pathwayId	pathwayName	isDisease
R-HSA-9613829	Chaperone Mediated Autophagy	false
R-HSA-1632852	Macroautophagy	false
R-HSA-5205647	Mitophagy	false
R-HSA-9613354	Lipophagy	false
R-HSA-9664873	Pexophagy	false
R-HSA-9646399	Aggrephagy	false
R-HSA-9615710	Late endosomal microautophagy	false
R-HSA-69620	Cell Cycle Checkpoints	false
R-HSA-69242	S Phase	false
R-HSA-69239	Synthesis of DNA	false
R-HSA-68962	Activation of the pre-replicative complex	false
R-HSA-69002	DNA Replication Pre-Initiation	false
R-HSA-453279	Mitotic G1 phase and G1/S transition	false
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	false
R-HSA-170834	Signaling by TGF-beta Receptor Complex	false
R-HSA-877300	Interferon gamma signaling	false
R-HSA-9705683	SARS-CoV-2-host interactions	true
R-HSA-157858	Gap junction trafficking and regulation	false
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	false
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	false
R-HSA-9833110	RSV-host interactions	true
R-HSA-168898	Toll-like Receptor Cascades	false
R-HSA-1679131	Trafficking and processing of endosomal TLR	false
R-HSA-975871	MyD88 cascade initiated on plasma membrane	false
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation  	false
R-HSA-450294	MAP kinase activation	false
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	false
R-HSA-112409	RAF-independent MAPK1/3 activation	false
R-HSA-166166	MyD88-independent TLR4 cascade 	false
R-HSA-5213460	RIPK1-mediated regulated necrosis	false
R-HSA-75153	Apoptotic execution phase	false
R-HSA-169911	Regulation of Apoptosis	false
R-HSA-109606	Intrinsic Pathway for Apoptosis	false
R-HSA-1257604	PIP3 activates AKT signaling	false
R-HSA-6807070	PTEN Regulation	false
R-HSA-1592389	Activation of Matrix Metalloproteinases	false
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	false
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	false
R-HSA-5625740	RHO GTPases activate PKNs	false
R-HSA-5625900	RHO GTPases activate CIT	false
R-HSA-5627117	RHO GTPases Activate ROCKs	false
R-HSA-5627123	RHO GTPases activate PAKs	false
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	false
R-HSA-373755	Semaphorin interactions	false
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	false
R-HSA-165159	MTOR signalling	false
R-HSA-1489509	DAG and IP3 signaling	false
R-HSA-9648002	RAS processing	false
R-HSA-5673001	RAF/MAP kinase cascade	false
R-HSA-1227986	Signaling by ERBB2	false
R-HSA-5663220	RHO GTPases Activate Formins	false
R-HSA-216083	Integrin cell surface interactions	false
R-HSA-3858494	Beta-catenin independent WNT signaling	false
R-HSA-9831926	Nephron development	false
R-HSA-201681	TCF dependent signaling in response to WNT	false
R-HSA-195253	Degradation of beta-catenin by the destruction complex	false
R-HSA-3238698	WNT ligand biogenesis and trafficking	false
R-HSA-9830674	Formation of the ureteric bud	false
R-HSA-446728	Cell junction organization	false
R-HSA-9759475	Regulation of CDH11 Expression and Function	false
R-HSA-9764302	Regulation of CDH19 Expression and Function	false
R-HSA-9764265	Regulation of CDH1 Expression and Function	false
R-HSA-5654736	Signaling by FGFR1	false
R-HSA-917937	Iron uptake and transport	false
R-HSA-8978934	Metabolism of cofactors	false
R-HSA-202131	Metabolism of nitric oxide: NOS3 activation and regulation	false
R-HSA-448706	Interleukin-1 processing	false
R-HSA-5620971	Pyroptosis	false
R-HSA-9686114	Non-canonical inflammasome activation	false
R-HSA-9956593	Microbial factors inhibit CASP4 activity	true
R-HSA-446652	Interleukin-1 family signaling	false
R-HSA-975155	MyD88 dependent cascade initiated on endosome	false
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	false
R-HSA-5686938	Regulation of TLR by endogenous ligand	false
R-HSA-5654743	Signaling by FGFR4	false
R-HSA-202733	Cell surface interactions at the vascular wall	false
R-HSA-211000	Gene Silencing by RNA	false
R-HSA-1234174	Cellular response to hypoxia	false
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	false
R-HSA-5693606	DNA Double Strand Break Response	false
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	false
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	false
R-HSA-2559580	Oxidative Stress Induced Senescence	false
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	false
R-HSA-2559585	Oncogene Induced Senescence	false
R-HSA-9753510	Signaling by RAS GAP mutants	true
R-HSA-9753512	Signaling by RAS GTPase mutants	true
R-HSA-9649948	Signaling downstream of RAS mutants	true
R-HSA-9652817	Signaling by MAPK mutants	true
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	true
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	true
R-HSA-9652169	Signaling by MAP2K mutants	true
R-HSA-9726840	SHOC2 M1731 mutant abolishes MRAS complex function	true
R-HSA-9726842	Gain-of-function MRAS complexes activate RAF signaling	true
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	true
R-HSA-9656223	Signaling by RAF1 mutants	true
R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	true
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	true
R-HSA-2555396	Mitotic Metaphase and Anaphase	false
R-HSA-68877	Mitotic Prometaphase	false
R-HSA-68875	Mitotic Prophase	false
R-HSA-453274	Mitotic G2-G2/M phases	false
