKGNASIEIQDPQTGDSLETFITYTVPWFKDWFEDYWSQISVGDTLRVTGGMGWIMSVIFMPTERWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V689</accession>
    <name>A0A133V689_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01953">
        <property type="protein sequence ID" value="KXB01953"/>
        <property type="gene ID" value="AKJ44_01740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="111" mass="12179" checksum="818A07061BDCD783" modified="2016-07-06" version="1" fragment="single">MEKIKLKKGDVLRVEGSLILQVDEGEVTVSGGAHDEGDEVTIPKAKSLPLEAITDAVLEYEKGEGGEVERLSKRTIPSEWDSLVDEIVEKRPGTIIVLGEVYTGKTFFTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V694</accession>
    <name>A0A133V694_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01916">
        <property type="protein sequence ID" value="KXB01916"/>
        <property type="gene ID" value="AKJ44_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="189" mass="22890" checksum="B2B15F8784063DC7" modified="2016-07-06" version="1" fragment="single">KRGKHIPRTSINKVLRDYSLNGYGREEKAWKFFRAKKPDELWQLDVKDPFWLHGQKYWFPVCVDDYSRYLLVCERFDHEPTTDELTGLLEKLPRKPEKILTDNGGQFRETWKRWCSDNGVEPLFAHPYYPQDKGKVERTIRNVAEEFVNLLKKFPEWLTSIWRYRKWYNKHRFHRGIDTQPANPYPASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6F1</accession>
    <name>A0A133V6F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000018">
        <property type="protein sequence ID" value="KXB01976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01976">
        <property type="protein sequence ID" value="KXB01976"/>
        <property type="gene ID" value="AKJ44_01715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="238" mass="26403" checksum="BD3A5507D2560113" modified="2016-07-06" version="1">MKSKILQDLAEKGIKSLNEVEARGVLKEYDIACPEEIMVKYGAEKGGKDYLREMKEGGMPEYPVFLKVISRAITSKTDANAIERVSSDEEASKSIDRILKNAKRYDEKAEVQGVLASEDASNETREVFLGAAVDDHFGHMISLGFGGIYVEVYGDVEFRAVPLEESDVHSMINGLRGKEILGDFRGMRAIDMDSLVETTLKFSRLIEENPEIREMDVNPLLAGPGRTVAVDTLIRISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6F3</accession>
    <name>A0A133V6F3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02017">
        <property type="protein sequence ID" value="KXB02017"/>
        <property type="gene ID" value="AKJ44_01575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.174"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="265" mass="29236" checksum="C431A5A1020A0702" modified="2016-07-06" version="1">MEAEIAIIGGSGIYSVDLIKNPQTTQVSTPYGESPEIIVGKVEDRKVAFIPRHGKAHSTPPHLINYRANLWSLNDLGVERVLATTAVGSLNPKVEPGQFVLLDQFVDFAKRRPLTFYEGGEEGVVHVDITEPYCPELRNTLEETAGDLKINLIPTGTYVCTEGPRYETRAEIQLFHDLGFDVVGMTNATEAILARELEMCYSTVSMVTNFGAGISKEKLTHKEVSELMSKNIDRVKKLLFTSIPAVPEERNCPCKDALEGARVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6G0</accession>
    <name>A0A133V6G0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="6" type="ORF">AKJ44_01615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02024">
        <property type="protein sequence ID" value="KXB02024"/>
        <property type="gene ID" value="AKJ44_01615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="HYPK_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00264">
        <property type="entry name" value="TIGR00264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="123" mass="14118" checksum="3CE9F87437931142" modified="2016-07-06" version="1">MFEGVKQVFGRGGLDPRKMKRMMRQMSIKMEELEDVEEVIIRMSDRELVIPDAEVSITEMKGQKTYQIMGDAQERERETKPEISEEDVTLVVEQANVDENTAKKALEETNGDIAQAILNLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6G7</accession>
    <name>A0A133V6G7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">AKJ44_01665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01996">
        <property type="protein sequence ID" value="KXB01996"/>
        <property type="gene ID" value="AKJ44_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="131" mass="14651" checksum="65CC1C4B54EA4A10" modified="2016-07-06" version="1">MAILDTDLLIGLLREKKDANKTLKILEDREEPLRTTTITAMELYVGAWQSSQAEQNVPAVDELLGDLFVLSMTSKSSRLAGKIIAELEDRGEPIGTLDCAIGAIARSYNETIWTRNTDHFERIEGVQVESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6H5</accession>
    <name>A0A133V6H5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02049">
        <property type="protein sequence ID" value="KXB02049"/>
        <property type="gene ID" value="AKJ44_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="60" mass="6386" checksum="FC3B5B9C4759E6ED" modified="2016-07-06" version="1">MGLEDLPLQPDTIGGATPTTILIIGVSPINRRNYSSGPFLVDVAIGLWGMRAGFILCTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6L0</accession>
    <name>A0A133V6L0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02071">
        <property type="protein sequence ID" value="KXB02071"/>
        <property type="gene ID" value="AKJ44_01450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.145"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="380" mass="43169" checksum="5EEFF91666CE04E9" modified="2016-07-06" version="1">MSEKAELKILREEDLKDKVCVVLGTRPGIIMFSPIIRELENRGLNYFVIHTGQHYSYNMDQTFFEDLELPEPEYKLDTVKNCKFHGEQTAEMLKGCEGVLLKEKPKIVLVGGDANTNLAGALAARKLHIKVAHVEAGERSNDWRMPEEQNRVIIDHISNFLFVTNEKGRENLIEDNVKGRIFITGNPIVDALNQNLEIAKDKSTILSDFNLEPKEYLLLTLHREENVDSERNLTDFLKGIELVCQEVGKKVIFLAHPRTRKRLREFDLMTRAEDIEGFEVRDAVGYPDFLKLLANTRLIFTDSGGVQQESCILKVPCVTLRENTEWTETLEIGANTLSGTNPQKILDSTKKMMNTEVKGKNPFGDGKSASHIIDVIEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6M0</accession>
    <name>A0A133V6M0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="10" type="ORF">AKJ44_01415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02100">
        <property type="protein sequence ID" value="KXB02100"/>
        <property type="gene ID" value="AKJ44_01415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.137"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="337" mass="36561" checksum="82C33579BA8A7174" modified="2016-07-06" version="1">MPCTIIAGGQWGDEGKGKIAAYLALTDKPKIIARAGVGPNAGHTVVWKGEKLGLREISCGFVHEGARVLIGPGVLVNPEVVLDEIEKTEIGDRMGIDRKCAIIEQKHIEQDRSSKHLKGEIGTTGTGCGPANAERVNRSSKLAEEIEELKEFLTDVPQEVNVALEKGERVFIEGSQGFGLSLIHGTFPYVTSKDISASTLAADVGVGPTNVDEVLLIFKAYISRVGAGPFPTEMPLEKAEEMGIVEHGTVTGRRRRIGEFDFDLAKRSIMINGATQLAITNVDRLFDGNKGIQKYDKLTKEARDFIEKIESEVNVPVTLVSTGPKTEDIIDLRSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6M7</accession>
    <name>A0A133V6M7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmS</name>
        <name evidence="8" type="ORF">AKJ44_01400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02095">
        <property type="protein sequence ID" value="KXB02095"/>
        <property type="gene ID" value="AKJ44_01400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.134"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="452"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="603" mass="65510" checksum="91B57B7E5B691587" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6N1</accession>
    <name>A0A133V6N1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">AKJ44_01380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02099">
        <property type="protein sequence ID" value="KXB02099"/>
        <property type="gene ID" value="AKJ44_01380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.130"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="248"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB02099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="627" mass="71197" checksum="3ADC7507D422388D" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6P6</accession>
    <name>A0A133V6P6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LAGLIDADG_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02118">
        <property type="protein sequence ID" value="KXB02118"/>
        <property type="gene ID" value="AKJ44_01310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAGLIDADG_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="123" mass="14328" checksum="C39A6A0C9F951BB7" modified="2016-07-06" version="1" fragment="single">ITSLWDADGSIPADKTKGLGFRGEITQSYNPESGENGIRLLKEMRDSLEKHWKIRSNLRPVRKGDYKKSYETKKPRYILHISQNDLSKFAKELGTYLEHPSKRNRMLKIIENPKKHFAEVTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Q9</accession>
    <name>A0A133V6Q9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tnp_DDE_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02129">
        <property type="protein sequence ID" value="KXB02129"/>
        <property type="gene ID" value="AKJ44_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13737">
        <property type="entry name" value="DDE_Tnp_1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="93" mass="11422" checksum="50A72C77D7556C14" modified="2016-07-06" version="1" fragment="single">MTINWSEYNEELVRRGEFYLSPDFLDSWDEELERMNEGKVGRPYEYPESFIQFAALWYEFFHLPYRQLEGALRKLGELLPELKVADYTRLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6R0</accession>
    <name>A0A133V6R0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_01360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02128">
        <property type="protein sequence ID" value="KXB02128"/>
        <property type="gene ID" value="AKJ44_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="42"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="215"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="877"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119428" checksum="28B237A3E49D2F22" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6R7</accession>
    <name>A0A133V6R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02140">
        <property type="protein sequence ID" value="KXB02140"/>
        <property type="gene ID" value="AKJ44_01255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="61" mass="6669" checksum="2839D3A66FA15B71" modified="2016-07-06" version="1">MVIGKEAWSEVYMSRVLEQIDGRILKSLIVLAIISVAFDLLVLSGHGVLRVSASSALRPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6U1</accession>
    <name>A0A133V6U1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02143">
        <property type="protein sequence ID" value="KXB02143"/>
        <property type="gene ID" value="AKJ44_01275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="170" mass="19425" checksum="2DF2AF4CD0A7DEB1" modified="2016-07-06" version="1">MSLRKPMSRKEISRKRFKLYQDGLSDREIAERMNVSHQAVQEWRSRRGLPPNPSERRNRIGKGLEGNIKPYLIEKIGKKPQLDSESVASEILEALDEGMGKDEAWMMARKLLYERISKVMPVDLISRAGEKLGTPVELEEEARRLVSEYRERKSISGSRNAIAAGAIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6U7</accession>
    <name>A0A133V6U7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ44_01220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02174">
        <property type="protein sequence ID" value="KXB02174"/>
        <property type="gene ID" value="AKJ44_01220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.696"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB02174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="685" mass="77237" checksum="F5C577DB728712CA" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6V3</accession>
    <name>A0A133V6V3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_01225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02175">
        <property type="protein sequence ID" value="KXB02175"/>
        <property type="gene ID" value="AKJ44_01225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.697"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="158" mass="16006" checksum="BD53D800202BC996" modified="2016-07-06" version="1">MVSDLLFVVLGIGLAVTIPGFMSALGVGMTGVAAAGATAEKPGEFSRMFVLEILPGTQGFYGFIAGILIMMGTGILGGAFGLPADVTGLVVLAAAVPAILQGFTAYYQGKVATASVSAVSKTPETFGSCVIYTVMVETYAILGFLTAFLLVYGLGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6V9</accession>
    <name>A0A133V6V9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="17" type="ORF">AKJ44_01205</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02171">
        <property type="protein sequence ID" value="KXB02171"/>
        <property type="gene ID" value="AKJ44_01205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.693"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005726">
        <property type="entry name" value="ATP_synth_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01043">
        <property type="entry name" value="ATP_syn_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="15">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="16">
        <location>
            <begin position="82"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="14">
        <location>
            <begin position="211"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXB02171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="586" mass="65106" checksum="F89EE997231613E7" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6X7</accession>
    <name>A0A133V6X7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="7">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpS</name>
        <name evidence="9" type="ORF">AKJ44_01185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02167">
        <property type="protein sequence ID" value="KXB02167"/>
        <property type="gene ID" value="AKJ44_01185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.689"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_A">
        <property type="entry name" value="Trp_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020653">
        <property type="entry name" value="Tryptophan-tRNA-ligase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="74"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="368" mass="41737" checksum="493CCE9407482AB8" modified="2016-07-06" version="1">MAIQIDPWSDSIPQDYAKLMEDFGIKSFEKIAEKTPDPSHLMRRKIIFGHRDFERILKAIKKENDYVVMTGLMPSGRMHLGHKLVVDELIWYQDHDAKIYLCVADLESHITREISLQEAREAAINEYLTNFQALGLNLEECNLYFQSQSDAVQKLAHTLGNKVNFSELKAIYGFGGDSNVSHIFYPMIDVADILHPQLEEFEGPTPSIVPVGIDQDPHLRLARDVARRSENDYGFILPSSTYHRLMPGLTGGKMSSSKPKSAIFLTDSIEEVEKKVADAITGGGHTVEEQKKEGGNPDECIIYSLYVYHLMPDDEELLELRKACESGKLICGDCKKKAIKFLNKFLKNHKKNRKSVKKKIGKLIEDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y1</accession>
    <name>A0A133V6Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02166">
        <property type="protein sequence ID" value="KXB02166"/>
        <property type="gene ID" value="AKJ44_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="116" mass="13725" checksum="57ABBE33F1281CBD" modified="2016-07-06" version="1">MMPRLKPNERRQMVKLVRAGLSKKLVAELFGVSRQTVWKWCKRAHHRGRESFKDLPRRPRKRKITRKVEDAIIAIRTTFGWGTARIQQALFNLPRFMREKLNACVQAIRLSRTVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y2</accession>
    <name>A0A133V6Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02205">
        <property type="protein sequence ID" value="KXB02205"/>
        <property type="gene ID" value="AKJ44_01115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="133" mass="14946" checksum="BF604206A5784072" modified="2016-07-06" version="1">MENVEPSMEDEHFASTSVPVSQGDSLKGLLDWSIRYGWVIKFSNESTGEFSSLRTSAIGHKNVETVVDLEVHNAEETNDLYGDTNFTDMKFWDYGGEPVDIQWEGYVNPDTPFSGLDVMVYGDSHVELKTGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Z9</accession>
    <name>A0A133V6Z9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type ATP synthase subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">V-ATPase subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_01230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02176">
        <property type="protein sequence ID" value="KXB02176"/>
        <property type="gene ID" value="AKJ44_01230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014272">
        <property type="entry name" value="ATPase_V0-cplx_c_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02923">
        <property type="entry name" value="AhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="383" mass="43591" checksum="4009CC970B4EFB77" modified="2016-07-06" version="1">MNEILILLIVLGIIGGISAFIVIRTRRIMPYVYCGARVNAWGAKLLSDSRLDELTESPGTGRILGALEDTGYQPYISDISREEGVDVEEVEGALNYCLNDTYQELIEMTPEERRDIVEKIVERINVRNLQAILTGVEKEIPKEDRMKVLTPSPTIPEDKLEMLASAGTLDRILEYLEESEYYDTLSETMEEGYAEWGVSALIWALDGFYYSNLWENIRTKKAQRSILEKMIGIELDAINIKLILRLKKEDVHPGTIAEFTVPSHLLSNEQIERMTTAEDVQSAAEVTSDTPYGPVVQGALQQFEETGSLFALEKALDEEILKMSREISLVQPFTIAPVINYLRLKETEVRNLRTIIRLKAEEVKPEDIRNALVRKREIELRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V705</accession>
    <name>A0A133V705_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02230">
        <property type="protein sequence ID" value="KXB02230"/>
        <property type="gene ID" value="AKJ44_01000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="384" mass="44983" checksum="435E5BE752E46F9E" modified="2016-07-06" version="1">MGSSIYSVNSDFFQNWNSKMAYVLGFVFSDGCVDRTTLSFELQLRDMELLKKIRKVMKSTHPIKTREKRNSARLRISDATIAHHLKWFGLTPNAQMKLPPISPHLFRHFARGFLDGDGWIIASRERSEICVGFSNGDRRFLEKFVKKLNASIRLTINNLRERSKTTKNKKMSIIHQIEWYGANAFRVIKFLYDDLKSGSLYLKRKYERQLKARKLYLGLRKGRKWRAIERKHDTTMKKLLSKLLNKKKLNGSQIAEKLGVSSATVYRWLEKTGVRLPRKKKAKEYITKCPVCGKRIERMGRPKKYCSENCRVIGRRTGKMVNCVICGKEIYRPEWWFKKNTVPLCSRACVGKWQMMRIEKGLVKRSDETGRFLPSNFIQEDFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V718</accession>
    <name>A0A133V718_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02228">
        <property type="protein sequence ID" value="KXB02228"/>
        <property type="gene ID" value="AKJ44_00990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007368">
        <property type="entry name" value="DUF434"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041652">
        <property type="entry name" value="DUF5616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04256">
        <property type="entry name" value="DUF434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18481">
        <property type="entry name" value="DUF5616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF434" evidence="1">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5616" evidence="2">
        <location>
            <begin position="66"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="217" mass="24530" checksum="6C8FAF4BB5D39330" modified="2016-07-06" version="1">MLSPEVRKSIKNLRYLLNQGYPRSSAVEFVSNHYRLELDQRHLLARCVFSKEEATDHQDRVIDVGEVRDRRLGVDGYNVLISVESVLGGEQVVKCDDGFIRDLQAIFGKYKISDVTEKAIDEILNVVDEANPKEVAFFYDKQVSRSGELAGMTRGKLEERDLNGDAKTTVGTDADVRNFEVVASSDRAIIKKSDRVWDISAEILKHKEANLLDLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V733</accession>
    <name>A0A133V733_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02216">
        <property type="protein sequence ID" value="KXB02216"/>
        <property type="gene ID" value="AKJ44_01110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10955" checksum="1F09318F4B14343F" modified="2016-07-06" version="1">MAVKLRTPTEKAPYLIWKGSEAWVARDVRTGVASQGETRQEALENLDEAISLHEGEDSESIESWGEEREFLKELGIDPEEVKRARKSSRELPELMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V735</accession>
    <name>A0A133V735_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MgtE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_00900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02261">
        <property type="protein sequence ID" value="KXB02261"/>
        <property type="gene ID" value="AKJ44_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="184" mass="19020" checksum="2A0E03A1FE8CB154" modified="2016-07-06" version="1">MRVFKFGKIIIESYKVLLGGVAIAIAAGHLLHTYSPRLTATVLMMVPLINGLGGNLGSLFGARLSSALHLGTIEPKLKGQETLQINLSALGILGGVIFIFAGGLLFGMNLIGGASLLASLKASFAFLIAGLILTVLIALIALTAAFASYTRGIDPDNVVIPIVTSTVDLLGITCLLITVHLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V737</accession>
    <name>A0A133V737_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02269">
        <property type="protein sequence ID" value="KXB02269"/>
        <property type="gene ID" value="AKJ44_00940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="449" mass="51541" checksum="98FB4357F0142E5F" modified="2016-07-06" version="1">MDRGARAIVSGILILILFLNTIPLTSAGENKSEQDYVTYVTIENYSPGDFTLNITDNDGNDLGSLTRGWIENTYEDVVIENFIDTRQVLDHYEYEPSYTVWSYGTPIRDDTPLDDELHWDLNLSDWEIQDIGRSTRFWLHTYIKKLHRHWYRFLTEEVEPNRFQEFNNGWQKSQKFYNWGSTIIHYESGTQGFYSIPIPYHMNYLVKNGEYKIPVYREEEYTRWRTTTYQINDWTPENWPQLQTQITLTGINGYDENVYLTVETDNELLNASLEDQVVHVGSTATTNLTIQPQRELHGSLHTITVTATDQYGREKQATYQLDLQTSEKPPVENQVIDVTVTDKKPDQDVGGPTHKSDSRLGVKGSVYDAETNSGVSNGLNVTVDGHSADKVWSNNYEDVDIIGDLSGIKTYNVTAKTTDYNKQSGSATDDDMGRELANLDFHLQPESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V744</accession>
    <name>A0A133V744_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02271">
        <property type="protein sequence ID" value="KXB02271"/>
        <property type="gene ID" value="AKJ44_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="73" mass="8542" checksum="3BE8E2944F403195" modified="2016-07-06" version="1">MSGFKSEVDKKGRIVIPVEIRRELNIKPLSEVEVEIEEVTPRKSFVESARELREHVKEKEDAVKVLHEKSPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V748</accession>
    <name>A0A133V748_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_01035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02237">
        <property type="protein sequence ID" value="KXB02237"/>
        <property type="gene ID" value="AKJ44_01035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.652"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="302" mass="34133" checksum="A457D072A52550F4" modified="2016-07-06" version="1">MKVLVTGGAGFIGSNIVERLVERGDDVTVLDNFSTGSEENLEKVKNQIQIIKASCSDIPQLDLSDFELIFHIGIPSSSPMYKENPLLVGEAINDFIKVMELAKSTGAKVVYASTSSMYARCSPPHREDMEFEPFDYYTEARLVMERLAEVYHDLHEVESVGMRFFSVYGPHERAKGKYANIISQFYWKMKEDEKPVIYGDGEQTRDFTHVSDVVNACLKAAEADIECEVINVGTGRATTFNQIVDLLNQELEKSIEPKYVENPIPNYVYHTQADITKIKELLDYEPSVSLEEGIKMMIEDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V751</accession>
    <name>A0A133V751_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02270">
        <property type="protein sequence ID" value="KXB02270"/>
        <property type="gene ID" value="AKJ44_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="138" mass="15785" checksum="91089107849D8355" modified="2016-07-06" version="1">MKYLDASIPLCPIIEKPGEKVEECERIMKSVETGVERVKTSTFTVAEMFHILLHREKLPRKKVGENLNSFLKCAGLRLVDAEKAFCGEAIELSLDRKVDFVDAHHVLTMQKLGIKEIYSLDPHFDGFRNIDRLEAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V777</accession>
    <name>A0A133V777_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="11" type="ORF">AKJ44_00760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02319">
        <property type="protein sequence ID" value="KXB02319"/>
        <property type="gene ID" value="AKJ44_00760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.541"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="53"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB02319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="309" mass="35525" checksum="9074C963D5CD1110" modified="2016-07-06" version="1">MMLSIEAKTNLEDSGYRIVGQHQHSAVKTCRWTKKSILDQGFCYKQKFYEDIHGIKSHRCLQMTPSLPFCDHRCIFCWRNVDLNSPTWQGEADEPTEILDGAIEAQRLLLSGFKGNPNANKKKWEEAQNPNLCAISLDGEPTLYPKLSELIEECHHRNIVPFLVTNGQHPEHLEEISEPSQLYISTVAPDEKTYTQICRPLVTNSWERLNESLELMPSFNCVKVLRLTLVKGWNLKDLSGYAKLVEKAEPDYIEPKGYMFVGHSRKRLQMNNMPTHEEIAQFAEKLEKLTGYKITDESEPSRVVLLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V780</accession>
    <name>A0A133V780_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02302">
        <property type="protein sequence ID" value="KXB02302"/>
        <property type="gene ID" value="AKJ44_00775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="83" mass="9366" checksum="76279FC3D698272D" modified="2016-07-06" version="1">MVEAIETNASIELPFSSPEEAEVIHDSLKPEELLPKTTRTKVDITRRKNILYLKINAKDTAALRAAVNSFLRWAVVARDMTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V781</accession>
    <name>A0A133V781_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02300">
        <property type="protein sequence ID" value="KXB02300"/>
        <property type="gene ID" value="AKJ44_00765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="327" mass="35462" checksum="093978C308E7D636" modified="2016-07-06" version="1">MKKLAKFLAKSAKDGKQILVIGHPHADPDAIGSIVALREILEELGFKVDSGVPTGIDRLAREVLTSLGGGGITVDPPLDADMVIVVDTSSLDQLEDYEEKMKQTKTKVIIIDHHRPNSETRKAASIYWVDEDASSTAELVLQLANELKTDLSPKTAFLLLAGIITDTGHFRLANESTFRAVNKLLEMGADYKKTLDSVQIPEDPSKRVAMLKAAQRAELHKSHGRWIIFSEIGAFESDAASLFVKIGADVALAGGKDGDEVRISARSRRGVVSETHLHLGKLMSKIAENLNGTGGGHAGAAAMTVERNLDEVKETTLRELKKMLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V792</accession>
    <name>A0A133V792_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rrp42</name>
        <name evidence="5" type="ORF">AKJ44_00785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02304">
        <property type="protein sequence ID" value="KXB02304"/>
        <property type="gene ID" value="AKJ44_00785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.547"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="257" mass="28521" checksum="8FE939271D8F1E0F" modified="2016-07-06" version="1">MTQEEIVASVKRDYIFNLAQQDKRTDARALDQYREISVEPGWAGNAEGSALVKIGNTQVLAGVKLEKGTPYPDKPESGVLTTTAELVPIAHPTFEPGPPGEETVELARVTDRGIRESEMIDLDKLCIEPEEEVWMVYIDIYVLDHDGNLLDASALASATALWNVEISEDLEDWTLPSFPISKKPISTTLAKVNGKLMVDPSFNEESVMDARITISTLENGDICAMQKGGSGPLTRKDLRQAREWARTKSEELRKYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V793</accession>
    <name>A0A133V793_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation-associated GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ychF</name>
        <name evidence="3" type="ORF">AKJ44_00840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02312">
        <property type="protein sequence ID" value="KXB02312"/>
        <property type="gene ID" value="AKJ44_00840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.558"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="399" mass="43903" checksum="A367DF77BE0C4887" modified="2016-07-06" version="1">MLELGLVGKPNTGKSTFFNAATLADAPIAGYPFTTIDANVGVTYVRGDCPCQEFEVECNPRNSRCVDGVRYVPVRTIDVAGLVQGAYEGRGLGNQFLDNLRMASVLVHVVDAAGATDDEGKPCSAGSHDPLDDIEFLENEIDHWICGILEKGWARFARKARLENKSLAKAITERMSGLGIRRRHVTTAMRSIGAPDNPKDWSEEDLTHFASEIRRVSKPIMIAANKIDIPAAKDNVERLTKTGRLTVPTSAIVELDLRRAAEKNLIDYVPGEGNFEILESNKLSDKQAQGLKSIKEFLNEWGSTGVQQAVDEAIYHLLGMIVVYPVDDENKLADKKGNVLPDAMLVPEGTTARGFAYEIHSDLGDTFIHAINARTKRRIGEDYRLKDGDVIKIVARRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V798</accession>
    <name>A0A133V798_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02321">
        <property type="protein sequence ID" value="KXB02321"/>
        <property type="gene ID" value="AKJ44_00835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.557"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="104"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="300" mass="32595" checksum="CCFFA880A2EB1343" modified="2016-07-06" version="1">MKVLVTDPIHEDGIKKLEEFADVEVATGLDQESLLEKVPDFGAMIVRSATKVGKDLLDAGGNLKLIVRAGVGLDNIDLDAAKERNIKVVNTPEAPTTAVAELTISLMLAWARKIPKADKAMKEGKWIKSQLVGTELKDKTLGIIGTGRIGREVARRAKALGMNLLGYDVEKSDEFKEMGGEYVGLEELLQNSDYVTLHVPLIPPTRHMISEEELNLMKSTAVLVNAARGPIVDEEALIKALKNEKIAGACIDVCEHDPPEESPLTQLDNVILTPHLGASTREAQRTAGVLAAEKIRENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7A6</accession>
    <name>A0A133V7A6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ44_00680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02339">
        <property type="protein sequence ID" value="KXB02339"/>
        <property type="gene ID" value="AKJ44_00680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.464"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="4"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="386" mass="42371" checksum="569196CEAE9AD3F5" modified="2016-07-06" version="1">MKAYLDNGNTTPVAEEVVEAMLPYLTEKYGHPLFIYSLGREANETVESASESIANTVGAKGSELTFTSGATEANDLAVRGIAKANKSKGKHIITSRVENPSVLRITEELERRGFKVDYLDVDSEGFIDLKQLGDLITNETILVSIIHASDEIGTIEPLKEVGEILEDQDHKVFFHTDAAASCARIPIDMDEMNLDLISISAHKIHGPKGIGALIAREGVKIEPINYGYLSLSNLRPGTENMPGIVGFQKAAELAFEDFDSKIDHMKKLRDKLMDGIEEKITETILHGPRGDDRSPANVNYSFKRVEGESILMQLDMRGISVATGSACATRKLEPSHVLTAIGVKPAVAHGAIRFTLSRMNTEKEIDYTLEVLPEVVEKLRELSPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7C3</accession>
    <name>A0A133V7C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02340">
        <property type="protein sequence ID" value="KXB02340"/>
        <property type="gene ID" value="AKJ44_00685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.465"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="109"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="265" mass="28182" checksum="C1BB0ADBDADEED0E" modified="2016-07-06" version="1">MSARVFQKINELISEGKTFAVATIVRVEGSSPRGPGAKMVILEDGSTFGSIGGDCAERAVVDEALKVLDKDKPKTLSIPLEEEEKGGVGMKCGGEIEVSIEVVHPSPELVITGAGKIATSVVELAEKMGFSITVVDPFAKTGDFPDSVKIIDEPVEQGLSNVEITSNTYVVIITRHKDDIPALKAVLNKGAAYIGLMGSKSRVKAQFKELVKEGFSKEELSQVHAPIGLDIGAETPEEIAVSILAEVIKQRRKPESSGESLKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7C4</accession>
    <name>A0A133V7C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02307">
        <property type="protein sequence ID" value="KXB02307"/>
        <property type="gene ID" value="AKJ44_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="356" mass="40696" checksum="F6AF45CA585D1ABB" modified="2016-07-06" version="1">MNKMKLMAKNIQQMRLDAFIKGLKNKEIKYVPKESSSSKIDWSKYDKAQVNELKDMIIFIKDVVDKAVVRLSLDEAGEGSRGRPPYPPEDLAKGILIQQYFGVSNRVAEGFVDLFKEKLGIEESFSYKTLERAYDYPHVAMILMEVFKMTQDPVKDKETKFSPDGTGIPNSIKGNWEKDSKSDEDGKGFTKMIAMLGTTNQLISAVRFPDNPYAHESPYFESLLEETAETYSAIDQISGDAAYLSRDNCDLVESVGGTPHFYLKEGITLKREGSWAWTDMLLDFMKDPQQWLRDFHSRSNVESGFSTFKRGFLAPLRKCIHRRRKAEAFARVCDYNLKRVSRLHHQEGLPVPWVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7D3</accession>
    <name>A0A133V7D3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02344">
        <property type="protein sequence ID" value="KXB02344"/>
        <property type="gene ID" value="AKJ44_00705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="90" mass="10177" checksum="0C0F16A0199DB130" modified="2016-07-06" version="1">MVKRNEDKKKRWNPFKSLDKKLNEMTKGFGGAGAGHSISIQQGPNGTRIDVSGDVDIDKLKERYGKDAKIYKDGKRVDKPLIEVIEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7F3</accession>
    <name>A0A133V7F3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase Nep1</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">16S rRNA (pseudouridine-N1-)-methyltransferase Nep1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nep1</name>
        <name evidence="6" type="ORF">AKJ44_00550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11633"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02375">
        <property type="protein sequence ID" value="KXB02375"/>
        <property type="gene ID" value="AKJ44_00550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.360"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00554">
        <property type="entry name" value="NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023503">
        <property type="entry name" value="Ribosome_NEP1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="199"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes Arg-xx" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="230" mass="26639" checksum="B970BEBF9AD82E3F" modified="2016-07-06" version="1">MLHLILADSELETVPPEISSEKSIRWKAQRRGRKPTELILDSNYDHRIMRKLPDSERRGRPDIIHVCMLAALDSPLNREDLLKLYIHTRNDKIIDVASETRIPRSYNRFIGLIEQLFLTGEVPPEGPLLRLRDGTLRGIVEEINPEKAITFSSREQEFRRESLFDEVKKEDDVCIIVGGFPHGDFLSRVGELSDEIVRIYPEEFEALTAVTHAIHFYEDEFEVLKGSFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G2</accession>
    <name>A0A133V7G2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AA_TRNA_LIGASE_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02389">
        <property type="protein sequence ID" value="KXB02389"/>
        <property type="gene ID" value="AKJ44_00640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.379"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005246">
        <property type="entry name" value="O-Pseryl-tRNA(Cys)_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041590">
        <property type="entry name" value="SepRS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF38">
        <property type="entry name" value="PTHR11538:SF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18006">
        <property type="entry name" value="SepRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00470">
        <property type="entry name" value="sepS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="1">
        <location>
            <begin position="48"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="526" mass="60253" checksum="E2F84A8362F48912" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7H0</accession>
    <name>A0A133V7H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02391">
        <property type="protein sequence ID" value="KXB02391"/>
        <property type="gene ID" value="AKJ44_00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="110" mass="13103" checksum="F03B0FE2A7ADECC8" modified="2016-07-06" version="1">MGRHGLWREIKDDVNISDLELKRRYEEIAKKAKNPDHVKFTVTYDFQNPEQKRARIRRFYRNLEKLLEDGGWRKTRSEITFKNLEAAERVRTLAQECGAKAYMSASIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7J1</accession>
    <name>A0A133V7J1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02420">
        <property type="protein sequence ID" value="KXB02420"/>
        <property type="gene ID" value="AKJ44_00460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.239"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="185"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="352" mass="39791" checksum="E08FCB369C59244C" modified="2016-07-06" version="1">MGTPKYVGALSGRDVLNTQEFSQEELNQILDAAEDLKKKFGKREETPYLSGRTLFLMFYNRSLRTRNSFEAGIHQLGGHANFLSPQDVYTPTLPEDMIPYKTESISDVARVLSRYGDGIAIRIYGDAAKWTIGRGNKIVREFAKWSDVPVLNMEDDLYHPFQALADMMAAREAENKLEGKKFVVSYAYSGGLKPLAVPQSVTLAAAHFGMDVTLAHPEGFELEDEIVEGAKKNSDRYDGNFEIVNDMKEAFDGADFVYPKAWSPKKFVPPYNDEVDKDGAVKYQSKFKDWIADTDLLDLTNNAYYMHCGPADRGQEVTDKVIDEYKNSLYFDEAENRLHVQKAVMTMTMAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7L6</accession>
    <name>A0A133V7L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02424">
        <property type="protein sequence ID" value="KXB02424"/>
        <property type="gene ID" value="AKJ44_00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="88" mass="10150" checksum="A805F7422BD54194" modified="2016-07-06" version="1">MRVKIINGTHLRDLPLKREWREELPEGGTVEDLLSKLGLSERYFNLDRIEDKSAPYMIILKNKKPVPTSEVELSDGDVIKFIHPFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7M9</accession>
    <name>A0A133V7M9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02436">
        <property type="protein sequence ID" value="KXB02436"/>
        <property type="gene ID" value="AKJ44_00520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="123" mass="14013" checksum="16D43AC16C563E29" modified="2016-07-06" version="1">MNYRRGFELFRQYAEEKLEKSLSEFLENGDDWERKPTSVRGVFVLKLPKYKGSPPRLAAEVNLVDSRGNPTKKRGLLIGNPVELKKFRGLIKEEGLDGLLDSVDDVNPGPSKEVRPEEEVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P8</accession>
    <name>A0A133V7P8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02427">
        <property type="protein sequence ID" value="KXB02427"/>
        <property type="gene ID" value="AKJ44_00525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="84" mass="9509" checksum="F4A3138558648991" modified="2016-07-06" version="1">MEIKIKNSTNLKELRLKREWEEELPRESTIGDLLTKLNLNKLKNEDGSLSTLVLIFKNKKSVRSTSEKLADGDEVKLIPKVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P9</accession>
    <name>A0A133V7P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02480">
        <property type="protein sequence ID" value="KXB02480"/>
        <property type="gene ID" value="AKJ44_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="204" mass="23659" checksum="8A0DA148F9CE8B0E" modified="2016-07-06" version="1">MKKHQIALREILYQNYEKRKKFLSQKSISEACSASIGTVNSVVKKLGDLGVIEKKPLGFRIRDVKKVLHYWAATRDLEKDVVYTAYSPDLPKTIEEKIPPEVAFTAYSGFRRRFGVTPTDYSKVYLYGDPNQIARIFRQKKKERNIYVLEQDARLKDLTSEGVVPLVQLYADLWQLPPPANRFLEELKQKLKPTKVKIGKITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q3</accession>
    <name>A0A133V7Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02464">
        <property type="protein sequence ID" value="KXB02464"/>
        <property type="gene ID" value="AKJ44_00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="238"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="434" mass="50733" checksum="1024EE0460E805BF" modified="2016-07-06" version="1">MSELGSLTGVERDIRTDIRRAMDLRHIKDVIGVRRAGKTTTLYQIIAALIEDGADPREIALLNLDDPELSKTGFKNLVKTLEKMHPSTKYLFLDEVQQKEEWERWIRTWYDTQRFEQIFVSGSSASLISRDVGRVLSGRHTTFTIFPFSFREFLKFHEWKSFEGEYLYHNRNELLHYQERYLEEGGFPETLGKTDAQKELILTNIYNDILSRDIAARFNASYDISKRISYHLLSNVSNEFSYNRVAQATDVSADTADKYINYLLEAFLILELDFFSYKTREQFKRNKKAYAIDTGLRNAVSFKFMEDKSSLMENVILLELLRRGYNPFYWKDKQGMEVDFLVRGKEETLGLVQSCWDPSGETREREVESLTTALDAFKMKEGCILTEDYEEEEQVEEKKIHFIPLWKWLLSPSILAGRENRNFGGRVEGSDRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q4</accession>
    <name>A0A133V7Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02479">
        <property type="protein sequence ID" value="KXB02479"/>
        <property type="gene ID" value="AKJ44_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="348" mass="40101" checksum="BBB6E389C516F503" modified="2016-07-06" version="1">MDWEEALDQYGGLVEERLEDFLSELVEDRKYYHPFISDLYSKIREYVLRKGKRLASCSTLLTYKGYTGELDDRILNACIGVELFRHSILIHDDLVDQDEYRRGGPALHRLFSDEYDERFSEGTAIFMGDAMYALALQAFRNPRFTEEKISELLRLFEKGYREVNESQVLDLLFESKEPDVEEWQIMASRRAATLFRTTILAGAIPAEALEEDRNLLEKAATHVGYAFDIQDDIIDIFASEEQYGRPPGGDLRHGKTPLHMVHALKLAGEEDLKTLRGLVGKESLTREELESTREIIRKSGALEAAKNESKRHAETAKELIAKTRLDKETKEFLSSLISYIEQSLDWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7R2</accession>
    <name>A0A133V7R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02462">
        <property type="protein sequence ID" value="KXB02462"/>
        <property type="gene ID" value="AKJ44_00285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10685" checksum="0F4B2C7D6EF01793" modified="2016-07-06" version="1">MKIPERIMIDAGLFISCLTEDELTPKFSKVVERANRGEVKLLATSELYDDVISALRSQKIGLDKILDFLSDMRAIPHESIPVTIGIARKALQVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7R3</accession>
    <name>A0A133V7R3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02474">
        <property type="protein sequence ID" value="KXB02474"/>
        <property type="gene ID" value="AKJ44_00355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.73"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="236" mass="25584" checksum="7B10292443EA9463" modified="2016-07-06" version="1">MNLNQALDAIRKGEFVLISDSPDREGETDLVIAAEKVGPAHIAKMRRDGGGLICVALHPKIANNFGLPYMTKIYESASPTHEVLNATTPDDIPYDERSAFSITVNHRQTHTGVTDSDRALTIRELGKLGSGSFDGPAIKEFGREFRSPGHVPILRAAGELVAERQGHTELAVALMEMAGVTPVAVVCEMLDAETSEALAGNRVKTYAEDNDLVLLDGEKIVRAYSDWSEQDPQEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7T3</accession>