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	false
R-HSA-3299685	Detoxification of Reactive Oxygen Species	false
R-HSA-8956319	Nucleotide catabolism	false
R-HSA-71336	Pentose phosphate pathway	false
R-HSA-70326	Glucose metabolism	false
R-HSA-70268	Pyruvate metabolism	false
R-HSA-9857492	Protein lipoylation	false
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	false
R-HSA-880009	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	false
R-HSA-71403	Citric acid cycle (TCA cycle)	false
R-HSA-9854311	Maturation of TCA enzymes and regulation of TCA cycle	false
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	false
R-HSA-8963691	Phenylalanine and tyrosine metabolism	false
R-HSA-70895	Branched-chain amino acid catabolism	false
R-HSA-71064	Lysine catabolism	false
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	false
R-HSA-9707616	Heme signaling	false
R-HSA-189445	Metabolism of porphyrins	false
R-HSA-8956321	Nucleotide salvage	false
R-HSA-71737	Pyrophosphate hydrolysis	false
R-HSA-8956320	Nucleotide biosynthesis	false
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	false
R-HSA-389661	Glyoxylate metabolism and glycine degradation	false
R-HSA-390918	Peroxisomal lipid metabolism	false
R-HSA-9856872	Malate-aspartate shuttle	false
R-HSA-977347	Serine metabolism	false
R-HSA-9937383	Mitochondrial ribosome-associated quality control	false
R-HSA-5368287	Mitochondrial translation	false
R-HSA-9865881	Complex III assembly	false
R-HSA-611105	Respiratory electron transport	false
R-HSA-9864848	Complex IV assembly	false
R-HSA-5628897	TP53 Regulates Metabolic Genes	false
R-HSA-5661270	Formation of xylulose-5-phosphate	false
R-HSA-8853383	Lysosomal oligosaccharide catabolism	false
R-HSA-446203	Asparagine N-linked glycosylation	false
R-HSA-4085001	Sialic acid metabolism	false
R-HSA-428157	Sphingolipid metabolism	false
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	false
R-HSA-418597	G alpha (z) signalling events	false
R-HSA-397795	G-protein beta:gamma signalling	false
R-HSA-418594	G alpha (i) signalling events	false
R-HSA-111885	Opioid Signalling	false
R-HSA-416482	G alpha (12/13) signalling events	false
R-HSA-416476	G alpha (q) signalling events	false
R-HSA-114508	Effects of PIP2 hydrolysis	false
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	false
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	false
R-HSA-449836	Other interleukin signaling	false
R-HSA-109704	PI3K Cascade	false
R-HSA-74752	Signaling by Insulin receptor	false
R-HSA-5654741	Signaling by FGFR3	false
R-HSA-202403	TCR signaling	false
R-HSA-389356	Co-stimulation by CD28	false
R-HSA-177929	Signaling by EGFR	false
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	false
R-HSA-5654738	Signaling by FGFR2	false
R-HSA-8985947	Interleukin-9 signaling	false
R-HSA-8983432	Interleukin-15 signaling	false
R-HSA-351202	Metabolism of polyamines	false
R-HSA-70688	Proline catabolism	false
R-HSA-209776	Metabolism of amine-derived hormones	false
R-HSA-5662702	Melanin biosynthesis	false
R-HSA-6799198	Complex I biogenesis	false
R-HSA-9033658	Blood group systems biosynthesis	false
R-HSA-8982491	Glycogen metabolism	false
R-HSA-5653890	Lactose synthesis	false
R-HSA-70370	Galactose catabolism	false
R-HSA-191273	Cholesterol biosynthesis	false
R-HSA-196791	Vitamin D (calciferol) metabolism	false
R-HSA-5652084	Fructose metabolism	false
R-HSA-1638074	Keratan sulfate/keratin metabolism	false
R-HSA-174362	Transport and metabolism of PAPS	false
R-HSA-2022928	HS-GAG biosynthesis	false
R-HSA-1971475	Glycosaminoglycan-protein linkage region biosynthesis	false
R-HSA-2022923	DS-GAG biosynthesis	false
R-HSA-2022870	CS-GAG biosynthesis	false
R-HSA-2024101	CS/DS degradation	false
R-HSA-2024096	HS-GAG degradation	false
R-HSA-2142845	Hyaluronan metabolism	false
R-HSA-9634597	GPER1 signaling	false
R-HSA-418555	G alpha (s) signalling events	false
R-HSA-9845576	Glycosphingolipid transport	false
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	false
R-HSA-6806003	Regulation of TP53 Expression and Degradation	false
R-HSA-429914	Deadenylation-dependent mRNA decay	false
R-HSA-5696398	Nucleotide Excision Repair	false
R-HSA-6783310	Fanconi Anemia Pathway	false
R-HSA-5358508	Mismatch Repair	false
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	false
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA 	false
R-HSA-166658	Complement cascade	false
R-HSA-6803157	Antimicrobial peptides	false
R-HSA-1461973	Defensins	false
R-HSA-8941413	Events associated with phagocytolytic activity of PMN cells	false
R-HSA-1222556	ROS and RNS production in phagocytes	false
R-HSA-1222499	Latent infection - Other responses of Mtb to phagocytosis	true
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	false
R-HSA-194138	Signaling by VEGF	false
R-HSA-9833482	PKR-mediated signaling	false
R-HSA-1169408	ISG15 antiviral mechanism	false
R-HSA-909733	Interferon alpha/beta signaling	false
R-HSA-4755510	SUMOylation of immune response proteins	false
R-HSA-72613	Eukaryotic Translation Initiation	false
R-HSA-5626467	RHO GTPases activate IQGAPs	false
R-HSA-6804760	Regulation of TP53 Activity through Methylation	false
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	false
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	false
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	false
R-HSA-75157	FasL/ CD95L signaling	false
R-HSA-140534	Caspase activation via Death Receptors in the presence of ligand	false
R-HSA-75893	TNF signaling	false
R-HSA-418889	Caspase activation via Dependence Receptors in the absence of ligand	false
R-HSA-75158	TRAIL  signaling	false
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	false
R-HSA-9031628	NGF-stimulated transcription	false
R-HSA-167060	NGF processing	false
R-HSA-193704	p75 NTR receptor-mediated signalling	false
R-HSA-187037	Signaling by NTRK1 (TRKA)	false
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	false
R-HSA-5621481	C-type lectin receptors (CLRs)	false
R-HSA-6798695	Neutrophil degranulation	false
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	false
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	false
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	false
R-HSA-888590	GABA synthesis, release, reuptake and degradation	false
R-HSA-112310	Neurotransmitter release cycle	false
R-HSA-112308	Presynaptic depolarization and calcium channel opening	false
R-HSA-112313	Neurotransmitter uptake and metabolism In glial cells	false
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	false
R-HSA-181431	Acetylcholine binding and downstream events	false
R-HSA-451326	Activation of kainate receptors upon glutamate binding	false
R-HSA-977443	GABA receptor activation	false
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	false
R-HSA-9860276	SLC15A4:TASL-dependent IRF5 activation	false
R-HSA-983169	Class I MHC mediated antigen processing & presentation	false
R-HSA-9645460	Alpha-protein kinase 1 signaling pathway	false
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	false
R-HSA-2172127	DAP12 interactions	false
R-HSA-6783589	Interleukin-6 family signaling	false
R-HSA-68884	Mitotic Telophase/Cytokinesis	false
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	false
R-HSA-8964539	Glutamate and glutamine metabolism	false
R-HSA-166187	Mitochondrial Uncoupling	false
R-HSA-163210	Formation of ATP by chemiosmotic coupling	false
R-HSA-5694530	Cargo concentration in the ER	false
R-HSA-204005	COPII-mediated vesicle transport	false
R-HSA-6807878	COPI-mediated anterograde transport	false
R-HSA-196807	Nicotinate metabolism	false
R-HSA-71240	Tryptophan catabolism	false
R-HSA-71262	Carnitine synthesis	false
R-HSA-8849175	Threonine catabolism	false
R-HSA-71288	Creatine metabolism	false
R-HSA-8964540	Alanine metabolism	false
R-HSA-70921	Histidine catabolism	false
R-HSA-1614635	Sulfur amino acid metabolism	false
R-HSA-70635	Urea cycle	false
R-HSA-8963693	Aspartate and asparagine metabolism	false
R-HSA-2408522	Selenoamino acid metabolism	false
R-HSA-6798163	Choline catabolism	false
R-HSA-1268020	Mitochondrial protein import	false
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	false
R-HSA-8848021	Signaling by PTK6	false
R-HSA-5625970	RHO GTPases activate KTN1	false
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	false
R-HSA-8853884	Transcriptional Regulation by VENTX	false
R-HSA-9009391	Extra-nuclear estrogen signaling	false
R-HSA-389948	Co-inhibition by PD-1	false
R-HSA-9909620	Regulation of PD-L1(CD274) translation	false
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	false
R-HSA-9909615	Regulation of PD-L1(CD274) Post-translational modification	false
R-HSA-389513	Co-inhibition by CTLA4	false
R-HSA-9927354	Co-stimulation by ICOS	false
R-HSA-9927353	Co-inhibition by BTLA	false
R-HSA-9034015	Signaling by NTRK3 (TRKC)	false
R-HSA-388844	Receptor-type tyrosine-protein phosphatases	false
R-HSA-8849932	Synaptic adhesion-like molecules	false
R-HSA-6794361	Neurexins and neuroligins	false
R-HSA-9006115	Signaling by NTRK2 (TRKB)	false
R-HSA-375165	NCAM signaling for neurite out-growth	false
R-HSA-451927	Interleukin-2 family signaling	false
R-HSA-977225	Amyloid fiber formation	false
R-HSA-9609646	HCMV Infection	true
R-HSA-168255	Influenza Infection	true
R-HSA-162909	Host Interactions of HIV factors	true
R-HSA-73857	RNA Polymerase II Transcription	false
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	false
R-HSA-212436	Generic Transcription Pathway	false
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	false
R-HSA-8878159	Transcriptional regulation by RUNX3	false
R-HSA-1980143	Signaling by NOTCH1	false
R-HSA-1912422	Pre-NOTCH Expression and Processing	false
R-HSA-9013694	Signaling by NOTCH4	false
R-HSA-9012852	Signaling by NOTCH3	false
R-HSA-1980145	Signaling by NOTCH2	false
R-HSA-8986944	Transcriptional Regulation by MECP2	false
R-HSA-9634815	Transcriptional Regulation by NPAS4	false
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	false
R-HSA-8878166	Transcriptional regulation by RUNX2	false
R-HSA-8939902	Regulation of RUNX2 expression and activity	false
R-HSA-5610787	Hedgehog 'off' state	false
R-HSA-201451	Signaling by BMP	false
R-HSA-5632684	Hedgehog 'on' state	false
R-HSA-8878171	Transcriptional regulation by RUNX1	false
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	false
R-HSA-8934593	Regulation of RUNX1 Expression and Activity	false
R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	false
R-HSA-2028269	Signaling by Hippo	false
R-HSA-9614085	FOXO-mediated transcription	false