    <name>A0A133V7T3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="5" type="ORF">AKJ44_00075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02520">
        <property type="protein sequence ID" value="KXB02520"/>
        <property type="gene ID" value="AKJ44_00075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.17"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="226" mass="25835" checksum="160BC156EB990AA3" modified="2016-07-06" version="1">MRVIEHEKFENIHWIEFDEKKKKLATVNLSPGNKVYDEKLVEFRGTEYRLWDPYRSKLAAAILRGIKDVPIKEEFKILYLGAASGTTASHIADIIGAGGMVYCIEISSRPLRDLLTVCEQRKNMSPILADATEVESYHALVEQADLIYQDVAHPEQTNIALENSKTYLKDDGKLLVAMKARSIDVTKEPREIFRGEMEKLEEELEILDSKLLDPYAKDHAMLLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7T5</accession>
    <name>A0A133V7T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02486">
        <property type="protein sequence ID" value="KXB02486"/>
        <property type="gene ID" value="AKJ44_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="102" mass="11966" checksum="E2DA8FE62F16A760" modified="2016-07-06" version="1">MKRRVQMSLDSGHVEELDGILRDVGIPRSTFVNMLIEDVNFVIKNIEDNPGYYVVERLITRLYSLGLIKYHDLVKTLGPERASEVSTIIRTVRKYKRWREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7T7</accession>
    <name>A0A133V7T7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tfb</name>
        <name evidence="10" type="ORF">AKJ44_00005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02509">
        <property type="protein sequence ID" value="KXB02509"/>
        <property type="gene ID" value="AKJ44_00005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.3"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="319" mass="35979" checksum="14A7FAE3348BAB6C" modified="2016-07-06" version="1">MPKPKSKTKDESDSKAEEKWAKCPSCGGTAIVRDYQRGSLVCENCGMILKDDVMDRGPEWRAFDQEQREKRSRGGAPMTYTIHDKGLSTKIDWRNRDSKGKDLSPKRRSQMYRLRKWQRRARISDAMERNLAFALSEMDRMASQLGLPRNVRETASIIYRDAVQKQLIRGRSIEGVVSAAIYAACRECQVPRTLEEVAETSRVDKKEIGRSYRFIARELDIHLPPTSPASYVSRFGSELELSGEAQSKAIEIIKKAKEKGLTSGRGPTGIAAAAIYITSVMTGERRTQSDVAKVAKVTEVTVRNRYKELAEELDLAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7T8</accession>
    <name>A0A133V7T8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02467">
        <property type="protein sequence ID" value="KXB02467"/>
        <property type="gene ID" value="AKJ44_00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="129" mass="15185" checksum="EF6BCEFC16B8CE54" modified="2016-07-06" version="1">MGIHRWDGYVDYYEKAVNTIVHLLDNYCLDCHRGSFQIECPFEAEKIKVECGIGSALIQCIEYVENNDYLDDENMKRKLDQIASLARELKDNPWEPIPEEERNEEKFAPILRRNSKFDQLKELATQISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7X3</accession>
    <name>A0A133V7X3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_00095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02522">
        <property type="protein sequence ID" value="KXB02522"/>
        <property type="gene ID" value="AKJ44_00095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.21"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="164"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="396" mass="42658" checksum="8EDCC0A5C57AE6ED" modified="2016-07-06" version="1">MLIDDGVIRSVGLSEKALDILSEPDRILQFKLRRHVPSYEIVDCYLVYHNTARGPPCKGGIRMSSDVTLDETVQLAEIMTYKNALMDLPFGGGKAGIVADSRLSREKKATLMQGFTHEIREELYSGAYVPAPDLGTGPSEMAEIFDETHVRATVTGKPVGVGGLPGREEATGYGVMINTKHAAQEILDAELSNLTVAVQGFGNVGYWACKFLSEEGAKIVAVTDSQGGTLQEDGINVGELNKYRIKNDTVKGYGGNDLSNRDLLRLDVDVLIPAAVGGVITREVAKNVQADLVVEGANAPVTKDGDKALDAKNVPVIPDILANAGGVVASYVEWRGGKSGSKTKKEETYATIEDNLLEAFNQVLDTQYQEEVPLRQAAMIVATTNLVDTMEGRGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V808</accession>
    <name>A0A133V808_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <shortName evidence="1">PGP</shortName>
            <shortName evidence="1">PGPase</shortName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-phosphoglycolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal SPP-like hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02527">
        <property type="protein sequence ID" value="KXB02527"/>
        <property type="gene ID" value="AKJ44_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01419">
        <property type="entry name" value="GPH_hydrolase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006382">
        <property type="entry name" value="PGPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="229" mass="24668" checksum="552F6BCBD6773BB3" modified="2016-07-06" version="1">MIKALAIDIDGTITFRDRQLDTEAVTAIRRAEEADLPVILATGNVLCFAEAASVLLGTSGPLIAEDGGVVYDNSSNQEHILGSVEEVDKGIKIIEEELSVVKHTRSSDMRRTGRTLERTFDPSDATKIFQRERLNLVAIDSGFAIHVKNPEVNKGVALQKAATLLKIKTSDIAAIGDAQNDIEMLETAGVGFALDNSHPDIKKTADHVLSQSHGAGVKTAVERIIQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V816</accession>
    <name>A0A133V816_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02537">
        <property type="protein sequence ID" value="KXB02537"/>
        <property type="gene ID" value="AKJ44_00210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.45"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="326" mass="35861" checksum="F956DFAF70420FF9" modified="2016-07-06" version="1">MARQGKRIVVALGGNAIKQADEEGTTVEQFKNCEATTKLLAKMVEQMNPEDRLVITHGNGPQAGNLLVQQDAGKDKVPPQDMDVVGAMTQGQISFMLQQTLENYLRELGINIPVCGVFNRVQVSRDDPEFEGENASKPVGNFLTKEEADQLKQEHPEYIVKKVKPKGERCWRRVVPSPDPIANVEAEAIKRMVDEGIIVIASGGGGIPVTLDEDGHYRGVEAVIDKDLAGEKLAEVVSADIFLILTDVEKVKLNFGKPNEEEIDRMTLDEAKEYLDEGHFLPGSMEPKVRACIRFLEWGGEKAVITSLDKVVEALEGKAGTEIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3F5</accession>
    <name>A0A133V3F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_03075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000061">
        <property type="protein sequence ID" value="KXB00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00963">
        <property type="protein sequence ID" value="KXB00963"/>
        <property type="gene ID" value="AKJ44_03075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.638"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="114" mass="12716" checksum="B916029276340713" modified="2016-07-06" version="1">MHDKIRDYSVKDVKKRAKKVIESSVKYRCTKIRAQADISTIGGLIPLKGVLATKKECQDIADIQVVAFPQEGILRDEGTEELLYQAMEEGADVVGGMPAAEWSREESQKHVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3G4</accession>
    <name>A0A133V3G4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tnp_DDE_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000060">
        <property type="protein sequence ID" value="KXB00973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00973">
        <property type="protein sequence ID" value="KXB00973"/>
        <property type="gene ID" value="AKJ44_03070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13737">
        <property type="entry name" value="DDE_Tnp_1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="93" mass="11493" checksum="44B96D6329AFCDB8" modified="2016-07-06" version="1" fragment="single">MTRDWREYNEELVKRGEFYLSPDFLDSWDEELERMNGDKVGRPYEYPESFIQFAALWYEFFHLPYRQLEGALRKLGELLPELKVADYTRLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3J4</accession>
    <name>A0A133V3J4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_03045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000058">
        <property type="protein sequence ID" value="KXB01003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01003">
        <property type="protein sequence ID" value="KXB01003"/>
        <property type="gene ID" value="AKJ44_03045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="164"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="442" mass="51255" checksum="3B695027F2E5CA44" modified="2016-07-06" version="1">MTSEAKNFPVCSATCPAVTALQRKVEELEEELARKDEKVEKLKGRLRMYENAHTPSSKKRKGKTERNRRKEEETDERPESERENDKKRFPGKPEGSNGGGISVPNPDRVKHHMLEEEGFEEIDTRERTLIELHEKPFEVVRHVIHVYEDLEGQRVEPEVNLPEGIYGKRLQAFITLLRGTCGASHEKIAELVQLVRPDLSFSPTTSLNLTDKIARQMRGKREGILEEIKQNPYVHMDETGLREDGVNGWVWEVADQRRVVYEVDRSRSKEVPEKTMGNYDGVVVDGYSAYNSFTKQRDWDHLKREVKETEIEGAVSKFRELHGRAKRAKEKPPTERERFIQEARDSEFPSLIETLREKGEEEKATGIENALPDMFRGVKDPTIPLSNNHAERLLRKVVVHRKLWGCIRNEKGARFIENVLSCMETWKLQDKNVFQELLKFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3K7</accession>
    <name>A0A133V3K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_03035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000057">
        <property type="protein sequence ID" value="KXB01020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01020">
        <property type="protein sequence ID" value="KXB01020"/>
        <property type="gene ID" value="AKJ44_03035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="207" mass="24170" checksum="39FF5823A2DA3EFD" modified="2016-07-06" version="1">MREKLRRRAYLVWKRTGFKNKIKANLAKHGVRRKFSYSKDGREWLKSLRIEAVDDYLAIIESLNNPIDRIEREIKREAKKDKETEIVMTVPGIGFVWGLTFTTEIGNVNRFSGPEKLCSYAGMIPSTHQSGPMERHGSITKEGNRYLRWAAVECTWSHLKHAEDTKLTRFYGKLARKKGKQVAAVATGRKLLVTLYWMLKRREKFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3M0</accession>
    <name>A0A133V3M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000056">
        <property type="protein sequence ID" value="KXB01034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01034">
        <property type="protein sequence ID" value="KXB01034"/>
        <property type="gene ID" value="AKJ44_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06067">
        <property type="entry name" value="H2MP_MemB-H2evol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004420">
        <property type="entry name" value="Pept_A31_hyd_mat_HycI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00142">
        <property type="entry name" value="hycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="158" mass="17279" checksum="9079A5B03899A806" modified="2016-07-06" version="1">MKLNLPTLEEVDRITVVGVGNDLRGDDAAGVKVVRNLKEELNSHKLLIIDAGPAPENFISKIRDFNPTHVILIDAVDFGEEPGKIAHVNPEDIVGQATSTHRLPLSILMNYLRERTGAEVILIGIQSAQVKMGSEMTAQVEEGVRELVGFLTRKFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3Q6</accession>
    <name>A0A133V3Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000054">
        <property type="protein sequence ID" value="KXB01078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01078">
        <property type="protein sequence ID" value="KXB01078"/>
        <property type="gene ID" value="AKJ44_02970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="252" mass="29417" checksum="EFAF2AD78F05E5C0" modified="2016-07-06" version="1">MEEEYKEFLSDLKEVKTALKYLGMSYYKRRIPKRLRKLRGSWKTLKDKSKSQRSKKLSEVIETLDQYLKVVFDEEKSSGERIRTIEKIRDERFDIDIKSETRKAEEKRAEIKRLRGILGGDFETELNDLEIVYGESALCTAFLLRRMLEKALYFSFVRNGKLDRIESGQSGKKFIGLKKMIGKAQSEVAKDGSPFLNNKTAGNLMRIKFLGDYAAHNFLSEVKMDDIDRNFTYLCKALEELSRCFKQLTLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3R8</accession>
    <name>A0A133V3R8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000054">
        <property type="protein sequence ID" value="KXB01080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01080">
        <property type="protein sequence ID" value="KXB01080"/>
        <property type="gene ID" value="AKJ44_02980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="138" mass="15918" checksum="C066C0AC25F32F30" modified="2016-07-06" version="1">MTEDLEIKIKYGDLQAEVKGEYSSVWKYTNEFFKKVRKEFKPEGESTFSVEGKTLPEVITDLRDNGFFDKPRNSRATHRRVKELGKTGHTKSAVAMQLKNLSGKGELVRKSMEFFGLDGQGYAYVSPWYDLDQHRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3S3</accession>
    <name>A0A133V3S3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000053">
        <property type="protein sequence ID" value="KXB01094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01094">
        <property type="protein sequence ID" value="KXB01094"/>
        <property type="gene ID" value="AKJ44_02950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="107" mass="12421" checksum="6352CE66583EE271" modified="2016-07-06" version="1">MPKRIWFKPDCIKWIREGIKTTTFRNTKRNGVYDVAKGSWFNATPIGLRLKLTPTNLMSGENVINKHYEIEGQFKSPQEFRGWLEKVGLELPTAGWLNEIKVLTRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3S4</accession>
    <name>A0A133V3S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000054">
        <property type="protein sequence ID" value="KXB01081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01081">
        <property type="protein sequence ID" value="KXB01081"/>
        <property type="gene ID" value="AKJ44_02985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="80" mass="9403" checksum="0C2AC574DAC6EDB1" modified="2016-07-06" version="1" fragment="single">FLYFLGTEVSFRLGLREERSVSTDELCQHFKLSRNYGNARVSDLHDENLIEKVDRGEYKLDLIHSFDYIRALKAKYGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3W1</accession>
    <name>A0A133V3W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000051">
        <property type="protein sequence ID" value="KXB01137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01137">
        <property type="protein sequence ID" value="KXB01137"/>
        <property type="gene ID" value="AKJ44_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="94" mass="11351" checksum="1D92F16F4C6BABD9" modified="2016-07-06" version="1" fragment="single">RKRAVRTRDYKYIFAPSEAAAKCQYCNCIHGEVKELYDLRKDPQEVENILNDEKERGKELKNKFLNWSRKLKQEKLERERIREKIGKLKKLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3X4</accession>
    <name>A0A133V3X4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000051">
        <property type="protein sequence ID" value="KXB01135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01135">
        <property type="protein sequence ID" value="KXB01135"/>
        <property type="gene ID" value="AKJ44_02890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="143" mass="15789" checksum="FA37129199236FAF" modified="2016-07-06" version="1" fragment="single">MKILITGGAGFIGSHLTDKLLTNNHEVIVLDNLFTGKPENLAQHENNEKFTFVNADITNRKKVRESLKEARGVIHEAAITNVPLSIKKPELTEKVNVKGTKTLLEESANADVERFVYASSCAVYGEVKDLPISEDFELNPISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V415</accession>
    <name>A0A133V415_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="3 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adkA</name>
        <name evidence="9" type="ORF">AKJ44_02880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="3 8"/>
    <dbReference type="EMBL" id="LHXY01000050">
        <property type="protein sequence ID" value="KXB01156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01156">
        <property type="protein sequence ID" value="KXB01156"/>
        <property type="gene ID" value="AKJ44_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="173" mass="19892" checksum="FC127AB2CEA41F34" modified="2016-07-06" version="1">MDKALEKLREEGVDYQLLNYGDLMLEIAKEEKGVKDRDKMKDIKLETYRDIQKEAAYSIAEVREEIPVLVDTHCTIKKPEGYYPGLPQWVLERLQPEEILIIEALPKEIAGRREKDASRKRKKELEEAISEHQELNRAIATSYAMMVGAGVRIIKNREGKIGEAVQKVVEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V421</accession>
    <name>A0A133V421_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_02825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000048">
        <property type="protein sequence ID" value="KXB01185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01185">
        <property type="protein sequence ID" value="KXB01185"/>
        <property type="gene ID" value="AKJ44_02825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.536"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="341" mass="34708" checksum="AB91E763F5E26A7E" modified="2016-07-06" version="1">MSLILVVALIAIFYVAWNIGTNDAGNAMGTAVGGRVLTYRRAVAIMIIFVALGAVLEGWKVMETVGTGIVTSPEGLNPLTQLPLIAAISMIAAGLWVTIASIFGMPVSTHQSIIGAIMGAGILISALEPSGVTANVEYGALGTIALCWVFTPIGAAIFAFIIYKLFTPALRRMKSAVTINRVFGALVVAGGAFTAYSLGANGVGTATAVLYAVSGGGESTIWSPQLIALFGGVALAIGALTYSRRVMRTVGSGITRLDAPTACAAQFGAALTVWSFTQFGMPVSTSQSIVGGVLGVGLVKGIATVSKGKLGRIGVAWILTPLAGAGITLLFGWIAVTIGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V437</accession>
    <name>A0A133V437_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps12</name>
        <name evidence="6" type="ORF">AKJ44_02810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000047">
        <property type="protein sequence ID" value="KXB01205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01205">
        <property type="protein sequence ID" value="KXB01205"/>
        <property type="gene ID" value="AKJ44_02810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.533"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="145" mass="15933" checksum="6584FFFB767904B4" modified="2016-07-06" version="1">MSKGARGEFAARKLKRSRQKDRWKDVDYKRRVLGLDKKTDPLEGAPQGKAIVLAKVGVEAKQPNSAIRKCVRAQIVKNGRQVTSFVPGVNAISFIDEHDEVLIEKIGGAEGGAYGDIPGVRFKVVKVNGVSLKELVRGRKEKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V456</accession>
    <name>A0A133V456_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S49 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000046">
        <property type="protein sequence ID" value="KXB01224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01224">
        <property type="protein sequence ID" value="KXB01224"/>
        <property type="gene ID" value="AKJ44_02775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="1">
        <location>
            <begin position="71"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="248" mass="27220" checksum="070250B6DEE05420" modified="2016-07-06" version="1">MSKSIALIPVKGPITSGSQALVPILGSWNTPERTSKMIERAEDEDVDGVIFEIDSPGGTPYPSKELAQKVKELKIPTVACIKENGLSGAYWIASSCDKIVADELSKVGGLGVAAVRLDFSEFFKKLGIKFDTSASGEYKELGLPLGGRGDEELMEEQLEAVNEIFREKIAENRNLDEQEVEKIFEGKPYLGKDAKEAGLVDRLGGREEAIKIIKETLGAEEIEVHDYGEKMREESEGFMGKVIKKFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4C5</accession>
    <name>A0A133V4C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000043">
        <property type="protein sequence ID" value="KXB01292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01292">
        <property type="protein sequence ID" value="KXB01292"/>
        <property type="gene ID" value="AKJ44_02700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.505"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="59" mass="6652" checksum="767320E11D09057E" modified="2016-07-06" version="1">MIGDIVFVDKLPKTRSGKIMRRTIKDIMLDNPLGDISTMEDPTTADEIKSACKEIEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4D6</accession>
    <name>A0A133V4D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000044">
        <property type="protein sequence ID" value="KXB01266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01266">
        <property type="protein sequence ID" value="KXB01266"/>
        <property type="gene ID" value="AKJ44_02710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="218" mass="24939" checksum="C6856C4B10E585A7" modified="2016-07-06" version="1">MPILFDQPFQILLDLAREEKIDPWDVDIEKLTDVYADRVREMEEHDLRVSGRAIYSASTLLRMKSNQPPYDGDSEDNGGELPEELTLGLPELGPLTVIKRSPRKITLPDLVDTLQETLKEPSHERARKETKVDSIKRMLDDYHVNIEEHIREFHEKVAALAPNGGMVSLNQLYPKENRLELVRALLLALFLSTTGKISLHQEESFGEIYVRLEEKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4M3</accession>
    <name>A0A133V4M3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01402">
        <property type="protein sequence ID" value="KXB01402"/>
        <property type="gene ID" value="AKJ44_02570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="152" mass="17142" checksum="408EBDE550D95548" modified="2016-07-06" version="1">MSDKVAVDTGVVIEYIDQKGKYHHQAETVFSSLLAGNLKILLPHPVLAEVHYVSVRLYEALELENPRERAAKLVKWLRGLPTVEVSDSSADLAVEAGKAKLNFGLALTDCYVLAASRMCECKALFRKREKEMRKNADALEREYQIIFLKDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4R8</accession>
    <name>A0A133V4R8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000038">
        <property type="protein sequence ID" value="KXB01434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01434">
        <property type="protein sequence ID" value="KXB01434"/>
        <property type="gene ID" value="AKJ44_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="124" mass="14570" checksum="7B63464089F93257" modified="2016-07-06" version="1" fragment="single">MKKRDALIQYISKHIDKIIIIASYVMLLLLLLTLIPGVLYKERLIREGRWQENRKISNDYFTITYALNTGEHAPLISDQEGNRLITINGFKSNIKIDNRESRSFWNHEFRNVVEGDTTVRHNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4Z2</accession>
    <name>A0A133V4Z2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol_B_exo2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000036">
        <property type="protein sequence ID" value="KXB01491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01491">
        <property type="protein sequence ID" value="KXB01491"/>
        <property type="gene ID" value="AKJ44_02485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019288">
        <property type="entry name" value="3'-5'_exonuclease_PolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10108">
        <property type="entry name" value="DNA_pol_B_exo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_B_exo2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="200" mass="23464" checksum="4B10AAB9D0FD18BA" modified="2016-07-06" version="1">MGSEKSYLTLDIETVPVIRDSSVQEYLEDKEYEIAAHPVFSKVMVVGTKENGREPKIFCGENEKEVLNNFWEYCSNGYRKKFDRIVTFNGYKFDIPFLNVRTLANGIPMSSTVRLNTNIWRMRESNHFDCMLALAQVNKFAWVKLEVACKQLGIEVPEIKSRIRTEDLIKCYERGDWETIREYNKTDLNLTEKLYNKIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4Z3</accession>
    <name>A0A133V4Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000036">
        <property type="protein sequence ID" value="KXB01487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01487">
        <property type="protein sequence ID" value="KXB01487"/>
        <property type="gene ID" value="AKJ44_02465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="171" mass="20672" checksum="DE0117A2FE71EF41" modified="2016-07-06" version="1">MRSDMAQYKKWLVNESKREDMKIKVRFIKDDYTGHSNHHLTWFIKISSYIGTIKIPEVLFTSKNPKFTENERKAIGLHELGHLKMWKNFGFRGVLSHQKENQEWIESEADAYVKRRGLGKSLASYLRKTRKLKKKLSRESLKLRIKIWWRKHTWSHRYPDLNKRIEKLVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V561</accession>
    <name>A0A133V561_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000033">
        <property type="protein sequence ID" value="KXB01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01584">
        <property type="protein sequence ID" value="KXB01584"/>
        <property type="gene ID" value="AKJ44_02385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="114" mass="12946" checksum="2A605AC160807A18" modified="2016-07-06" version="1">MIECRDFEVEAELLEDERPETCNAMWEALPIEGVATIWKEEIYFDIPVEINPEDATPETEQGDVSYWPDGPGFCVFFGDSQPASPVNTFARIGEGIEKFREVESGDKIKIRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V593</accession>
    <name>A0A133V593_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01615">
        <property type="protein sequence ID" value="KXB01615"/>
        <property type="gene ID" value="AKJ44_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="309" mass="35913" checksum="A02F853AEDDB197B" modified="2016-07-06" version="1">MTENTAYEESLSHLLEEINISNIKDSLQKSDFKKLERAHDSTHEFMLLAPYSFPITEEKWHAKSAFLIYHWEAFHKAHRSLLEALTGHYNSGYILLRSCLENLLRGALWECLAHKKFREDADVIKEKAGTKIGDTKKTILDWINGLIEREPSIEKDLENTSGGIFDKIAPLFEDADLRDLIPYPKTTLQQLREWGILEAISNPVEEIYEDLYSELSADVHVIPDATDIGRRLLSESEENIFQVKVNLNELMRFTEILHRVIDIGIVIELNVLEDWIKKSEDARKNLRKRQPTIENLELEFSSEKLRKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5C4</accession>
    <name>A0A133V5C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000031">
        <property type="protein sequence ID" value="KXB01642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01642">
        <property type="protein sequence ID" value="KXB01642"/>
        <property type="gene ID" value="AKJ44_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="85" mass="9407" checksum="147C0CC683FB787C" modified="2016-07-06" version="1">MVVISGVGVGADSGLGLEVGCGLLEERKIVGRSERSWGWGGIGIERETSRVLAVDEPRTEDRFRWITLGYLLKKQNITSQRAFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5C5</accession>
    <name>A0A133V5C5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000031">
        <property type="protein sequence ID" value="KXB01645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01645">
        <property type="protein sequence ID" value="KXB01645"/>
        <property type="gene ID" value="AKJ44_02325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="1">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="151" mass="16356" checksum="B2B99CD56289F606" modified="2016-07-06" version="1">MRDNSTVKLSLLCSLTGIAVLYAGAVQMRPGLTPIAKLDEDYVGLKVKVSGQVIDISDHPDGHLFLKLKDDSGGVISVPIFSRVRSELGENIALLDNVQVTGQVKLYKGELELVPDKAGTIQIVQTPYTDLSRVTRERLGQIIKTRGVISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5C8</accession>
    <name>A0A133V5C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000031">
        <property type="protein sequence ID" value="KXB01644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01644">
        <property type="protein sequence ID" value="KXB01644"/>
        <property type="gene ID" value="AKJ44_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="67" mass="7631" checksum="2C64897C794184CC" modified="2016-07-06" version="1">MTLRDNGSELKVFVPSSVAELEEFPETQVGYSVGVGGWLQLYRDELELKLEDSINLRVIRTFSKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5D0</accession>
    <name>A0A133V5D0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS240 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000031">
        <property type="protein sequence ID" value="KXB01641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01641">
        <property type="protein sequence ID" value="KXB01641"/>
        <property type="gene ID" value="AKJ44_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS240" evidence="1">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="214" mass="24767" checksum="7D20A24407BF8702" modified="2016-07-06" version="1">MSGLEKLVEHLKEKRVSKRNKRSLRTKAKAFLLYQNGLSHKEIADQIGLETGKRPSKSSAYRWVERVGDSLGTSHERKRREVYVDETKLELRGEHIFCWTATDDERKLSAIGASEGRSSLEALKFLRKLRESREEGSIIYANHGTWCPWACGGLGFEHMPVDFGGNNRVERLFRTLKDRTRWFYNSFAKRAEKTLGRFSSVKSCLKHICERLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5F5</accession>
    <name>A0A133V5F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01674">
        <property type="protein sequence ID" value="KXB01674"/>
        <property type="gene ID" value="AKJ44_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="207" mass="23312" checksum="A88936DA415F027E" modified="2016-07-06" version="1">MCDFKIKDPNGGLDLLECKRIHPEGNGYDASNPNSYGGLVDKIHQKSESASDQLSSTQKNLSLENANTHLLMDISQYSRQSRSDHHPKMEIEGFSEGEVSNLKEKLEQNPVPEIDRITLCWTNKIFMDNIPCALVQYSKIVPLTEKSEQVLGYDGWTIEGYPANLTGTISELRVSSSSHPSSWIKYTYCGLSDNLVSWGPEETRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5J4</accession>
    <name>A0A133V5J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01714">
        <property type="protein sequence ID" value="KXB01714"/>
        <property type="gene ID" value="AKJ44_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="136" mass="15826" checksum="89156AB9A2864A53" modified="2016-07-06" version="1">MRLINLENGKVIADKVELANSFWKRFRGLMLKGSFWSGQALVFPFSKPKRYSIHTFFMRFPIDLLYLDQELEVIESRKELSPWKIHKSGEEASILVELPPGRIEEANVRVDDELDFREKGESINFCDFSPTLCKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5R3</accession>
    <name>A0A133V5R3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ44_02180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000028">
        <property type="protein sequence ID" value="KXB01757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01757">
        <property type="protein sequence ID" value="KXB01757"/>
        <property type="gene ID" value="AKJ44_02180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="165"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB01757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="382" mass="44671" checksum="CB22311EA8967A55" modified="2016-07-06" version="1">MKYTYKFRLYPTQEQEVKLGETLELCRRTYNRFLSQINETDEIPKRTNLQFQLPEMKKRDSDLKQVYSKVLQMVLYQLYSNLRSLSKLKKNGRKIGRLRYKDKGWFKTFTYNQSGFKIIKTNNRLDKLHLSKIGDIPIRVHREIEGKIKQITIKRTNSGKWFACICVEKRPQQEKSIKSAIGIDVGITYFATDSDGRQIENPHNLEKSLGRLRKEQQKLSRKRKGSENYEKQRKKVAKLHEKIKNQRDDFLHKLSRHYVDNYDLIAVEDLNVKEMIGNNHLSRYISDASWSKFVRYLSYKAESAGKVVVKVDPKGTSQEHKHGELDRDYNASLNILERGMKEIGMGRAESTLVETEPLLHLSSQDVITGQVQSSKQEAHAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5S2</accession>
    <name>A0A133V5S2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ORF">AKJ44_02110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000027">
        <property type="protein sequence ID" value="KXB01792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01792">
        <property type="protein sequence ID" value="KXB01792"/>
        <property type="gene ID" value="AKJ44_02110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.321"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="143" mass="16045" checksum="C1291F6A5FA0FD06" modified="2016-07-06" version="1">MWLIDGTDLILGRMASRVAKRLLDGEEVTIVNADKTVISGRKKSTLSEYDAWTKIRGLVDPAQGPFHPRKPEDLVRQSVRGMLPMKKAKGREAFGRLKAYSGIPGELEGEEFESISKAHLDQLGSRRFIRIGELSKHLGMENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5S4</accession>
    <name>A0A133V5S4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps9</name>
        <name evidence="9" type="ORF">AKJ44_02115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000027">
        <property type="protein sequence ID" value="KXB01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01793">
        <property type="protein sequence ID" value="KXB01793"/>
        <property type="gene ID" value="AKJ44_02115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.322"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_A">
        <property type="entry name" value="Ribosomal_S9_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_S9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03627">
        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="132" mass="14818" checksum="69BB2A95A932D931" modified="2016-07-06" version="1">MKVIQAVGRRKSAIARATVKNGSGNVYINNHSLEVHEPELARLRIEEPLQIAPEVAEKVDVKVNVSGGGFMGQADATRTAIAKALTKWADDEELREKFKEYDWAMIKSDTRRKESKKPGGPGARRKRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5T0</accession>
    <name>A0A133V5T0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000027">
        <property type="protein sequence ID" value="KXB01795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01795">
        <property type="protein sequence ID" value="KXB01795"/>
        <property type="gene ID" value="AKJ44_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="129" mass="14387" checksum="7AF84C186611EC75" modified="2016-07-06" version="1">MVKSYDVVKIEISLIPLKDKINEASGGEEMINEIEEIEESQVGASEVSTLRIVSKRGEDKEPYTVNIPVKGGMFSLVLPNGYINWPEGKPYPDPVRIGIDETKNLWVNFGTSKDHGFYASLKVSENGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Y7</accession>
    <name>A0A133V5Y7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuC</name>
        <name evidence="8" type="ORF">AKJ44_02050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01855">
        <property type="protein sequence ID" value="KXB01855"/>
        <property type="gene ID" value="AKJ44_02050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.304"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="418" mass="45143" checksum="7A95E2188A35F92D" modified="2016-07-06" version="1">MGMTIAEKILARNSGRGHVEPGDIVRATIDKAMANDITAPLTVDAIKDIDLKEVWNPEKIVIVFDHQAPPTTVKAAEDQDTLRKFASQQEIQNIYGDFEGVCHQIMLEKPHVLPGQLVVGADSHTCTYGALGCFAAGIGSTDMAAVFSEGKLWFRVPESVKIQVKNRLRKHVTSKDLILKIAGDIGADGAIYRSIEFVGTGIGLISTSSRMTLCNMGVEMGAKTAIVPPDEKTREYISKKTDEDYVETHPDPDAEYAEELQYSALKIDPMVACPHSVDNVKTMDELEDVKIQQAFLGSCTNGRLEDLAKAADILKGEQIDKGVKMLVAPASREVFLRAMEEGIIGKLVESGAIIEPPGCTTCWGGHIGILAPGETCISSSNRNFRGRMGSPEAEIYLASPTTVAASALTGEITNPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Y9</accession>
    <name>A0A133V5Y9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01859">
        <property type="protein sequence ID" value="KXB01859"/>
        <property type="gene ID" value="AKJ44_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="586" mass="67255" checksum="584C07E03F7AECA3" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Z3</accession>
    <name>A0A133V5Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000024">
        <property type="protein sequence ID" value="KXB01868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01868">
        <property type="protein sequence ID" value="KXB01868"/>
        <property type="gene ID" value="AKJ44_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="142" mass="15566" checksum="6EA2D20C0C4B80BB" modified="2016-07-06" version="1">MSETLSEVVKARGHPKITARHSTTFMITKDEEIGTEADCVVGVKADKAAVDLKKEVKLAINSGASVEVTLEANDIRETIKGQGHPDLQLSDSNDLVIRESDYTCGRTLMIKADKAADDLSRDLIERLKNPDTTLKMTIKVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V616</accession>
    <name>A0A133V616_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">16S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_01960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01885">
        <property type="protein sequence ID" value="KXB01885"/>
        <property type="gene ID" value="AKJ44_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribo_biogen_C" evidence="8">
        <location>
            <begin position="41"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="171" mass="19389" checksum="0BB697F6113B6EF7" modified="2016-07-06" version="1">MKLFVYNALECDPERCTAIRLEEDDKVEAFYQIRKIPMEVILLDPLTEKAFSPADEEIVEQHGLLAVDCSWKNIDSIGEIRTGRESRSLPYLVAANPTHYGRPTILSTVESLAAALCILGHREKAESLLEGFKWGHTFFELNEEPLEAYSKAEDSAEIVRIQEEFLPGEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V628</accession>
    <name>A0A133V628_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01899">
        <property type="protein sequence ID" value="KXB01899"/>
        <property type="gene ID" value="AKJ44_01915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="66" mass="7766" checksum="F9028C0F09D3E7B8" modified="2016-07-06" version="1">MLGKDINSSIQDPVCMTYEVETTESFDKEFKKKHKDKRDYLKSIISKLEKYPDKYGKPLRGRLHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V629</accession>
    <name>A0A133V629_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01887">
        <property type="protein sequence ID" value="KXB01887"/>
        <property type="gene ID" value="AKJ44_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="277" mass="30909" checksum="9F403E033BB42505" modified="2016-07-06" version="1">MKVKDVMTSDVKGVEIPGNREEALELLKELKVSALPAIKQGTNKLIGIIRLRDFFENPDESQLGMLVNRDIITITPDAPVEEAAKKMLENNVRRLPVIEDEKLSGIITVRDIVYRVIAEREIEAPALGYMQKSITLIWEDTPLKVAVEILGAAKARALPVIDSDGKLVGIIGDADIINVSEVETEEIKEQMGGRSESDSWTWDSEDRIYITKRSLKPSDKLVKDVMTKDVVTITKRTDATKCAKLLKEHQIEQVPVTSGRKLLGIVRDDDLLKVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V640</accession>
    <name>A0A133V640_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01900">
        <property type="protein sequence ID" value="KXB01900"/>
        <property type="gene ID" value="AKJ44_01920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.272"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="353" mass="41695" checksum="8BA21069A35DEE5B" modified="2016-07-06" version="1">MKRKDVTKELASEVKYYREEVGLNVRTVSKFMNISMQDVTKIINSKVYKEVTAEEPSERDTHWKMEGIRDLSTEQIIQKLRHFGVEFSEERFLKDVKNLYSPGKLADHWMEIHPVTAKGFDEDFIWMAATILWERLAPNVVNSEQINEAMQKGYDLMAENNTREGCEKWLETWGLIREVTPPEVTTLGEIDGILRMTQSVFNWCQDFEMELRNAGRRDKKYYRELIDYVNEFFSTFPDHENELIDLNMRRAEADSYFELGEFARGEEKYEELTERHPNNVYGYLSWGDQYCWDRAKPEPDYERAENLYLSGLENALKGDREGDVEAALNRLEDLYEKTSDPEKIEIVKEEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V644</accession>
    <name>A0A133V644_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01902">
        <property type="protein sequence ID" value="KXB01902"/>
        <property type="gene ID" value="AKJ44_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="196" mass="22520" checksum="4C84B8FEA4E5A467" modified="2016-07-06" version="1">MRILSIRRLFSSDHSSTTYYFVSTKHLSREERAMVNSLTTQARVQGDQISLTYDGEWSDLGRGREKEFLNYFDVEVVEDYDWWSLTVIFRDNAEIAEKISDFETEGGEAYLEVEMEDEDTVLSFHGALLDYGACHPDDPFDLMAEIGVEMREEILAGQYAGLEVLKTYCEENKVTAPVGEKHTYSSERLVQILTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V649</accession>
    <name>A0A133V649_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01919">
        <property type="protein sequence ID" value="KXB01919"/>
        <property type="gene ID" value="AKJ44_01860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="90" mass="10042" checksum="5F9ADCB1964EC73D" modified="2016-07-06" version="1">MGLSRAAMKLDNKWGYRRFSWIVFISLFFIVYGITGIPGLLLMFVCTGIGLMPVLFRSRRLNCMAVLLVPIFLNMAGFGPRIIEALGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V664</accession>
    <name>A0A133V664_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_01810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01938">
        <property type="protein sequence ID" value="KXB01938"/>
        <property type="gene ID" value="AKJ44_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="123" mass="13564" checksum="F3D8E8A06ABE2D36" modified="2016-07-06" version="1">MKIHSINREALKLILGASKTSHPNEFAGILRADKGVITEVLLLPGTFSSEQSAIMRLHMMPIDSTACGTVHSHPTPNPEPSQADLELFNKFGEVHIIVASPYKEESWCAYDHQGRGIELKVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V670</accession>
    <name>A0A133V670_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01939">
        <property type="protein sequence ID" value="KXB01939"/>
        <property type="gene ID" value="AKJ44_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="493"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="605" mass="66755" checksum="C5430259CB87D26A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V678</accession>
    <name>A0A133V678_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroneopterin aldolase</fullName>
            <shortName evidence="1">DHNA</shortName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptD</name>
        <name evidence="4" type="ORF">AKJ44_01830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal dihydroneopterin aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01941">
        <property type="protein sequence ID" value="KXB01941"/>
        <property type="gene ID" value="AKJ44_01830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02130">
        <property type="entry name" value="DHNA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027508">
        <property type="entry name" value="DHN_aldolase_MptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036839">