R-HSA-9614657	FOXO-mediated transcription of cell death genes	false
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	false
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	false
R-HSA-8953750	Transcriptional Regulation by E2F6	false
R-HSA-186797	Signaling by PDGF	false
R-HSA-1433557	Signaling by SCF-KIT	false
R-HSA-1236394	Signaling by ERBB4	false
R-HSA-1170546	Prolactin receptor signaling	false
R-HSA-6806834	Signaling by MET	false
R-HSA-8983711	OAS antiviral response	false
R-HSA-194441	Metabolism of non-coding RNA	false
R-HSA-448424	Interleukin-17 signaling	false
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	false
R-HSA-9772573	Late SARS-CoV-2 Infection Events	true
R-HSA-9772572	Early SARS-CoV-2 Infection Events	true
R-HSA-9678108	SARS-CoV-1 Infection	true
R-HSA-9692914	SARS-CoV-1-host interactions	true
R-HSA-156842	Eukaryotic Translation Elongation	false
R-HSA-1221632	Meiotic synapsis	false
R-HSA-912446	Meiotic recombination	false
R-HSA-453276	Regulation of mitotic cell cycle	false
R-HSA-774815	Nucleosome assembly	false
R-HSA-157579	Telomere Maintenance	false
R-HSA-373753	Nephrin family interactions	false
R-HSA-391160	Signal regulatory protein family interactions	false
R-HSA-9856532	Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	false
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	false
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	false
R-HSA-9840373	Cellular response to mitochondrial stress	false
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	false
R-HSA-3371556	Cellular response to heat stress	false
R-HSA-9755511	KEAP1-NFE2L2 pathway	false
R-HSA-9818032	NFE2L2 regulating MDR associated enzymes	false
R-HSA-9818035	NFE2L2 regulating ER-stress associated genes	false
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	false
R-HSA-9818749	Regulation of NFE2L2 gene expression	false
R-HSA-9818028	NFE2L2 regulates pentose phosphate pathway genes	false
R-HSA-9818030	NFE2L2 regulating tumorigenic genes	false
R-HSA-9818025	NFE2L2 regulating TCA cycle genes	false
R-HSA-9818027	NFE2L2 regulating anti-oxidant/detoxification enzymes	false
R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins	false
R-HSA-432047	Passive transport by Aquaporins	false
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	false
R-HSA-8949215	Mitochondrial calcium ion transport	false
R-HSA-8949664	Processing of SMDT1	false
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	false
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	false
R-HSA-382556	ABC-family proteins mediated transport	false
R-HSA-9959399	SLC-mediated transport of oligopeptides	false
R-HSA-9958790	SLC-mediated transport of inorganic anions	false
R-HSA-442660	SLC-mediated transport of neurotransmitters	false
R-HSA-189200	Cellular hexose transport	false
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	false
R-HSA-425410	Metal ion SLC transporters	false
R-HSA-9955298	SLC-mediated transport of organic anions	false
R-HSA-9958863	SLC-mediated transport of amino acids	false
R-HSA-549127	SLC-mediated transport of organic cations	false
R-HSA-429593	Inositol transporters	false
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	false
R-HSA-5223345	Miscellaneous transport and binding events	false
R-HSA-8981607	Intracellular oxygen transport	false
R-HSA-983712	Ion channel transport	false
R-HSA-156580	Phase II - Conjugation of compounds	false
R-HSA-9707564	Cytoprotection by HMOX1	false
R-HSA-9818026	NFE2L2 regulating inflammation associated genes	false
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	false
R-HSA-381119	Unfolded Protein Response (UPR)	false
R-HSA-380994	ATF4 activates genes in response to endoplasmic reticulum  stress	false
R-HSA-381038	XBP1(S) activates chaperone genes	false
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	false
R-HSA-9648895	Response of EIF2AK1 (HRI) to heme deficiency	false
R-HSA-9639288	Amino acids regulate mTORC1	false
R-HSA-5661231	Metallothioneins bind metals	false
R-HSA-5660489	MTF1 activates gene expression	false
R-HSA-3247509	Chromatin modifying enzymes	false
R-HSA-9932451	SWI/SNF chromatin remodelers	false
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	false
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	false
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	false
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	false
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	false
R-HSA-9931530	Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	false
R-HSA-9932298	Degradation of CRY and PER proteins	false
R-HSA-9931529	Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	false
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	false
R-HSA-9942503	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	false
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	false
R-HSA-5682910	LGI-ADAM interactions	false
R-HSA-9793380	Formation of paraxial mesoderm	false
R-HSA-9824272	Somitogenesis	false
R-HSA-9796292	Formation of axial mesoderm	false
R-HSA-9761174	Formation of intermediate mesoderm	false
R-HSA-9758919	Epithelial-Mesenchymal Transition (EMT) during gastrulation	false
R-HSA-9834899	Specification of the neural plate border	false
R-HSA-9823730	Formation of definitive endoderm	false
R-HSA-9754189	Germ layer formation at gastrulation	false
R-HSA-9832991	Formation of the posterior neural plate	false
R-HSA-9758920	Formation of lateral plate mesoderm	false
R-HSA-9823739	Formation of the anterior neural plate	false
R-HSA-525793	Myogenesis	false
R-HSA-1181150	Signaling by NODAL	false
R-HSA-9616222	Transcriptional regulation of granulopoiesis	false
R-HSA-9820865	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	false
R-HSA-9819196	Zygotic genome activation (ZGA)	false
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	false
R-HSA-9821993	Replacement of protamines by nucleosomes in the male pronucleus	false
R-HSA-9821002	Chromatin modifications during the maternal to zygotic transition (MZT)	false
R-HSA-9830364	Formation of the nephric duct	false
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	false
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	false
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	false
R-HSA-9690406	Transcriptional regulation of testis differentiation	false
R-HSA-376176	Signaling by ROBO receptors	false
R-HSA-927802	Nonsense-Mediated Decay (NMD)	false
R-HSA-373760	L1CAM interactions	false
R-HSA-2682334	EPH-Ephrin signaling	false
R-HSA-8853659	RET signaling	false
R-HSA-373752	Netrin-1 signaling	false
R-HSA-8866376	Reelin signalling pathway	false
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	false
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	false
R-HSA-6805567	Keratinization	false
R-HSA-9733709	Cardiogenesis	false
R-HSA-186712	Regulation of beta-cell development	false
R-HSA-9856651	MITF-M-dependent gene expression	false
R-HSA-9856649	Transcriptional and post-translational regulation of MITF-M expression and activity	false
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	false
R-HSA-9937080	Developmental Lineage of Multipotent Pancreatic Progenitor Cells	false
R-HSA-9925561	Developmental Lineage of Pancreatic Acinar Cells	false
R-HSA-9927426	Developmental Lineage of Mammary Gland Alveolar Cells	false
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	false
R-HSA-9938206	Developmental Lineage of Mammary Stem Cells	false
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells	false
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	false
R-HSA-8935690	Digestion	false
R-HSA-8963676	Intestinal absorption	false
R-HSA-9845622	Defective VWF binding to collagen type I 	true
R-HSA-75892	Platelet Adhesion to exposed collagen	false
R-HSA-9845620	Enhanced binding of GP1BA variant to VWF multimer:collagen 	true
R-HSA-9845621	Defective VWF cleavage by ADAMTS13 variant	true
R-HSA-9845619	Enhanced cleavage of VWF variant by ADAMTS13	true
R-HSA-9846298	Defective binding of VWF variant to GPIb:IX:V	true
R-HSA-9672387	Defective F8 accelerates dissociation of the A2 domain	true
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	false
R-HSA-9674519	Defective F8 sulfation at Y1699	true
R-HSA-163841	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	false
R-HSA-6806664	Metabolism of vitamin K	false
R-HSA-9672391	Defective F8 cleavage by thrombin	true
R-HSA-9672395	Defective F8 binding to the cell membrane	true
R-HSA-9672393	Defective F8 binding to von Willebrand factor	true
R-HSA-9672397	Defective F8 secretion	true
R-HSA-9672396	Defective cofactor function of FVIIIa variant	true
R-HSA-9673218	Defective F9 secretion	true
R-HSA-9673202	Defective F9 variant does not activate FX	true
R-HSA-9673221	Defective F9 activation	true
R-HSA-9673240	Defective gamma-carboxylation of F9	true
R-HSA-9657689	Defective SERPING1 causes hereditary angioedema	true
R-HSA-9657688	Defective factor XII causes hereditary angioedema	true
R-HSA-9672383	Defective factor IX causes thrombophilia	true
R-HSA-8876384	Listeria monocytogenes entry into host cells	true
R-HSA-9640148	Infection with Enterobacteria	true
R-HSA-9638482	Metal ion assimilation from the host	true
R-HSA-9638737	Action of antimicrobials and antimicrobial resistance	true
R-HSA-8942233	Intestinal infectious diseases	true
R-HSA-5210891	Uptake and function of anthrax toxins	true
R-HSA-168799	Neurotoxicity of clostridium toxins	true
R-HSA-5336415	Uptake and function of diphtheria toxin	true
R-HSA-9635486	Infection with Mycobacterium tuberculosis	true
R-HSA-9679191	Potential therapeutics for SARS	true
R-HSA-162587	HIV Life Cycle	true
R-HSA-2161522	Abacavir ADME	false
R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translation	true
R-HSA-9828806	Maturation of hRSV A proteins	true
R-HSA-9820962	Assembly and release of respiratory syncytial virus (RSV) virions	true
R-HSA-9820960	Respiratory syncytial virus (RSV) attachment and entry	true
R-HSA-9662851	Anti-inflammatory response favouring Leishmania parasite infection	true
R-HSA-9664422	FCGR3A-mediated phagocytosis	true
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	true
R-HSA-9664424	Cell recruitment (pro-inflammatory response)	true
R-HSA-5655302	Signaling by FGFR1 in disease	true
R-HSA-5655332	Signaling by FGFR3 in disease	true
R-HSA-5655253	Signaling by FGFR2 in disease	true
R-HSA-5655291	Signaling by FGFR4 in disease	true
R-HSA-9669921	KIT mutants bind TKIs	true
R-HSA-9669936	Sorafenib-resistant KIT mutants	true
R-HSA-9669926	Nilotinib-resistant KIT mutants	true