        <property type="entry name" value="MptD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007181">
        <property type="entry name" value="MtpD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04038">
        <property type="entry name" value="DHNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143560">
        <property type="entry name" value="SSF143560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHNA" evidence="3">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="127" mass="14242" checksum="8FE1346FA797A5B8" modified="2016-07-06" version="1">MPKNPQEDPAKEHFDSNTTDRERAIFEGAITLGAIYHQFVGAPIHDPKVLERAMEKTATAQPFTESAEVKITSDSGKKEPPYEYPELTGKMLEIGILAKYGEAQVELGMQYVPELDYPLMFIKTLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V686</accession>
    <name>A0A133V686_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01906">
        <property type="protein sequence ID" value="KXB01906"/>
        <property type="gene ID" value="AKJ44_01910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="60" mass="6991" checksum="2AF91629D6561B82" modified="2016-07-06" version="1">MTVEAKDRLVSIKKSDLESLEATIETLQNEEVMRQLKESDQDIKEGKTRTTKKLLRELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V693</accession>
    <name>A0A133V693_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="7">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">kae1</name>
        <name evidence="9" type="ORF">AKJ44_01780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01960">
        <property type="protein sequence ID" value="KXB01960"/>
        <property type="gene ID" value="AKJ44_01780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.222"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022449">
        <property type="entry name" value="Kae1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
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        </location>
        <ligand>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        </location>
        <ligand>
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            <position position="258"/>
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        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_01446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KXB01960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="327" mass="35301" checksum="3BA98539CE41E4C4" modified="2016-07-06" version="1">MLCLGIEGTAHTFGVGIVNSNGEILANSVKAYEPEEGGIHPREAAQAHSRNARKVLDKALSESGVKAEDLDLIAFSQGPGLGSCLRTAATAARALSIHLGIPIVGVNHCVAHVEIGRLTEKVEDPVTLYVSGGNTQVIAFDAGCYRIFGETLDIPIGNCLDVFAREAGLPHPGGPRVEELAKKGENYLELPYSVKGMDLSFSGLMTEAVRRHKNGDKLEDICYSLQETAFAALVEVTERAIAHTEKDAVMLTGGVAANSRLREMLKTMTEARGVKFYVPLMGLCGDNGAMIAWTGILAHEHGVKQKLEETQVIQRWRTDQVNTPWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6D4</accession>
    <name>A0A133V6D4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_01680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01997">
        <property type="protein sequence ID" value="KXB01997"/>
        <property type="gene ID" value="AKJ44_01680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
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            <end position="111"/>
        </location>
    </feature>
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            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="179"/>
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    </feature>
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        <location>
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            <end position="206"/>
        </location>
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            <end position="246"/>
        </location>
    </feature>
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            <end position="286"/>
        </location>
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            <end position="362"/>
        </location>
    </feature>
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        <location>
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            <end position="393"/>
        </location>
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        <location>
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            <end position="421"/>
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        <location>
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            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="345"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="512" mass="55583" checksum="3DA752C71E89C7EC" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6E7</accession>
    <name>A0A133V6E7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
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            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02019">
        <property type="protein sequence ID" value="KXB02019"/>
        <property type="gene ID" value="AKJ44_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="121" mass="14123" checksum="905C7D839555F708" modified="2016-07-06" version="1">MDRTQYAVKFLEKLREVGKAKRVSIDFVLERDGFNLPSDDTRVRAINDLIDLGMVERKGKWYSCWVIVTSSVLMWFVVQLVRRLWHCLRTAGGGVFANVFRAERRKRLHLTVIGFARLEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6G2</accession>
    <name>A0A133V6G2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZT_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_01610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02023">
        <property type="protein sequence ID" value="KXB02023"/>
        <property type="gene ID" value="AKJ44_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="289" mass="31900" checksum="187B0D60BB6C154B" modified="2016-07-06" version="1">MDIGKKRMMVRRVVIILIIVNFGLFFVKWIPTLISPSISVEADAFNSLGDFAYSGLFLLGFELLLRPKDESHPHGHERFEPFISLMVAGAISLTGILVVVHAVQSVSNPVYSFSPYLILALVASIMVKSWLAIYLRKKAGEVDSTALESSSKDAKVDVLASATALVGVIGAGIGFPLLDTVVGAVVSVWIFFTAFSIGRKSFRYLTGAVAPKKVTDKIREILDSREEVVSFHELEAHYVGPEIHVSLSIHLPKKLGFDRVHQIEEELRREIGSIKGVDTVYLHLEPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6H1</accession>
    <name>A0A133V6H1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02027">
        <property type="protein sequence ID" value="KXB02027"/>
        <property type="gene ID" value="AKJ44_01630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="63" mass="7680" checksum="CF8D7E1896166931" modified="2016-07-06" version="1">MRRYWEKNKWKKLILETYEAKKWSQIQEKVVALRGSIKKEVSECVTKAEEKYRSRQAEKEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6H9</accession>
    <name>A0A133V6H9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02044">
        <property type="protein sequence ID" value="KXB02044"/>
        <property type="gene ID" value="AKJ44_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="63" mass="7283" checksum="4789A05038835B35" modified="2016-07-06" version="1">MDSPEKLPFVGEIEHLDAFGEYSPRTEEYTIEDVVLGKVPKEETLITWLLKNQNQFTSGLRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6I8</accession>
    <name>A0A133V6I8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">radA</name>
        <name evidence="9" type="ORF">AKJ44_01550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02051">
        <property type="protein sequence ID" value="KXB02051"/>
        <property type="gene ID" value="AKJ44_01550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.167"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="84"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="8">
        <location>
            <begin position="260"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="319" mass="34271" checksum="CB59E9EA4BEFFC13" modified="2016-07-06" version="1">MGEDYSRKKMKRLEDLPGVGSATAEKFSESGFDTLESVATATTHELAGAANIGTQTATKIIRSAREAANMGYEKATDLMERRKLVGRISTGSGSLDEMLGGGVETQAITEFFGEFGTGKTQLAHQLSANVQLPPGEGGLEGGVVYIDTENTFRPERISQMAEAVGLDPKGALENIFVARASTTDHQMLLAEKAGEMARDDGVKLLVVDALMSIFRTEYVGRGALAERQQKLGRHLSTLHKLAEGHNLAVLVTNHVMSNPGVFFGDPTKPIGGHVLGHAATGRVYIRKSRKNTRKAKLVDHPSQPPSTVKFKITGEGIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6J7</accession>
    <name>A0A133V6J7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02052">
        <property type="protein sequence ID" value="KXB02052"/>
        <property type="gene ID" value="AKJ44_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="246" mass="28062" checksum="CAE37F9EECFD0DBC" modified="2016-07-06" version="1">MKTRTVFKDKNKLSPRYVPGKLVDREGEFRELVRLFHHVLEEGGSQRVIVCGSLGSGRTILTRVFAREMRKFGKKRGIDILPVYADCRKDRTPREVLGRLQRACDLEKPVRGVSYASILERVVEQLKSRGAYLAIILDDLDFLIPRNGSDFLYMTTRVGEELGERNPISLIGVSGEPSVLARLDSATQSTYQHNRVVLEDYDRRQLRRILEDRAKAAFTKDSIKGEVLDYILGSEPRVPERDRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6L2</accession>
    <name>A0A133V6L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02073">
        <property type="protein sequence ID" value="KXB02073"/>
        <property type="gene ID" value="AKJ44_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="236" mass="27692" checksum="79796982AA75149C" modified="2016-07-06" version="1">MSVILRFDVDRAYPNAVYNHLRVFWNVFPSLDFLGYLDFVKKLLDDLNYRGIKASFFFRPSTLPKEDFAERILRDRHSVGLHAVRTQSFKDFSGELSKISKRFEGKVLGFSKHGSGRRLSRKHEASYNPRKYVQYAKRANLQYFLGNGEDPSEEETVINGVLFFPSAFWLNRNFREDKFTVDWLVEKSTHRDVVLLAHPCQILLEIERGGLIAREYEEIIDRVDDFKTIDEIVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6L3</accession>
    <name>A0A133V6L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02046">
        <property type="protein sequence ID" value="KXB02046"/>
        <property type="gene ID" value="AKJ44_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="99" mass="11883" checksum="3D9351474D333626" modified="2016-07-06" version="1">MLENIFGRTTTVKIVEAFLKKENRSRWMNLREVSRHSQTNPGTVSRNIHVLVENEILVEERPSEWSRIFKLNTDNKYVLLMIEFYEKLLETRPTHLRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6M3</accession>
    <name>A0A133V6M3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02077">
        <property type="protein sequence ID" value="KXB02077"/>
        <property type="gene ID" value="AKJ44_01480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="287" mass="32376" checksum="E6EDDACA53253D38" modified="2016-07-06" version="1">MFVYDLRSNSWVQKLEYPTDYSIHVACCSDGNRIYCFGGSDGSRLSKDLYILDPSTGSWSRGSDFPANSGLRGASAICYKNKIYVVGGFKDGRTSADVTVYYPSRDVYDFRSRRTMPTPREWFNLSCINGVLYAIGGGNEEYPQLRTVEAYDISSDRWTVKEPMPSARYGLARENSAINGKILVSSGMYRYPPLSSGFSSRFIKITRKIGSYFRLIKPFFFYNDLLRYDASTNSWATVGRTGYRRDGASQGVLDGKLYVIGGRNSIPAISGLDYCEQFDFSLFNNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Q7</accession>
    <name>A0A133V6Q7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_01340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02124">
        <property type="protein sequence ID" value="KXB02124"/>
        <property type="gene ID" value="AKJ44_01340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.121"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="67"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="217"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="515" mass="58154" checksum="4465B78FDE3E5726" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6S3</accession>
    <name>A0A133V6S3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">AKJ44_01260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02150">
        <property type="protein sequence ID" value="KXB02150"/>
        <property type="gene ID" value="AKJ44_01260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.94"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="216"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="31"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="351" mass="37115" checksum="369FB012CA057477" modified="2016-07-06" version="1">MKNPTSKPEEDEFERAMREARPRIVAVGCGGAGGNTISRLMEDGISGVKTIAVNTDAQDLIHTNADNRILIGREVTGGLGAGGDPELGEEAATEDEDLLKDSLYEVDMSFITCGLGGGTGTGAGPIVADVSKRMGALTVGVITLPFSVEGERRARNATAGLAEFREVLDSILIIPDDKLLEIVPDLSIEEAFRLADRLLADSIKGIIELVTMPGLMNLDFADIETILRDGGVSMMGIGESGTGDRAIDAAEEALESPLLEADLPKAGEALVSISGGPSMTLGEAERIADKVSEALAPDAQVNWGAQISEDLEEAIRVMIIIPGVHSPWARGIEARRKQKEVEEGLRGLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6T1</accession>
    <name>A0A133V6T1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02149">
        <property type="protein sequence ID" value="KXB02149"/>
        <property type="gene ID" value="AKJ44_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="213" mass="24482" checksum="FC933D58CAEC33FF" modified="2016-07-06" version="1">MRKLGELLPELKVADYTRLYRRIRDLEIEIPKSSDKIVVAVDSTGVKVTNRGEWMRKTHRGERRGWIKVHIAVDVENKRLLSIEVTDEKTKDSKMFEPLVEDLNLKDCLGDGGYDDKEVFEILEKKGLDPPGIKLRKDAKVGLSPRGQAAKEFQELGYEEWKKKHEYGKRWAVEGFFSAVKRCFGETVRAASPAGMVREAKRKFGLYNLVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6T3</accession>
    <name>A0A133V6T3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Big_13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_01285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02145">
        <property type="protein sequence ID" value="KXB02145"/>
        <property type="gene ID" value="AKJ44_01285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="3">
        <location>
            <begin position="880"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="1253" mass="131047" checksum="AABDEBC2047599C1" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6V4</accession>
    <name>A0A133V6V4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02178">
        <property type="protein sequence ID" value="KXB02178"/>
        <property type="gene ID" value="AKJ44_01240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.700"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="105" mass="11737" checksum="7AB1F2FFF66E0283" modified="2016-07-06" version="1">MSAEDIEVIKDAESEAERKIEEAHEEAEKIVEKAEKKAQKLGADIKENAKKKAEEIVEERKEEAEKKAGEISKNTEKEITEIEKAAEERASEAVELVVKRVSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6V7</accession>
    <name>A0A133V6V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_01180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02180">
        <property type="protein sequence ID" value="KXB02180"/>
        <property type="gene ID" value="AKJ44_01180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.688"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="PTHR21227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="2">
        <location>
            <begin position="69"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="162" mass="18025" checksum="C1B2D21D1392D674" modified="2016-07-06" version="1">MPDEAQANQIHQKGAIGKPLSGGRLQLAPTEALHLLDRKKIRVIKKESGEELSFDELSSKLSKDDPDLMLKLLAYQDLKSRGLVVKTGLKYGAHFRVYARGEGPSTGHAPYLVHAISEDVSLTTQELSRAVRLAHSVRKKMIFAVVDNEGDVTYYSLKREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y5</accession>
    <name>A0A133V6Y5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02177">
        <property type="protein sequence ID" value="KXB02177"/>
        <property type="gene ID" value="AKJ44_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10669" checksum="65F399E0A5C77EA7" modified="2016-07-06" version="1">MGSWQRKALIALFYPFTLLMIVAGFTAFVLLVFDFSTFFAATVALCFFSFSATILYLIFRPVIKLLNVRRIFLGLVVAADVLAILSLGTLLLRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y7</accession>
    <name>A0A133V6Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02214">
        <property type="protein sequence ID" value="KXB02214"/>
        <property type="gene ID" value="AKJ44_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="153" mass="16533" checksum="C901017DDEA2EEFC" modified="2016-07-06" version="1">MAVGFWGLVGFWLVKVLILALICFLLGWLGLRALDALTPRIHEREEIGKDPIATGLFISGFLIYVALVIHGAVTTLPGGSFVGSLFMRRLGIIAIAFVVSLLLAIGIFNLLDRLTPQIPFAKLRHSSLGTGLYVFGYLIFLGLITNAAFAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Z4</accession>
    <name>A0A133V6Z4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02211">
        <property type="protein sequence ID" value="KXB02211"/>
        <property type="gene ID" value="AKJ44_01150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="92" mass="10276" checksum="D1CBE6ACE03129BA" modified="2016-07-06" version="1">MREAGGRLYSKGAAILKMDAYPGSSVCDFTVEKVYQGNAILKVNGKWRAVLAAEDYDGPRHLIKKGARFKGIAKLYHEDGKFRAWIKEVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Z7</accession>
    <name>A0A133V6Z7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ44_00995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02229">
        <property type="protein sequence ID" value="KXB02229"/>
        <property type="gene ID" value="AKJ44_00995"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.644"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="37"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="208" mass="23031" checksum="AB0CE98441E4ACA1" modified="2016-07-06" version="1">MKSNSEKDTKQTLEELENETEACTRCELHKTRTNVVFGTGPAKADVMMVGEAAGYYEDQAGEPFVGAAGKKLDGLLKKAGLSRENDVYITNILKDRPPENRDPTPEEIEACRPYLEKQIRMIKPKLIVALGRFAAGELLGRSVSVSKEHGSLEDSSYGGWHCRLFISYHPAAALYGADAAMKLEEDFEKLGEVVEKLDEFKTAEQTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V704</accession>
    <name>A0A133V704_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02212">
        <property type="protein sequence ID" value="KXB02212"/>
        <property type="gene ID" value="AKJ44_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="108" mass="12795" checksum="A5F33A57832D208A" modified="2016-07-06" version="1">MDRQARLSVGDHWMYERSFPRQEPKIIVEYRIVGNEKIKDVNTLIVEWEERLRGGERSLISGKLWIDEETEHFLKGERSFHDESGGMLEAEPLGKSRLENWRVKGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V710</accession>
    <name>A0A133V710_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02213">
        <property type="protein sequence ID" value="KXB02213"/>
        <property type="gene ID" value="AKJ44_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="267" mass="29756" checksum="F0130034F8028947" modified="2016-07-06" version="1">MRKLALASLVTLVLLSSVGSCIATSSNFYTRDGEKYDNWSLCRTRCWREDGFFQVHNTTFRPAIAFESLGELKNTAWEVGEGLAERYSGNELAKQIFDYVRDHVIYTSDSIQFAYDEFARNADEVAEEIESNGSSRGDCEDYAVLLAVMFKAAGFRSAVVLAPEHAAALVYLPGYPGANAFWDFRGEGGWIWAEATGRTNPLGWTPPELMRSDLLAYEIGEEPVLEGEGKSEKLATSGGGGQMFFGGSSFFSMLLFLWMLSLFKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V714</accession>
    <name>A0A133V714_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02232">
        <property type="protein sequence ID" value="KXB02232"/>
        <property type="gene ID" value="AKJ44_01010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="230" mass="26492" checksum="31FE75934F60C91F" modified="2016-07-06" version="1">MVEEVRTVKLNLLNLTERKSKLLSELLNVCKSAGDHLFKTAVYLEVFNKPESRFALQEVEYDHIKERFALHSQIIVDLCKDVFTAYRNGGLNFFKYTIPYNVPRSSKLAETENGNPVISVATLDGRIGLPISQDGAWERFNEFLEDGYEFTSFRLKKEQDDWHILVSLRRESEVKGEFDSVLGVDVGSRTLASVTVLSKERVEEQLYFGRDVWEKTEGYLHQTKRTPVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V734</accession>
    <name>A0A133V734_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02243">
        <property type="protein sequence ID" value="KXB02243"/>
        <property type="gene ID" value="AKJ44_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="141" mass="16393" checksum="FE5EED8D9A1E3139" modified="2016-07-06" version="1">MSQKRVERYRGKVERIEVRASDIEKWISDLSESDFEQDKKTRLAIYKAFQELVESIADICAMYAADTGRVVGDDHENIEKAAGRLYESELSDDLKNSNGLRNRIIHEYNGLNHKIAYDSINELLPSLKKFGEEVKRWIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V742</accession>
    <name>A0A133V742_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02265">
        <property type="protein sequence ID" value="KXB02265"/>
        <property type="gene ID" value="AKJ44_00920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="245" mass="27437" checksum="9B03199A6F45371D" modified="2016-07-06" version="1">MRSTAYKVKIEDLVNGRYVSSAEGEPNYLVTPWNQQVLRVNLIATIIDKFIREDGTYATLQIDDGTATIRAKAWEEGAERMDEFNVGALVKVIGKVREYEGEIHLVPEVIRKIEDPNWEIVRELEILDNRKELLAQGVTPKLPSKTGEKETEKKKGEEVAPTTLEVEQVGTIEKIEGEPRPEISDDLKDKALLALEKLEGEDGTTPPDLAAELDISASKAEDVIATLINDDKIYEPNPGKFKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V749</accession>
    <name>A0A133V749_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02236">
        <property type="protein sequence ID" value="KXB02236"/>
        <property type="gene ID" value="AKJ44_01030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="88" mass="10120" checksum="92E491C179D185DC" modified="2016-07-06" version="1">MSEVVKVGKKGQITLPKEIREREDLKKGQLLEVKDLGGGLIFLTSIDRKKEAEAALRLLGKNVEMTDKEVVEYCRKIRKEVFQEWSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V776</accession>
    <name>A0A133V776_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2b</name>
        <name evidence="11" type="ORF">AKJ44_00925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02266">
        <property type="protein sequence ID" value="KXB02266"/>
        <property type="gene ID" value="AKJ44_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00311">
        <property type="entry name" value="aIF-2beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="10">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB02266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="136" mass="15203" checksum="38DE7243EB7A409F" modified="2016-07-06" version="1">MGEDYDELLDHALDQVPEFTAEKERFETPEADIDVSGNQTALQNLKSIADELNRNPDHLMKYLLGELGTAGNREGARGVFQGRFGKESVQDRINRYVEEFVLCPECKKPDTKLVKEGRITLLKCEACGARSSVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V791</accession>
    <name>A0A133V791_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13935"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02318">
        <property type="protein sequence ID" value="KXB02318"/>
        <property type="gene ID" value="AKJ44_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_P" evidence="6">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="333" mass="36633" checksum="2F37B28E4425E81A" modified="2016-07-06" version="1">MDEIVEKRPGTIIVLGEVYTGKTFFTTYVANSLLRHDVKSAVVDTDVGQSDVGPPGTVGMGIVDNPIGLMTEVRTQSAYFVGSMSPSGHMLEFMVGMKKVAEDGLEKADLVIVDTPGWVSGGSGRALQLYGAELLEPDLIVALQREDELEHLLRSIPGETRRISVSEKVRKRTRKERSFLRQKTLADYFEGSKKISLDLEKVKLERCYLNTGKNLDPESLGVKGILHAEKIPEGLVIVSENGASEKEIQKLEEEYGRVISIKKGDEKYVFAALIDEDKDLLGIGVIDKIDCEKKKLDVLTPIQNGEKVAAVQLGSMKVKLDGEEVGTVRPRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7A8</accession>
    <name>A0A133V7A8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl37ae</name>
        <name evidence="3" type="ORF">AKJ44_00780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02303">
        <property type="protein sequence ID" value="KXB02303"/>
        <property type="gene ID" value="AKJ44_00780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="93" mass="10578" checksum="F1A162AB8604C6AE" modified="2016-07-06" version="1">MPEEERKKKVGSAARFGPRYGTKIRKRVQAIEKEQKKPHECPNCGAKKVKRISSGIWKCTRCNVKFAAKAYSPKTREIEPSALESIESAEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7C0</accession>
    <name>A0A133V7C0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02348">
        <property type="protein sequence ID" value="KXB02348"/>
        <property type="gene ID" value="AKJ44_00730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.476"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="158" mass="17183" checksum="D8206CE97DB124BB" modified="2016-07-06" version="1">MSKHKISLTVNDEKHELEVSSNRNLLRVIREDLGLTGTNCSCERGDCGTCTILIDGVPTKSCLVLAVEADGREITTIEGLRENGELNPGQKAFIKHGAVQCGFCSPAFILTGHALLEENPNPTEDEVKEAIGGILCRCTGYRQIIDAILDAAKEYPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7D0</accession>
    <name>A0A133V7D0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_00750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02352">
        <property type="protein sequence ID" value="KXB02352"/>
        <property type="gene ID" value="AKJ44_00750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.480"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="41"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="252" mass="27087" checksum="0DE90E6F4E0C8B2A" modified="2016-07-06" version="1">MGVILLILFFFFVGLIVVTFLYTGGGEIISALSSEETLFAIKLSLLTATITTIISVLVAIPAAYALSKFDFPGEDVIDSTLNLPIVLPPVAVGAILLIFFTTPPGATVESVFVRFTYAVPGIILAQFVIVTALAIRVLKPAFDDFDSEYENVARTLGYNKFQTFFKVTLPMCKKAIIAAGVLAWARAIGEFGATVMLAGATRMKTETMPISIFLNMAEADVAQVAALILITIGISISVLYVTKKVIGGFRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7D2</accession>
    <name>A0A133V7D2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2061 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02350">
        <property type="protein sequence ID" value="KXB02350"/>
        <property type="gene ID" value="AKJ44_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018638">
        <property type="entry name" value="DUF2061_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09834">
        <property type="entry name" value="DUF2061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2061" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="63" mass="7364" checksum="F18B01D3C1A9D932" modified="2016-07-06" version="1">MHETKKRSIAKSISYRIGCIIITLAVVYLISKDIKLAGIITVVHQIIVTMFYYLHERVWNRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7E5</accession>
    <name>A0A133V7E5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02343">
        <property type="protein sequence ID" value="KXB02343"/>
        <property type="gene ID" value="AKJ44_00700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.468"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="PTHR11093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="65"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="459" mass="50666" checksum="0672640C12853807" modified="2016-07-06" version="1">MPEIEEVSEEEAGRFERISAHTHIRGLGLKEDGTARDIGDGMVGQKKAREAAGRVVELVKKGKLGGRLILFAGPPGTGKTALAVAIARELGGREVPFVNLSGSEIYSSEKKKTDILTESLRKALGVRLHEKREVYEGEVKSLDIKTGQTGLNPYQQAPSEARITLKTKDEEKTLRLGRSVAASLQSQQVEEGSIIQIDAESGRVINLGVSRDAWEEEKKADISVSPELVDVPTGSIMREREFVTTLNIHQIDSVAAARSAGGLSLFFGGGGTEITDEIRQRTNEQIRAWIEEGKGELLPGVLFMDEVHMLDIEAFSFLNRATEEEFSPITIMASNRGLTKIRGTDYESPHGMPLDSLDRLLIIDTHPYNKGEIKSILKIRAREEDAELSEEALDFLSDVGEKTSMRYAVQLIAPANEVAESRGKKKITREDAEEARRLFISVGDSVEFLKKYEEKMMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7F5</accession>
    <name>A0A133V7F5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pfdA</name>
        <name evidence="7" type="ORF">AKJ44_00585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02380">
        <property type="protein sequence ID" value="KXB02380"/>
        <property type="gene ID" value="AKJ44_00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PTHR12674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="153" mass="17201" checksum="1FF96F3029133E4F" modified="2016-07-06" version="1">MEEKTEGESQELQKILLDLRESQQRAQGLQTQIKLLSNSVEEIDNTIGTIQGIKNMNSETDILVPIGGNSFLKAKLIETDKVLSGFGAELVAERNPDQAIEFLEQQKKEFNESIERARGELEKLSQHIEDLRRKAEELMAKTEGEEGASKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G5</accession>
    <name>A0A133V7G5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02392">
        <property type="protein sequence ID" value="KXB02392"/>
        <property type="gene ID" value="AKJ44_00655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="142" mass="16072" checksum="1B8C1DB9A1D08126" modified="2016-07-06" version="1">MNLKEIASVIVLVIILQGGLTLLLFGLQGSTPGVGFWSIGVGILVMVVVSGGIAIVLYWLVHRYTTERAIRTAMMAMSDDEQEILRIIMQEKKIRQDDLRRRVDFSKSKVSALVTNLVEKNAVKKTQYKRTNHLEPTEQFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7H1</accession>
    <name>A0A133V7H1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02374">
        <property type="protein sequence ID" value="KXB02374"/>
        <property type="gene ID" value="AKJ44_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="55"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="211" mass="22898" checksum="43E8596CA5DA4DFA" modified="2016-07-06" version="1">MFPIKDENPTETTPYLTIALIVVNLGIFLATFLSGSFDQIIGDYGMKPAELLAGKNLHTLFTSMFLHGGFLHVIGNVWFLWIFGDNIEDYFGREKFLLIYFSTGIVASLAHAALNPGSVIPTIGASGAIAGILGAYIVKYPRAKVYTVLFFFLFYVIKIPAVAFLGIWIGIQVLSATVTAVAGVAVSTAYWAHIGGFALGAAMVYLWEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7I8</accession>
    <name>A0A133V7I8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02418">
        <property type="protein sequence ID" value="KXB02418"/>
        <property type="gene ID" value="AKJ44_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="228"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="504" mass="56107" checksum="3BFBB73CC90C71AE" modified="2016-07-06" version="1">MLWKERDTNSSSNQAVSCLIYLIYKRGKHILRKLLILALLILLITAIHLPTVDASESSESAIYEVRKEYVIKNYGQNQALEENVSFYLLDNREIIGQQILSENIEVEGSYKGIQIYATEDNRRARVVGLDSMDPGETKTVEVTYILKVDSVPQIDPELVGNTHPSSVDKFTKAVEGIWNSNDSRIRDKAHELTKNENNYWYKAKRIFDFVQEHLKYKPQSVVQDDIWAYLNKEGDCSEYAFLFISLARAAEIPTKFVGGYLYSFAEAEASPTGLANYGHAFALVYLPKVGWIPVDPTESSQGGGWYFAELPVNHIVELTSDGSNLRVGETSETPPPDVHWTQYSGQGTTVDFVDEETKVDIIPLVAIDPTIYPSDKAEDSTWSFRVKVKNWGSQSISNVKVKLQVDNAYFEAPGSEDLGTINPGTPAYASFDVHVKKSVENSPITAVVTYDAGKYDSFIARETIPATAELAQPPYGLPLSLPMIMILATIVAGIIVGAAVILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7J5</accession>
    <name>A0A133V7J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02429">
        <property type="protein sequence ID" value="KXB02429"/>
        <property type="gene ID" value="AKJ44_00535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.257"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="161" mass="17300" checksum="E28B938AE1D6B9BD" modified="2016-07-06" version="1">MSDDVGRVEVSFTINGEKREISIDPNRRLLDFIREDLGLTGTKYGCGTGDCGVCKVLIDGEPVSSCTVPAKEVDGKKVITIEGLSEDSGGLHPIQEAFMESGAVQCGYCTPAMILVAKSLLDKNPDPTREEARQAISSVLCRCTGYQKIVDGVLLAAERME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7J6</accession>
    <name>A0A133V7J6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-binding protein AKJ44_00565</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02377">
        <property type="protein sequence ID" value="KXB02377"/>
        <property type="gene ID" value="AKJ44_00565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.363"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00026">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022889">
        <property type="entry name" value="DNA_bind_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PTHR10840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="106" mass="12788" checksum="8C8362EDC834F708" modified="2016-07-06" version="1">MDLDELKKKKLRELQAQMKQAKEDEEKKKQLEMQKKRLLKKILTPEARSRLSNLRVAKPQFVERIELQLIQLARTGRVNLPIDDEQLRKILRQLQKSKKTFKIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7J9</accession>
    <name>A0A133V7J9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="10" type="ORF">AKJ44_00450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02430">
        <property type="protein sequence ID" value="KXB02430"/>
        <property type="gene ID" value="AKJ44_00450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5007936520" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023394794" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="203" mass="21951" checksum="1C3AF871F2F41230" modified="2016-07-06" version="1">MYGFQGTVVGLRYKDGVALAGDTRATSAYLVMSKRAKKLFKIQRAIGVAISGSPGDTRSLVDILETEANLYRLKRKEEITTKSLASFTANLLHSQKMFPYITSVILAGTSGDGSRLYSLDPVGGRLEEEKFASAGTGASVSYGVLEQNYQKDVGEEDGVKLAAQAIQQAIERDAATGDSIIVAKIDEEGYQELSEEEVKELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7M4</accession>
    <name>A0A133V7M4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bmp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02434">
        <property type="protein sequence ID" value="KXB02434"/>
        <property type="gene ID" value="AKJ44_00485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.244"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="2">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="385" mass="43121" checksum="C1914B84DB723950" modified="2016-07-06" version="1">MLRESVPSAVLRELGQKKLKAGFIYVGPVGDYGWTRAHDRGRKIVDKKYDWLTTTTAESVAPADTGDYIDSMFEGGADVVFTTSFGYLEPTVNKASDWPNKMLYHCSGGPLPYKQITGKEFQSKNTGFYFGDFYQIYYLNGMMAGALAKNDKIGYVAAHTTSEVVRHLDSFMLGAKEVNPDVKMKVIETGAWYNPGASTTAANTLISWGADAIAFTCDSPAVVQACQSHYEETGERVYAFSHYTPMLSQGPDIVISGQLVHWEKLYEDLLLKARAGVVENFQHWRLLHSGAVQMGSTWEDKINPEFVDDLKAVTVSDPVYGDINVYDLIMKRLDQFKQLRVNFHPFTGPIKDSDGNLRLKDGEVLPQDNLRWGMNWYIEGTIPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7N5</accession>
    <name>A0A133V7N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02461">
        <property type="protein sequence ID" value="KXB02461"/>
        <property type="gene ID" value="AKJ44_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="429" mass="49070" checksum="7DEA176431C04634" modified="2016-07-06" version="1">MPELTIPAHLHQSTPRQAEKLRELMSRFGRARRRAYNLLRKGVNKSEIERSLQEETGLNARYVKDALNSVKDLPPNVTFGGKYNQELRMRHKISKDEYKTRRNSIIISRGEKYHKGNLNLRVIHEDDQLKLRINVGNREWIYPRLYIPRKYLDKYSHLLDGSKPYQVIIKRRDNDSGYDVKVAVRVNPEVRESRRVMALDVNSGHIDYAVLNENLELIQVGKIECQALLHASRYKRENLLHQLVDKIAGIAKHFNAKVVVGKLNTGKFSSWNSRANRRVKQMLQYKLRQILGYKLPLQGVPVEERSEAWTTKLGQELAPLIGLDVHKASSIMFALKIINYEKFEELRSSFKGEELHRGVRADEDDGSPSARLSVGSGLTAPRQAQSLACNEVTTQCDGGYPATPGSWGLSQFAESLKPNLVRKTVKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P3</accession>
    <name>A0A133V7P3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02454">
        <property type="protein sequence ID" value="KXB02454"/>
        <property type="gene ID" value="AKJ44_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="63" mass="7351" checksum="0350B3ACEDC6B0E5" modified="2016-07-06" version="1">MEAVPAKMTKKLLGELDRMVEEGWYASRSEAVRDAARELIEKRKLDRLESAIDEDIKWGLHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q9</accession>
    <name>A0A133V7Q9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ribK</name>
        <name evidence="20" type="ORF">AKJ44_00350</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02473">
        <property type="protein sequence ID" value="KXB02473"/>
        <property type="gene ID" value="AKJ44_00350"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="18">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="CTP-dep_RFKase" evidence="19">
        <location>
            <begin position="96"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KXB02473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="217" mass="24397" checksum="B64E507BA31ECB3E" modified="2016-07-06" version="1">MRRLSILLELARLGAHSEPCQITSKELGEKIGCSQQTAARWLKKLSEEGLIDQDVGSRGQTVSLTSEGIDVLRSLRKDLNEVLGEVPQSLKLTGRIVSGLGEGSYYVDKEEYKKQFQEKLGFNPYPGTLDIKLDRKSLRIKERLHSTQSKRIEGFSTQKRRFGGGKCFSARVGDMEAGIILPDRTHHKKIIEVIAPEKLRDKFSLEDGDEITVEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7R1</accession>
    <name>A0A133V7R1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_00360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02488">
        <property type="protein sequence ID" value="KXB02488"/>
        <property type="gene ID" value="AKJ44_00360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.74"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006399">
        <property type="entry name" value="Ribfl_synth_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01506">
        <property type="entry name" value="ribC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="138" mass="14898" checksum="66A51C9A53E71104" modified="2016-07-06" version="1">MASAAIDELKQLCSVKFERKTVPGIKNLPVAVKGLLDEGCDIVMAFGMPGAEPIDKQCAHEASTGLIQAGLGAGKHVIEVFVFEDEADSDKELAELADQRAREHARNVYRLLFKPEELEKLAGTGQREGGPDAGPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V2</accession>
    <name>A0A133V7V2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02513">
        <property type="protein sequence ID" value="KXB02513"/>
        <property type="gene ID" value="AKJ44_00025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.7"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011830">
        <property type="entry name" value="LEU1_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02090">
        <property type="entry name" value="LEU1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="500" mass="54146" checksum="C57146EDB57E8E6C" modified="2016-07-06" version="1">MENKTIKVLDTTLRDGEQTPGVALNPDEKLELAKALDDLGVDIIEAGSAITSKGEREAIRRISREGLNAEICTYARGLKTDVDAALECDVDSVFVVVPTSDIHLKHKLKKSRTQLKEMMTETIQHARDHGLIVELGAEDSTRTDLEFLKEVFQVGVEQGAERVCVCDTVGVMMPEQTQELFSDLTQTLEVPVTAHCHDDFGVGTANTIAAVRGGAREVHVTVSGLGERAGNAALEEVALALTKFYEYETNVDLKKVYGVSKLVERITGLPVPPTKAIVGDNAFSHEAGIHTHGVLSHPSTYEPISPEMVGQKRRLVFGKHVGSHAIKSELEKRGLKPNDEQLEEIFAKIKELGDRGKLVTDAEWTAIVDEVMGRTLEKIVELEELTVTSGNKVTPTASVKIKFQDKDFTESGVGVGPVDAAINAIRKVVEEISSIKLQEYHVDAISGGTDAMVSVVVKLTDGKRIITSRGSSGDIIMASVQAVLNGVNRLLWDKKLGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V9</accession>
    <name>A0A133V7V9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_00085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02541">
        <property type="protein sequence ID" value="KXB02541"/>
        <property type="gene ID" value="AKJ44_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="155"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="380" mass="41888" checksum="E37B8114E1778510" modified="2016-07-06" version="1">MRLLQSTKVIGGTCEICGKSSPDISTTLRVCGDCVRDRFDEAKPHIEAAHGEVRARYGLPETMPSDPNGIQCDMCGNACKIPEDGVGLCGIVENDSGKLVRKFGTSERGLLNWYQDSIPTNCVSAWCCAGSSGAGYPKWCRTPRGDIGYNNLAVFIGSCTSNCLFCQNSSFRELTVKGKPVMSARELAGKADEDVGCICYFGGDPASQMPFVIESARLALKAAEEDERILRVCLETNLSMNRSSLEEFAELSMKSGGGIKADLKSWSPEILYALSGIKYHTTYENFKLIGDRQEERPEVPFARASTLLVPGYVDEEEIRGIASFIADIDPTIPYSLLAFHPLYYMSDMPRLREEEANKFLEICEEEGLERARLGNPWLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W0</accession>
    <name>A0A133V7W0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02487">
        <property type="protein sequence ID" value="KXB02487"/>
        <property type="gene ID" value="AKJ44_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="285" mass="32487" checksum="93A91B0CC4AAA5C4" modified="2016-07-06" version="1">MATVGEEQIRLLKELGLKEYPAKTLAHLIELGESKAPELSSASGVPKARIYGVLDDLADRGLVEVKPGRPAKYRPKSPNEIIERIIHNKKARMDNEIERIEDLRSDFEPVFQPIYESTVKKTREPLLKTVSVGEPAEEETRLMYQEAEKEIDIVSRAMEWLPEVKESLEEALKRGIQVRVLLLAPDQLEDEEDKTLQEATRKTLEEELSGVKVRFSKFILPLRGSIIDPSYDYSSGKAIFLVEERGVPFTLRDAAITENPSLVAGMKRYFDLIWEHESLEIKEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W2</accession>
    <name>A0A133V7W2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02523">
        <property type="protein sequence ID" value="KXB02523"/>
        <property type="gene ID" value="AKJ44_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="76" mass="8369" checksum="0A7B389D7A9B5230" modified="2016-07-06" version="1">MAGALILISTAIDKMKDVYGEIKAQEKIQEAQMITGPYDIMAIAEAEDITGVTDVLMEKIRDMDGIEDTVTCIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W3</accession>