R-HSA-9669924	Masitinib-resistant KIT mutants	true
R-HSA-9669914	Dasatinib-resistant KIT mutants	true
R-HSA-9669929	Regorafenib-resistant KIT mutants	true
R-HSA-9669934	Sunitinib-resistant KIT mutants	true
R-HSA-9669917	Imatinib-resistant KIT mutants	true
R-HSA-9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	true
R-HSA-9680187	Signaling by extracellular domain mutants of KIT	true
R-HSA-9669935	Signaling by juxtamembrane domain KIT mutants	true
R-HSA-9669933	Signaling by kinase domain mutants of KIT	true
R-HSA-5339717	Signaling by LRP5 mutants 	true
R-HSA-5339716	Signaling by GSK3beta mutants	true
R-HSA-5339700	Signaling by TCF7L2 mutants	true
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	true
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	true
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	true
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	true
R-HSA-5545619	XAV939 stabilizes AXIN	true
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	true
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	true
R-HSA-5340573	LGK974 inhibits PORCN	true
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	true
R-HSA-5467343	Deletions in the AMER1 gene destabilize the destruction complex	true
R-HSA-5340588	Signaling by RNF43 mutants	true
R-HSA-5467345	Deletions in the AXIN1 gene destabilize the destruction complex	true
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	true
R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	true
R-HSA-9607240	FLT3 Signaling	false
R-HSA-9645135	STAT5 Activation	false
R-HSA-9702509	FLT3 mutants bind TKIs	true
R-HSA-9706377	FLT3 signaling by CBL mutants	true
R-HSA-9703465	Signaling by FLT3 fusion proteins	true
R-HSA-9702581	crenolanib-resistant FLT3 mutants	true
R-HSA-9702614	ponatinib-resistant FLT3 mutants	true
R-HSA-9702998	linifanib-resistant FLT3 mutants	true
R-HSA-9702577	semaxanib-resistant FLT3 mutants	true
R-HSA-9702620	quizartinib-resistant FLT3 mutants	true
R-HSA-9702590	gilteritinib-resistant FLT3 mutants	true
R-HSA-9702596	lestaurtinib-resistant FLT3 mutants	true
R-HSA-9702624	sorafenib-resistant FLT3 mutants	true
R-HSA-9703009	tamatinib-resistant FLT3 mutants	true
R-HSA-9702636	tandutinib-resistant FLT3 mutants	true
R-HSA-9702605	pexidartinib-resistant FLT3 mutants	true
R-HSA-9702632	sunitinib-resistant FLT3 mutants	true
R-HSA-9702600	midostaurin-resistant FLT3 mutants	true
R-HSA-9702569	KW2449-resistant FLT3 mutants	true
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	true
R-HSA-9664565	Signaling by ERBB2 KD Mutants	true
R-HSA-9665348	Signaling by ERBB2 ECD mutants	true
R-HSA-9665737	Drug resistance in ERBB2 TMD/JMD mutants	true
R-HSA-9665251	Resistance of ERBB2 KD mutants to lapatinib	true
R-HSA-9665250	Resistance of ERBB2 KD mutants to AEE788	true
R-HSA-9665233	Resistance of ERBB2 KD mutants to trastuzumab	true
R-HSA-9665249	Resistance of ERBB2 KD mutants to afatinib	true
R-HSA-9665247	Resistance of ERBB2 KD mutants to osimertinib	true
R-HSA-9665246	Resistance of ERBB2 KD mutants to neratinib	true
R-HSA-9665245	Resistance of ERBB2 KD mutants to tesevatinib	true
R-HSA-9665244	Resistance of ERBB2 KD mutants to sapitinib	true
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	true
R-HSA-9842640	Signaling by LTK in cancer	true
R-HSA-9842663	Signaling by LTK	false
R-HSA-5674404	PTEN Loss of Function in Cancer	true
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	true
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	true
R-HSA-5362768	Hh mutants are degraded by ERAD	true
R-HSA-5358346	Hedgehog ligand biogenesis	false
R-HSA-5658034	HHAT G278V doesn't palmitoylate Hh-Np	true
R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	true
R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	true
R-HSA-3656535	TGFBR1 LBD Mutants in Cancer	true
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	true
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	true
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	true
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	true
R-HSA-9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	true
R-HSA-9673766	Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	true
R-HSA-9673770	Signaling by PDGFRA extracellular domain mutants	true
R-HSA-9673768	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	true
R-HSA-9674403	Regorafenib-resistant PDGFR mutants	true
R-HSA-9674401	Sunitinib-resistant PDGFR mutants	true
R-HSA-9674404	Sorafenib-resistant PDGFR mutants	true
R-HSA-9674396	Imatinib-resistant PDGFR mutants	true
R-HSA-9674428	PDGFR mutants bind TKIs	true
R-HSA-2660825	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	true
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	true
R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	true
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	true
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	true
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	true
R-HSA-5637812	Signaling by EGFRvIII in Cancer	true
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	true
R-HSA-9700645	ALK mutants bind TKIs	true
R-HSA-201556	Signaling by ALK	false
R-HSA-6783783	Interleukin-10 signaling	false
R-HSA-9717316	alectinib-resistant ALK mutants	true
R-HSA-9717301	NVP-TAE684-resistant ALK mutants	true