    <name>A0A133V7W3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="1">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">top6B</name>
        <name evidence="3" type="ORF">AKJ44_00045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOP6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02516">
        <property type="protein sequence ID" value="KXB02516"/>
        <property type="gene ID" value="AKJ44_00045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.11"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006553">
        <property type="entry name" value="TopoVI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01052">
        <property type="entry name" value="top6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="518" mass="57843" checksum="796E4C25D78BB5F3" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W6</accession>
    <name>A0A133V7W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GXGXG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02524">
        <property type="protein sequence ID" value="KXB02524"/>
        <property type="gene ID" value="AKJ44_00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012061">
        <property type="entry name" value="Glu_synth_lsu_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006519">
        <property type="entry name" value="GOGAT_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="1">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="221" mass="23299" checksum="EAEE2C6EDD020CBE" modified="2016-07-06" version="1">MSAKKIDVSKIGTKKTNRKLKELEGEAQLVKPNSAHFLVAGLQNKLDITIEGSAGYYLGTCMHGPKIHVHGNAGWYAGDNITEGKIQIEGSAGDGTGQGLYGGTVVVKKSCGSRTGQLMKNGTIVVGGDSGFMTGLYAFGGQIIVCGDVGPSAGESIIGGIIYVGGDIPSLGKNARKEKANQDEQTKIENILKEANIDPPSKFTKIVPAEKRFYRLDIGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W7</accession>
    <name>A0A133V7W7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02525">
        <property type="protein sequence ID" value="KXB02525"/>
        <property type="gene ID" value="AKJ44_00125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.27"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="422" mass="45421" checksum="254386822A79AFB6" modified="2016-07-06" version="1">MSKSSEISGFYKLGVDERLEIVKDFADLEDKEVSLLKKTGTLDLEKADKMIENVIGTLELPLGVAVNFRINEKDYLIPMAIEEPSVVAAASNAAKMARDKGGFETESTPPHMIGQIQVTNLEDIEKAKKAIEENKEEILELANEQDPVLIKLGGGAEDLELREIDTQRGPMLIIHLIIDTRDAMGANVVNTMAEAVAPMIERITGGRVYLRIVSNLATHRLARAKAVFSKEALGGEEVVDGILEAYAFAAADPYRCTTHNKGVMNGIIALALATGNDTRALESGAHSYSAIEGNYKPLTKWEKDEEGNLTGEIEVPVAVGIIGGATKVNPIARISLKILGVESAKELGEVMAALGLAQNLAALRALSAEGIQSGHMRLHARNVATTAGAEGELADKVANRLIEEGQINVERAKEILNELTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7X9</accession>
    <name>A0A133V7X9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02535">
        <property type="protein sequence ID" value="KXB02535"/>
        <property type="gene ID" value="AKJ44_00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="446" mass="49664" checksum="CF66DFC8619F4FDB" modified="2016-07-06" version="1">MSDLTIRNAKLFLPTGVFQGGLAVEDGIITKISKSGLPKSDREIDAEGKLVIPGVIDSHAHLYDPEYSHREDFESGSRAAAAGGVTFTVLMPLDTPMFSPEDLKHTISVGEEDSLIDFGLHAGNMSEESIKYIKPDIELGVRSFKLFTSSPYALDRVTRRNLMENIDELGGISFIHAEDEEILTKKIEELKKAGRSDPLAHAESRPNRAEEKAVREVVADAKELDCRLHLAHITTRQGVEIVRKAKREQEKLTAETCPHYLIFTKEDVKEKGPYLRINPAPKTKKDIAAVWKALSEGVIDTVATDHAPGTREEKEVGWEDIWSAQIGIPGIETLLPLMLSEGLAKKRLTLERLVNSLSTNPAKAFGFYPQKGVIQEGSDADLVMIDRKKQWEIRAEDMHYKVGWTPYEDMELEGKPVMTISRGEIISENGEVTGKPGRGRFVPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3G1</accession>
    <name>A0A133V3G1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000059">
        <property type="protein sequence ID" value="KXB00988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00988">
        <property type="protein sequence ID" value="KXB00988"/>
        <property type="gene ID" value="AKJ44_03050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="99" mass="11674" checksum="45ED977F011C27C2" modified="2016-07-06" version="1">MGVLSSRVSDRMNKRIEEFAKSESLKKSEVLRKIMERGLRELELERAIKLYREGKVTLWKAAEIADVSLWEMMEVVRERKIPLKYTAKDAEEDLERVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3R9</accession>
    <name>A0A133V3R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000054">
        <property type="protein sequence ID" value="KXB01079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01079">
        <property type="protein sequence ID" value="KXB01079"/>
        <property type="gene ID" value="AKJ44_02975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="340" mass="38533" checksum="FB44A0C3EF3F27A6" modified="2016-07-06" version="1">MKITATENFKDRLLRCSPKVAVETLKAVLPLRKRTVSKAASKLNLSEGTIYNRLKDLKILGLLESEEGKIILRDQATIKDICVGKNYDSLKKSFLKLSYSGIIDELDKDGVRVEDLGRDIALKSTSIASDPQTVETYGTIFAKWADFFSLASYDHQNKILYPPDVDISKAKKRTTKLRIPKATVGEFFDLLPVLTRNPNSREEIAERLSISPTSVDKHLSTAYLWGLAERKGNQYQLTESGKKFMSKSEGNKKAYIRKKLKSLPIFQAFVYFLRQGNLPQESVNKISKRYTKGWKESYAKTISKKIVSWGKYADILEGRGDEIKLTVKGVKLDPQLPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3T3</accession>
    <name>A0A133V3T3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dUTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000053">
        <property type="protein sequence ID" value="KXB01095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01095">
        <property type="protein sequence ID" value="KXB01095"/>
        <property type="gene ID" value="AKJ44_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="192" mass="21742" checksum="CA6EBA8E78651D51" modified="2016-07-06" version="1">MENGSIEIQPYNESQLQPNGYDVRVGPTYHILKEVVDAFFPFTERLVDEAYEKREARDEAINVNCCEARGKFIRLPPHGFILASTIERTKTIKNITASLRCRSSLARTAISIARCAGWGDVGYDGVWTMEIVNHFKVPYHLSVGIRVGQLVFFKTESPPKNPYEGKYSGSREPVLPSLYDDKDLGKLIEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3U9</accession>
    <name>A0A133V3U9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_02910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000052">
        <property type="protein sequence ID" value="KXB01110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01110">
        <property type="protein sequence ID" value="KXB01110"/>
        <property type="gene ID" value="AKJ44_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="65" mass="7104" checksum="E5F4167C2675416B" modified="2016-07-06" version="1" fragment="single">VRTPQDLEKINPETHAARISSTVGAKKRGQIISRAKELGVKILNVKDSELGGRESELEDTEETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V422</accession>
    <name>A0A133V422_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000048">
        <property type="protein sequence ID" value="KXB01183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01183">
        <property type="protein sequence ID" value="KXB01183"/>
        <property type="gene ID" value="AKJ44_02830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="81" mass="8980" checksum="4CB8958C99E0EDB2" modified="2016-07-06" version="1">MELWQVVYIIGVFAGLAVAGTISPYVAVAFIWAFIIIGEVTHYWGELKKFEEEVEEAGEELEEREGPIEAGEETTGESEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V424</accession>
    <name>A0A133V424_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_02840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000048">
        <property type="protein sequence ID" value="KXB01184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01184">
        <property type="protein sequence ID" value="KXB01184"/>
        <property type="gene ID" value="AKJ44_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="341" mass="38031" checksum="A7C28E8AAE93AED4" modified="2016-07-06" version="1">MPRMRFSLRKMLPLFLLGVLIILVMAAYTGVGDILSILRDVDIRFYLLAIGAQIVAILVWLTKWKILTNAINLDAKTHRMFPILLSGILVNTVVPSARVGDIPLRAYMFSRIGDISPDKSFATVAADRALDGIPLVMIIFFALAMVLLTWSLPLYIILLLSLTAVLIAFVAITFIYVCLRPDPARRLVMWFIQRLRRIIERFRPINYVEEKAEDFMKGFSRGARTILRQKRYVAPALTLSFVYWLLVIVRMYLVFLALDQTISFGAIGIAITVGLVLHAVPIPGGLGFVEGAYVLIFSAAGVPPQVSLTAALLDRGISFWFTGLISGSGIVWSGHKLFKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V445</accession>
    <name>A0A133V445_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="8" type="ORF">AKJ44_02805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000047">
        <property type="protein sequence ID" value="KXB01204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01204">
        <property type="protein sequence ID" value="KXB01204"/>
        <property type="gene ID" value="AKJ44_02805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="7">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="142" mass="15559" checksum="886C09E96BE3E5CE" modified="2016-07-06" version="1">MKVKLDADKIRKIALFEKVTGAAALDCVESQNGRKLTFVVKEGEVGKAIGKNGRKIRKFRQMLGKSVDIVEHSENPGDFIANVFSSINVKNVEVIDSGEGKIAKVDVDNSEKGKAVGRNGWNIKRARELLARHHGFADVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V457</accession>
    <name>A0A133V457_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000046">
        <property type="protein sequence ID" value="KXB01225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01225">
        <property type="protein sequence ID" value="KXB01225"/>
        <property type="gene ID" value="AKJ44_02780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="121" mass="13416" checksum="2F6EABD4E6408FD9" modified="2016-07-06" version="1">MKSSRKGYGSHSFLNEYIVRNSCKKIMEIGVAGGENAKTMVKAASQNSPVDKIEYYGFDTFGGKDNSRMKNVSRKLESTGCKFRLFKGNSIETLPEAVKSLPLMDFIFIDGGHSYQAVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V462</accession>
    <name>A0A133V462_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000046">
        <property type="protein sequence ID" value="KXB01223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01223">
        <property type="protein sequence ID" value="KXB01223"/>
        <property type="gene ID" value="AKJ44_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="182" mass="19775" checksum="68C32DAEC6803638" modified="2016-07-06" version="1">MTVNIGNHYKLLAPRPTVCVSTLSSDGTSNLAPFSFATPLSFDPPLLGVSVGHGKDTLLNARETEDFVVAPLTSRWKEKGVRAEISLGRDESEFEEIGLTENPSKEVDSPSIKEAPINIECEYWDDFKAGDHSLLVGKVVSISAEEEAIKNGRINLEGMGAIGHVTGEEFCLSDVTIKIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V495</accession>
    <name>A0A133V495_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000044">
        <property type="protein sequence ID" value="KXB01268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01268">
        <property type="protein sequence ID" value="KXB01268"/>
        <property type="gene ID" value="AKJ44_02730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.511"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="274" mass="28928" checksum="7F2D34A93CD7E416" modified="2016-07-06" version="1">MSQVQLTFTPPESKRLIAKGVASLDEVQEAYKNHTVIIALGTTTGRVAEELLDEEINRDGFVAGIILPKGNCIVPREDRTSHIIIQKGKVVDVKAKEVLKDLSSKDVIIKGANAIDSKGTAGVLLGSPTGGTLTSVVAPAISRGTKVIIPVGLEKLVPGKIEELCNVTGINQPQSSIGVPVGLGVLHGKTITEVEAIQTLAKVKATPLAKGGVSGGEGSTVLVVEGLDEEIEKIKKIADEVKGEEPLSFETDCEVCDRETWPYAGEKSPLKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4C0</accession>
    <name>A0A133V4C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000044">
        <property type="protein sequence ID" value="KXB01267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01267">
        <property type="protein sequence ID" value="KXB01267"/>
        <property type="gene ID" value="AKJ44_02725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="138" mass="16215" checksum="BD24A2A37C8337EA" modified="2016-07-06" version="1">MKIYTIGYGDKEFKELVKLLKRIDIKQVVDVRSFPKSKWPEYEKESLQKTLPEQGIEYVHLRELGGYRDGGYENYMETKNFQKGLDKLIELAQKQSTVIMCLESYPNGCHRRFISQKLSELGWEVIHLVGKKGKQRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4C6</accession>
    <name>A0A133V4C6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OB_aCoA_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000043">
        <property type="protein sequence ID" value="KXB01294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01294">
        <property type="protein sequence ID" value="KXB01294"/>
        <property type="gene ID" value="AKJ44_02685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="115" mass="12942" checksum="553C7A510B9CE173" modified="2016-07-06" version="1">MTGYKCKNCGRIGHIHGARCLNCRGTEFEEIELGDECELLTYTQVYNPPAGVDVDPPLMVGLVEFPNEVKAMGQLEIANPEDLQIGRKLKPVWGELRKIRGEKVYGFKFKLAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4D1</accession>
    <name>A0A133V4D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000043">
        <property type="protein sequence ID" value="KXB01293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01293">
        <property type="protein sequence ID" value="KXB01293"/>
        <property type="gene ID" value="AKJ44_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="252"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="376" mass="39710" checksum="AE038EA58B12D14E" modified="2016-07-06" version="1">MTDFRDRSKSLLEMATEASLEAIENAGAEEEDFDAIYFANMASGAFNSQTAVASAIADQLNLVPAGAHRIENGPASGGSAIRSAFMGVASGIQDLVLVVGAEKMSDVSGAIATDILASMNHPKAEYKHGVPMPGMGALFTRLYMEQYGVTEDQLAAAAVKNHTNATKNPKAQLRHKPATIQGVKDSIMIADPIRLYHTCPVTDGSAALVVCPADKAGEFTDKPIQIVGSGQATDIQALEEREDPLKLRSVEIAANEAFEMAGLKREDIDVIETHDAFITLELAEIEAAGFFQPGEAGKATLEGKTAIDGELPVNPSGGLKARGHAVGATGIAQAVEIITQLRSEAGERQVKDARTGFCCNFGGFGNNTVIHILRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4G7</accession>
    <name>A0A133V4G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000042">
        <property type="protein sequence ID" value="KXB01333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01333">
        <property type="protein sequence ID" value="KXB01333"/>
        <property type="gene ID" value="AKJ44_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="154" mass="17208" checksum="BF093DD3D105A586" modified="2016-07-06" version="1">MKTLILGIGNEIRRDDAVGLIVAREVYNRIGKEGIDLKEASSAGLSLLGKIKGYDRVFLIDSIMTKDGKPRDWYSLSLDDLAERRSGITSHTVDLRTMKEMGGELGEAMPKIRVYAIEVKEPFEFSENLTKEVEDSIWEVISGVLNSIKEEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4P8</accession>
    <name>A0A133V4P8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000038">
        <property type="protein sequence ID" value="KXB01429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01429">
        <property type="protein sequence ID" value="KXB01429"/>
        <property type="gene ID" value="AKJ44_02525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="82" mass="8933" checksum="DD5B8C3415292776" modified="2016-07-06" version="1" fragment="single">LTNVPMSEVWIVSMLVLILAVNLPLCLWSGQLGAQRGVYVFYRLRGKTVDPDFGSKPFSKFLLILTASIAVGVVGAIIFSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4Q4</accession>
    <name>A0A133V4Q4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01401">
        <property type="protein sequence ID" value="KXB01401"/>
        <property type="gene ID" value="AKJ44_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="126" mass="14367" checksum="7D850DB986E190A1" modified="2016-07-06" version="1">MTVLVDSWAWIEYFKGSKAGGRVREIIEDPSETIVLSTINIAEVYRRILEDYDEAKAEEKREVMKDRSFVHPVDEDIAVDSAKIKFERGWSLGDSIIYATAKRENAKVLTGDPHFKGLEETIFIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4T6</accession>
    <name>A0A133V4T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000037">
        <property type="protein sequence ID" value="KXB01460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01460">
        <property type="protein sequence ID" value="KXB01460"/>
        <property type="gene ID" value="AKJ44_02495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.435"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="203" mass="23661" checksum="B871A600C93A4FA5" modified="2016-07-06" version="1">MSLERGGGKIQAKTLQLKIILDGVKPPIWRRFLVKNSMTFRDLHKIIQIVMGWEDYHLYEFSVNDLRIEDAERFSVDSMWKAFRPKAETESAKRTRLSELLKTEKQKFSYLYDFGDSWRHTVVVEKILDDGERETPACLAGERACPPEDCGGVWGYEELLKIKEDKNHPLYQERIVEWLGEGFDPESFDLDGVNEALSSLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4U6</accession>
    <name>A0A133V4U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000037">
        <property type="protein sequence ID" value="KXB01465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01465">
        <property type="protein sequence ID" value="KXB01465"/>
        <property type="gene ID" value="AKJ44_02520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="155" mass="18089" checksum="94D710B9AE5620A1" modified="2016-07-06" version="1">MLEESPSIKSLEVSREDLQLKFEINAILKAGQHLKQICNQTRLQFTVEKREITEWLLNSIRSNEAKAFIRGWLGKKYDYQDFPVMEGIINYLGGWRETNPDFVREVIDILKNANRYQVGRLAFEAGYNIFDDEGYLKEAEQDPSQAIRKWVAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V510</accession>
    <name>A0A133V510_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_02435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000035">
        <property type="protein sequence ID" value="KXB01524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01524">
        <property type="protein sequence ID" value="KXB01524"/>
        <property type="gene ID" value="AKJ44_02435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.418"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="260"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="510" mass="56586" checksum="A1086B9DEFB71571" modified="2016-07-06" version="1">MKRGETVLKAEGITKKFPGVVANDHIDFEIKAGEIHAILGENGAGKTTLMNILYGLYKPDEGEIYVRGKKVKFESALDAIDLGIGMVHQHRKLVPAHTVIENMVFGHPKAGKILDLKAAEEEVEELCKKYGFEIDLRKKVWQLSAGERQMVEILKALYRGAKLLILDEPTSALTPPETEKLLASLKAMVKDELAIIPFITHKLPMVLAISDRVTILRKGKVVDRLKTKNTTKKDLAKKMIGREVLFKTKKVKVKKGKPILQVKNLSAMSDAGFLILKGVSFSIHEGEIFGIAGVSGNGQRELAEVIAGLRKAEKGKILFRGKDITHSSILDRWKMGIGYIPPERVEVGTISEFSLVENMAMNLYFDPDFSERGILDYNKIRKHTEEAISEFDIMAPSADTKAAHLSGGNLQKLILARMLSQRPQLLIANLPTHGLDVGATEFVRNKLVERKKEKIGILLISEDLDETLSLSDRIAPIFEGKFMGIFPKKSVKKAEVGAMMAGTPYEEVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V576</accession>
    <name>A0A133V576_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_02380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000033">
        <property type="protein sequence ID" value="KXB01581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01581">
        <property type="protein sequence ID" value="KXB01581"/>
        <property type="gene ID" value="AKJ44_02380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.407"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="163"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="339" mass="38596" checksum="570BECD289A0A575" modified="2016-07-06" version="1">MVDLYGRDLITSQEWSKEEIDATIELAKKLKRQYYEGTLGDPLKEQTFFMLFYNTSTRTRASFEAAMTALGGHAQFVDVSTTRVGEGEMPKDVARMYERYGHGLGIRILESAVGYVYGRGNEFIRKYAENCDVPVISLADDKYHPCQGLADLLTVQEKIPDYQGKKYVISWAYSDKVRSWGSVQEEAMLMSRYGIDVTIAAPEGFELDQEIIDTCRKNAKGSGANFETTNDLDGALEDAHIVFPRSWASHKCMMDGIKKFGKEREQKLHENYVDWKLTQERLDLMDDDAIMMHVLPVFRGQEASDEVVDGPHSIIYDQAENRLHAQTAILTQTMSKNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5C6</accession>
    <name>A0A133V5C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01617">
        <property type="protein sequence ID" value="KXB01617"/>
        <property type="gene ID" value="AKJ44_02350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10854" checksum="49B191905A6B2E98" modified="2016-07-06" version="1">MAVANLSWDMIAAFAASGAFIIAIYAQFIRPRLQAYRRGGKVKKLKKKKPRLDPKILWGPPGSEEERKEESCLRRAPLNSSIFGLRTRQKIALTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5F4</accession>
    <name>A0A133V5F4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01673">
        <property type="protein sequence ID" value="KXB01673"/>
        <property type="gene ID" value="AKJ44_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="129" mass="14087" checksum="B04CF2E6FEA4704D" modified="2016-07-06" version="1">MLNTGVSSKISFKKLASKVRNVYVGLSGEDIPADANSLIKRRLEVLKTIKEEAKNFRELDCGEIDVFLKAHLDAVGIVAAVNGDIVDLSAENFGIFGHTGIRRGRVFVGTCSQADDWFFSDLSSRVGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5J7</accession>
    <name>A0A133V5J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01720">
        <property type="protein sequence ID" value="KXB01720"/>
        <property type="gene ID" value="AKJ44_02220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="105" mass="12626" checksum="F8954E0CA37DBA87" modified="2016-07-06" version="1">MRTTYQVPVVRPTRKKEAFLESLSGKYPKMIQWFLTIFEKEGLDFREMGLNEARTIVKELCYPTKERNSRYNCKGAIHFPHSHYYDTAITEAIQKWNSFLTWRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5J8</accession>
    <name>A0A133V5J8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_02185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01713">
        <property type="protein sequence ID" value="KXB01713"/>
        <property type="gene ID" value="AKJ44_02185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="161"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="278" mass="32570" checksum="B102EBDB1E75CD83" modified="2016-07-06" version="1" fragment="single">EEVKAKEIKQLQVIPKAKAQYFEYRLIYEEEKTRIETEKGTWLSIDLNVDNLAVCGDHSGRSFILDGRKLKSINRWYNREIARLQSIKDKQGIQENTRRTNKLYRDRRNKIHDYFNKAVHWILEYCKANKIELVLVGDGKEWKQESEMGDKNNQNFMQIPFDLFKRKLKAKLELHGINFELVEESHTSKCSFFDGEPVEHHEEYVGTRVKRGLFKTSNGILVNADVNGYLNIARKYFEENGEKGKLKTLKGVESSGVVATPRRIREPFEFQPSLKPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5N9</accession>
    <name>A0A133V5N9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000028">
        <property type="protein sequence ID" value="KXB01755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01755">
        <property type="protein sequence ID" value="KXB01755"/>
        <property type="gene ID" value="AKJ44_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="90" mass="10030" checksum="AB86EE6C3AE4391E" modified="2016-07-06" version="1">MAKVFASSLRDMKILTDKGLRVGRIFDMTVDENNGKIETIVVKPESREIAQSLNTDEDGNAVIPFSSVVAVRDYIVVSEKSLAIQRMKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5P3</accession>
    <name>A0A133V5P3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_02200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01716">
        <property type="protein sequence ID" value="KXB01716"/>
        <property type="gene ID" value="AKJ44_02200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.337"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="186" mass="20135" checksum="012225BE01C5C419" modified="2016-07-06" version="1">MSEKDEITTLSPPLSEEEVKELKAGDMVKITGTIITARDKAYARILEFSRAGKELPADLEGGVVYHCGPLVKKTDDEWEIISAGPTTSARLDNMQIEFVENTRVRALIGKGGMSQKIAEKIGEFGCIYLAFTGGAGALAADAITSIEDLVWEDLGTAEGIWVLKVKEFGPLLVAIDTKGGNLYEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5T4</accession>
    <name>A0A133V5T4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="7">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ileS</name>
        <name evidence="12" type="ORF">AKJ44_02175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000028">
        <property type="protein sequence ID" value="KXB01756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01756">
        <property type="protein sequence ID" value="KXB01756"/>
        <property type="gene ID" value="AKJ44_02175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.332"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="686"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="968"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="599"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB01756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="1062" mass="122949" checksum="7B45171BFCE21B86" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5W9</accession>
    <name>A0A133V5W9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000026">
        <property type="protein sequence ID" value="KXB01844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01844">
        <property type="protein sequence ID" value="KXB01844"/>
        <property type="gene ID" value="AKJ44_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="80" mass="9213" checksum="051BB1FE04715109" modified="2016-07-06" version="1">MDEQAAEIASVNLMLKGMQKNERFPDIFGYRVIPAFGSCSVCYIFYWVILGFFVPSLLFRKLSGKSAFCLDLLLDRNLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5X4</accession>
    <name>A0A133V5X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000026">
        <property type="protein sequence ID" value="KXB01842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01842">
        <property type="protein sequence ID" value="KXB01842"/>
        <property type="gene ID" value="AKJ44_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="111" mass="12770" checksum="CCD5066DB0FD580B" modified="2016-07-06" version="1">MVPHHPTSDQYVSNHSPSNHSISKNVRFPLILGENIKVGNSLVTEPIDKIGEYFDNPDDRKPFLWKEEFSEIFQEGGFDVIIGNPPYFTIRKSGTRGEATFYYEYLKNSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Y0</accession>
    <name>A0A133V5Y0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">AKJ44_02040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01854">
        <property type="protein sequence ID" value="KXB01854"/>
        <property type="gene ID" value="AKJ44_02040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.302"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB01854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="329" mass="36138" checksum="1973D90E1D83EBE7" modified="2016-07-06" version="1">MAKIYMDEDASLEPLEDKTIAIIGYGNQGNAQANNMRDSGCNVIIGNVSGDPFWKQAKEDGFDVYEISEAAKRGDIVHMLIPDEVQAKVYSNEIAPAMGEGKTLCFSHGFNIHFKEIVPPRDADVIMIAPKAPGARLREEYQAGSGTLGLLAVAQDPSGNAKQVALAMAKAVGLTRIGVVETSFREEVETDLFGEQSVLVGGVSELMKAGFETLIDAGYQPEVAYFECINELKLIIDLVHKQGIEGMMKAVSNTAEYGGRTRGPEIIDEKARKKMKKILKDVQDGAFAKEWVAENERGAPKLKKMREEAKEELVEQVGKELRKWAEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5Y1</accession>
    <name>A0A133V5Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000026">
        <property type="protein sequence ID" value="KXB01843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01843">
        <property type="protein sequence ID" value="KXB01843"/>
        <property type="gene ID" value="AKJ44_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="578" mass="66376" checksum="AC6942DCF6AD63C0" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V604</accession>
    <name>A0A133V604_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_02030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000024">
        <property type="protein sequence ID" value="KXB01872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01872">
        <property type="protein sequence ID" value="KXB01872"/>
        <property type="gene ID" value="AKJ44_02030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.300"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="472" mass="50155" checksum="D42AA482C2FD080F" modified="2016-07-06" version="1" fragment="single">TILDEMEVEHPAAKIMVEIAKTQEDEVGDGTTTAVALSGALLEEAGDLLDKGIHASIIALGYKEAAEKAQEILNEIAIDVSRDDEETLEHIVQTAMSGKGAEVRGEELSHTCIKAVNQIAEEKDGKLVADIDHIKVEKKTGKSSADSQLIDGIIIDKGRVHPGMPKQVEKAKIALLNTALEVRETETSAEVEITSPDQLKAFLDEEEGMLREIVDHLKDIGANVILCQKGIGDIAQHFLAKENTLAVRRVKKSDMRKLARATGGRVSSNYEDLSADDLGSADLVEERKIAGDEMLFVEGCESPKAVSVLVRGGTEHVVDEVERAVHDGLSVISVALEDGKFVPGGGAPEIEVAKGIRDYAGSVGGREALAINAFADAIEIVPRTLAENAGLDPVDILVELRAAHGEKGGKKKGLNVISGEIEDTAKAGIVEPLRVKTQAVSSAADAAEMILRIDDVIAASELEEETGAGPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V607</accession>
    <name>A0A133V607_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="15" type="ORF">AKJ44_02025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="LHXY01000024">
        <property type="protein sequence ID" value="KXB01871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01871">
        <property type="protein sequence ID" value="KXB01871"/>
        <property type="gene ID" value="AKJ44_02025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.299"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="53EXOc" evidence="12">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="13">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXB01871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="341" mass="38367" checksum="806C696925B2E6BC" modified="2016-07-06" version="1">MGVQIKDIVPIQESSLEQLQGKIIAIDAMNTLYQFLSIIRQSDGTPLKDSKGRITSHLSGLFYRTSNLIEKGIRPVFIFDGEPPELKSKTIETRRTLRAEAEKARKKALKEGKEKEALKYAQRSARLTEEMSGESKTLLDAMGVPWIQAPEEGEAQAARLTQNEDSWAAGSQDFDSLLFGAPRLLRNLTITGKRKLPGKDVYKEIVPEVISLEKLSEEQEITREQLIAIGILVGTDYNPGIKGIGPKRALKLVQEHGTISDILEAEEDLEFEVDPIEIEEIFLEPNVTDDYEVSWSEPNPDAIKEFLCEEHDFSESRINTGIERLEKGASKRSQESLEKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V613</accession>
    <name>A0A133V613_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000024">
        <property type="protein sequence ID" value="KXB01870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01870">
        <property type="protein sequence ID" value="KXB01870"/>
        <property type="gene ID" value="AKJ44_02020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="87" mass="9711" checksum="B06FA22A7C8A030B" modified="2016-07-06" version="1">MSNKLQKKGKLAKSEEGELVLMNDDDQVFEADRIVIAIWDRCEGDISSSELSEEISEKSGEDQDKIQAAVVKIVDQLENANLLKTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V619</accession>
    <name>A0A133V619_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_01980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01889">
        <property type="protein sequence ID" value="KXB01889"/>
        <property type="gene ID" value="AKJ44_01980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="248" mass="26359" checksum="25B9F6833AFF225F" modified="2016-07-06" version="1">MGLGTTAALSAIFTHVARADKEKSIAVFLNASFMNYTFLGLAVVYVIGGALPSVTAVDALGMASIYAVTMGVVHLTVGVALAASSSSEKKPSLRSITLSILTFPAAFALIVALLFVGFNVTWPMELQSWVDMFANPAVFLMLLAAGYHMPVVDPRKYLPTISLVGFIRLLVCPLVTYGAITLAGVGQTVATTALILAAMPPAVFNIILAEKFDLDLELYSATIFYLTLISLFISVPLIVHFFMGVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V627</accession>
    <name>A0A133V627_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01904">
        <property type="protein sequence ID" value="KXB01904"/>
        <property type="gene ID" value="AKJ44_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="109" mass="12611" checksum="33A8A01CA641F513" modified="2016-07-06" version="1">MNSRHPHHAHLLNIPSQKLETPKEYVRIGFAGYTFQRRISKEVKIRLENEKGKIKGFSMPSVSVLEPLPILPPTEFKELESILGMDFLNNTGLHLHLWPRKKEAWLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V634</accession>
    <name>A0A133V634_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="14" type="ORF">AKJ44_01955</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01892">
        <property type="protein sequence ID" value="KXB01892"/>
        <property type="gene ID" value="AKJ44_01955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB01892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="62" mass="6749" checksum="674C635B2C445CD6" modified="2016-07-06" version="1">MARRRRGGEDESMPATGAGLIRYFKEDTHGVKVSPKTIVGIAVGIIILEVLLRFYGTAILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V647</accession>
    <name>A0A133V647_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01924">
        <property type="protein sequence ID" value="KXB01924"/>
        <property type="gene ID" value="AKJ44_01900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10930" checksum="BB5A8664C1006960" modified="2016-07-06" version="1">MVSGLKDVTKEELEELYWGQNLTLSQIGDMFSVTYPTVIYWMEKRGVRRKGVRKYKTKVFNGDELEKAYLMGLRLGGSKCSAVSKTDPGQNFNQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V648</accession>
    <name>A0A133V648_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01918">
        <property type="protein sequence ID" value="KXB01918"/>
        <property type="gene ID" value="AKJ44_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="155" mass="17612" checksum="1374B54E4D0FFA70" modified="2016-07-06" version="1">MRGITHFIMGALIVTFIGSAMYGVLEYTSLIIMMGAFFGLLPDTLDFKFNRYIETHDLTIDPLPDDFDPQEIADAIAEEIDKADKLKPGDEQKIELHTMKIGPDRWKSYSPFFDTRKREVVVREGPECDTGQNMLPGTEPSPEDEKNHWKSSIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V666</accession>
    <name>A0A133V666_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="7">BPG-independent PGAM</shortName>
            <shortName evidence="7">Phosphoglyceromutase</shortName>
            <shortName evidence="7">aPGAM</shortName>
            <ecNumber evidence="7">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apgM</name>
        <name evidence="9" type="ORF">AKJ44_01890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01922">
        <property type="protein sequence ID" value="KXB01922"/>
        <property type="gene ID" value="AKJ44_01890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.266"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01402_A">
        <property type="entry name" value="ApgM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="8">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="406" mass="43587" checksum="3284945E41C1292D" modified="2016-07-06" version="1">MKTVLAIVDGLGGRPTDYNGKTCLEAAKTPNIDELAKRGSTGLLDPIKPGVKPESDTAHLSIFGYDLDKWYTGRGVFEALGIGMKVKRGDVCFRTNFATVDENLNVQDRRAGRIQEGQKGLEGALQDLKSSQPDVKVIFKASVEHRGALILRGPGLSGQITDIDPHETGVKVGKAEPLADEESAKETAKIVNEIVQQSHEILSGLSLNIDRRKEGKLPANILLFRGASEKIGIPSVRERYGVNGVVIAAGALYIGVGRALGLEFKQAEGVTGRADSPIIDKAKLAVKELRDDDTGFAFIHMKGADSCGHDQDAEAKIAYIEKADEVVGYLLDNLDWNQTRIAFTGDHTTPIAVGDHTSDPVPIVFAGQDITPDEVGEFNEKTVRKGSVGRISGQVVPILLGCSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V671</accession>
    <name>A0A133V671_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01937">
        <property type="protein sequence ID" value="KXB01937"/>
        <property type="gene ID" value="AKJ44_01805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.229"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="333" mass="38433" checksum="FA96676566DBBECA" modified="2016-07-06" version="1">MREKLSKLGLDLPTLPTTAVGSYPKPAELKKARRKFLKGELKVEDLRPLEEKATREWIKIQEDVGLDVLVDGEMYRGDMVTYFARNLEGFSISGLVRSYDNRYYRKPVIKDKIEWTKPITVDYWRYAQELTEKPVKGVLTGPYTMMDWSFNEYYPNRKEACLALARALRKEVEVLADAGAKIIQIDEPASSARPEELPEFSEEAMKIMTNGIDAYFITHICYGAFEFIYPEMLSLSVDNFDLEMSNSDLDLVELFEKKPFTKDISFGVIDVHSHVIEDEDTVKSRIERALETLDTNQVWIDPDCGLKTRTKEETIEKLKVLVNSVKETRKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V679</accession>
    <name>A0A133V679_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01954">
        <property type="protein sequence ID" value="KXB01954"/>
        <property type="gene ID" value="AKJ44_01745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="142" mass="16331" checksum="22F3C36AEA834F4B" modified="2016-07-06" version="1">MTLEHSDFQDLFEKLMRIIERYQDDPAALEAISTELENLYKKIPIYPGIIAMSLNDIVKPAKMDELEEGSRITVLLKDGKLVSGEVIGFDSGKLKLKNCRQFKKPEELDEATISEEDVREVRRLVRDTLAKSWPSLDFEVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V684</accession>
    <name>A0A133V684_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="5">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_01770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01958">
        <property type="protein sequence ID" value="KXB01958"/>
        <property type="gene ID" value="AKJ44_01770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.220"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="191" mass="21417" checksum="5834B03D4F555B08" modified="2016-07-06" version="1">MTLAFVTSNRHKFEEAESLAENFGVELEHRDVPYVEIQADVLEDVAKPSAQQACALIDSPCFVEDAGLFIKSLEGFPGPYSSFVFKTLGNEGILKLMEGEEDRQAEFRSAVGYCEPRAKPKVFKGKVRGVITRETRGSKGFGFDPIFSPERGEGITFGEMELEMKNSFSHRSEAIEKFLKWYTKNKKPSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V685</accession>
    <name>A0A133V685_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01942">
        <property type="protein sequence ID" value="KXB01942"/>
        <property type="gene ID" value="AKJ44_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="112" mass="12761" checksum="9D8AECFFD08538C2" modified="2016-07-06" version="1">MIESYSFGKIVIDGQKYTNDVIIFPNRVKDDWWRKEGHSLHPEDLEEVMEEEPEVLVVGKGHSGLVTISEETKKFIESRGIDLIAKPTEEACEEFNELSKTKKVVAALHLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6A4</accession>
    <name>A0A133V6A4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_01710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000018">
        <property type="protein sequence ID" value="KXB01975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01975">
        <property type="protein sequence ID" value="KXB01975"/>
        <property type="gene ID" value="AKJ44_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="457" mass="49735" checksum="6C1B017BF4F4B8A0" modified="2016-07-06" version="1">MNVEEQLEPFFDAKSVAVVGASRSTGPGSFNVVENMIEFGYEGDIYPVNPKADKILDLKAYDDVREIEGPVEHAVMMVPRKIVPMILEGCVEKKIPAVTIASQGFAELGGEGKELQDKLLEIIDGTNTRIVGPNTLGTHNYVDKFTTSFIPFKERSYEPIGVVSQTGMWAASVPRLRYAKILDIGNASDVDHVDVLKYYKDDPDIKQVFLHIEGLHPSRGKELIATAREAIEEGMSIIAFKAGGSKTGAEYAKSHTGALAGEDRVFRGALKQAGIVSVNDYTQAEIASKALLKLPKMEGREIGMLTHHGATGTMAIDAFEQFGLEMAELSDETLKPIREMSPDWLEIGNPVDIWPALMGGPERAHKVALKALLEDENVKGILLSIHIADPTSWNLGVYGHIDACRELAPKYSKPVAVVPVGTDQGETRNELEKIENVAVFDNIRAAARALSILSKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6A8</accession>
    <name>A0A133V6A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000018">
        <property type="protein sequence ID" value="KXB01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01974">
        <property type="protein sequence ID" value="KXB01974"/>
        <property type="gene ID" value="AKJ44_01700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="62" mass="7338" checksum="97C0BA0FBA01F87C" modified="2016-07-06" version="1">MNLTNDYYLKLANFFLLYIIEAPNVSEALRLRPIRSHIIRWGDIITKTSQKSEITQLNEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6C5</accession>
    <name>A0A133V6C5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01991">
        <property type="protein sequence ID" value="KXB01991"/>
        <property type="gene ID" value="AKJ44_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="80" mass="8738" checksum="4B953B0695B25383" modified="2016-07-06" version="1">MAVKTKVSKGFQTVLPAPVRKKFGVNPGDEVIWTIIGDEIFVRVRKKGGEDPLSELIGALPTQEKANATREIDATVYGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6C7</accession>
    <name>A0A133V6C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01999">
        <property type="protein sequence ID" value="KXB01999"/>
        <property type="gene ID" value="AKJ44_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="82" mass="9501" checksum="77789310F02AABB1" modified="2016-07-06" version="1">MSLPYWSAHWGQVVTKDVPERAIVYGSPARIRGIWRKTGQSNIPIQLWEESSYLSYIVGNTFSRNPDIYMSKIALATLNRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6C9</accession>
    <name>A0A133V6C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01998">
        <property type="protein sequence ID" value="KXB01998"/>