R-HSA-9717319	brigatinib-resistant ALK mutants	true
R-HSA-9717264	ASP-3026-resistant ALK mutants	true
R-HSA-9717329	lorlatinib-resistant ALK mutants	true
R-HSA-9717326	crizotinib-resistant ALK mutants	true
R-HSA-9717323	ceritinib-resistant ALK mutants	true
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	true
R-HSA-3371599	Defective HLCS causes multiple carboxylase deficiency	true
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	false
R-HSA-196757	Metabolism of folate and pterines	false
R-HSA-3371598	Defective BTD causes biotidinase deficiency	true
R-HSA-3359475	Defective MMAA causes MMA, cblA type	true
R-HSA-3359474	Defective MMACHC causes MAHCC	true
R-HSA-3359457	Defective CBLIF causes IFD	true
R-HSA-3359473	Defective MMADHC causes MMAHCD	true
R-HSA-3359463	Defective CUBN causes MGA1	true
R-HSA-3359462	Defective AMN causes MGA1	true
R-HSA-5683329	Defective ABCD4 causes MAHCJ	true
R-HSA-3359467	Defective MTRR causes HMAE	true
R-HSA-3359471	Defective MMAB causes MMA, cblB type	true
R-HSA-3359454	Defective TCN2 causes TCN2 deficiency	true
R-HSA-3359469	Defective MTR causes HMAG	true
R-HSA-3359485	Defective CD320 causes MMATC	true
R-HSA-5579028	Defective CYP17A1 causes AH5	true
R-HSA-196071	Metabolism of steroid hormones	false
R-HSA-5579030	Defective CYP19A1 causes AEXS	true
R-HSA-211945	Phase I - Functionalization of compounds	false
R-HSA-8937144	Aryl hydrocarbon receptor signalling	false
R-HSA-5579024	Defective MAT1A causes MATD	true
R-HSA-5579027	Defective CYP27B1 causes VDDR1B	true
R-HSA-5579026	Defective CYP11A1 causes AICSR	true
R-HSA-9035968	Defective GGT1 in aflatoxin detoxification causes GLUTH	true
R-HSA-5423646	Aflatoxin activation and detoxification	false
R-HSA-5579032	Defective TBXAS1 causes GHDD	true
R-HSA-5579013	Defective CYP7B1 causes SPG5A and CBAS3	true
R-HSA-5579012	Defective MAOA causes BRUNS	true
R-HSA-5579015	Defective CYP26B1 causes RHFCA	true
R-HSA-5579014	Defective CYP27B1 causes VDDR1A	true
R-HSA-5579009	Defective CYP11B2 causes CMO-1 deficiency	true
R-HSA-5579011	Defective CYP2U1 causes SPG56	true
R-HSA-5579010	Defective CYP24A1 causes HCAI	true
R-HSA-5579021	Defective CYP21A2 causes AH3	true
R-HSA-5579020	Defective SLC35D1 causes SCHBCKD	true
R-HSA-5579022	Defective GGT1 causes GLUTH	true
R-HSA-5579017	Defective CYP11B1 causes AH4	true
R-HSA-5579016	Defective UGT1A4 causes hyperbilirubinemia	true
R-HSA-5579019	Defective FMO3 causes TMAU	true
R-HSA-5578997	Defective AHCY causes HMAHCHD	true
R-HSA-5578996	Defective CYP27A1 causes CTX	true
R-HSA-194068	Bile acid and bile salt metabolism	false
R-HSA-5578999	Defective GCLC causes HAGGSD	true
R-HSA-5578998	Defective OPLAH causes OPLAHD	true
R-HSA-5578995	Defective TPMT causes TPMT deficiency	true
R-HSA-5579005	Defective CYP4F22 causes ARCI5	true
R-HSA-5579004	Defective CYP26C1 causes FFDD4	true
R-HSA-5579007	Defective ACY1 causes encephalopathy	true
R-HSA-5579006	Defective GSS causes GSS deficiency	true
R-HSA-5579000	Defective CYP1B1 causes Glaucoma	true
R-HSA-5579002	Defective UGT1A1 causes hyperbilirubinemia	true
R-HSA-4085023	Defective GFPT1 causes CMSTA1	true
R-HSA-5609974	Defective PGM1 causes PGM1-CDG	true
R-HSA-4719360	Defective DPM3 causes DPM3-CDG	true
R-HSA-5609977	Defective GALE causes EDG	true
R-HSA-5609976	Defective GALK1 causes GALCT2	true
R-HSA-4085011	Defective GNE causes sialuria, NK and IBM2	true
R-HSA-9931929	Defective GALM causes GALAC4	true
R-HSA-5609978	Defective GALT can cause GALCT	true
R-HSA-4755609	Defective DHDDS causes RP59	true
R-HSA-4043916	Defective MPI causes MPI-CDG	true
R-HSA-4755579	Defective SRD5A3 causes SRD5A3-CDG, KHRZ	true
R-HSA-4755583	Defective DOLK causes DOLK-CDG	true
R-HSA-4717374	Defective DPM1 causes DPM1-CDG	true
R-HSA-4719377	Defective DPM2 causes DPM2-CDG	true
R-HSA-4043911	Defective PMM2 causes PMM2-CDG	true
R-HSA-3656244	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	true
R-HSA-3656243	Defective ST3GAL3 causes MCT12 and EIEE15	true
R-HSA-3560796	Defective PAPSS2 causes SEMD-PA	true
R-HSA-3656253	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	true
R-HSA-3560792	Defective SLC26A2 causes chondrodysplasias	true
R-HSA-3656248	Defective HEXB causes GM2G2 (Hyaluronan metabolism)	true
R-HSA-4420332	Defective B3GALT6 causes EDSP2 and SEMDJL1	true
R-HSA-3595174	Defective CHST14 causes EDS, musculocontractural type	true
R-HSA-3595172	Defective CHST3 causes SEDCJD	true
R-HSA-3656225	Defective CHST6 causes MCDC1	true
R-HSA-3560801	Defective B3GAT3 causes JDSSDHD	true
R-HSA-3560783	Defective B4GALT7 causes EDS, progeroid type	true
R-HSA-3656237	Defective EXT2 causes exostoses 2	true
R-HSA-3656234	Defective HEXA causes GM2G1 (Hyaluronan metabolism)	true
R-HSA-3595177	Defective CHSY1 causes TPBS	true
R-HSA-5083629	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	true
R-HSA-5173105	O-linked glycosylation	false
R-HSA-5083628	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	true
R-HSA-5083630	Defective LFNG causes SCDO3	true
R-HSA-5083625	Defective GALNT3 causes HFTC	true
R-HSA-5083627	Defective LARGE causes MDDGA6 and MDDGB6	true
R-HSA-5083636	Defective GALNT12 causes CRCS1	true
R-HSA-5083633	Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	true
R-HSA-5083632	Defective C1GALT1C1 causes TNPS	true