        <property type="gene ID" value="AKJ44_01685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.198"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="272" mass="31013" checksum="B4D33DA2D2CA791A" modified="2016-07-06" version="1">MIHERDWDCLVILDACPYDYFEKVYEDYSDGKLQKVISAGYSTLGWLKETFGDSKHSGIIYVSGTAYVNSRGLEVIEGFIGVNHFYKVIDVWDHGWSEELETVLPERMSKATRLARAKYPSKRLISHFNQPHYPHLSIGSIREITENSAFIPAKKGIVWERSLVDKVRGFAGTASEEILGAALTCRVRDILNLRRSKPCELIAREYGDRTLYEAYENNLRAALAEVKKLAERLPGKTVVTSDHGELLGEDGLYGHGWRHPLLREVPWLEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6D0</accession>
    <name>A0A133V6D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB02000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02000">
        <property type="protein sequence ID" value="KXB02000"/>
        <property type="gene ID" value="AKJ44_01675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.196"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="200" mass="21526" checksum="32F16038EEF59C88" modified="2016-07-06" version="1">MGTWMYAKLGKNCEVQENVTLGLKYKEDCGEAIIGDDAVIRKGTIIYADVEVGNDFRTGHNALIREKTRIGDGVLVGTNVVIEGNVVIGDQVKLESNAYIPTHSGIGDRVFIGPGATLTNDKYPLRAREEYTPNGPTLEDDVTVGANTVILPRVKIGEGSFVGAGSVVTKDVPPWSLAIGVPAEVKSLPEKLKERNEFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6E9</accession>
    <name>A0A133V6E9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02020">
        <property type="protein sequence ID" value="KXB02020"/>
        <property type="gene ID" value="AKJ44_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="104" mass="11313" checksum="251227CE2D87C1A1" modified="2016-07-06" version="1">MIIAELKIVPLGVSGTSLSSYVSKAVKEIKNSGVEYQVHATGTVIEAPSVEKVLKVTRKAHKAVLEAGAPRAITTLTFDERTDKEEKMSDRVKKSPSKIVKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6I1</accession>
    <name>A0A133V6I1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_01530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02048">
        <property type="protein sequence ID" value="KXB02048"/>
        <property type="gene ID" value="AKJ44_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="117" mass="12549" checksum="F4A746925EA1A7F2" modified="2016-07-06" version="1">MVVSKPEVEPGETTTISADVTNTGGTPSTYTVELSIEGEMVDSRDVPLDPGDSETISFDVAKEEPGAYDFAVDDLTGSFDVRKPPAFPWATVIAIIVIIAAIIAVGIWYWTRGRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6J1</accession>
    <name>A0A133V6J1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02053">
        <property type="protein sequence ID" value="KXB02053"/>
        <property type="gene ID" value="AKJ44_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="286" mass="32438" checksum="94D0EC9434A94C77" modified="2016-07-06" version="1">MYLNGIGSGAENARENPSGPSGPEIENVRENSTRPSTPEAENARENSTGQPPASWWNEHDLHAIPGLENASVEDLPTAEEVENILFNWPVFENIWTGCWIDWNGSYQDVLNILKDFNIEYHFGENNKLIINTPGIFYKKPGEPIPDWMTLYDNSEYRIWNYSDTLNSLYCSRYLDNLGIRNGIAIIPVFTATPPLIEAKVVVPVRKGLAYYIPTAGERAHWAGIWYALNLKPGGSNPYYTDPESEPLGDIEIHWRLGEGEYVDWLYTPQDGEPVMTWSDNGEPVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6K7</accession>
    <name>A0A133V6K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02075">
        <property type="protein sequence ID" value="KXB02075"/>
        <property type="gene ID" value="AKJ44_01470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.149"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="527" mass="60112" checksum="159DE48F951F8C7A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6L1</accession>
    <name>A0A133V6L1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_01370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02090">
        <property type="protein sequence ID" value="KXB02090"/>
        <property type="gene ID" value="AKJ44_01370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.128"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="120"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="268" mass="31409" checksum="40BF599FB7375855" modified="2016-07-06" version="1" fragment="single">VYHMMPGLPGSNCERDLQAFKTIFNDPRFKPDMLKIYPCLVTKETELYDWWKAGKFDPLEGEEAIELIAKMKEQIPRWMRIQRIQRDIPAHLIEAGVQKGNLRDIVKEKLASWNSHCECIRCREVGHKAREGIEPQMDDVKLLTQKYRASDGEEIFLSFEDVEQDIILGYLRLRIPPRDVTRPEIDDATALVRMLYVLGELIPVREDKRPDAWQHKGLGKRLLSEAERIAREDYDMERVAILSGLGTRPYYRRYGYQLEGPYMVKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6N6</accession>
    <name>A0A133V6N6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatD</name>
        <name evidence="13" type="ORF">AKJ44_01390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 8"/>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02093">
        <property type="protein sequence ID" value="KXB02093"/>
        <property type="gene ID" value="AKJ44_01390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.132"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="SSF141300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD_N" evidence="12">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="11">
        <location>
            <begin position="305"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB02093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="443" mass="48698" checksum="796C1B9A0B653E3B" modified="2016-07-06" version="1">MQGYRGKALELLKSISAEVGDRIKIEKAERIYEGLLMPRTELGDPEHIVVKLDSGYNLGVKVDKNTKISKIGKGKKPKMGMPPTEFKPDPEKPDITIVGTGGTIASRIDYRTGAVHPAFSTQEIYNAVPELADIANIKTVVASNVLSENMTPELWTKIAETVAEELNKGVDGVVVAHGTDTMGYTSAALSFMLKNLTKPVVLVGSQRSSDRPSSDASLNLIGAVTVARSDLAGVYVVMHGSTEDEFCLIHRGTKVRKCHTSRRDAFQTVNEIPIGEVREGEISLFQEVERRSDGKAKVDSKFEEKVALVKTYPNIQSDIIEDLLDQDYKGIVLEGTGLGHTPKSLYPGIKKAIKEKVPVAMTSQCLWGRVSMRVYSTGRDLIQMGVIPCEDMLPETTYVKLMWVLGRVKNLDKVRELMLDNVAGEISSRSRPDIFLKPILPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6N8</accession>
    <name>A0A133V6N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02092">
        <property type="protein sequence ID" value="KXB02092"/>
        <property type="gene ID" value="AKJ44_01385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="140" mass="15493" checksum="2125EC0D3F515F2B" modified="2016-07-06" version="1">MLIEKEEPDVSYVLTSDYSYDYVDEEGGFDKSSGEVIADAAEKIGTEVKFMKCDTFDPEEIGEKIGEILGGLDPDDEIIINYTAGSATIKIILGTTAVAISRFMENLRIVYAIRYPDGTEKYLDQTEALGKLFTQLNQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6P2</accession>
    <name>A0A133V6P2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02097">
        <property type="protein sequence ID" value="KXB02097"/>
        <property type="gene ID" value="AKJ44_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="71" mass="7663" checksum="85FD728609C8D44D" modified="2016-07-06" version="1">MTELPVAAVDRIIRKAGARRVSEGAAEALAEVLEERALSIAGEASRLAEHAGRKTVRDVDIRLASRRSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Q6</accession>
    <name>A0A133V6Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02125">
        <property type="protein sequence ID" value="KXB02125"/>
        <property type="gene ID" value="AKJ44_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="73" mass="8037" checksum="DDAC00B3C8135F83" modified="2016-07-06" version="1">MIFLETHAKLVLVILPEDAYAVRLLAIEKLARAIGQVGNVNPFSIPDIYPQKQSFFSLDEPQVEVAVLGLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6R2</accession>
    <name>A0A133V6R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02122">
        <property type="protein sequence ID" value="KXB02122"/>
        <property type="gene ID" value="AKJ44_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10743" checksum="2F82325533F26E8F" modified="2016-07-06" version="1">MSGITLLGGNVLIFIGIFLIAEAIFSIIYYFKSSTLPHSFRGIRAVLGAYLVWRGATYSIYKTIGLFWSQVAFFTIVGLSILAGYEVAKVLEKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6R5</accession>
    <name>A0A133V6R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02096">
        <property type="protein sequence ID" value="KXB02096"/>
        <property type="gene ID" value="AKJ44_01405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="95" mass="11080" checksum="244DF213C213B68F" modified="2016-07-06" version="1">MPRLFNVFDMPEVKSVRATTNIRMNVELKKILKNAPRARKIRTAGKKVVKFEINKGEYLLFFPSGYVQIHAPNEGRIREVLKAFRNELYECGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6T9</accession>
    <name>A0A133V6T9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02147">
        <property type="protein sequence ID" value="KXB02147"/>
        <property type="gene ID" value="AKJ44_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10130">
        <property type="entry name" value="PIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="139" mass="15815" checksum="DE9121F253A89CBD" modified="2016-07-06" version="1">MIAVVDTNIYFSTFYNPQGNEAEVIRRANRGEVELLSPDSVREELEQVLKTKLQWSKEEVTSSIDALPTVWIPKSEYSSKLDHAKSIITHEKDSPILACALQFKTGILTGNTKHFDIPQIKKEVPILDSRNLLQYLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6X4</accession>
    <name>A0A133V6X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02204">
        <property type="protein sequence ID" value="KXB02204"/>
        <property type="gene ID" value="AKJ44_01105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="296" mass="33850" checksum="7CBC45772C51F790" modified="2016-07-06" version="1">MLGNKTVEVMDRCLSGQPSMSELEEIASSRTIHKVIPQLEVLGIIERYTFKKGVGRPKTRCKLTRRGLKLKRMLDDIRYHAEYDRISRSGIPVTAGVYKSIADGYGAPLITDQRLAVPSRLTEKAQDMLEWSEVKLDGVPWSGFHERSVQVEDLRYLGLEDLIVLTNINEKDPARLQACITTIIKDFTEKIDYNLLLQIALEAGTVNEVGGLLHLTNRMSGETVIPLEILDEFQKHVKKRDVDRHLRYYLLVERGVPSSEAEHPVDREIRENWYAKLPTFMECREVFGWRGDGKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y4</accession>
    <name>A0A133V6Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02201">
        <property type="protein sequence ID" value="KXB02201"/>
        <property type="gene ID" value="AKJ44_01085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="295" mass="34602" checksum="B720321F90941349" modified="2016-07-06" version="1">MEAWLLDLYPTDDDKMAIWLKKNDGKAFMLKDDYRPTLYVHGSRYRLRKLEPELEESESAQDWTIVRGRVRLRDPEKSEVLRIECGSMEDLVENVEPSMEDEHDVRWLDLYLPLERGGEEIAIPMHVIKLNLPRMDEPSFSVGFFKHSRYFEVERGDEEIDDLYAEIIGEAARFLSILREADGELIERLVPYDYREGKIKRKRVEKSELSPAEAEKIRKDYQEHAKKNMGEEGCSLNDYLDTASICYGSAFEEATSDKSSLELYEHFADFRHEGMLDLEDADSKSEFARWYESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y9</accession>
    <name>A0A133V6Y9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02215">
        <property type="protein sequence ID" value="KXB02215"/>
        <property type="gene ID" value="AKJ44_01170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="60" mass="7245" checksum="75EAE84C36AC6F8C" modified="2016-07-06" version="1">MEDFLCVRISRRAVEALRESSDREEIERARQVLRKYPQTYLRVIGGWAEEKYEELKEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V706</accession>
    <name>A0A133V706_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02235">
        <property type="protein sequence ID" value="KXB02235"/>
        <property type="gene ID" value="AKJ44_01025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="145" mass="16619" checksum="41C1598CDE64235E" modified="2016-07-06" version="1">MERVLIDTNVMVIGARDYAEDKDTPGSIILKLALKNKMRVIMNSVLLEEYHRVAVDLEGKDLAGWFRNVIMKDLSISYVDETAIKRLMERYDGEVPSEDLPHFASCLLGGVDFLISVNRDFLKKTSKFNFRCVKPKEYLKESDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V707</accession>
    <name>A0A133V707_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02239">
        <property type="protein sequence ID" value="KXB02239"/>
        <property type="gene ID" value="AKJ44_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="101" mass="11588" checksum="1A4995E636675C84" modified="2016-07-06" version="1">METVTARIPKDLLQDLKEIESEEKTERAEVIRKLLDDAVKEWKVKKALEKLRDGKVTFRTAAKLAGLTYVQMLDQAEQANIPLEYSMKDLEADLVKLKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V720</accession>
    <name>A0A133V720_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02234">
        <property type="protein sequence ID" value="KXB02234"/>
        <property type="gene ID" value="AKJ44_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="142" mass="15845" checksum="6A71E998D753C068" modified="2016-07-06" version="1">MKTYSKEIEFATDKPRQVIDMTDKVLNVVRESGIKNGILIAQLPHATAMLALNENESGVKQDLLDKLNDFAPIDGGYRHDRIDDNAHAHLKAALVGSSRVLPIIDGRVIRGTWQSFLVIEQDGPRSRRRLVVTVFGESTTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V728</accession>
    <name>A0A133V728_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02242">
        <property type="protein sequence ID" value="KXB02242"/>
        <property type="gene ID" value="AKJ44_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="217" mass="23718" checksum="CCE2E3936B1CC8A7" modified="2016-07-06" version="1">MNTWIVIPAYDEECSIGGVLEGLKREGYEQIIVVDDGSQDKTPEIAKAKGVKVISHKNNQGLGAALRTGLQEAYDQGAEIAVTFDADGQHDPRAIPELINALNGADLAIGVRDRGEMPWNKRVGNFGLDFITHLLGGPYTDSQSGFRAFNRRALEKIQIQTNRYAVSSEIMIQSQEKNLKVKGVPIKGIFTDYSKARGTTIASGIKIFLSLLRLKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V730</accession>
    <name>A0A133V730_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02217">
        <property type="protein sequence ID" value="KXB02217"/>
        <property type="gene ID" value="AKJ44_01135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="79" mass="9015" checksum="801DA01581F1F2E4" modified="2016-07-06" version="1">MVKVTSKGQLTVPAEIRRDLGIDKDDYLYVAEAGDLILMKRIGVDPKEILNIFQRAAKDIGFTRKELDQAIREIRQAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V756</accession>
    <name>A0A133V756_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NMD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02268">
        <property type="protein sequence ID" value="KXB02268"/>
        <property type="gene ID" value="AKJ44_00935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="259" mass="29043" checksum="E49D1D469BD70C18" modified="2016-07-06" version="1">MQKFCYKCGALEEEKGPLIEGLCQDCFTSEHPLIKTPDQVELRVCGQCGAYFLNNKWHDPREKSELSLLRASEELVHSEIKVAQVQPTGVRYVNLEEASGIDVELESESVPQGIKVGIRARGKIHESQESSQTAEGVVRVKVETTTCDVCSRKSAGYYEAILQVRGEAPLSRKRLREVYQVLESTFLEEQSRNRGEFVSKIEEKHGGLDLYTSSTTLARRLAEALKEKYGAKTDESSKLIGQTSDGRKKYRVSIVARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V773</accession>
    <name>A0A133V773_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02309">
        <property type="protein sequence ID" value="KXB02309"/>
        <property type="gene ID" value="AKJ44_00820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="106" mass="11966" checksum="244D5E84037F92DF" modified="2016-07-06" version="1">MRKMGAPQRFRSRYIAFKVEGEASIEELRKAISKSSREISRLNPRPRIVIYDGDEGCGLVKCSHLQVDELKRELKKIGGTGNESFKVRLLGVSGTIKATKRKFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V783</accession>
    <name>A0A133V783_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02267">
        <property type="protein sequence ID" value="KXB02267"/>
        <property type="gene ID" value="AKJ44_00930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.619"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="10781" checksum="E26AAA94BD8DDB79" modified="2016-07-06" version="1">MPQLRIRHTQGETLVTICDEELIGEKFEEGELKLEVKNSFYEGEEASVEECINALKEATIANLVGSIVKHAIKAQIINPKNVLRIQDVPHAQMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V795</accession>
    <name>A0A133V795_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02310">
        <property type="protein sequence ID" value="KXB02310"/>
        <property type="gene ID" value="AKJ44_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="150" mass="17368" checksum="B2FFE05C79F98038" modified="2016-07-06" version="1">MKLPFKSVEVRSFVHATEDLKKVKEIFRSLLPEEIEIEESRAKGHHGDKITILSARINRNPDIREFWHQAMKMMSNKEKEKLSEIAVDRIADDCRLYLRFDKQAAVGEELILADSGDALHIRINVSAYPAKREIAVEEMRKFISSGLKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7A0</accession>
    <name>A0A133V7A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ44_00855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02314">
        <property type="protein sequence ID" value="KXB02314"/>
        <property type="gene ID" value="AKJ44_00855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.561"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="152"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="252"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="382"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB02314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="447" mass="47961" checksum="15688CCC186A3EE0" modified="2016-07-06" version="1">MPKLFGTSGVRGIINEDFTPETALRLARALATSLENSGTIVIGKDPRTSSDLIEDIITSGLLAGGCSVKKLGVVPTSVVGFAARNLGADAGIMITASHNPPEYNGVKFFDSSGMAYTPDKELEIEEIYFEERFESVEWSEIKDVSSTTILREYMQDISKVVDVDKKFKVVVDCANGAASQVTPYLLEGLGCEVITLNSQLDGTFPGRPPEPVKENLQELCKIVKSTAADVGLAHDGDGDRIAAADENGHVVEGDKLLALASAYAVQKFGGKIVTTIDASKVVDEQVIEAGSEVVRTKVGDVSVAQEMESQEANFGGEPSGTWICGDVHLCPDGPLAGIRILEMIDDSGKTLSELVDGVSSYPVCRAKIDCPNKEKEKVMQSVEEQAPQVFGDIVEKLTLDGLRLEFEDGAWLLVRPSGTEPYIRVTAEADDEDRAKSLVGEAKQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7B7</accession>
    <name>A0A133V7B7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NTP_transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ44_00850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02313">
        <property type="protein sequence ID" value="KXB02313"/>
        <property type="gene ID" value="AKJ44_00850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.560"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023915">
        <property type="entry name" value="Bifunctiontional_GlmU_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03992">
        <property type="entry name" value="Arch_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="419" mass="45518" checksum="94554786EDA8C701" modified="2016-07-06" version="1">MKAVILAAGKGERMKPLTNTRSKMLLPIAGRPVLEYVLSSLRDTEIRDVTLVVGHRKEEIKNRFGDGDELGLSLSYVEQPEQKGTAHAISFTDIDETFVVLNGDVYCDAESLVGTIRKHEGEDAVATVGTYRVKSAASYGVVRVKDGRVAEIVEKPGKTSDQLINAGVYVFEPEIYDAIKETPYSERREKEITTSIENLVEEGKNILANELGSWVHVGRPWDLLAANERALKHKTPIVKGEIEPNAQVPDDVTIDEGTNVKSGTYIEGPAYIGKNCEIGPNCYIRPFTSIGNGVHIGNAVEIKNSIILDGTHAAHHSYVGDSIVGANCNFGSGTKVGNLRLDAGNVMMTLRGKLVDTGRRKLGAVLGDEVQTGINSMINPGVKMGPRSAIGPGVVLYKDLSPNRCVLVKQKGEERAWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7C5</accession>
    <name>A0A133V7C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02345">
        <property type="protein sequence ID" value="KXB02345"/>
        <property type="gene ID" value="AKJ44_00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="67" mass="7476" checksum="A25CA762C441C4FB" modified="2016-07-06" version="1">MITVKLTPKKEVKKLEWREGLTVEDILRESKWTSSSVRTLVDGVPVSKEKELKDGDELILIPIVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7E7</accession>
    <name>A0A133V7E7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ORF">AKJ44_00580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02379">
        <property type="protein sequence ID" value="KXB02379"/>
        <property type="gene ID" value="AKJ44_00580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.367"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="76" mass="8865" checksum="0C63B83077BB3BCB" modified="2016-07-06" version="1">MVKTFRITGWFKHNDREQKFTKEMRAHSKDNVIESVYSDIGSRHGVKRNLIQIGKIEEIKPEEAEDPRIRALAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G3</accession>
    <name>A0A133V7G3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02390">
        <property type="protein sequence ID" value="KXB02390"/>
        <property type="gene ID" value="AKJ44_00645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="206" mass="23816" checksum="7B99A381A7E63EA1" modified="2016-07-06" version="1">MPQEPVKRIREYLDSQEKVRERILDVSHRAIRNSSRAMTAIHRGESASDILKNVKEDIESLTKILGSEPQFSDYGALLAAHREYAEAIITRTLMNGEKLPELEDLGVLKKAYLQALAESVGELRRHVLDLLREDELDEATNIYEKMEETFDILIEFDYPDSILPGFRHRKDVARRTIEKTRGDITNAVRQQKLEESLERVERKLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G6</accession>
    <name>A0A133V7G6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ORF">AKJ44_00575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02395">
        <property type="protein sequence ID" value="KXB02395"/>
        <property type="gene ID" value="AKJ44_00575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="216" mass="22428" checksum="CDF7E927B3A45A2B" modified="2016-07-06" version="1">MNLNKIPYIGIFALATDDYLIVPQRFGKIPKKQILGTMDVKIVPSEISQSPLIGILSAGNKSGLVVPDLIESGEKELEEKLSIRVARVPGKYTALGNQVLANDNGAIVSPNLPDKAVKIVEKTLNVQAERGTIAGLKSVGSAGVATNKGVLLHPDASKEELGKVEEALGVQGDIGTALGGVKYVGACMVANSLGVLTGESTTGPELGRIESSLGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G8</accession>
    <name>A0A133V7G8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease V</fullName>
            <ecNumber evidence="2">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Deoxyribonuclease V</fullName>
            <shortName evidence="2">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfi</name>
        <name evidence="3" type="ORF">AKJ44_00635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endonuclease V family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02388">
        <property type="protein sequence ID" value="KXB02388"/>
        <property type="gene ID" value="AKJ44_00635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.378"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Interaction with target DNA" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="234" mass="25921" checksum="B5AA0339CAC99FE7" modified="2016-07-06" version="1">MMLEILKPPTTNLDELSKIQRKIAKQVIKEDKTGDINTIAGCDISFSKGNQACAASVLLQYPDLKELDHWTEEVEVDFPYIPTYLAFRELEPMLKVLDDVEADVYMIGAQGLAHPRRAGLASHLGAIIDKPTLGVAKNILCGEAKEPEPEKGSYTLLKDKGETIGATVRTRSNVKPVYVSIGHKVSLEKAIEIALKTAPKYKLPEPIRAAHNLATKAMKENPDRSLMKKLTDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7I0</accession>
    <name>A0A133V7I0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02373">
        <property type="protein sequence ID" value="KXB02373"/>
        <property type="gene ID" value="AKJ44_00540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="334" mass="38302" checksum="FB86D7A8BCD32B17" modified="2016-07-06" version="1">MQKTILRLTTILLILFLLGGLNGSVTANSSDTPERVHLTWQSDDTAHTMTITWWTPTKNTDDNVLYDTVSRDGAPENYAYSENGSHHTFTNFNGYIHDVELTNLSPDTTYYFICGGENGGYSQEWSFQTAPTTSENLKFAAGGDSRPLHSGEARPSDFPENRDLLSQEMATRNPAFAIYTGGFVLDSDSGDQWENWFDAMQKYWVTSENRMIPIIPTIGNHEITYPQPQKYSPKNDAPYYYEQFALPENERWYSLDWGPDLHITILDSEILDRDSKIWNEQKSWLEDDLSQHEDFRWKIVAFHRPPPSVQTHLTGAILEFERNGLNYSTLTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7J3</accession>
    <name>A0A133V7J3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5667 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02393">
        <property type="protein sequence ID" value="KXB02393"/>
        <property type="gene ID" value="AKJ44_00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043725">
        <property type="entry name" value="DUF5667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18915">
        <property type="entry name" value="DUF5667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5667" evidence="3">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="401" mass="43919" checksum="31AF327B4B7BCA6E" modified="2016-07-06" version="1">MKKMLNMSQAGVATVTITVAVVVVSGGAVGPPVAVDEMDVQPDSPLYGLERAGEAIKEATFAGGQGWEIARGHERTSEFVNMANKRKAEGYTGLLNEAEDRFKKAIESAGDVKSIQKAKEAINKHISTLENVREKVPDVAKPAISLAISQSARGKSVVADVAAGKSPGEELGETVRERVRTQLREIKQETKTLRKEVKENLEKAPAKANEIVQNIEINTAKKIANQAKEMVKKNKGQCAQCASGVIEEAQCHLETAAMFAENETGLEKAISASQKHLSTLQSVYENVPDVAKPAISLAMQRSSQYIKVLENVKENQLSPGEQISNQIRERIRNRVHEIKENVKKIQEQVRNRIREAAGQASEISKIIQEYENKAKRIVESVTENQEENESYGTPGKGSPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7J4</accession>
    <name>A0A133V7J4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02428">
        <property type="protein sequence ID" value="KXB02428"/>
        <property type="gene ID" value="AKJ44_00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="777" mass="84827" checksum="05818C61B2AEEC3A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7L5</accession>
    <name>A0A133V7L5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02431">
        <property type="protein sequence ID" value="KXB02431"/>
        <property type="gene ID" value="AKJ44_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="249"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="498" mass="56123" checksum="682D5283A3B33F24" modified="2016-07-06" version="1">MKRITKEFPGVIANDHIDFDVKAGEIHALLGENGAGKTTLMNILYGLYQADEGEIYIAGKRVEIRSPRDALRHGIGMVHQLFRQVHRHSVVENVALSASTKQILPVEEIMEDFQKLAEKFAWKIDLNAKIWQLSAAERQRLEILKVIFQGVKILILDEPTSVLTPQGKEELFVHLKRMKEEGYAIIYITHKLDEVLEISDRVTVLRKGKKVKTLSTAKTTKKALARRMVGREVLFRLEKEPLERGDVVLEAENLIIRGDRGETAADGVSFKIYENEILGLAGVGGSGQRELIEALAGLRKVEDGSFKVFGENLTNASPREIIERGISYIPEDRDERGLIPSMSVKENLMLKDYWKRPYCKKFLLNMDYIRQDIEEKVSKYNVVTPNIETPAELLSGGNLQRLMLARETSGAPNLLIAAYPTHGLDVGSVEDIRKLLLEQRKEGSAIFLISEDLDEIMMLSDRTAVIYEGRLMGIVDVDEVSKEDLGLMMTGTPKEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7M3</accession>
    <name>A0A133V7M3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_00490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02422">
        <property type="protein sequence ID" value="KXB02422"/>
        <property type="gene ID" value="AKJ44_00490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.245"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="72"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="413" mass="44499" checksum="BCAA11478557440A" modified="2016-07-06" version="1">MFVKEFECLKCGKTFSPSEEIYVCRECGGKLAISYDYDGISKKINREELEKRPGGVWKYRELLPISDPKNMVTLGEGGTPLIKAENLSKVLRIDDLWLKDETRNPTSSFKDRPMSVGVSKALEFGAETVCTASSGNAATALAAYSAKGGIDCYAFVPEDVPEAKLAQLALHGANVVRAAHQEKGDPSYELMKMGFENFGWHPIPSGGAFNPYQPEGNKTMSYEICEQMNWETPDWYLVPVGAGTLLSGNAKGFFELEELGLIDEIPRIGGIQAEGCAPLVKGFKEGTDPYDIPTWEGPNTVAGGLIDPYPWDADTALPAIKKSGGTAESVPDEDILSALELLARTEGIFAEPSGAAGLAGLIKLVENGEIDRSEKAVISVTGGGLKDQKTAVELAGEIPTIKPNLEELKKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7N1</accession>
    <name>A0A133V7N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02460">
        <property type="protein sequence ID" value="KXB02460"/>
        <property type="gene ID" value="AKJ44_00275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.58"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="205" mass="23340" checksum="9BB5B3463D8A0C2C" modified="2016-07-06" version="1">MTDTSEKESIRGEMKSRRRELAREEVLAKSDQIQNSLFSQAEFAKAKTISFYVAKQEDREVETEHMIKDCLQSDKQVLVPLVSGETKLSLCELEDYDRELEPGAFGVLEPKPSCRRIRPLEQTDLLIVPGLAFDLQGYRLGYGGGYYDSLIQDLSSTQPNISTIGLAYEFQILEKIPHESHDMPVDKVITEERVIHTSSNRPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7N6</accession>
    <name>A0A133V7N6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02435">
        <property type="protein sequence ID" value="KXB02435"/>
        <property type="gene ID" value="AKJ44_00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="185" mass="21159" checksum="331774E741FAEB95" modified="2016-07-06" version="1">MRRGFRLFGEEEPFEERIRDPFEDMVRDLEEGAPSEMEEFIREEDTPRGKVRKYGPFVYGFSYSKRPGEEPEIQEFGNVRPSGRGRIRPAPEGGREPLTEVTDLDGKYEIVVELPGVKRGEVDVSATEDGLRVKTTGERKYRKEVELGEPIDPDKVDANFQYGMLTIDAEKREGGGDRGKKIDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P5</accession>
    <name>A0A133V7P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ44_00340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02471">
        <property type="protein sequence ID" value="KXB02471"/>
        <property type="gene ID" value="AKJ44_00340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.70"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="253"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB02471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="449" mass="49104" checksum="D7E433A0E64EFFD2" modified="2016-07-06" version="1">MGKLFGTFGVRGIVGEEVTPDLAYNLGLALATHLNGEGKVTVGYDTRTSSVMLEHAIVSGLTAGGCDAARLGMVPTPVLSFGIKHFSCDAGIVITASHNPPEYNGFKFWDEEGAGFVREREREIEELFEKGGELKNWDEFGRAVKADALSPYLDSLADRVPEIDQELKVVVDCANGAGSVATPEILSRLGCKVIAMNSQPDGSFPGRLPEPTPEHIQELVKTVKSTDADLGIAHDGDGDRTIIVDENGEILSGDRVFALVALHYLRGMENPRIITTVATSSVLDDVAEQLGGEVVRTRVGEPDIISEYREDSGDLGGEENGGVIFPDWLLCRDGVMTAIQFVEYISQTGEKVSEANKTLPEYHQFKKKTDCPDKLKPKVLDDLAKKFEHYNPDRTDGVRVVLEDGWFIVRPSGTEPIFRCFSEAQTEERAEELVEEGMQALEESINKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7R6</accession>
    <name>A0A133V7R6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02465">
        <property type="protein sequence ID" value="KXB02465"/>
        <property type="gene ID" value="AKJ44_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="98" mass="11565" checksum="1336EA71A7EF1C5D" modified="2016-07-06" version="1">MKVLTVRVDEEIVKDLDEIGEREKADRAEVVKRLLDKAIKEWKLDRALEMISRGTWTIRKAADYADLSYYQMLEEMSTHGIDSGSTLEDFRWERDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7S1</accession>
    <name>A0A133V7S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02510">
        <property type="protein sequence ID" value="KXB02510"/>
        <property type="gene ID" value="AKJ44_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="78" mass="8762" checksum="12A80C14D3E66520" modified="2016-07-06" version="1">MLVEEFESKSELSKILGVSHAAVIDWLNSDGSHPSNRNLERIIKLALESDARGTLGELRGDLMYHRTLFEGIEDTYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7S8</accession>
    <name>A0A133V7S8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02457">
        <property type="protein sequence ID" value="KXB02457"/>
        <property type="gene ID" value="AKJ44_00260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="205" mass="22887" checksum="59C5547F9C0B4707" modified="2016-07-06" version="1">MKLSAIIPAYNEENRIKSVIEETKKHVDRVIVIDDGSSDRTAEVSRKAGADVLVHEDNKGYLKALKTGFNEAQEGIVITIDADGENDPKFIPELVQPILKEKTDLVLGKREHVPRVSERFISFTTSLVVDVSDTGTGFRALKADLAKKLDLEGLCPCGTFVLEAKKLGARIEEVPVKARRVDKPKKIAWKHLPQLWYVAKALIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7T1</accession>
    <name>A0A133V7T1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02511">
        <property type="protein sequence ID" value="KXB02511"/>
        <property type="gene ID" value="AKJ44_00015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.5"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="376" mass="41758" checksum="1BFCA2208DA38400" modified="2016-07-06" version="1">MNHKIAVIPGDGIGPEVIREGVKVLNAIEDSTQGLSFDLEEFPYGSNHYLETEELIPEEGFKRLEEKDAIYLGALGDPRVETGILEQGILLNLRFHFDQYINLRPVKLYPGTPCPLREKGPEDVNFYVVRENTEDFYVALGGRGKGRTSQELELKRSLYEVKFDLDLKADRDEIAYQIGVISRKGAERAIKFAFELAKRKNRKRLTSVDKANVLSHAYGFWREVFEEVAENYPEIETEFAFVDAITMWFVKSPEWYEVVVTPNMFGDIITDLGAMIQGGLGLAPGGNINPDGVSMFEPIHGSAPKHAGKNKANPLATILAGQMMLEELGEQKAADLIEQAVIGVLKEGKVRTYDLDGDSSTSDVGDAVAEKIGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V0</accession>
    <name>A0A133V7V0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02531">
        <property type="protein sequence ID" value="KXB02531"/>
        <property type="gene ID" value="AKJ44_00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="64" mass="7371" checksum="9E0AC852965D941C" modified="2016-07-06" version="1">MPIWVFVALAYCIIFVIAAIIRVRSELPSESTKVVGTRHRARPETRGELEEKKFERQAPSELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V5</accession>
    <name>A0A133V7V5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dCTP deaminase</fullName>
            <ecNumber evidence="2">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dcd</name>
        <name evidence="4" type="ORF">AKJ44_00035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02514">
        <property type="protein sequence ID" value="KXB02514"/>
        <property type="gene ID" value="AKJ44_00035"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="188" mass="20697" checksum="957AB3494F75CFCD" modified="2016-07-06" version="1">MILSGDQIQEYIEQGKIVIEPFDEDLIGPSQIDLRLGDKFRVFKEIELVDPEDRETIEENTELVETGGGPFTLDSGQLVLAVTKEKVAIPNNLVASIEGRSSIARMGVFIHISSGHVNPGSGSKKPFPVTLEVLNMNPSPVKICPGTRICQLLFYTMDKAVKRGYDEIGGKYRGKLEPSSSLAFQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V7</accession>
    <name>A0A133V7V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02515">
        <property type="protein sequence ID" value="KXB02515"/>
        <property type="gene ID" value="AKJ44_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="182" mass="20486" checksum="55E5A8CB681C765B" modified="2016-07-06" version="1">MRVRRLRIPKERIGSVIGPDGEVKNRLEKETETEIDLDSETGEVIVKSSEEKPLQALAACDIIKAVGRGFSPEHAFNLLDDDMYLEVIDITRYTGGSEKAKSRLKGRVIGRNGRTRQAIEENAEVFVSIYGKSIAIIGGPERLQIAREAIAMLLDGAPHSAVYKFLEQKRRELKRLPDLWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V8</accession>
    <name>A0A133V7V8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02529">
        <property type="protein sequence ID" value="KXB02529"/>
        <property type="gene ID" value="AKJ44_00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="432" mass="49100" checksum="4C8D07DD2F34A1FB" modified="2016-07-06" version="1">MGPQLKIAVLSDFHLGAKQRSPREQDPLIQAREAFEKAVQENVQLILISGDIFNQRTPSQELWAKAMRILNLPPSKDESRVELLEALGKDGGEISPLALRGIPVIAIHGNHERRGVGLVDPVEALEAAGLVIRLNQNTILLKTPEGKVAIHGMGFVPEEEARNVMGLWNPKPIKGAYNVLMIHQSLGQYTYSEDEKPVLVPSDLPEGFDLYISGHVHYQADTKIYGKPLLFPGSTFRTQLLPIEAEVPKGFFIINTGGDPTYRFIELDSVRDFFYEEKEFDGVTIRQIEDWITRKMREILEKPRKNKDKRPLVRFRLRGELAKGNTKDELIAADLVDKFVNDSILHISKRELVSLDLEEQTQLLQDLRERKIPLEEMTMNILKSKLEEVKYDKLFEIDSLYELLSEGMEDEALRRISGTIDQLTETELEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W1</accession>
    <name>A0A133V7W1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02538">
        <property type="protein sequence ID" value="KXB02538"/>
        <property type="gene ID" value="AKJ44_00215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.46"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="273" mass="30425" checksum="6A8F1E715CC7FDFB" modified="2016-07-06" version="1">MTKKFADLHVHTQASDGKYTPDEAVKEAHKAGLAAVGIADHDSVDGIEEALAAGKKYGVEVIPGVELSSELGESEIHMLGYFIDWHDRKLRVLLNIIQDVRRWRAKKMVEKLQDLDLSITFEEVLEEAGEAKAICRPHIARVLLKHGHIKEFQNAFEQYIGNEGPAYVKRYEISPRSAIQIIRDAGGIPVLAHPVFAQADEMLPAYIELGLQGIEVYHINHDDETSKHYEKLARKHKLIITGGSDAHGADSPVGAVQLPYEYVEKLKTKHKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W8</accession>
    <name>A0A133V7W8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 1A</fullName>
            <shortName evidence="1">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eif1a</name>
        <name evidence="5" type="ORF">AKJ44_00030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02539">
        <property type="protein sequence ID" value="KXB02539"/>
        <property type="gene ID" value="AKJ44_00030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.8"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="90" mass="10685" checksum="946C86D6D4CB1364" modified="2016-07-06" version="1">MARLRLPKDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQSDEKADIVYRYTRTQVKWLSQKGIWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Y6</accession>
    <name>A0A133V7Y6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02544">
        <property type="protein sequence ID" value="KXB02544"/>
        <property type="gene ID" value="AKJ44_00175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.38"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="409" mass="46277" checksum="8901355E3E3B08AA" modified="2016-07-06" version="1">MRLSGLVLDLVDTPEVQRLRRIKQLGLANLVFPGANHTRFEHVLGTAHLAERLGGELGLSQEELDLLVAAAVLHDVGHAPYSHTLEYLMTDHLDQGHMELTGDVLRGEASTCTPEEIEVLEDLGAPRIVDVLSDHEIDPDEVARLLLGENEKPYLGQIIHSDIDIDQMDYLLRDSHFTGVALGRIDIDRLMRTLKISEDQLVIESKGVEAVEGLLTARALMYSSVYFHHTTRIAELMVTNAVNHALSEDTPITKQNFYRMSDEELSERLYEIPGYPREMIMRIRYRQLFKTAYLEERQKLEADEKENILKTYGEWHLIQEKQEEIAEKAGVSEGKVILDVPIVDILISEPRIEKVEIPVKTEKGLSKLSDISTLAPALRERQAPRYLIRVATPAEHVKAVKKVLPEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3S1</accession>
    <name>A0A133V3S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000053">
        <property type="protein sequence ID" value="KXB01097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01097">
        <property type="protein sequence ID" value="KXB01097"/>
        <property type="gene ID" value="AKJ44_02965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="93" mass="11249" checksum="DF198D17332F9155" modified="2016-07-06" version="1">MDFEELKKKREEVHEDIFYEHFSNYYGDKNILTKEEFDFWWEIEDPTTKERASKTVEIEGVTYNIYAIRVVQDGYIIDDMNTQILVVRKSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3T6</accession>
    <name>A0A133V3T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000053">
        <property type="protein sequence ID" value="KXB01093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01093">
        <property type="protein sequence ID" value="KXB01093"/>
        <property type="gene ID" value="AKJ44_02945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="80" mass="9339" checksum="CD1B644EB9726E36" modified="2016-07-06" version="1">MRVRLLSHTANPEHLVWIAARSCWTREGASKLDPDPQKTRETRQEGSRARTRLDPRAREIHFLDRGNLTRLQSSIGQRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3Y3</accession>
    <name>A0A133V3Y3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AKJ44_02885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000050">
        <property type="protein sequence ID" value="KXB01157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01157">
        <property type="protein sequence ID" value="KXB01157"/>
        <property type="gene ID" value="AKJ44_02885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.574"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB01157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="383" mass="40946" checksum="6E368FC6219D9B0B" modified="2016-07-06" version="1" fragment="single">VLASRAGTLMQLGIGPIVTAGIVMQLLVGAKIINLDLSHPRDKALFTGTQKILAVLVGIFQASAFVMAGSFGPIATMGGLRILFLIIQLTLGVLVVLYLDELVSKYGFGSGISLFIAGGVSATVFWQAFNFTAPQGIIRGAIPNFISALASGSPGAISTAFFRTPAPNMMGVIATIIVFFIVIYAETMRVEVPLAYSRYGGLRGRYPIKFLYASVIPVILSLVLFTNFRIIGRILGGPVQGFVSTYMVSPQGLGAVTADPLRAVVYMLILMGSCMAFAWLWVQMTNMGPRDVAQQLKRSGMSIPGFRRDTRIMEKRLARYITPVTLLGGAFVGALAAGANFLGALSSGTGILLAVSIIYRLYQEIARGRVSEMFPAARRLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V411</accession>
    <name>A0A133V411_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000049">
        <property type="protein sequence ID" value="KXB01177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01177">
        <property type="protein sequence ID" value="KXB01177"/>
        <property type="gene ID" value="AKJ44_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="344" mass="39917" checksum="115C922A3F8603AC" modified="2016-07-06" version="1" fragment="single">QNKIYSVSCPHKGELRTFIKKKGKISMKFPFKLRGPEAAKALTFPFTDGYILKDYSGYVRLGYVNSDLRMHQEIIRCIQNTFGDVSYSQRRVRGAYETYFAGVLGKIYVKSLGFIPQSKLKTNTHLHEILLKSKDPTEIGASLSQIMDDEGNFSQMTFYVGFSGGEVPREEIDEVLNNFHSHHIQQEYMPNILKDVKAMLEKLHINSRVRSPVRYVDCTRGVTKLMWYLVIQGSAALLKINSTCKFENNDLRKKFARYVKHRKNIIKVLKDVEKKKGFLTTDSVKNALNISKRAAVNIIRVMKRDKMLDLLEKGRYCYLREAKKRQHQQDTFRLIKPNIEKAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V441</accession>
    <name>A0A133V441_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L30e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl30e</name>
        <name evidence="5" type="ORF">AKJ44_02800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000047">
        <property type="protein sequence ID" value="KXB01203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01203">
        <property type="protein sequence ID" value="KXB01203"/>
        <property type="gene ID" value="AKJ44_02800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_L30e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="4">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB01203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="103" mass="10966" checksum="5C56DF5E48F3501D" modified="2016-07-06" version="1">MDIDKELRRADRTGEVVLGSKKVLEAIKHGNAKLVLITPNCSDSTTLEINQTTELGKIPTHMYNGTSEDLGLAFGKPFLVSAAAIIDPGNSQILQLGGTISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4A9</accession>
    <name>A0A133V4A9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000045">
        <property type="protein sequence ID" value="KXB01246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01246">
        <property type="protein sequence ID" value="KXB01246"/>
        <property type="gene ID" value="AKJ44_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="129" mass="15132" checksum="195E6FE8293873B5" modified="2016-07-06" version="1" fragment="single">MVEMRIINLQDLPPSAYIRFGEKKGDDFVEDRKFLSSIIKDFKNEVSSVKSTSRKIGVPRTLVYKILEGKRKKIRLEYLIKIANFLQDNEKRKHSISRLQNKIYSVSCPHKGELRTFIKKKGKISMKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4B8</accession>
    <name>A0A133V4B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000043">
        <property type="protein sequence ID" value="KXB01290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01290">
        <property type="protein sequence ID" value="KXB01290"/>
        <property type="gene ID" value="AKJ44_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="229" mass="25940" checksum="DEADB37DDEDAC09E" modified="2016-07-06" version="1">MSEERKYVGIESERVTEAEIEYLGKDADMPVMGTDVNWDEVMKPYPPRKITLPNGDEMIVKSMEKDEVEEVAEALQPKTLQHKQLFDLIAHELCTELYLWRENRPMWCCPPESHFNLVGRVGDEIVGCSNGVLSSPKVGNSLHTVAILEGQQVGAQLWGCKLEHYFDVLGIEALHAGAESYRGSTELFAMFGFKELPDKVTHFGVSPEQYLTKEQWARLRPGKITGERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4G3</accession>
    <name>A0A133V4G3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F420-nonreducing hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000042">
        <property type="protein sequence ID" value="KXB01332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01332">
        <property type="protein sequence ID" value="KXB01332"/>
        <property type="gene ID" value="AKJ44_02665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.497"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="492" mass="54602" checksum="67C5080230642AD6" modified="2016-07-06" version="1">MKKIEINPVTRLEGHAKIAIFLNDEGNVENAYFQAPELRGFERFCQGRNAEEMPRITTSICGVCPVAHHMAGAKVLDDLYNVEPTPTGEKIRKLMYNTYIFSDHVLHFFYLGAPDFYVGPDADPAKRNLLDMIEKVGLDFGKKVIKHRSYSQNILKTIGGDPIQPVNCMAGGVTKGLSGVERQDIEKKAGECLEFAKFALKTFNDVVLENEDYVELIKSDPYTLDTHYMGLVDENDHVNFYDGIVRAVDTSGDEIVRFEGQNYLDHIAEKVHDSWTYLKFPYLKEKGWKGIESGGESGIYRVGPLARLNAAEGMATPLAQEEYGRMFEVLGGKPVHATLAYHWARLIEVLFAAERMVELASDEDITRGEIRNIPEESPDEGVGVVEAARGTLIHHYKTNERGVLEDVNVIVPTTQNNGGICMAVEKAAKGVISGGEIDQGTLNRVEMAFRTHDPCIACATHSLPGSMPLEVLVYDSEQNEIARSSKGLDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4I4</accession>
    <name>A0A133V4I4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000041">
        <property type="protein sequence ID" value="KXB01355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01355">
        <property type="protein sequence ID" value="KXB01355"/>
        <property type="gene ID" value="AKJ44_02630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.488"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="76"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="350" mass="39453" checksum="57D479F530D72B2A" modified="2016-07-06" version="1" fragment="single">MSSKEPKEKVLPPNLEKLITEGKENPEKLWSKVAKDLNWFEPWDKVYEEEGHGKFRWFKEGKTSLSYNCLDYHVEQGRGDETALIYETGERDARRVLTYEELLCKVKEFASTLRAFDIQKGDRVTIYMPQCPEAVIAMLACTRIGAIHSVVFAGFGTGALADRIELAGSKLLLTADVGFRKGKTIDLKGIVDKALDEYPKAGELIEKIILLKRGEEEVNMEEGRDVFWKDAIERGEGEDSSYVVMDANEPAFILPTSGTTGRPKGTVHMHGGYQVHIYGMGKWIFGLTPQDTWWSTSDIGWIVGHSYIVYAPLLTGCTTIIFEGIPTYPDPGIWWKTIEENKVTKIFTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4J9</accession>
    <name>A0A133V4J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000040">
        <property type="protein sequence ID" value="KXB01378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01378">
        <property type="protein sequence ID" value="KXB01378"/>
        <property type="gene ID" value="AKJ44_02605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="69" mass="7796" checksum="E560BB8B299061DE" modified="2016-07-06" version="1">MGSIDVKEPSFARNIVRVEQSTEEVREFLEGENIKSRLHSAKERGERPVIRAGQIFVNGRRICRADAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4K6</accession>
    <name>A0A133V4K6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000040">
        <property type="protein sequence ID" value="KXB01382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01382">
        <property type="protein sequence ID" value="KXB01382"/>
        <property type="gene ID" value="AKJ44_02625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="98" mass="11160" checksum="C24617108E21A335" modified="2016-07-06" version="1" fragment="single">RKGGVFHPHLLQISTKLIKKDKLKITCGGTDVFLIGRPGCGKSVVYHDLSKRLLEGKLIEETTRIDDFPILQEILREDKELEKHVNKEGGFEVTDLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4N3</accession>
    <name>A0A133V4N3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01400">
        <property type="protein sequence ID" value="KXB01400"/>
        <property type="gene ID" value="AKJ44_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="64" mass="7452" checksum="3C8F57D1E13B345C" modified="2016-07-06" version="1">MVTTVRVHEDTLKRLKTLKEEFGAKSNEEVIDLLLKRAKTPQKSHFGTLPKLEAFEREEIDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4N4</accession>
    <name>A0A133V4N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_02580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01403">
        <property type="protein sequence ID" value="KXB01403"/>
        <property type="gene ID" value="AKJ44_02580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="82" mass="9421" checksum="CA542D23D369B1F7" modified="2016-07-06" version="1">MSATKFSGLEVVKALVRNRFQIVGRTGSHVKLRYEHPTNKSDIRIVIVPMYDSVDTGTLRSIANQAGARDFQKFKKWIDRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4N7</accession>
    <name>A0A133V4N7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000039">
        <property type="protein sequence ID" value="KXB01405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01405">
        <property type="protein sequence ID" value="KXB01405"/>
        <property type="gene ID" value="AKJ44_02590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="125" mass="14957" checksum="631F638E7A9C8467" modified="2016-07-06" version="1">MDRQTIEKDFSFLKERKGVLAVLLFGSRVTKREHERSDVDICIVAPEEDPWSLWLDVDRRVRSKGRYDFHIFEDFGLKMKHQVLENHEIIWCRDEPKLHEYFYTYRKLWDDQAKARGVAARAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4Q7</accession>
    <name>A0A133V4Q7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ORF">AKJ44_02530</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="LHXY01000038">
        <property type="protein sequence ID" value="KXB01430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01430">
        <property type="protein sequence ID" value="KXB01430"/>
        <property type="gene ID" value="AKJ44_02530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.441"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="FBP binding" evidence="15">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="FBP binding; shared with dimeric partner" evidence="15">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXB01430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="364" mass="40333" checksum="B5D0A80A6020E7A2" modified="2016-07-06" version="1">MKTTVSVIKADVGSLPGHVKVPQDMLDVCEEALSKAKDDGIVKSYYVTNCGDDINLIMAHDKGVDAEEIHELSWNTFMTAGDLAKERGYYGAGQDLLKEAFSGNVRGMGPGIAEFEIEERPSEPIIVWACDKTAPCAFNLPIFKMFGNPFNTAGLIIDTKMHSGYTFEVHDIKKGRRIFLNCPEEMYDILSLIGIVDRYVIKRVFRKSGEIAASVSTEKLSLIAGEYVGKDDPVAVTRAQSGYPAVGEELEAFAFPHLVPGWMRGSHQGPLMPVSHEDATPTRFDGPPRVMALGFQLKNGELQGPEDLFDDPSFDGARAKAVEIADYMRRHGPFQPHLLPEQELEYTTLPDVIEKMEDRFEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4R2</accession>
    <name>A0A133V4R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000038">
        <property type="protein sequence ID" value="KXB01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01433">
        <property type="protein sequence ID" value="KXB01433"/>
        <property type="gene ID" value="AKJ44_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="374" mass="43235" checksum="459F82BC52872025" modified="2016-07-06" version="1">MEELTYEARSDFGASWSSYYLYYTYPPMPMFIYYPFAQAYRLIHPTPSELSFAPAGVDPYPQVPLTLNLLWKLPIFLADIGIAILLLKMTNGSEKSMRMFLFNPFVIFISACWMFDSIAVFFLLLATYLFEQERYDLSAILLAFGFLTKYYPIFALPIFCLEFIRRKSWKFFRYTLIFGAVSFIFILPFLDGFTLGLGFQASRPPAGLTPFAAYPAFEHLGLIGGEGMNHLAYIALPALGAFTLITGMSLIYAYLSKKEMSLRTKLLLTFIVYLIVTKNVHEPYPFVLIPFFILLLHENFSKEKLWMYRLVWILPLMYAVFNVPITRFLYGFTLNEEILTFLVLPTTINAIILGSIMIVFHLTLWRALIKLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V500</accession>
    <name>A0A133V500_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000035">
        <property type="protein sequence ID" value="KXB01522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01522">
        <property type="protein sequence ID" value="KXB01522"/>
        <property type="gene ID" value="AKJ44_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="75" mass="8969" checksum="18B9E577DABB60DE" modified="2016-07-06" version="1">MHGYVDKSNYGQYTYEREGLLERVPYRKLIKGVFILGRRDLEKFVELLEKYQAEYYVRSIKLTSQDKEILSGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V520</accession>
    <name>A0A133V520_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_02445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000035">
        <property type="protein sequence ID" value="KXB01521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01521">
        <property type="protein sequence ID" value="KXB01521"/>
        <property type="gene ID" value="AKJ44_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="295" mass="32113" checksum="B3E1C7EBBEF2AD6C" modified="2016-07-06" version="1">MWTFAARCLEAATIFIFAGIGELINQRSGVLNVGVEGLMLSGATSGFITVMLTGNFLLGFLVGMVIGGILGLLHGFLSITLKVDQVVSGMGIWLLGFGLTTYVMYLYNALGPLPTEVGKLSTILGLSPFFYIGISLVFITWFILYRTSFGLRIRSVGEDPSVAEVSGINVAKTRYICVIIGGILGGLAGSVFSLFYVTTLSYNMTMGWGFIALALVFFSMWNPLILLGGSLLFGTLWKLSVTPEVVLPGVMPLYFWRMVPFIVPILILVIISTKWFRTRWGLAKPGALAKPYIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V551</accession>
    <name>A0A133V551_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000034">
        <property type="protein sequence ID" value="KXB01547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01547">
        <property type="protein sequence ID" value="KXB01547"/>
        <property type="gene ID" value="AKJ44_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="37"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="217" mass="23728" checksum="6F03F238F29E8730" modified="2016-07-06" version="1" fragment="single">MDLQDLQEKYGLPEEVTEVLEESGITELYPPQAKAIEKGVLDGKSLTFAIPTAAGKTLVAELCMLKSILEEGGKCLYVVPLRALASEKFEEFKGKYESLGVEVGVATGDYDVSGSELARYDILVATSEKVDSLLRHKAKWLADLSTVVVFDEIHLINDPGRGPTLEVLAARLRQLNPDLQVLGLSATISNSSSIADWLSAQHVRSEWRPVPLKEGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V566</accession>
    <name>A0A133V566_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000033">
        <property type="protein sequence ID" value="KXB01582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01582">
        <property type="protein sequence ID" value="KXB01582"/>
        <property type="gene ID" value="AKJ44_02390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="259" mass="30225" checksum="75F22594B31B1D99" modified="2016-07-06" version="1">MGFVQRLSGNTHMPDYGAVCDVSVLVSRDSVNRARELFNGRGFYLPNSTYSWLSHNRFIKVRDQAVGYSLLSQLVRTRQVYPILLPEIYNELSRKIMFEVDNNVPLTDLRTVFLSAHLRLPLLTFDEKLTERLFNHIETYKLWNIRGHANWLTIRQILELYREFLFGVGEELNERIREKDSFSRIVSGVKGERGERLQKITSSIQKIGQGQTNPGTLRFQCLAWDIQPSIREYLDQHVLEPEIIRELCERALILTAQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V594</accession>
    <name>A0A133V594_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01613">
        <property type="protein sequence ID" value="KXB01613"/>
        <property type="gene ID" value="AKJ44_02330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.392"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="171" mass="18821" checksum="9ECEE0F46828D78B" modified="2016-07-06" version="1">MEVLEAIRTRRSIRKYKERSVPEDLVKKILEAGRWAPSASNAQPWNFIVLRSQGVREDVAEATTYGKFLAEAPIGIAVVTDPEASTHPVEDGAIATQNMLLAAHALGLGACWIGAYGSTYEDEVKEILDVPKNKRLLSIVSVGFPDQSPKSSRKNLEELASENRFGKIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V597</accession>
    <name>A0A133V597_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000032">
        <property type="protein sequence ID" value="KXB01618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01618">
        <property type="protein sequence ID" value="KXB01618"/>
        <property type="gene ID" value="AKJ44_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="64" mass="7837" checksum="ED16C9A165CF98ED" modified="2016-07-06" version="1">MNYRELKELARRVDQSWGEERERLLQKLLRKLPELDPFEGHSDFAVMVAKMLARVKWFPYHKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5C3</accession>
    <name>A0A133V5C3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000031">
        <property type="protein sequence ID" value="KXB01643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01643">
        <property type="protein sequence ID" value="KXB01643"/>
        <property type="gene ID" value="AKJ44_02315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="133"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="452" mass="53188" checksum="1DFED452B7F92630" modified="2016-07-06" version="1">MIESKEDLRKIMKDVKISSQAGRDFLDKYDKPTRSQYESCLKSYLAYRRGKGSSKTDCDDLKEEAKKDWEKGKREREFVPEGMFSNYRKKMRDLGYSAHTIANVETCLCAFYKFHQYPLNTDRFTKMRRQNQNTFKRINREEVGRLYNATTSKRNKALLLFLYQTGQAVKQIVDLKYGDVKKELEEGKEPLMIQYPGRKGRGSGYVTFLGSDGVHALKKYLNEREKKFGRKLKYDDVLFASQKDPEDGITQASVASMMSYLAVKSGLVEEEDLKHERNPYRPHAFRHNFKSQLATKCSNFVIEYMMGHEIGVEKEYFLADFDGKEGLREYYAKNMEPELSVQTTSMEKKAVISRRFADEREGKLRELVGEEIEEMSERWKDKWLDERLERRALEEKISEIEHNVEETIEDGIGEMMVEKLTGDPEFMRVFEEKIVEQARKIVSQEWPEEEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5F1</accession>
    <name>A0A133V5F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01670">
        <property type="protein sequence ID" value="KXB01670"/>
        <property type="gene ID" value="AKJ44_02255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="99" mass="11200" checksum="224776B6DCCA3B70" modified="2016-07-06" version="1">MARPKFDEAVDVLSLKSARAILRSILRDSKTVREVHEELENLNASLEYRESVYKALERLVAAGLVEKIRDGRSVKYGSRYSEVSADFVREKLSLEGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5K2</accession>
    <name>A0A133V5K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01719">
        <property type="protein sequence ID" value="KXB01719"/>
        <property type="gene ID" value="AKJ44_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="231" mass="26705" checksum="E899E375319B9FAF" modified="2016-07-06" version="1">MFELDLDSEWVTLKTKRGEENIHIPIKIPNKSYYERLDEDKITSIRLCKRDDQFTFHLMQKIGGRGSPAQNNQDSGVYALTIDLGERHLATEASVKITPNGETSGKPVQRVGFHDDSHGKRQAYREHHIRRKMQNQGKSSTILRHNWRAKNVRRERVQQITNRIAKRVEQAQVEGLETLAFVGNLHTPIPKNRGSLSRRLNSFPRAELRDTLIYKLAKLGVRVEMIPWHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5K3</accession>
    <name>A0A133V5K3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01722">
        <property type="protein sequence ID" value="KXB01722"/>
        <property type="gene ID" value="AKJ44_02225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="95" mass="11164" checksum="A5BFCF2B483F222C" modified="2016-07-06" version="1">MEEEIELDEVIIFGSRAREDYRSGSDIDILIVSQDFENVPKARRSREFYLKWGYEKFPEPEFICLTPQEFAEKKVKKPHIVRTAIEEGIAIVQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5X5</accession>
    <name>A0A133V5X5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_02080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000026">
        <property type="protein sequence ID" value="KXB01841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01841">
        <property type="protein sequence ID" value="KXB01841"/>
        <property type="gene ID" value="AKJ44_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025931">
        <property type="entry name" value="TaqI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12950">
        <property type="entry name" value="TaqI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TaqI_C" evidence="8">
        <location>
            <begin position="189"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="578" mass="68046" checksum="E3F2CF43C8D092F6" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V603</accession>
    <name>A0A133V603_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ORF">AKJ44_02045</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01860">
        <property type="protein sequence ID" value="KXB01860"/>
        <property type="gene ID" value="AKJ44_02045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.303"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXB01860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="543" mass="58024" checksum="3AF6B1B0694A3A7B" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V611</accession>
    <name>A0A133V611_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ORF">AKJ44_01950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01884">
        <property type="protein sequence ID" value="KXB01884"/>
        <property type="gene ID" value="AKJ44_01950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.282"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="71"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB01884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="292" mass="31744" checksum="2361C88FBC7FEF29" modified="2016-07-06" version="1">MGAHIRTVCLLVLLTVLLVGIGYAVGFFLGIPVTYTLTIAFGFAILLNIVTYWYSHKWVLKMYKAKIVSEKEEPKLHQMIGRLAAYADLPKPKVAITKSDTPNAFATGRNPSHAVIAVTKGAKNLLSEEELEGVLSHEMAHIKNRDMLVNTMAAMIAGAIAYIGFAGRFGLFFGGGRRGGGILALIAIILLPIAAILVRFSISRTREYGADREGANISGKPLALASGLKTIENSVKNKVKSGRRPEKGNPATSHLFIVNPFRGSSLTELFSTHPATEKRIERLEKIAADRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V612</accession>
    <name>A0A133V612_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_02000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000024">
        <property type="protein sequence ID" value="KXB01867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01867">
        <property type="protein sequence ID" value="KXB01867"/>
        <property type="gene ID" value="AKJ44_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="346" mass="38128" checksum="E0AA0235BDB26F37" modified="2016-07-06" version="1">MTKESQEVSVNLRRTLIPIFIVTAIIIIAVVLLLQENIGGIVTALQNANYLFILLAFIIYFSSAFFWAARWRIGLFALGKNASMRNLFPIIWGSMFINNMTPLNRAGGDPIGRPYLLKKTSGIRFRMGFASVVAEQLFQIPVVLFLLAMGLILRVQMTANPGLVSIATVVISLSLAIVLVPFFILLFGKKEFSSKITGFLTKILKFFRREADPTKILKTVEDFRVSARKIINSKHNAAWMMGFSAALWILDLVRISLILYALGINISLPMLFLASTLPQIAGLVPLLPGGIGAVEVTMVSVFMWFGVSPVLALSATLIERSMSFVFSTLIGAGALSYLGIKIWTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V632</accession>
    <name>A0A133V632_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01905">
        <property type="protein sequence ID" value="KXB01905"/>
        <property type="gene ID" value="AKJ44_01945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="113" mass="12905" checksum="21BC5DBFDA030957" modified="2016-07-06" version="1">MITAHKMSSHVFQGSADNMDVEVNDEVLKIEIKATDGFDFGTSNEMEYKCTNCKNPIPVEDEDVRALEKAVRVQRGGAECPNSFEAWWFCDMECFTKYCKRRVLHSLVSKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V637</accession>
    <name>A0A133V637_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">leuD</name>
        <name evidence="4" type="ORF">AKJ44_02055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01856">
        <property type="protein sequence ID" value="KXB01856"/>
        <property type="gene ID" value="AKJ44_02055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.305"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="158" mass="17303" checksum="07ECF52F347254E2" modified="2016-07-06" version="1">MPRAWVFGDNISTDLIIPGRYLVERDPESLAKHAMEGADPDFAENVEEGDIIVAGKNFGCGSSREHAPIALKTAGVSTIVAESFARIFYRNAINQGVPVLELPRVREEFESGDQIEVNLDEGIVKNLRSGKELKAKPLPPLLKDIVSAGSLLDYLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V655</accession>
    <name>A0A133V655_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01925">
        <property type="protein sequence ID" value="KXB01925"/>
        <property type="gene ID" value="AKJ44_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="169" mass="19851" checksum="7BACA078D6509486" modified="2016-07-06" version="1" fragment="single">MLKLFRDVFQKYSHVNQFPLFNSTKKPHFDWQIYALLDESFELMLSETIPSEITADENEFYSFLSGYTDAEGCITISPNGEWIRFRFILGSEDSKILSLIATKLKEMEYNLKLRITAKKEESFGRGHCYTRDYWELRIATKSDVKDLLEQLKLCHPETVLTQVELDCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V659</accession>
    <name>A0A133V659_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01921">
        <property type="protein sequence ID" value="KXB01921"/>
        <property type="gene ID" value="AKJ44_01870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="143" mass="15925" checksum="22D35B309CECF518" modified="2016-07-06" version="1">MPQVNVNINQISAEKFWKSGKQIPLKVQVSTNVNIVEVERESEDILSVPFVISISYNPSIAQITLKGEARVGGEKSELEAIYEGYENKESPPPRLIQQITNNSLAEATMLSRTLNIPPPIPLPTPQARKKKEGKEEERPSYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V667</accession>
    <name>A0A133V667_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01886">
        <property type="protein sequence ID" value="KXB01886"/>
        <property type="gene ID" value="AKJ44_01965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.285"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="52"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="384" mass="42142" checksum="38FCE5FE34837D02" modified="2016-07-06" version="1">MMMAEKVFSNGTILAGEELEAVKGYLTVRDGVVNEIGEGQPPKRGIDLHRGFIIPPFVNAHTHLADSVIKDIYAGRKQEDVVGARSEKFVALNSSSEEAKIKAIESSLHDMIRTGTSAHCDFRESGKAGIHLMRKAKESGVKSILLSRPEKQDEVKDLLTISDGIGLPSLNSFSDEEIRKISALTAKAKKFFSIHVAEVRNAQKSSIENTGKTEIQRALDFDPSFLIHGTWASDEDLTLMKKKGVPLVICGRANHLLSVGAPPLNQALEKGVEIWIGTDNVTACQPDMFCELSFDWALLRKNNSQVGSEEARALLKSATVNSSRGLRLPFGALEKGNKAVFTILGRKNNLINLKDPYVGIVNRARADNIRMVFCPDGGVRKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V691</accession>
    <name>A0A133V691_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ44_01775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01959">
        <property type="protein sequence ID" value="KXB01959"/>
        <property type="gene ID" value="AKJ44_01775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="PTHR12209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB01959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="220" mass="25228" checksum="2720E3397C3DF6D1" modified="2016-07-06" version="1">MPVIRKGAEANLLLEDFTRVLHPTGEGKVLVKHRISKGYRVKELDKNLRESRTALEAKLLADAKRAGVPTPLIYEVDRTGMKIIMEYVEGERVKTFLEDLNPSERQEVCELIGEQIARLHKFGIVHGDLTTSNMIRTQEGKIYFIDFGLGEYDPSTEARGTDLHLLWRTLQSTHHKVSNESFKAVLNGYKREFGESASEIIQRVKEIKHRGRYIPKEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6A3</accession>
    <name>A0A133V6A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000018">
        <property type="protein sequence ID" value="KXB01978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01978">
        <property type="protein sequence ID" value="KXB01978"/>
        <property type="gene ID" value="AKJ44_01730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="209" mass="23587" checksum="5370879BCC8D854D" modified="2016-07-06" version="1">MRWGMVIKLKRCVGCQTCLVACSFGNAFPPTNYQNKTIDYEEGEFPDVERVLLPALCMHCGEAPCEDVCPTDAIQRTESGVVWIDYNECIGCKSCMLVCPYGVISFFDGDVGRYEGLPIGERIKREYPKDVCIKCDLCRERVEKGLEKGLEPGEDLEATPLCVIRCPTEARVFGDLDDSDSEVSKLIKEEKGFQLYPQYETDPAVYYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6A6</accession>
    <name>A0A133V6A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01962">
        <property type="protein sequence ID" value="KXB01962"/>
        <property type="gene ID" value="AKJ44_01790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="237" mass="27299" checksum="E989CE5B36328E61" modified="2016-07-06" version="1" fragment="single">MTENMVFKKIKDFFSGKPEEEPEIRRLTLDELKKEIIERKEDLKSKAEADLEAPLKRIIKTSGKIRRLIDDLEDAETTEEVHPRIYKSASEEKRLLIKKTRRALKKLDAPSSPTWGRLSKFSSSLTRSINLLGKASSSHRLRVATLFEGRMKRLEDLLDNLQTASKDFNETLANTNTRLNELDELSSTLSEREDLLRRSTALEKRINSLVDEIVEKRPGTIIVLGEVYTGKTFFTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6A9</accession>
    <name>A0A133V6A9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S Mo/W bis-MGD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000018">
        <property type="protein sequence ID" value="KXB01979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01979">
        <property type="protein sequence ID" value="KXB01979"/>
        <property type="gene ID" value="AKJ44_01735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.211"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="904" mass="103068" checksum="250888ED4CF3A8C7" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6B8</accession>
    <name>A0A133V6B8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CoB--CoM heterodisulfide reductase iron-sulfur subunit A</fullName>
            <ecNumber evidence="4">1.8.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HdrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000018">
        <property type="protein sequence ID" value="KXB01977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01977">
        <property type="protein sequence ID" value="KXB01977"/>
        <property type="gene ID" value="AKJ44_01720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.208"/>
    <dbReference type="UniPathway" id="UPA00647">
        <property type="reaction ID" value="UER00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="646" mass="70908" checksum="3E01857ACED27067" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6D5</accession>
    <name>A0A133V6D5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01992">
        <property type="protein sequence ID" value="KXB01992"/>
        <property type="gene ID" value="AKJ44_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039018">
        <property type="entry name" value="VapC20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42188">
        <property type="entry name" value="PTHR42188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="138" mass="15380" checksum="005F272A2D74CE67" modified="2016-07-06" version="1">MYCVDSGVWIGAFNPKDAHHERAKPIIKAVTDGEPGGIIITDHIFGEVATYTRRKIGIEKSVKAARAMLDTDHVEIIVINDDLFSASYHIFERYPQLSFADAASIVVMRNQDVTEIFSFDSGFDGVREVNRLNALPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6F5</accession>
    <name>A0A133V6F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02025">
        <property type="protein sequence ID" value="KXB02025"/>
        <property type="gene ID" value="AKJ44_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="71" mass="8230" checksum="9BB38394A9862FCD" modified="2016-07-06" version="1">MNSDTMIWLGVILILLGVTLILIPTLGKFIQLEKIPDWLIYVYESDGFYFVTSPILLLITILTVIMFFLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6G8</accession>
    <name>A0A133V6G8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000016">
        <property type="protein sequence ID" value="KXB02022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02022">
        <property type="protein sequence ID" value="KXB02022"/>
        <property type="gene ID" value="AKJ44_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017700">
        <property type="entry name" value="Aminohydrolase_SsnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03314">
        <property type="entry name" value="Se_ssnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="58"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="444" mass="49653" checksum="7DB8144519577461" modified="2016-07-06" version="1">MTETILIEDGTLVTLGEEDKVIENGAVLIEGNKIKGFGKASKLKKEDFDQKINASGKIIMPGLINTHHHLYSTFARGMAIHGEPPKDFVEILEKLWWKLDENLDKEGIYCSALIPLIECIKSGATTIIDHHESQSYQKGSLNEIAKAIEEAGIRASLCLGTSDRYGRGEEGLEENKRFLSELDEESSELLRGMVGLHASFTVNDDTLDKSVELAKKHDVGIHVHCAEGKYDQEKTQEEYDQRVIERLDSHNALGEKSIAVHAIHVNDRELEILSETDTNVVHNPESNMNNAVGYADVPKMMEKDIRVGLGTDGMSSDMLAQMRCAYLLHPHAQKDPRIGFLEAPKMLLDNNREIVEKVSGWKIGEITEGALADIILIDYHPPTPLNENTFLGHLIFGLVYAPVDTTICNGKILMKNRELVNLDEEKIVKEALRVASRIWKRIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6H7</accession>
    <name>A0A133V6H7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02045">
        <property type="protein sequence ID" value="KXB02045"/>
        <property type="gene ID" value="AKJ44_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="123" mass="14719" checksum="CD3C02F30376B85F" modified="2016-07-06" version="1">MIGLTYEKMRRFMREGFRKGNWHDLKSSEKALFRAAKWCIKKGMMIVARTPLKNLLKVIKKLTSTVKRKIWQKGLEKAYKMRRQFEEKGVFEWCPQARDWLQDMDYIFYLGVSSMNSNGRGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6I4</accession>
    <name>A0A133V6I4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02042">
        <property type="protein sequence ID" value="KXB02042"/>
        <property type="gene ID" value="AKJ44_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="145" mass="15798" checksum="1B163E6E29BC05D3" modified="2016-07-06" version="1">MSFSVDLNNQGMARILVRIEGMRGSAIYLFLVDTGSTYTTLPENDCVNLGLVKSEKIVHLRTAGGIISAPLYSASKMTIEGTELTAKNVKVIAKTIPGIPALLGMSFLKGFDFYLRESKGKFVIERSHCNRGENFKIPAGLPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6J3</accession>
    <name>A0A133V6J3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02070">
        <property type="protein sequence ID" value="KXB02070"/>
        <property type="gene ID" value="AKJ44_01440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="334" mass="37229" checksum="E7B7C753E0A2A1B6" modified="2016-07-06" version="1">MPGKNPLASVFIPVRNEEEHIEECLNSLVNQDYPNDKYEIVIVDGKSEDQTREIIKKFMKKHTHIRLIENPELNVSAGRRIGVEESRGKYVIAFSGHSYAEPNFIRKLVERLEKADDDIAGVGCRHETPPGDASTARAIGLAMSSTFGGAGTTFKHPEEEQVMDSIAFTAYRKKIIDEVGGPSNPDLERTGNDAELNLRIKEAGYKLLYIPDTTAYHHKKESLSEFFKWSINYGIARAKIIKKHGWSSSKIYTIPTLLILTLILTGILSFLNQVFFYLFLLELGGYLILALASSIHSSQGQGLRYVPLVMSAYLTEHIGYGLGFLTGILGSGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6J5</accession>
    <name>A0A133V6J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02069">
        <property type="protein sequence ID" value="KXB02069"/>
        <property type="gene ID" value="AKJ44_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="71" mass="7919" checksum="96DB889ECCB89A9E" modified="2016-07-06" version="1">MKILLVTEYFPEDGITGGVEARFYCLSKHLAENHEVSIKGIFTDYSKTRETTIASGIKIFLDLLKQKVGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6J6</accession>
    <name>A0A133V6J6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02068">
        <property type="protein sequence ID" value="KXB02068"/>
        <property type="gene ID" value="AKJ44_01430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="125" mass="14376" checksum="18B649F0F2F7FA5A" modified="2016-07-06" version="1">MTVLVDSWAWIEYFKGSEAGGRAREIIEDPSETIILSTINIAEVYRRILEDYDETKAEEKREVMKDRSFVHPVDEDIAVDSAKIKIERRWGLGDSIIYATAKRENAKVLTGDPHFKGLEETIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6L4</accession>
    <name>A0A133V6L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02067">
        <property type="protein sequence ID" value="KXB02067"/>
        <property type="gene ID" value="AKJ44_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="64" mass="7394" checksum="3281B42A7DDC818A" modified="2016-07-06" version="1">MVTTVQVHEDTLKRLKTLKKEFGAKSNEEVINLLLKKAKTPQKSHFGTLPKLEAFEREEIDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6M5</accession>
    <name>A0A133V6M5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adenylate kinase</fullName>
            <shortName evidence="2">AK</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02098">
        <property type="protein sequence ID" value="KXB02098"/>
        <property type="gene ID" value="AKJ44_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="LID" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="181" mass="20242" checksum="85C36F471B69AA34" modified="2016-07-06" version="1">MPERQIIAVTGTPGVGKSSFARELAKKLNAKLLDLNEVIEESKIYSSDENGTKVTATEDLREEFKQVISGESQDIVVDGLLSHLLAPNQVTHVVVLRTNPEVLRERLSSREYHNEKLEDNLEAEALGVILSEAIGIHGVEKIYEIDTTDKPTSESVKLFEKALKDELPLEPGDIDWLEEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6N0</accession>
    <name>A0A133V6N0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="8" type="ORF">AKJ44_01395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02094">
        <property type="protein sequence ID" value="KXB02094"/>
        <property type="gene ID" value="AKJ44_01395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.133"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="484"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="629" mass="70216" checksum="70BEB5F482194382" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6P0</accession>
    <name>A0A133V6P0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nse4_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02120">
        <property type="protein sequence ID" value="KXB02120"/>
        <property type="gene ID" value="AKJ44_01320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4_C" evidence="2">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="265" mass="30649" checksum="56E5B47AF808C244" modified="2016-07-06" version="1">MVSKKKRELMLRIIDLAKSVREKGIDPFEVEVKELFQRLREIFPEVEDPEELLLDVRAVLGLTDVISQQGDWIKHKSSLLYFDPMLVQWKLRELSGKQLARVLTKSWHPIVGLECISQPGIRESVDYWTNLAPLSERGIELETTEVSPGEVGLNALSELGVESEKDFNELIEKTWRELKEIAGEEERVSYWDFVDAENFHKTVRRAWLVSFLVSYGYATLEIQPLEEEIIIKPRKERKTPSEEVSSSIPVSISHSDWKARRTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6P3</accession>
    <name>A0A133V6P3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02076">
        <property type="protein sequence ID" value="KXB02076"/>
        <property type="gene ID" value="AKJ44_01475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="398" mass="45921" checksum="D5C20C42CC70F526" modified="2016-07-06" version="1">MEILMLVYHVTRKPLGNRTGNIALALSEAGHNVSAIKIDWNGTEPKHQQMNGIDIENIKFQRIGGTLGQAIRLPTILYRKLAEIVRDKEFDVIHCENPLLLPFGIYVGKLKNKKIIYDAYEMYSLMFAENFRFFSSILEKFYGLTENNLVRFVDYIFTVDSRDDILEKKYLRYNDNVKVLYNVPILNSEKVTESKKVQGLRKKYEKNRVIAYVGGITKAKGSMQLAETLHLTKEKIPNVKLLLIGKFKDNSKQEIESYIRKQNLEENIEFTGWLPYEEMLQYLKITNLGLALHQPKGIYKFVSKGNGRKFFTYMQASLPVIGPDFGEIGQVVREEECGILVDTTNPNEVAESIIYLLDHPKEAKSMGKKGRKAIEKKYNWKTEKKKLLQAYGELSVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Q0</accession>
    <name>A0A133V6Q0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMC_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02119">
        <property type="protein sequence ID" value="KXB02119"/>
        <property type="gene ID" value="AKJ44_01315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027131">
        <property type="entry name" value="SMC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="PTHR45916"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="165"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="322"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="436"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="632" mass="73298" checksum="D5BB029747ACA5AB" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6S0</accession>
    <name>A0A133V6S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02123">
        <property type="protein sequence ID" value="KXB02123"/>
        <property type="gene ID" value="AKJ44_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="141" mass="14870" checksum="98E6281F451C1299" modified="2016-07-06" version="1">MAEIGARSFRFESVLGIAGIITLVSLFLPWAESGSVSLNGFEVWQGNMTFIGSWLMIIGSMISYGAFNSLTLESLRPWSDLGLGGGGAILVLSGVFAFLHNVPSLFSPAWGVFLAIAGAFSALFSALVLYWEKAGGRTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6S6</accession>
    <name>A0A133V6S6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02148">
        <property type="protein sequence ID" value="KXB02148"/>
        <property type="gene ID" value="AKJ44_01300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="81" mass="9665" checksum="98D6A36F7B45449B" modified="2016-07-06" version="1">MVTTISVSEDTRKELTRLKTDLGSRSFDALLKEMLAEMRNRRLEEISKRFRESLKEKGLTLDDIQKEARRIRGEIYEEEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6T2</accession>
    <name>A0A133V6T2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02141">
        <property type="protein sequence ID" value="KXB02141"/>
        <property type="gene ID" value="AKJ44_01265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="245" mass="27755" checksum="A1E85E1CEB5A73D6" modified="2016-07-06" version="1">MERSVTFHSNGSVIRGNLRYACENAPCVVCLHGLEGGKDKGKWPLVASKFAEAGYASLRFNFRGCGRGGEKSEGKFEDTTLTARIRDYKSSLNFLQSLKWIDVDRIGTIGSSLGGMVAISGRDERVKTIVTMSSPYKVPRYGEPRIPEKRGDYYILPSGRRFKEGFYEDIRGYDILEDVKEAPPLLIIHGTSDEIVPPEHAQTLYDHAWKPKRMEMIKGADHAFSESRHLEEALQISIDWFERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6T4</accession>
    <name>A0A133V6T4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02142">
        <property type="protein sequence ID" value="KXB02142"/>
        <property type="gene ID" value="AKJ44_01270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="87" mass="9897" checksum="24CBE8D863261409" modified="2016-07-06" version="1">MFKFCRAQCRVHNLLQGGVNKSKIEKNLQEEIKLNARYAVGVISPSMKSYRTEATRRHQVAGDSPNLLKPKAELSSENYESEDIKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6U3</accession>
    <name>A0A133V6U3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpB</name>
        <name evidence="11" type="ORF">AKJ44_01200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02170">
        <property type="protein sequence ID" value="KXB02170"/>
        <property type="gene ID" value="AKJ44_01200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.692"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="9">
        <location>
            <begin position="135"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB02170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="464" mass="51856" checksum="CDDBBCF6D22F0FFC" modified="2016-07-06" version="1">MVEEKTREYRTVAEISGPLMVVEDVEGVGYDEIVEIETPEGVEKRGQVLEVEEDRAVVQVFEGTSGIDTSGTKVRFTGSTIKFPVSMDLLGRVFSGKGLPRDGGPHIIPEDELDIHGAPINPAARDYPTDFIQTGISSIDGMNTLVRGQKLPIFSGTGLPHSELAAQIARQARVLGEEEEFAVIFCAMGITHEEASFFRKDFERTGAFERVTMFLNLADDPAIERILTPRIALTAAEYFAFTQGMHVLVILTDMTNYGEALREVSAAREEVPSRRGYPGYLYTDLATIYERAGRVKGKKGSITQMPILTMPSDDITHPIPDLTGYITEGQLVMTRELHRKGIYPPINVLPSLSRLMKDGVGEDKTREDHEGVSNQLYSAYAEGRDVRALVEVVGEAALSERDRRYLEFADKFENNFVNQGTDENRDLEQTLGMGWDLLSELPEEELKRVEPEYIEKYHPARQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6V1</accession>
    <name>A0A133V6V1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpD</name>
        <name evidence="8" type="ORF">AKJ44_01195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02169">
        <property type="protein sequence ID" value="KXB02169"/>
        <property type="gene ID" value="AKJ44_01195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.691"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="210" mass="24678" checksum="6B2A8B0E35BB297B" modified="2016-07-06" version="1">MAAAARAVQPTRGELLKLRKRIDLAKRGHELLKEKRDALVTEFFDTLDRFEKVRGEMREKLENAFEKLIYSQIIMGSLDLRKAAEASMRDLEVDIGTRNIMGVKVPVVEPEDVKRKIMERGYSLHQSSPKLDEATEEFESVLETILELAEIYKTVKFLAREIEKTKRRVNSLEHVLIPRIEESIEYIEMRLEELERENFFRLKRVKAKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6W9</accession>
    <name>A0A133V6W9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">AKJ44_01250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02181">
        <property type="protein sequence ID" value="KXB02181"/>
        <property type="gene ID" value="AKJ44_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="258" mass="28999" checksum="4B53594E5A6EDD44" modified="2016-07-06" version="1">MESAKELISSSLREKQTITLVGSCVVNYKGRAGSVLPEGERIVILKPDGTLLVHQKEKRKPVNWNPPGCEARVKLGSEGLQVISRRSKPKESILILFNELKLASSFELIDEEELQLVGSESDLVDMVMADPNLIEEGFKPMEREKTTRYGVIDLYGVDAEGNGVVVELKRSKISPPAVYQLGRYIEELEKKLDKKIRGIVAAPQITSSALELVRKQGLEYVEMEEPPSHAFEKISFDKSQKKIKEFQLKSNEDSEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y8</accession>
    <name>A0A133V6Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02202">
        <property type="protein sequence ID" value="KXB02202"/>
        <property type="gene ID" value="AKJ44_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="103" mass="12051" checksum="6BC257072FE2C770" modified="2016-07-06" version="1">MRPPVEELNFKYRLGLTNYAYAEKFIKMITALIDHNVSFTAPILEDVLEYLTGEAHLSVNKFSGARWGTFDYIPGEEECEKYFNYIKWKKLKSPKFSTSKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Z8</accession>
    <name>A0A133V6Z8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02208">
        <property type="protein sequence ID" value="KXB02208"/>
        <property type="gene ID" value="AKJ44_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="147" mass="16716" checksum="634254F72DA4A019" modified="2016-07-06" version="1">MTRKPRVFLDTNTLVSGIVFAGNERKLLDAIIDGKIEWVLSTNVIDEANAVLEKKFPKHAVLFTLFLNLVRHEKTPKSKYKNSVKQYSKLVNKKDAPILAAAIEGNVDYLITGDKKLRDLKQVKNTKIIRTRKLLKLEKLAEESANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V711</accession>
    <name>A0A133V711_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02231">
        <property type="protein sequence ID" value="KXB02231"/>
        <property type="gene ID" value="AKJ44_01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="167" mass="19104" checksum="6376AB2803665865" modified="2016-07-06" version="1">MIYLDIETSATKADHGMVVAIGLLKDENPEVKPAITQEDERKALEWMNSKIGDDTIVTWYGSEFDIPFLLTRAAFLNIDSQPLIEAPKLDLFKVCKGTFRLSSYSLRSVADFFGIHEKDRFTGKDVPTLFKLAEDGDEEAQKLVIRHCKSDLQLLKRVHEWVKPYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V713</accession>
    <name>A0A133V713_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02241">
        <property type="protein sequence ID" value="KXB02241"/>
        <property type="gene ID" value="AKJ44_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="86" mass="10101" checksum="90A01987987BB0A5" modified="2016-07-06" version="1">MLKKLDRISEEENLDRSTLVRKLLSRGFESFLKERAAEKFKRGEITLSKAAEEANITLWEMEEFLIESGYISKYSIKDLKQEITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V723</accession>
    <name>A0A133V723_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02206">
        <property type="protein sequence ID" value="KXB02206"/>
        <property type="gene ID" value="AKJ44_01120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="209" mass="23178" checksum="209ECF9DA922DF72" modified="2016-07-06" version="1">MEDIPRNLREKAIVVGVLIASASIASAFLYSSAHSTNASTPPLAKLKLKQSKTYYGPGFTKAVLEVDALTDNQIEPLSDLYYDDREPDEPTDLSLAWGMGWYYAGKVQEKGDTFTSEGENVQVFYRDNIIVHPGEREAIIIKLIFDEASPGKNVSLIPQVVGTKHVRDAKQKLDKYKIEVRIRIEDLGIVGELPIGVTVTKPNQKDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V726</accession>
    <name>A0A133V726_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OrfB_Zn_ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_01015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02233">
        <property type="protein sequence ID" value="KXB02233"/>
        <property type="gene ID" value="AKJ44_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="5">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="178" mass="20041" checksum="0A5142B167D181C0" modified="2016-07-06" version="1">MKNYESNFVKTRCYQVAHKIVKLAKQYNSVVAIEDLTGLKNARGHRKSDRRTKRMPYCTFRVALESVCKREGVPLIAVDPYHTSQSCPNCGRLGKRKQKGVIFECECGYRANADRVASLNIALRASETIHNSKRIFAQSPKGNVPVNGHDWRDWGSEIMSSHGYSPPERKPTTSIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V729</accession>
    <name>A0A133V729_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02259">
        <property type="protein sequence ID" value="KXB02259"/>
        <property type="gene ID" value="AKJ44_00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="198"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="390" mass="43174" checksum="477D9DD63AE77854" modified="2016-07-06" version="1">MSPFESQHCFEHIDKLAYEIGPRQAGSRGDSQAADYIKQHFKDCGLQTRFQKFGFVNKITRARTTVSILAGAFILTLFFNPLLSLAITLAGLALAYSLPKMMPGKWSQNVIGSLKPKGEAKRRLVLGAHYDSAPCTRGRKWTLYLRILLPAVSIAFLILALLRFFGLIPLWWLAWLALGVFLIPTCILPFFIYRKFVSSGANDNATGTAIVLELARVMSESPPENTEIWFAAFGAEEQGLIGSKEFLQRSAEPSTLINLDSLGTGSQLSLILGNGVLRRHHTSPLLNDQISEAAQKLEIGVESVWAPLSGHDHIPFSDKEVNVATLSSIELREKNRLDNFLEGVFKLSQVQTRRHSGLHSLEDVPEKIKLENIENAGSLVLDVIEGYDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V731</accession>
    <name>A0A133V731_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000008">
        <property type="protein sequence ID" value="KXB02238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02238">
        <property type="protein sequence ID" value="KXB02238"/>
        <property type="gene ID" value="AKJ44_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="168" mass="18620" checksum="D98BCD198C5E3D07" modified="2016-07-06" version="1">MVVCDSAPLIHLSRVNKLGLLKDLFGEVEIPPSIYREVVEEARELGKPGVSTIEGAIDDGWLKVTKIRGRKKIKKLAESEKIQIEDAEVLYLAKDLATSLVTSDGWLIKIAKGIGVETLWTTTLVLLSIKEGKMSKKEGKNLLRELVTSGLYIKPDVYAMLLQAIDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V762</accession>
    <name>A0A133V762_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02274">
        <property type="protein sequence ID" value="KXB02274"/>
        <property type="gene ID" value="AKJ44_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="138"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="510" mass="57258" checksum="FCC592C9DFADA61F" modified="2016-07-06" version="1">MTDEIGTVICTSDGPSSTQFSFVVTTREGRIPVRRGQFIELESEEGRVIAQVQDLFKTNRYFMRPESVKEYEKGNKSLNSIFPADRWEYLVARAKASGVQTNNGLEQTTFPVSPGQKIYEANLDELAQFLGTDTNDGVELGKLKFHDLPARLDLTKLLRKHVAILAMSGSGKSYTAAVLVEELLERAREEGRVASIIVDTHGEYTTLAQANDGVDYSDRATVVKGGNVKIGVPNMSAYQFREFSPDMSGSQVRELNRVLKGLRSEMRSGKGRYDLDDVIARVEEDGESKKNTRQALLDRLYDLKSLQIFGKNDYPNWRKLAQPGEVAILDLSGVLNLRKKRVILTYFTRKLFNKRKTGQAPPFALFLEEAHQFAPSKKSVISSSILKTLAREGRKFYASLVLISQRPVRLSTTILSQANTNIILRVTNPYDLDHIKQSSERITRDTADIISSLPVGQALIVGEAVNHPIFVKIRQRKTQEAKHGASLKEVAKKYEKQHDQELEDAKAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V784</accession>
    <name>A0A133V784_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ORF">AKJ44_00770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02301">
        <property type="protein sequence ID" value="KXB02301"/>
        <property type="gene ID" value="AKJ44_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="121" mass="14119" checksum="4D93F72668BF8610" modified="2016-07-06" version="1">MEELPPQVQHQLTQFQQTQQRAQALATQRRQLEINLRETERALKELENLGEDATLYKSVGRIMAETNSSNAKEELEDRKETLDLRVKTVERQQERINKKMEEMRAKIQDALRGQETPSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V785</accession>
    <name>A0A133V785_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02273">
        <property type="protein sequence ID" value="KXB02273"/>
        <property type="gene ID" value="AKJ44_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="124" mass="13604" checksum="DFD643157AB72D87" modified="2016-07-06" version="1">MSPKKILTITIIAIIAVGLLWITKPWQKIGGEEGGETGENQQLTENQQEGGGIDVPPGYTLFKYQASFQYLSSSDNAPIANDLFMVFPCPNIDNKPVIPIGPDTDAENTGWQLIAHYIENNENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V787</accession>
    <name>A0A133V787_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02308">
        <property type="protein sequence ID" value="KXB02308"/>
        <property type="gene ID" value="AKJ44_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="11706" checksum="047FDCD7768A105F" modified="2016-07-06" version="1">MIIIYRIRNLPQAKKVKFGREFRGYTDKSNRGQYEYYRKGLLDEIPHRKFIRGVLLIKREDREKMLDFMKEYKVEVHARNVELTPKDIEILSTRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V797</accession>
    <name>A0A133V797_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02277">
        <property type="protein sequence ID" value="KXB02277"/>
        <property type="gene ID" value="AKJ44_00880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="159" mass="17411" checksum="FBE94980C2FB900E" modified="2016-07-06" version="1">MSDTHDRLEAVEKAVKFFNEAGVEQVLHAGDLVSPFVAPKFADLKAELHYVWGNNEGDHGHTRTKFSEIGVEPLGDFAVIELENRKIALLHGTNEDFVQALAKSGDFDAVVRGHTHEPGVQEDPLVINPGEVCGYLSGRQTVALLDLEVLKTKIVELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7A4</accession>
    <name>A0A133V7A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02322">
        <property type="protein sequence ID" value="KXB02322"/>
        <property type="gene ID" value="AKJ44_00845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018662">
        <property type="entry name" value="DUF2095"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09868">
        <property type="entry name" value="DUF2095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="108" mass="12439" checksum="2FE08C769DCFC086" modified="2016-07-06" version="1">MTKLDSKYLKRKFPHLAQEIDEQAETISLDGVRTDVEEARKATYPNRAKGPTVIDFLRLCDTDEEALEIIDFSVERGKIDSKRAKKLKRQLVNRGLRSFGSKREPGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7C2</accession>
    <name>A0A133V7C2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoCF_biosynth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02342">
        <property type="protein sequence ID" value="KXB02342"/>
        <property type="gene ID" value="AKJ44_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="174"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="324" mass="35704" checksum="A236298678DCAC8B" modified="2016-07-06" version="1">MKRVRVEDSIGKPLAHDVIQYGPEVKRVLFKRGHLISSEDLDKLKNAGNYYVYISEEENDRCIHEEEAALRIARASAGENISITEPSKGRVRLLSETPGLLKVKPDIVGQVNLEDGFVFATRLNNSGVRKSQEVASTKIVPLVIEEEKLEQVEKILEDNKPVIEVIPPKIEKIGVIIAGKEVYEERIEDAFKPVLEEKLKPYGLTITKSIILPDDEEKIKEKIIEYKNGGLELILVTGGMAVDAGDVTANAIRGTGARVIPRGTPIFPGNMAMVAYLEDVPVLGLPACVIPDPQTSFDFLLPRVLAKEEITNEDIAELGHGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7C9</accession>
    <name>A0A133V7C9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NifU_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02351">
        <property type="protein sequence ID" value="KXB02351"/>
        <property type="gene ID" value="AKJ44_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="115" mass="12245" checksum="E02A156E0B740B32" modified="2016-07-06" version="1">MDDADVTVQEGDPTCGDMIQLQLKIEDNVIEDVKFLSFGCAANIATGSALTEMVKGETLGESKKVTVKDIKEEVGGLPPVKMHCAVLATRALESALKKAIEMYESGEGSESEPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7D1</accession>
    <name>A0A133V7D1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serS</name>
        <name evidence="9" type="ORF">AKJ44_00865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02316">
        <property type="protein sequence ID" value="KXB02316"/>
        <property type="gene ID" value="AKJ44_00865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.563"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="187"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="6">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="350"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="429" mass="49613" checksum="5E3FE700E67EEF5E" modified="2016-07-06" version="1">MLGIELIREDPEKIRKDLQKRGYKEKLAWVDELREKDEEWRKLKQETDRLKHERNVLTRKIAEKKGEGKDVDDEIQKSKDLLEEIESEEEKKEDLRKEIDGKLMKLPNILHPSVPQGESDEDNEELYTVGEPKTPGYSLRPHGQVLEELGVGDFDRAAKVAGHGFVYLKNDLVLLDYAIMNFGLNKLVEKGYELIEPPFMMKREPYEGTVDLSDFEDVMYKIEGEDLYLIATSEHPMAAMYKDEILSEDELPIKLVGVSPCFRREVGSRGVDTKGLFRMHQFNKVEQFIFSKPEDSWDYHEELLENTEELMKELEIPYRVVNVCTGDIGTVAAKKYDIEAWSPRQDKYIEVISCSNCTDYQARRLNIRMGKVGEEKGKEFVHTLNSTALATSRTMVAILENNQTKDGAVEVPKALRKYMNGKKVIKPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7D5</accession>
    <name>A0A133V7D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02317">
        <property type="protein sequence ID" value="KXB02317"/>
        <property type="gene ID" value="AKJ44_00870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="77" mass="8385" checksum="FAFA87B521980F85" modified="2016-07-06" version="1">MGSKARISCVYDDESISQTISSSLEPDNIQAPENVKIKTTRDGNKVITEIEVDGRIETLLATLEDLLSCTSTAEKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7F6</accession>
    <name>A0A133V7F6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenylosuccinate lyase</fullName>
            <shortName evidence="9">ASL</shortName>
            <ecNumber evidence="5 9">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ44_00665</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5 9"/>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02337">
        <property type="protein sequence ID" value="KXB02337"/>
        <property type="gene ID" value="AKJ44_00665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.461"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="360"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB02337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="449" mass="50543" checksum="7F91F88383F3A7ED" modified="2016-07-06" version="1">MPVHPIENRYGSDEMRAVFEEETRFQRMLDVEGALAKALAAEEMIPKTHGQKIARKAKIKHVPVKKIRKLEEKTGHETMALVLALAEVSGTGSRSVHFGATSNDILDTAMALQFRDALEVLEKRMRDLLEVMIKQAKENVDTVIVGRTHGQHAVPTTLGMKFAIWASEMGRNLKRLEEVKSRVLVGQMTGAVGTGAAWGEKASKIQKRVMEELELESVEISNQVIQRDRFAELISFLGLLGGTLAKVGREIRNLQRTEISEVSEPFGEEQVGSSTMPHKRNPIKSERVCGLARVLRANVQAGLENMVIEHERDLTNSSCERVLLPESFLIIDQMFLDQKEVLENLRIRAKRMEQNLKLTQGLNMAEAVMIEVTRRGMDRQKAHKALRECTSYALREGVSLSSALQQNGEILEHISKEEIRDLLDPKKYLGNAKSTVKKVIKNLEKIQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7F8</accession>
    <name>A0A133V7F8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsY</name>
        <name evidence="6" type="ORF">AKJ44_00590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02381">
        <property type="protein sequence ID" value="KXB02381"/>
        <property type="gene ID" value="AKJ44_00590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.369"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="304" mass="33232" checksum="28F2CB43DF60151D" modified="2016-07-06" version="1">MLENLKQKFKRVTKRITRRGLTPEDIKDISWDLKVELLESDVAVPVADEIIDRLQEEVTGEKLGLREDAEESAREILRGTIGDILTPEREVEILETIKKKQDSGAPAVLLFVGVNGCGKTTTIAKLTKYLQDKGYKPVLAAADTFRAAGIEQLEKHGKKLGVRVIKHERGADAAAVAYDAIEHAKAQNLDAVLIDTAGRMQSNVNLMDEMSKISKVTNPDLTIFVGDALTGNDAIEQAKKFNDAVKIDGSILCKMDADARGGATLSVTKITGSPILFLGTGQDYDDLVEFKPEIILDAIFPEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7F9</accession>
    <name>A0A133V7F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02353">
        <property type="protein sequence ID" value="KXB02353"/>
        <property type="gene ID" value="AKJ44_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="216" mass="23655" checksum="4802D75B8B62754D" modified="2016-07-06" version="1" fragment="single">ELHFSGSGTMLSQMKMSRSGDLYIPGSPDYMVRAIDDNVVDPNTIQKIAYLVPAIITPKGNSENVNSLEDLANPGVEVGIGDPESVCVGEYAVGVLEYNGLYEEVEPNITVHAESCSKTANLAALGTVDAIIGWRVFHFWNPEKTKIVYIRENRIPRISFVPAAVSKFTDNTGKAQQFIDYLASSEGNHFFREYGYLATENEARELAPSASILSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7H6</accession>
    <name>A0A133V7H6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ44_00610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="4"/>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02384">
        <property type="protein sequence ID" value="KXB02384"/>
        <property type="gene ID" value="AKJ44_00610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.373"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043891">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="7">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="7">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB02384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="336" mass="36160" checksum="BDC2A118D1BEF216" modified="2016-07-06" version="1">MKLGINGFGRIGRCFLRSALERGKNFDVVAINDLAPASTLAHLLKYDSNFGELEEEVEATENSIIVGDMEIEFISEKNPAELPWDDLGVDLALEATGLFRKRKDAAKHLDAGAGKVLITAPGKGEGSDKTFIPGVNDDQYDPEEHVIMDLGSCTTNCAVPTAKVLDDSFGIEKALLTTIHSYTNDQRLLDAVHGKLTRARSAPNSIIPTTTGAAIATTKVLPQLKGKMHGIALRVPVPDAAVVDLVAVLGEEVTEDDVNSAYKKAAEGELNGILDYTEEPLVSVDYIGNPHSATVDGSFTTVRAGNLVKVLSWYDNEWGYSSRLVDMSNKIGEQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7K2</accession>
    <name>A0A133V7K2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02387">
        <property type="protein sequence ID" value="KXB02387"/>
        <property type="gene ID" value="AKJ44_00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="117" mass="12738" checksum="FDA9E8B9DF8902A3" modified="2016-07-06" version="1">MKKVLVAVDGSAPSEKALEYALEDSKKLDSQLTILRVVISLPHGRKYPKEALKEEIENAEEYLEELKDKAEGGGVKANTKVLTGSNAAAEIVRFAKEEDYNEIVVGGRGKLGLRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7L7</accession>
    <name>A0A133V7L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02433">
        <property type="protein sequence ID" value="KXB02433"/>
        <property type="gene ID" value="AKJ44_00480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.243"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="291" mass="30693" checksum="EF3ED09C62A5A33F" modified="2016-07-06" version="1">MILATPLTLGTLGEIYAERSGVLNLGIEGMMATGAAVGVIGAFMAKSAVVGALLGMVSGGVLALGFGLVTINFKGMQVPAGLGLFLFGLGLSGVIGRPYVGLNLPYHFSPAPVPVLSEIPVLGEFLFSHGALVYLALALVPIMWFILFKTKLGLHIRSVGEDPRAADSAGVNVTRIRYLCVIIGGILAGLGGAFLSLSWTPGWTEGMSAGRGWIVIALTIFALWNPLRALLGAWLFGGIFALQYQFQGMGIPVRILGMFPYLITIVALALVLIFYERIGAPSALLKPYERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7M7</accession>
    <name>A0A133V7M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02458">
        <property type="protein sequence ID" value="KXB02458"/>
        <property type="gene ID" value="AKJ44_00265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.56"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="70" mass="8185" checksum="144B400A538CB8C3" modified="2016-07-06" version="1">MAKKKKSTVSIPPELFKKIKERIKGTGFDSVSEYVTYVLREVVEEEEEEEFSEEDEEKVKERLRALGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P4</accession>
    <name>A0A133V7P4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02469">
        <property type="protein sequence ID" value="KXB02469"/>
        <property type="gene ID" value="AKJ44_00320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.67"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="4">
        <location>
            <begin position="390"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="3">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="712" mass="82102" checksum="733A1DFB506053A5" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P6</accession>
    <name>A0A133V7P6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_00245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02456">
        <property type="protein sequence ID" value="KXB02456"/>
        <property type="gene ID" value="AKJ44_00245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="4">
        <location>
            <begin position="548"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115725" checksum="B6DC44AE3012AAE1" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q6</accession>
    <name>A0A133V7Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02455">
        <property type="protein sequence ID" value="KXB02455"/>
        <property type="gene ID" value="AKJ44_00240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.51"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="105" mass="11864" checksum="97324AD13A7842F1" modified="2016-07-06" version="1">MELTDKNFEEEVLKSELPVFVDFWGSWCPPCKMTEPIVSELEGEYNGKVKIGKLNIDKYPSVASRYAISGVPTFIIVKNGKEVAREIGAKSKKQLRKLIESNVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7R0</accession>
    <name>A0A133V7R0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02466">
        <property type="protein sequence ID" value="KXB02466"/>
        <property type="gene ID" value="AKJ44_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="269" mass="31145" checksum="5F36546E688D6990" modified="2016-07-06" version="1">MNSIVEIDDERVEKFVTCTLACHSKVKTLLIIGSAAHGELTKYSDIDGVMLTEVSEKDVISELEEDFNELAAKRFGKSSGNEFYSPHWSLFIYPEKAFTDKSIFSEYCPLPLEFTLYNLKHNSKLVFGQDARKDISVKYNEGLIDEWLSFAPKYHLTQSEIMINNGENLRKSTYALSRAILQTARGVAWKEDKNTSSSYESIVQSMKKLEHHSTNLAEWALEKRRKDFESTIRETKSKLKPAENFLDNTLKRYVQIKRRRCPYSSQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7R9</accession>
    <name>A0A133V7R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02483">
        <property type="protein sequence ID" value="KXB02483"/>
        <property type="gene ID" value="AKJ44_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="174" mass="20056" checksum="49B2F46458D4C8C4" modified="2016-07-06" version="1">MSEVVSDSTVLIFLAKLNKLPLLKMIYPKVLIPEKVHDEVVGKGRRKGERNATIVRNAIKEGWIEVRETETREDVNEFKLGRGESEALSLSKNLNHEEILVDDESARDAARFLGVKPRGTLFFLAEGLRKSKIDFDEYLKSLEKLIEIGFYMHEEIYLEAVRMDRKIAAQKHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7S0</accession>
    <name>A0A133V7S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02484">
        <property type="protein sequence ID" value="KXB02484"/>
        <property type="gene ID" value="AKJ44_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="158" mass="17857" checksum="7AE3B1AD0FC21007" modified="2016-07-06" version="1">MSSRSRKKYTPGEDEFIRENWRDMSDVAKAVEKSVSDLEVVIGKIKEALGNGKGGYLYVKTPDGIYDRELEEEFGKRIPQNPNPRRNTFFWSEPFSDFVVQDRFGKEVEAAIRARYGDGVRIVKNPEWASKENTWQIKAEKGATGGETAPISPASKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7U1</accession>
    <name>A0A133V7U1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="6" type="ORF">AKJ44_00090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02521">
        <property type="protein sequence ID" value="KXB02521"/>
        <property type="gene ID" value="AKJ44_00090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.20"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="15"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="302" mass="33063" checksum="8DDDD733DCF411B9" modified="2016-07-06" version="1">MQRKTEELIAEYGTERLKRGFARMQKGGVIMDVTNAEEALIAEEAGAVAVMALEKVPADIRKAGGVARMGDPAVIKEIMDKVTIPVMAKCRIGHFAEAQVLEALGVDMIDESEVLTPADREAHVDKRKFKVPFVCGSRDLGEALRRINEGAAMIRTKGEAGTGNIVEAVKHIKQTIRQIKELEDLSPEGLEEKAEEYHVPVELVKEVAELQRLPVVWFCAGGIATPADAALAMQFGVDGIFVGSGIFHSEDPPRMARAIVEATRNYDDPEKVLEACKRLPVPMKGRDIESLSPEERLQARGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7U7</accession>
    <name>A0A133V7U7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Methionine aminopeptidase</fullName>
            <shortName evidence="6">MAP</shortName>
            <shortName evidence="6">MetAP</shortName>
            <ecNumber evidence="6 7">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">map</name>
        <name evidence="9" type="ORF">AKJ44_00070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6 7">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6 7"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02519">
        <property type="protein sequence ID" value="KXB02519"/>
        <property type="gene ID" value="AKJ44_00070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.16"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="8">
        <location>
            <begin position="14"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="303" mass="33553" checksum="EF44F4F6A4AE10E2" modified="2016-07-06" version="1">MVVISVLNEEKLKTYRKVGKLTGEIRDTIQEKVKLGETLLNIAETTEELIRDKGAEPAFPCNVSVNELAAHYSPPEGDETEIKEGDLVKVDIGAHIDGYIADTAISIATDEKGEKLVNAVNQVLEKAIQAVKPGVNVGEIGAVIENTANEAGFKPIENLTGHSLARWSLHSGITIPNVEKDTEDELREDDVIALEPFITDGAGEVEDQPEVYIFRYLSSEPVSGRMARQTIRRISKKYVKLPFAERWLARDMSKIRLQMTLRELLTSGAIHPYYVLKEIEDGMVAQAEHTLIVTKDGCEVTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7V4</accession>
    <name>A0A133V7V4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_00060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02540">
        <property type="protein sequence ID" value="KXB02540"/>
        <property type="gene ID" value="AKJ44_00060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.14"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="7">
        <location>
            <begin position="396"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="805" mass="92325" checksum="09BD168DD8C62CDC" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7W5</accession>
    <name>A0A133V7W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_00020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02512">
        <property type="protein sequence ID" value="KXB02512"/>
        <property type="gene ID" value="AKJ44_00020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.6"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011830">
        <property type="entry name" value="LEU1_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02090">
        <property type="entry name" value="LEU1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="516" mass="55247" checksum="772661BCAE3A3077" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7X4</accession>
    <name>A0A133V7X4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBFD_NFYB_HMF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_00195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02534">
        <property type="protein sequence ID" value="KXB02534"/>
        <property type="gene ID" value="AKJ44_00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="75" mass="8392" checksum="1C130ADACBE4B252" modified="2016-07-06" version="1">MPEFPLSTMKRLLRRAGNERVSRSAAIELSAVLESVGEDIAEQAVRSADNRGVKTVSEEDVRTAVKALNRPRIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7X5</accession>
    <name>A0A133V7X5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02536">
        <property type="protein sequence ID" value="KXB02536"/>
        <property type="gene ID" value="AKJ44_00205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.44"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="28"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="244" mass="26815" checksum="D9A0A322CCB8567F" modified="2016-07-06" version="1">MTDEEAIQEIIESAREDERTELTEYESKQLLSAWEIPTTRTRLAGNKLEAVRAARIIKYPVVAKIASPEILHKSDVGGVKVGLASEIEVRHAFDDMIANAKAQYPDAETWGVTVQEFIPGGREVIIGVSQDPSFGPTLMFGIGGIWVEVLEDVSFRLPPISDEEARKMIQEIKGYPTLTGARGGSPADIDALSEILQKISQLAMEIDQISEIDLNPVFVLDEGEGAKAADARIILKEPKEDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Y3</accession>
    <name>A0A133V7Y3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02545">
        <property type="protein sequence ID" value="KXB02545"/>
        <property type="gene ID" value="AKJ44_00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="42"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="433" mass="48190" checksum="A95CBAE79621597C" modified="2016-07-06" version="1">MDGNRKIIEKGSIEIEDKKIKRVGKFRGDKNPEKVIDASGKIVMPGLICSHTHSYGMLLRATPLKIGPPTDLMQILQRVWWPIDEAMVQSDAYASALIACLEFIKTGTTCFADTYSGSNSIGRSLDRISSAIGESGLRAFIGFEATERHTRAEGARGMQENVRFLKRTLKKKRSRVRGLVSIHASFTVSDELLRHARRVSRRFNAPITIHASEGQVDPQHNLQKYGKRAVERLHDVGILSSNTVLAHCVHVNEDELSIMKKTEAKVAHNPMSNMLNGVGVAPVPKMLEKEISVGLGNDGYIFDGFENLRSAYLIHKANARDPRVITPYQALEMATINGAKLYGLEDKLGSIETGKLADLIIINPDSLPTPLRRKNVVEHIVNSVRGCDVETVIVDGRLLMREKRVITLDEEEVVKMSKKSAEKIWKKLGAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3L9</accession>
    <name>A0A133V3L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000056">
        <property type="protein sequence ID" value="KXB01035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01035">
        <property type="protein sequence ID" value="KXB01035"/>
        <property type="gene ID" value="AKJ44_03015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.605"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="243" mass="26583" checksum="BFE42B35832B744E" modified="2016-07-06" version="1">MDPRLEIIHERFANVERLISVASGKGGVGKSLISSTLALILSEKGYRVGLLDLDFHGPSAHTILGAPNVYPEEDKGVIPPEVRGIKLMSIVYYVGDNPSLLRGSDVSNSIIELLAITRWGSLDFLIIDMPPGIGDETLDTIRLLDRAEFLVVTTSSNLVWGTVKRLVKILKELKVPITGIVENKKITESPSAKDQANELGVPFLGEIGFDKELETTIGNADELLKTRFAQDTEKALGHLTRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3P3</accession>
    <name>A0A133V3P3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000055">
        <property type="protein sequence ID" value="KXB01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01062">
        <property type="protein sequence ID" value="KXB01062"/>
        <property type="gene ID" value="AKJ44_02995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="421" mass="48904" checksum="DFE32FAE327991D1" modified="2016-07-06" version="1">MSSFTLKESTLKDCPVPPIWTTDPHGKIFVYEGVLGKLRRLLQQVDSGDLSQSETAKIIGVSRRTLRDWKSGRSEPKVFTDDEFRFTKTNLYWLGLFLSDGHLRRNGSQYSYTWQIGSCNPFQGYWYPQFVQKYSSIFQHKPTESKTYMKFSKTSGTWAFYTNVSSVSPIFVKFLEKEGLVSPKENSLTTGFEKSPLLKNVGNDSLKILFQGLMDGDGTYNMINNGIHMSLSFDYTRNHARNIDSMPLVPTLLRNSKKEAFEFKEYEKNDVSEIRFAPSSLSKLREGSIERIVNQFEFMIEAAGYSIRPDKVHALISIVERLASPEYGEYRHCLDIQRRIRDAIRKSNLLKAVEELKKRYPKKDHFFKPFRPKWSDEFGSKRVWLSEAWDFFLLSENLSHDKYDSKENLDFSRGVPIDFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3Q5</accession>
    <name>A0A133V3Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000055">
        <property type="protein sequence ID" value="KXB01063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01063">
        <property type="protein sequence ID" value="KXB01063"/>
        <property type="gene ID" value="AKJ44_03000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="96" mass="11330" checksum="4B147C96DF8EE43A" modified="2016-07-06" version="1">MGESDRALDEFRNALEYIESVLPSGRERISYLWFGLPEGVREMKAEMQFKVAQIYEEKGDIDRAKEYYKDSLKTYEALEDEEEPKKVREALENLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3U2</accession>
    <name>A0A133V3U2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl30p</name>
        <name evidence="2" type="synonym">rpl30</name>
        <name evidence="4" type="ORF">AKJ44_02930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000052">
        <property type="protein sequence ID" value="KXB01114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01114">
        <property type="protein sequence ID" value="KXB01114"/>
        <property type="gene ID" value="AKJ44_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="3">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="155" mass="17549" checksum="B8D3B6913D970E5E" modified="2016-07-06" version="1">MSKLAVIRIRGTVDIRRKVQDTLKILGLTRPNHCVLVNDDPSTRGMLQEAKDFITWGSLNPEVLEALIRKRGRLEGNAPVTDEVIDSKTRFKTIGEFAKAILEDEAELSELKGLKKAFRLRPPKKGYKSTKRPFKDGGSLGFRAEKMNELVKRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3V4</accession>
    <name>A0A133V3V4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl19e</name>
        <name evidence="9" type="ORF">AKJ44_02915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000052">
        <property type="protein sequence ID" value="KXB01111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01111">
        <property type="protein sequence ID" value="KXB01111"/>
        <property type="gene ID" value="AKJ44_02915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.579"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_L19/L19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_L19e_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015973">
        <property type="entry name" value="Ribosomal_L19e_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015974">
        <property type="entry name" value="Ribosomal_L19e_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="8">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="149" mass="17117" checksum="03C5BBD29AE84A12" modified="2016-07-06" version="1">MNLKTQKRLAADILGVGENRVWIDPDRVTEVSTAITRADIRSLIKDDAIKAKPKKSTSKARVRKHQKQVQKGLRKGSGSRKGAKGARTPKKEAWKKRVRALRRRLRELRDQGTIDSSHYRKLYRMVEGGSFRSKAHLESYLKKRGILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3V6</accession>
    <name>A0A133V3V6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps5</name>
        <name evidence="8" type="ORF">AKJ44_02925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000052">
        <property type="protein sequence ID" value="KXB01113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01113">
        <property type="protein sequence ID" value="KXB01113"/>
        <property type="gene ID" value="AKJ44_02925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.581"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB01113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="220" mass="23933" checksum="9C94450C3B816C20" modified="2016-07-06" version="1">MENPELEDWIPKTGIGRKVKEGEVTDLSQILRSGKRPREPEIIDALVPDLDEEILGVNLVQRMHRSGRRIQFRVTTVVGNEDGIVGVAHASGREVGPSIRKSITTAKLNVIEIVRGCGSWECGCSRPHSLPYEVSGSKGSVEITLKPAPRGLGLAAAEVPRLILEKAGVGDVWTRTSGKTRTTINFALATFDALNQAAKMEVRGTYAERIQIGEVGEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3X9</accession>
    <name>A0A133V3X9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug_translocon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000052">
        <property type="protein sequence ID" value="KXB01116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01116">
        <property type="protein sequence ID" value="KXB01116"/>
        <property type="gene ID" value="AKJ44_02940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="68" mass="7924" checksum="7AEA4670B38563F9" modified="2016-07-06" version="1" fragment="single">MDERSFRSKLYVLEPIIQRLPEVSVPKRHIGFKEKLMWSGIALIIFLIMTQVPLYGMTAQAQNWFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3Y2</accession>
    <name>A0A133V3Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ44_02870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000050">
        <property type="protein sequence ID" value="KXB01154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01154">
        <property type="protein sequence ID" value="KXB01154"/>
        <property type="gene ID" value="AKJ44_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="233" mass="26858" checksum="ACEC889B88A295DA" modified="2016-07-06" version="1" fragment="single">MRYLNEYSITAIISVLLVIGLFTIAVTEQSTQEDESNDLKKLLVTIDGSIKTLRLRGENSASDVLEGIQSQYNSFTSPYESDNFDNKPNLVKLNQEIDNKLAKLKQSPDKNSIRELRGMIQEMANELGVRLSFIYENSMIIILGVSFILSLIMSIIIKIGVNWEKIRGIRIELKNWQDKLRQAQLKSKKKEIRKLKLQQGEMSERQNTILMTDLKQAILYLIPFVLAWFWLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4I1</accession>
    <name>A0A133V4I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000042">
        <property type="protein sequence ID" value="KXB01331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01331">
        <property type="protein sequence ID" value="KXB01331"/>
        <property type="gene ID" value="AKJ44_02660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="16"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="324" mass="35537" checksum="CFF3C0CABD554F72" modified="2016-07-06" version="1">MRGEKLKFAFYWAASCGGCEVVVLDIDEKILDIAEIADIVFWPCATDFKYADVEAMGKGEIDVCFFNGAIRNSENEEMAKLMREKSKILIALGSCSAFGGIPGMGNVADKEQIFERVYVSTPSTTNEDNIFPEPRTEVPEGELTIPEFSDNVLVLDQVVEVDYYLPGCPTNPDLIGKAVEAIKKDELPPSRSNLASLADMETVCDECDRELAEEKSVKEFKRPHEAEDNGKDCLLEQGIICMGPATIGGCGARCIEASFPCRGCFGPPSNVEDQGAKMVGLLGSIIDSEDEEEIREIIDGITDPLGTFYSYGLPKSLLQRRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4I6</accession>
    <name>A0A133V4I6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TFX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000041">
        <property type="protein sequence ID" value="KXB01358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01358">
        <property type="protein sequence ID" value="KXB01358"/>
        <property type="gene ID" value="AKJ44_02645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029291">
        <property type="entry name" value="Tfx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036657">
        <property type="entry name" value="Tfx_DNA-bd_sf_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14601">
        <property type="entry name" value="TFX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89915">
        <property type="entry name" value="SSF89915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFX_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="78" mass="8905" checksum="928BC1A23D353BD6" modified="2016-07-06" version="1" fragment="single">FKTIRWPIRIDVKAGSNIYDASEDIFEKADGEGIDLSLNYSELVRLVTETLGREDLKRREALRDFSVMISSEGKVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4L2</accession>
    <name>A0A133V4L2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ44_02640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="LHXY01000041">
        <property type="protein sequence ID" value="KXB01357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01357">
        <property type="protein sequence ID" value="KXB01357"/>
        <property type="gene ID" value="AKJ44_02640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.491"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="5">
        <location>
            <begin position="190"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="4">
        <location>
            <begin position="352"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="531" mass="56430" checksum="C8434BCD910CDF47" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V4U0</accession>
    <name>A0A133V4U0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000037">
        <property type="protein sequence ID" value="KXB01462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01462">
        <property type="protein sequence ID" value="KXB01462"/>
        <property type="gene ID" value="AKJ44_02505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="78" mass="9224" checksum="F24EA1A395502AB3" modified="2016-07-06" version="1">MIAPSCRLNIDRFFKVFHWRTRDGDPWIVINFSTGRFSAYNPLFPMRLTEENRSEEGFVSGERTRLNCVVNQKRIGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V527</accession>
    <name>A0A133V527_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000034">
        <property type="protein sequence ID" value="KXB01548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01548">
        <property type="protein sequence ID" value="KXB01548"/>
        <property type="gene ID" value="AKJ44_02410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="281" mass="31661" checksum="A9B0858F671C3E8F" modified="2016-07-06" version="1">MPQKIRLGPAGNPVDYSGPSVKAPKFIREEGLSAYEYQGTRGVRISEENAQKLSENAEENDVWVTIHGQYWINFASAKKDTIEKSKDRLFKAARIGSLMGAHQVVFHPAYYSDRSKEEALKITIEGIKEVVERLEDEGIEILIGPETTGKKSQLGTLSEIIKICQEIPMTAPTVDFAHIHARTGGTLETKDDYLKIFEQIEDELGAKSAKNLHAHFTEVEFTEKGEKKHLTYETDYSPPFKPLAEVVVENDFTPVIISESPILDKDALKFKEELEKLGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V530</accession>
    <name>A0A133V530_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elp3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_02430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000034">
        <property type="protein sequence ID" value="KXB01552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01552">
        <property type="protein sequence ID" value="KXB01552"/>
        <property type="gene ID" value="AKJ44_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Elp3" evidence="8">
        <location>
            <begin position="82"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="297" mass="33184" checksum="3603AFFE6E66A4B6" modified="2016-07-06" version="1" fragment="single">MTDKMSKNSTEALRAILKEVIAGDINEKGELEHAKLRACREFGLSKVPSNAEILATASEDEREEVLPILRRKPVRSISGVTVLTVMPQPYTCPKEKPCVYCPGGPNFGTPQSYTGEEPASARALELDYDPTAQIEARMKQLYAIGHEVDKVELIVFGGTFLAQPLDYQERFMHHCLDTISGKKSPDLEAAKRQAETAGTRTIGITFETRPDYCKREHVNQMLRFGGTRVEIGVETIYEDIYELVGREHTIQDVVEATKTAKDSGLAIVYHMMPGLPGSNCERDLQAFKTIFNDPRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V560</accession>
    <name>A0A133V560_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMPdecase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_02370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000033">
        <property type="protein sequence ID" value="KXB01580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01580">
        <property type="protein sequence ID" value="KXB01580"/>
        <property type="gene ID" value="AKJ44_02370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="208" mass="22090" checksum="94413DF46E128741" modified="2016-07-06" version="1">MPISITYVNILSSLPPAGTPAIKRHGVDSLIPALREVAPEALIVADLKTMDVGGLESRIAFRAGADVSAVLATGGENKTIEAISEAARQGKVILIDFIGCPDPIEKLDELVQELEGHEDQVIFCLHRGISEQLKGRGIYEKKQLLAEARKHAGEFPLAVAGGIKEGVAKNVAGAGAEICIVGSAIYNSSDPKKASKRILGEVRENYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5F9</accession>
    <name>A0A133V5F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_02280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000030">
        <property type="protein sequence ID" value="KXB01675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01675">
        <property type="protein sequence ID" value="KXB01675"/>
        <property type="gene ID" value="AKJ44_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="108" mass="12350" checksum="7BB377653752BA3B" modified="2016-07-06" version="1">MNDKEVKRRQLAAVAREAGTSIRKKMIERQALSADLNLPLAEKVKEKIDECLQPLQKLENMSEKPVGEAIMDTIDTIIGFFNWSMKAEECVDQTNQLIKVTNNRQTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5K8</accession>
    <name>A0A133V5K8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000029">
        <property type="protein sequence ID" value="KXB01723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01723">
        <property type="protein sequence ID" value="KXB01723"/>
        <property type="gene ID" value="AKJ44_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="93" mass="10837" checksum="D5878FF3BB742897" modified="2016-07-06" version="1">MKQVKGNYKIEKALIFGSRARDDYLKESDVDILLVSSDFKGIRFPTRSARMMEYWNLDYGDPEFLCYTPKEFNQMKEKLTIVKTAVEEGVSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5R9</accession>
    <name>A0A133V5R9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl18e</name>
        <name evidence="6" type="ORF">AKJ44_02105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000027">
        <property type="protein sequence ID" value="KXB01791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01791">
        <property type="protein sequence ID" value="KXB01791"/>
        <property type="gene ID" value="AKJ44_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_L18/L18-A/B/e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_L18e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="PTHR10934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="5">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB01791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="121" mass="13341" checksum="D71056AEED8A8821" modified="2016-07-06" version="1">MTKPTGPTNPILRKLARKLRAKGKELDVSLWEDLADELLKPRRSRAEVNLSRLNRYASEGDTIAVPGKVLGAGKLDFPLKVAAFKFSSRVRRKIQSAGGQAMEIGELLEENPEGKGVILME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V5U9</accession>
    <name>A0A133V5U9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps2</name>
        <name evidence="7" type="ORF">AKJ44_02145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000027">
        <property type="protein sequence ID" value="KXB01797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01797">
        <property type="protein sequence ID" value="KXB01797"/>
        <property type="gene ID" value="AKJ44_02145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.326"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="194" mass="21808" checksum="917980AFAB7501C4" modified="2016-07-06" version="1">MEQYLASGVHIGTRQKTGAMNPYIYRVRPDRLFVLDVQQADERIDLAARLIASFEPEDTYVVSARQYGQRPVSKFGEVTGARISAGRFIPGTFTNPSYENYIEPKLLVVTDPVADEQPLAEAATIGMPVIGLCDTDNETRNIDLVIPTNNRGRKSLALVYWLLARQVLRERGELAPGEELDVSLEEFETKFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V602</accession>
    <name>A0A133V602_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000025">
        <property type="protein sequence ID" value="KXB01857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01857">
        <property type="protein sequence ID" value="KXB01857"/>
        <property type="gene ID" value="AKJ44_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="177" mass="20459" checksum="2478B14972592651" modified="2016-07-06" version="1">MCFGRDLKTRNRIRIRGHGGIARYDYGFISKIAQLRIEPSWNLVGPLMFIVVFRIHALRRIFKTLMSKPTIGVTPWVRFWFLAAMFFGLATTPYLAHSFLQNGSTFFLIDLLTLLTVVSWVLLVALTVWISRMSSKHSSRKLKRVKKSQRAHQWLLAPSSAVFFIFTGIYSFIIMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V605</accession>
    <name>A0A133V605_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ44_01975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="LHXY01000023">
        <property type="protein sequence ID" value="KXB01888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01888">
        <property type="protein sequence ID" value="KXB01888"/>
        <property type="gene ID" value="AKJ44_01975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.287"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="9"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB01888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="512" mass="58725" checksum="1E59E771960CF944" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V635</accession>
    <name>A0A133V635_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_01925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000022">
        <property type="protein sequence ID" value="KXB01901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01901">
        <property type="protein sequence ID" value="KXB01901"/>
        <property type="gene ID" value="AKJ44_01925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB01901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="148" mass="17886" checksum="4A68B16FD4B14EFF" modified="2016-07-06" version="1">MKESGEREKEPWEIIQDENEELINEFSDYLHEVKGLSKRTVDIHVYNLRMLNYYVAGYNCERLEETTPLDVSFFMNDWYIRKVAANEETMHKMPVSLKKFFTFLSHEKGFDMPLEEIVEICSDRKRFKKRLREWMDPEAIDGWWTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V662</accession>
    <name>A0A133V662_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000021">
        <property type="protein sequence ID" value="KXB01923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01923">
        <property type="protein sequence ID" value="KXB01923"/>
        <property type="gene ID" value="AKJ44_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB01923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="121" mass="14092" checksum="908318BF13842B00" modified="2016-07-06" version="1">MRPRLHYLTKEEVQPEELGVLNYILEEEYNSKNSNGCQMRLQKKRKILEAINPPDSLLGHVEVNGENSETVLRTLKKLSKAIPRLTWILYGENKIFNGEIQIKAGKILSERKEVESRKIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V676</accession>
    <name>A0A133V676_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="5">HPPK</shortName>
            <ecNumber evidence="5">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="5">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="5">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mptE</name>
        <name evidence="7" type="ORF">AKJ44_01820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000020">
        <property type="protein sequence ID" value="KXB01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01940">
        <property type="protein sequence ID" value="KXB01940"/>
        <property type="gene ID" value="AKJ44_01820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.232"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="6">
        <location>
            <begin position="43"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB01940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="241" mass="26816" checksum="F28CD1F638CF221C" modified="2016-07-06" version="1">MRWILWQPWYDQIVEKLELDKEADYDTAKILEEILPESDVTGLAELVSDKECIILGAGPSLETDLKKIEQTNNLDKVLISADGATSAVINYRNPDVIVTDLDGDVSDQLDAWNQGSWLVIHGHGDNLEKVREITPQLDKRVIGTTQTKAFGKLHNFGGFTDGDRAAFMAHELGASKIYLAGMDLGSEIGKWSGKKDEEKKLIKLEICRELLTWLADELKANLINLTSEGEEIPGAPKKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V681</accession>
    <name>A0A133V681_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01955">
        <property type="protein sequence ID" value="KXB01955"/>
        <property type="gene ID" value="AKJ44_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="449" mass="50374" checksum="88B9EC6243055FB3" modified="2016-07-06" version="1">MSDYQDQIARLKEESKGFNKIIQKIDELKDSNARILNFSHHDLDGVTSAVILKRLLERYANVDVTTRMPFEFRLTPDELEEELEGEDYDLLIISDKGTFAYYDDFLDQVNEVMIIDHHLKDGKPAKCIVFNPSLEEEVRASTSLLSHMLAAHFGVADDYDDFIALLGCRGDYIIDPVKGRIPSFAEPFANRARQKFNQLFVKIDDKPTLFDSGAGEKTALLNQVGEVLHVSLLAHLYTPLSEEVNVDHRPNLVPQALSNFAEQEKKLDFDNLQDFLEIIPKNDQISKVFELFKKDWSLLEERAENAIFLEEVEGVGIYLVFSKEAPAMQGVTFPAILPYVASAKLGELTEKGDHEAALTMVFCPKDIGVHISLRGGGQILSCDAIGRKLVERVQERRPKAKNDIGGGGHELAAECVAAKSIETHVVMHELLNIIKDLTEDPTEFEAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V695</accession>
    <name>A0A133V695_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000019">
        <property type="protein sequence ID" value="KXB01961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01961">
        <property type="protein sequence ID" value="KXB01961"/>
        <property type="gene ID" value="AKJ44_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="163"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB01961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="463" mass="55051" checksum="B27427C4513252B6" modified="2016-07-06" version="1">MKYVPESEWPEWIRNQLGERKNYEVRESKGNYYLYRYENVWDKENKRPKKKTEYVGSLKRNGRSVFEHGHVAFLIDLLSRHDVIESLRKHFPDYWEELLVFSMNRVVRPFPLKRVGSWMEKTSLGEFFEIDPPSGKKLSKVLGEVGVDVKSQSEFMRELIRDDEMLLYDGSMIYSTSNYNKLLEVGYDKDELFLPKVNIALLFSKDRNMPIHLRIFFGSVHEIKTIKTVIREIKDRDILFIADKGFYKNELYDDLDEGNVKFVLPLPRDDGRIQYDEDLSEVFKYRDRIIKSTSYPAGSYHLYLYEDQDLKHTETKNYYKLKLDGKDVSFNESWAGKIALLSNQKLDPEEAYLIWKNRGKIEKAFDVLQNLLETDRPYISSEDVFRGYLFTSFISLAIYYIVLNFLQEHEVNNRVSVKDVLFEFSKIRIEDRGYLAFSEIPKKVRELAEELEAENIMHKIWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6C6</accession>
    <name>A0A133V6C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase DegT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01994">
        <property type="protein sequence ID" value="KXB01994"/>
        <property type="gene ID" value="AKJ44_01655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.191"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="371" mass="41239" checksum="096A1A4D72D83382" modified="2016-07-06" version="1">MGEDFIPIANVELSDDEIQAAVEVLKSGYLRQGPKTKEFEEKFAEKVGSEHAVAVSSGTAALHIAYLAMLDSGDEVLVPSFSHISTASMVSFANCKPIFCDLDPRTFTLNLESAEERLTEKTRAIVPVHLFGNACDVDEITDFADEHELRIIWDAAQAHGTKYKGKDVGSFDDLVCYSFYPTKNMTTGEGGMITTNDSKINEECRLLREHGQVKKYFHTTLGLNYRMTDVEAAIGIRQLEKLDDFVSERRGNAEQLTEKLSEIDGVTPPLVKEGIKHSYHQYAILLDLDELECTRDEFIESLNKKGIGTAVHYPRPLHKQPIFQELLGDSPLPTSEDISKRILSLPVYPGLGEGDLERIIEGVRAIVKTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6C8</accession>
    <name>A0A133V6C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000017">
        <property type="protein sequence ID" value="KXB01995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB01995">
        <property type="protein sequence ID" value="KXB01995"/>
        <property type="gene ID" value="AKJ44_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB01995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="74" mass="8748" checksum="E9FC0910D4F5120F" modified="2016-07-06" version="1">MTKTISLSDKAYKFLSELKESGESFSDVVSRLARRDRSILRHAGSWKGSEEELEEIEKHIYEIRRTTRLREVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6G4</accession>
    <name>A0A133V6G4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1616 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02040">
        <property type="protein sequence ID" value="KXB02040"/>
        <property type="gene ID" value="AKJ44_01485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.153"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014495">
        <property type="entry name" value="UCP018671"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018671">
        <property type="entry name" value="UCP018671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="282" mass="31591" checksum="1BE86E650667A929" modified="2016-07-06" version="1">MQIDETNRDLLALDALGGVLILTILLTPTFRALRVILGVPFVLFLPGYFLVSALFPGRDDLEGIERLALSLGLSLALVPLIGLMLNYTPFGIRLWPVTLSLFGFMLAMTWIAQFRRERIAPKERFSIDFSSHLPSWGEIGGEDKLLIVGSIIAIIGAGVGASYLASNRHGEEFTEFYVLGPGGMMENYPTDLEVGGTGTVILGVVNHEYQDENYHIILTLENEPLKEIGDIQLGHGENWEKRITFQALEDGENEKLEFLLYKDDSVEPYRRLHLWLNVRVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6J2</accession>
    <name>A0A133V6J2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000015">
        <property type="protein sequence ID" value="KXB02047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02047">
        <property type="protein sequence ID" value="KXB02047"/>
        <property type="gene ID" value="AKJ44_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="81" mass="8778" checksum="805CF6760D212313" modified="2016-07-06" version="1">MKGELEAISERLGEIDAELAADLLKVIYDLPETPEAAALLESMSLVRSVGAIRIFVGRDEFGYVVGMFANLTDARMTSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6L9</accession>
    <name>A0A133V6L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000014">
        <property type="protein sequence ID" value="KXB02072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02072">
        <property type="protein sequence ID" value="KXB02072"/>
        <property type="gene ID" value="AKJ44_01455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.146"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="104" mass="11513" checksum="D0E74A5AFC3D47D9" modified="2016-07-06" version="1">MEKSEKPNHRRIIITVEEIRGECPIYQVGDKIIIEDFYVKANESKDTCIHALSAMTTFLTAFSHGVSAQRLGLGKQDDVAYVQCPDPGPPCTGGGTVLFKLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6M6</accession>
    <name>A0A133V6M6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ44_01375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000013">
        <property type="protein sequence ID" value="KXB02091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02091">
        <property type="protein sequence ID" value="KXB02091"/>
        <property type="gene ID" value="AKJ44_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="171" mass="19817" checksum="18EEBC76A99E7F37" modified="2016-07-06" version="1">MGLSFLRMEVNKMLRGSVKELDRKIIIQLIRNADQPIVNIAKKVGASRQTVSKKLKKFRKSGMIESHMVRLNPEMFGLDTRAYVFLREVPQDEVRARNEKVINKFSQVYSFRRLFGRYSAILEVLTKDRGELTSIVKEIHGLEGVRETETFIVHSTVKDKPKDPFLNILEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6R3</accession>
    <name>A0A133V6R3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02121">
        <property type="protein sequence ID" value="KXB02121"/>
        <property type="gene ID" value="AKJ44_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="1">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="193" mass="22471" checksum="2B07F4B791492D58" modified="2016-07-06" version="1">MPKEEKTEEEIEEERIEAIREKMGRAAQLILFKHHRQPGAKSWELKRALGKKYPEIVKMLDQELQKIGLTIKEVSEGEDKPARYYATMAGHPRLSDRTFGWRIDDMAALVITLSYIQSKRGGAPEKEVKEILREKFPKWRVNQILNKFTKKGYISEDDEGILYIDWRTRAEIDQKELLGRLIGKEGELEDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6S1</accession>
    <name>A0A133V6S1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_01280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000011">
        <property type="protein sequence ID" value="KXB02144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02144">
        <property type="protein sequence ID" value="KXB02144"/>
        <property type="gene ID" value="AKJ44_01280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="113" mass="13010" checksum="F79684C0112BCFFC" modified="2016-07-06" version="1">MPVISARVNEEMKERIGRLQGRMGKSTSDCIREALNTYIDITDEGRDWLAPLSVEKSVKEERGQEKTNQGNKEGELEVIHVGTHEPLLFPERLGVIASRPWKSLQKELRKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6U5</accession>
    <name>A0A133V6U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000012">
        <property type="protein sequence ID" value="KXB02126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02126">
        <property type="protein sequence ID" value="KXB02126"/>
        <property type="gene ID" value="AKJ44_01350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="111" mass="12844" checksum="67F8BAE1C3E813B9" modified="2016-07-06" version="1">MQTTIQGKIFPSEHQGERPDELMRIQSSCMRYSYNRLCEGKSKSEIEADLKQKFSSINSRYSRGGYFRAEANYESALELVKSGELKSPEKVVFVGRKNLKKRERGEITNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6X6</accession>
    <name>A0A133V6X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02200">
        <property type="protein sequence ID" value="KXB02200"/>
        <property type="gene ID" value="AKJ44_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="89" mass="10429" checksum="7CD86749E387A77E" modified="2016-07-06" version="1">MGRTVPTFREEIEDEMDRWREFRKALRKDDREAFDEMMEACKRYSSAGSQAKASSPFQAMVLSILLGQEKRLSRLEEEIGEIRKLLKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y0</accession>
    <name>A0A133V6Y0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpE</name>
        <name evidence="8" type="ORF">AKJ44_01215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000010">
        <property type="protein sequence ID" value="KXB02173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02173">
        <property type="protein sequence ID" value="KXB02173"/>
        <property type="gene ID" value="AKJ44_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="PTHR45715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="208" mass="23251" checksum="5A251B18A67E9DCE" modified="2016-07-06" version="1">MEGSDKIIQQISDKAKEEREGILEEARKKAENLKSAAQKKTDAEAKKVIREGEMEAEREKRRILASARTKARQTKLEAKEKLIQEVFETAKSELAKLRDDNQEYQEILENLIVSGGIAAGGGSLEVLVLRKDKELLSDDRVKELSKQISKETSEETSLNVLAKLTNATGGAIVQKSDGSIRCNNTFEARLERMKDSLRTEIAGMLFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Y3</accession>
    <name>A0A133V6Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02209">
        <property type="protein sequence ID" value="KXB02209"/>
        <property type="gene ID" value="AKJ44_01140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="179" mass="19033" checksum="BDF0D4E9A0469C65" modified="2016-07-06" version="1">MKCQIGVIGSSEKEARGKQKAKSIGREIAKAGCHLLTGGCTGLPYAAIEGAKEEGGFTVGISPATDQEEHLKKYGYPIEGHDLMVYTGFGYKGRNVILVRSCDGVVATSGRMGTLNELTIAHAEGKVMGLLKGVSGAGEEFEKLAKKLGRPEGKIVTSENPKKLVQKVLQKLDEKTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V6Z0</accession>
    <name>A0A133V6Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_01145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02210">
        <property type="protein sequence ID" value="KXB02210"/>
        <property type="gene ID" value="AKJ44_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="126" mass="14814" checksum="9318FA8360DEE48B" modified="2016-07-06" version="1">MTVINLFRIGGSCYFKHYFGSRELFDEFRAYYDSLEYRFEVGEGELEDVIGKLRSYGFEVNLVEEDEISEYTVIVDKFKKHGDLLRNAVDVVELGDEKALVMKDKVAKEEALERGRKPDEEWLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V722</accession>
    <name>A0A133V722_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_01125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000009">
        <property type="protein sequence ID" value="KXB02207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02207">
        <property type="protein sequence ID" value="KXB02207"/>
        <property type="gene ID" value="AKJ44_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="859" mass="95196" checksum="A2F7EE26DBE7B53A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V755</accession>
    <name>A0A133V755_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02272">
        <property type="protein sequence ID" value="KXB02272"/>
        <property type="gene ID" value="AKJ44_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="82" mass="9178" checksum="BEC8C7598BE20057" modified="2016-07-06" version="1">MIRVFTKFLVPDNQANKVTLVDNQGGIYIGANGYSGDNYKPIRYSVEVSLSKWVGDTFESLGTFSAIADNPPRYTWIELEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V768</accession>
    <name>A0A133V768_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Digeranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">DGGGP synthase</shortName>
            <shortName evidence="9">DGGGPS</shortName>
            <ecNumber evidence="9">2.5.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Geranylgeranylglycerol-phosphate geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ44_00975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18109"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="EC" id="2.5.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="9"/>
    <dbReference type="EMBL" id="LHXY01000007">
        <property type="protein sequence ID" value="KXB02278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02278">
        <property type="protein sequence ID" value="KXB02278"/>
        <property type="gene ID" value="AKJ44_00975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01286">
        <property type="entry name" value="DGGGP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023547">
        <property type="entry name" value="DGGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="277" mass="29213" checksum="279E47C81FB8A85F" modified="2016-07-06" version="1">MKPRAVFKLLRPHNCFFAGIGVLIGAIIASGGIPHFTAGFAFAAAFFVSGAGYAVNDYADRKIDAVNNPKRPIPSGELTPSDALGIARILFVLGILSSAFINLPCLFLAGFNAALLAYYASDLKRRGLIGNITISYLVGSTFLFGALVIGSLTAAGILAAMAGLSTAGRELIKDVEDIRGDRKSDSKTFPIRYGKKKTVGLAIILTIGAIILSPLPYLLGIFGWPYLTIVGAAIGVFIIGMTIIARRQRKKDAHHASLAYKIAMGLGLIAFLVGAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7A7</accession>
    <name>A0A133V7A7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ44_00670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000005">
        <property type="protein sequence ID" value="KXB02338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02338">
        <property type="protein sequence ID" value="KXB02338"/>
        <property type="gene ID" value="AKJ44_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="349" mass="39489" checksum="F868A82EBF4DA0EE" modified="2016-07-06" version="1">MSESDSQTILTPQHHEDCVLRESIQFKNLVKTERGEVVSIRPCASEKGKIMAEIELPTRKDELFLDSQLLCRLLRAYKRRFTKMKCSSKLGVGRVMWKARRTYIYKHGKFDVRFALSQDDALKTMDSIGRLILGSIFCKKCGQPAIECALGQCEECVSNNLQSVTLDELSTPLFIKGFEALTEALEISRVTLIETSEIRPISPSQVSKFKSKIQEGVEFFLDSSLKTPEWTNVSASVSSVSLAFSIEDFHEKAVELTEALAKRPGGREEDIQSIRQFEKLALETFKILLKAFHNDDPDRLKLVKQKNSELSELLEKLDSNLSGNILGRIREMYEDASSVWSGLLKSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7B8</accession>
    <name>A0A133V7B8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="5" type="ORF">AKJ44_00805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000006">
        <property type="protein sequence ID" value="KXB02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02306">
        <property type="protein sequence ID" value="KXB02306"/>
        <property type="gene ID" value="AKJ44_00805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.551"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="4">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="240" mass="25864" checksum="A9F76964ED8A9BE0" modified="2016-07-06" version="1">MAFVGRGRGYDRAITVFSPDGKLFQVQYAQEAVKRGYTALGVKVNSGVVLAAERRSPSKLVEDGSVEKIFQVDDHIGAGASGLIADARVLIDRARIEAQVNRMRYDEPIPVETLSRSIGDIKQMYTQHGGVRPFGTRFLIGGVDTNGPQLYETDPSGVVAAYKAHAIGGGATGAIEVLESRYEEDASLDDAISLALDALKTVIEGKLGSDKVEMAIIPAETEEFEKLSKDKVDEYIKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7G0</accession>
    <name>A0A133V7G0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="8">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gatB</name>
        <name evidence="10" type="ORF">AKJ44_00595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="8"/>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02382">
        <property type="protein sequence ID" value="KXB02382"/>
        <property type="gene ID" value="AKJ44_00595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.370"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="9">
        <location>
            <begin position="305"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="454" mass="51930" checksum="B25992C37BB98F56" modified="2016-07-06" version="1">MKIGFEIHEQLMTDQKLYCDCPTNYRDAPPNTNVCPVCTGMPGAKPAPPNERAIRAVIEIALMLDCDIVIGDTIYIQRKHYDYPDLPSGYQRTSLPIGLNGELKGVGIREVHIEEDPGKYDPTLGTVDYNRSGIPLVEVVTDPDLKSPEEVRTFMRSLIRVLEYTGKVRPEPSTLRADTNISLEGGARVEIKNINSIKGAYRAIKYEVMRQKKLRERGEEVVRETRAYLESQMVTAPMRTKEIAEDYRYIPDPDIFPMVIEESLVERIREEMYEAPHLREQRIIKEYGIEPSVARVLISERGLVELFEKIAKEVDPEFASHWFKDILKKVLNYENLRVEEVEFTPTQLVKLLQMIDDDKITPEQGELVLREMVKTPTDPEKLVKKLGLEKLSEKALEKAVKKAIEENPEAVADYESGKEEALNFLAGKVMEITEGRANPRKVMELLRKHPSLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7I5</accession>
    <name>A0A133V7I5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">AKJ44_00600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02383">
        <property type="protein sequence ID" value="KXB02383"/>
        <property type="gene ID" value="AKJ44_00600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.371"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="454" mass="48644" checksum="D57F8F23D56DEBD2" modified="2016-07-06" version="1">MSTREKLEKIRSGELSAVENVRQTLERIEELNDDVNAFIEPNPDAVTEAEAVDKKIEEGEEVGKLAGLAIAVKTNINTKGLRATCASKTLENYVATYDAEAIKRVRSEDGIIIGVNNMDEFACGSSGETSAFGLTKNPAAKGRVPGGSSSGGGASVAAGMCDIALGTDTGGSIRNPASHCGVVGLKPTYGLVPRQGLIDLAMSFDQIGPLSPDVFSAALMMEVIAGKNPNECIMFDVDSVSYLDQLDGSLEGMKIGVSPKFRELTQPEIMKVIDQTVDELSGLGAEVVEVDLPNLEKAMPTYYLIVSVEFFSGTRKFDGRKYGQKIEEVCGDEVLRRILRGKHISRKEFKGKFYQRALQVRTLIKRELDEALKEADVLVGPTVPKLPHKIGTELTPGEMYAYDYFTVPTNLGGLCGGVIKAGEVKGIPVGLQVQGASLDESSVLKVMRALEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7I6</accession>
    <name>A0A133V7I6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="6" type="ORF">AKJ44_00560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02376">
        <property type="protein sequence ID" value="KXB02376"/>
        <property type="gene ID" value="AKJ44_00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_S19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB02376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="146" mass="16631" checksum="CABC3E63A186D278" modified="2016-07-06" version="1">MGIKDVSPSDLTRQLSEELKKRDEIQPPEWSHFAKTGAHKERPPDQPDWWYLRSASILRRVYEKGPIGVSRLSTYYGGKKTHGSSPKKFQKGSRKITRTILQQLEDAGLIIKTKREGRKTSSDGLSLLTQISMQIQEESETGMEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7L1</accession>
    <name>A0A133V7L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02423">
        <property type="protein sequence ID" value="KXB02423"/>
        <property type="gene ID" value="AKJ44_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="318" mass="35810" checksum="24738AB829614209" modified="2016-07-06" version="1">MTMRTTGIPNGHYIYRDNRPRRNQGGCDNEPQTSPSKALGLPRGGTPISDYVTVNKDGTITQPGIDSRMERRLLTAIGRLGPISEEGLIEVLTPRDLTWEISGWSQLPGDYYMARDYEDVQAGHELVFTDKYHVNKEENPIFDMDDFKEALETLSENNFIERKSKAWRTTEEGDVLLETILEAPCERKITVPMGGPVKVLAADSEEGKNFIRRQLDANQKVIAEGNEWTDFLCTADLLSITSEEVLGAVLDQEERQWVIPLSVRDFTPRGTLTLEGGCIGSRVRIMGQRPGRASTTLKIEDRTSRENHLISVFPDVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7M0</accession>
    <name>A0A133V7M0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 9">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 6 9">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pgk</name>
        <name evidence="10" type="ORF">AKJ44_00615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="LHXY01000004">
        <property type="protein sequence ID" value="KXB02397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02397">
        <property type="protein sequence ID" value="KXB02397"/>
        <property type="gene ID" value="AKJ44_00615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.374"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB02397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="404" mass="43999" checksum="397D7766125C747A" modified="2016-07-06" version="1">MTLDDVKVKDKTALVRVDINSPIDPETGEILDDNRIRMCSNTLKELSEKEAKTAVIAHQGRPDSEDFTTLEKHAEKMSQVLDIQVDYIDDIFGSDAQKAISNLETGEILLLENVRFYPGELKNKPADEQAKTELVRKLSPLADIYVNDAFAAAHRSQPSLVGFAVALPAVAGRLMERELRELGRARDPEHPCVYVLGGAKVDDSLSLTNHVLEKEIADYVLTGGLVGNLLLAAGDHDLGESNIQVISEKGYENEIKRGRKILSTHGEKVKVPQDVRVEKEEGEAELISVSQLPTEMPIYDIGDKTISKYSELIQNSKTVVTNGPVGVFEKPAFAKGTNEILKAMSKSNAFTVIGGGHMVAAARELGVEDKLDHVSTGGGSCLSFLSGEKLPVVQALEQSAEQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7N0</accession>
    <name>A0A133V7N0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000003">
        <property type="protein sequence ID" value="KXB02425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02425">
        <property type="protein sequence ID" value="KXB02425"/>
        <property type="gene ID" value="AKJ44_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="87" mass="9295" checksum="6586A86963B3470C" modified="2016-07-06" version="1">MLLSSPPAKQSGLDPDSGSTPESAPTLDPPITATPPSSDQERVIVTVSQSLRYGSLRSPVCSREKIDEINHSPPQEKSRTGLVEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7P1</accession>
    <name>A0A133V7P1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">AKJ44_00230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02453">
        <property type="protein sequence ID" value="KXB02453"/>
        <property type="gene ID" value="AKJ44_00230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB02453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="138" mass="15398" checksum="71CF8A123C249500" modified="2016-07-06" version="1">MYCLDTNAVIDYLDGADAIGAFIKKHERELIFSSTVAIHEVFVGSIRTRGKRGLRDIREDLDWLIPLPLTIEGAAEAALIDAELHKAGEPIGPLDTLIAGIAREKSATLVTRDPHFERISNLDVLRYDERESGEKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q0</accession>
    <name>A0A133V7Q0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02463">
        <property type="protein sequence ID" value="KXB02463"/>
        <property type="gene ID" value="AKJ44_00290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="76" mass="8865" checksum="6E1676A3E5B90AB2" modified="2016-07-06" version="1">MRETVTLDSRGRLLLPAEIRRELGTQRFILKKKGGKLELEPLPAPESVKSKHKKLIKVSLEELEETQEKFIREGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Q2</accession>
    <name>A0A133V7Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02452">
        <property type="protein sequence ID" value="KXB02452"/>
        <property type="gene ID" value="AKJ44_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="77" mass="8947" checksum="FDE9C3103592E4DC" modified="2016-07-06" version="1">MTTTTISLSEEAYKNLKALKGENESFSDVVMRLSGGEKDKMKGFGAWSGTDLREKTRSYREEFNRDIRERRDVLSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7S3</accession>
    <name>A0A133V7S3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02476">
        <property type="protein sequence ID" value="KXB02476"/>
        <property type="gene ID" value="AKJ44_00375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.77"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="83" mass="9653" checksum="C35B31D295946A30" modified="2016-07-06" version="1">MLSDELQEEIERWTRKLDEKLPRLVARDEPGKEILENARAYRGDSQHFLQDDDLIKSFESLIWAWALIETGENLGHLKPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7S4</accession>
    <name>A0A133V7S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ44_00370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02475">
        <property type="protein sequence ID" value="KXB02475"/>
        <property type="gene ID" value="AKJ44_00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB02475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="213" mass="23279" checksum="E44054C4C10D4105" modified="2016-07-06" version="1">MKVGILALGSHHERHGAALPLDTDAQIAEHIAREAAKRASAEFFGVLKSSYELPEINTGEHQSLEELEGEVREAVQEAKDEGFDAIVLVNAHGGNEKLSERLNAIEENLGMKIIFNTIICKLEGPHAGTGELSIGSVIGITDESKLEEHANVGKHPEVGFAGLQEVREKYLWAEKHAREIEEFGVKIDKFLGEKILQCAIVDVINDVRELGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7T0</accession>
    <name>A0A133V7T0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02485">
        <property type="protein sequence ID" value="KXB02485"/>
        <property type="gene ID" value="AKJ44_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="180" mass="20557" checksum="1D3AE8232D0FA8DC" modified="2016-07-06" version="1">MERAVLDTSAILTLFTALKLKGSKLEELEIVVPSCVKGELENFTKHSDYLGKRASFALNKITVVDNPLSEDELKDERGRLGLKEERITDCDIQSLHLSFKLDLPFFTDDFSAHRHFTIHYPSKNLYYGIILALDVLGFNTSTEANDFIFNELLPKRFPQISDRTKSNIKTAIDEYLSPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7T4</accession>
    <name>A0A133V7T4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ44_00415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02482">
        <property type="protein sequence ID" value="KXB02482"/>
        <property type="gene ID" value="AKJ44_00415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="95" mass="11522" checksum="E5E53019001CB44F" modified="2016-07-06" version="1">MGREEKTEVDEEEKKAKGEYGRPSEEELAEKQKKDLKRLEEIIKEKKEGKPSETKKRKLTPLMKQYEEETGKNARRKDGELTKAYKKWRRKRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7U9</accession>
    <name>A0A133V7U9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ORF">AKJ44_00380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="LHXY01000002">
        <property type="protein sequence ID" value="KXB02477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02477">
        <property type="protein sequence ID" value="KXB02477"/>
        <property type="gene ID" value="AKJ44_00380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.78"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB02477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="261" mass="28435" checksum="503B610A93C0B718" modified="2016-07-06" version="1">MLIFIGLGLQEKGLTLEGLEEAQNADRTYAELYTSLIPDLDLDALSEKIGKKIKVIEREDVEEHPDEILETAKSEKVAFLVPGDPMVATTHVDLRLRAEKAGIETRIIHGASIEIAAPGLAGLQSYKFGRSATIPLPEKPSKTPYEVLVQNQEDGLHTLLLLDIEAPEERYLTANEAMEIMLDLESKGGKNVFTQETLVAVIARAGSEKPTVKAGKVGDLIDFDFGSPPHVLIVPGKLHFLEAEALQVFGGAPEEVEGYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V7Y1</accession>
    <name>A0A133V7Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ44_00110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261F17</name>
        <dbReference type="NCBI Taxonomy" id="1698274"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261F17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXY01000001">
        <property type="protein sequence ID" value="KXB02543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02543">
        <property type="protein sequence ID" value="KXB02543"/>
        <property type="gene ID" value="AKJ44_00110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698274.3.peg.24"/>
    <dbReference type="Proteomes" id="UP000070035">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="50"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070035"/>
        </source>
    </evidence>
    <sequence length="308" mass="33679" checksum="8336504044D73EFC" modified="2016-07-06" version="1">MCGIIGIMFKKEGNIGGYLLQTMKSLQHRGTDSAGVAVYANNLGEENAFVLVAEVADTPGAIGKLGNAIGSAGGDIRNISFRASPHGETGVNTYTIRVPNEEALQSVVKNINATDVGKVYSYGKSVRVIKDLGKVEKLEVGYHISEMNGTHGIGHVRFSTESRVDRKHAHPFHTDTFPDIAVVHNGQITNYHKIRGKLERKGFSFATENDSEVIVYFITDQLQQEKTLGEALEESVKRLDGPFSYIVSTPNAIGIARDKLGLRPMTLAQDDKGYYAASEEVALLDICDSSDLNYLKPGEVQVFEREEN</sequence>
</entry>
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</uniprot>