R-HSA-5083635	Defective B3GALTL causes PpS	true
R-HSA-4549349	Defective ALG2 causes CDG-1i	true
R-HSA-4549380	Defective ALG1 causes CDG-1k	true
R-HSA-4720489	Defective ALG12 causes CDG-1g	true
R-HSA-4341670	Defective NEU1 causes sialidosis	true
R-HSA-4793953	Defective B4GALT1 causes CDG-2d	true
R-HSA-4549356	Defective DPAGT1 causes CDG-1j, CMSTA2	true
R-HSA-4724289	Defective ALG6 causes CDG-1c	true
R-HSA-4793952	Defective MGAT2 causes CDG-2a	true
R-HSA-4793954	Defective MOGS causes CDG-2b	true
R-HSA-4724325	Defective ALG8 causes CDG-1h	true
R-HSA-4570571	Defective RFT1 causes CDG-1n	true
R-HSA-4720454	Defective ALG9 causes CDG-1l	true
R-HSA-4720475	Defective ALG3 causes CDG-1d	true
R-HSA-4793950	Defective MAN1B1 causes MRT15	true
R-HSA-5633231	Defective ALG14 causes ALG14-CMS	true
R-HSA-4551295	Defective ALG11 causes CDG-1p	true
R-HSA-4687000	Defective MPDU1 causes CDG-1f	true
R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	true
R-HSA-5579031	Defective ACTH causes obesity and POMCD	true
R-HSA-2160456	Phenylketonuria	true
R-HSA-9734195	Defective APRT disrupts adenine salvage	true
R-HSA-9734735	Defective ADA disrupts (deoxy)adenosine deamination	true
R-HSA-9734281	Defective HPRT1 disrupts guanine and hypoxanthine salvage	true
R-HSA-9735763	Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	true
R-HSA-9914355	Isovaleric acidemia	true
R-HSA-9914274	3-methylglutaconic aciduria	true
R-HSA-9916722	3-hydroxyisobutyryl-CoA hydrolase deficiency	true
R-HSA-9912481	Branched-chain ketoacid dehydrogenase kinase deficiency	true
R-HSA-9916720	Mitochondrial short-chain enoyl-CoA hydratase deficiency 1	true
R-HSA-9909438	3-Methylcrotonyl-CoA carboxylase deficiency	true
R-HSA-9865125	Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	true
R-HSA-9907570	Loss-of-function mutations in DLD cause MSUD3/DLDD	true
R-HSA-9912529	H139Hfs13* PPM1K causes a mild variant of  MSUD	true
R-HSA-9865113	Loss-of-function mutations in DBT cause MSUD2	true
R-HSA-9915355	Beta-ketothiolase deficiency	true
R-HSA-3274531	Glycogen storage disease type Ia (G6PC)	true
R-HSA-3828062	Glycogen storage disease type 0 (muscle GYS1)	true
R-HSA-3878781	Glycogen storage disease type IV (GBE1)	true
R-HSA-5357609	Glycogen storage disease type II (GAA)	true
R-HSA-3282872	Severe congenital neutropenia type 4 (G6PC3)	true
R-HSA-3229133	Glycogen storage disease type Ib (SLC37A4)	true
R-HSA-3785653	Myoclonic epilepsy of Lafora	true
R-HSA-3858516	Glycogen storage disease type 0 (liver GYS2)	true
R-HSA-3814836	Glycogen storage disease type XV (GYG1)	true
R-HSA-5662853	Essential pentosuria	true
R-HSA-2206305	MPS IIID - Sanfilippo syndrome D	true
R-HSA-9953111	MPS IV - Morquio syndrome B (CS/DS degradation)	true
R-HSA-9953078	MPS II - Hunter syndrome (CS/DS degradation)	true
R-HSA-2206307	MPS IIIA - Sanfilippo syndrome A	true
R-HSA-2206308	MPS IV - Morquio syndrome B (Keratin metabolism)	true
R-HSA-2206280	MPS IX - Natowicz syndrome (Hyaluronan metabolism)	true
R-HSA-2206282	MPS IIIB - Sanfilippo syndrome B	true
R-HSA-2206285	MPS VI - Maroteaux-Lamy syndrome	true
R-HSA-9953080	MPS VII - Sly syndrome (CS/DS degradation)	true
R-HSA-2206291	MPS IIIC - Sanfilippo syndrome C	true
R-HSA-2206290	MPS IV - Morquio syndrome A	true
R-HSA-2206292	MPS VII - Sly syndrome (Hyaluronan metabolism)	true
R-HSA-9953038	MPS I - Hurler syndrome (CS/DS degradation)	true
R-HSA-2206296	MPS II - Hunter syndrome (HS-GAG degradation)	true
R-HSA-9953097	MPS IX - Natowicz syndrome (CS/DS degradation)	true
R-HSA-2206302	MPS I - Hurler syndrome (HS-GAG degradation)	true
R-HSA-5657562	Essential fructosuria	true
R-HSA-5659898	Intestinal saccharidase deficiencies	true
R-HSA-5657560	Hereditary fructose intolerance	true
R-HSA-6791462	TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P	true
R-HSA-6791461	RPIA deficiency: failed conversion of RU5P to R5P	true
R-HSA-6791055	TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	true
R-HSA-5659996	RPIA deficiency: failed conversion of R5P to RU5P	true
R-HSA-9759774	Diseases of mitochondrial beta oxidation	true
R-HSA-5688354	Defective pro-SFTPC causes SMDP2 and RDS	true
R-HSA-5683826	Surfactant metabolism	false
R-HSA-5688849	Defective CSF2RB causes SMDP5	true
R-HSA-5687583	Defective SLC34A2 causes PALM	true
R-HSA-5688031	Defective pro-SFTPB causes SMDP1 and RDS	true
R-HSA-5688399	Defective ABCA3 causes SMDP3	true
R-HSA-5687868	Defective SFTPA2 causes IPF	true
R-HSA-5688890	Defective CSF2RA causes SMDP4	true
R-HSA-6809583	Retinoid metabolism disease events	true
R-HSA-975634	Retinoid metabolism and transport	false
R-HSA-2187338	Visual phototransduction	false
R-HSA-9918454	Defective visual phototransduction due to ABCA4 loss of function	true
R-HSA-9918438	Defective visual phototransduction due to RDH5 loss of function	true
R-HSA-9918436	Defective visual phototransduction due to OPN1MW loss of function	true
R-HSA-9918450	Defective visual phototransduction due to OPN1LW loss of function	true
R-HSA-9918449	Defective visual phototransduction due to STRA6 loss of function	true
R-HSA-9918443	Defective visual phototransduction due to OPN1SW loss of function	true
R-HSA-9918442	Defective visual phototransduction due to LRAT loss of function	true
R-HSA-2466712	Biosynthesis of A2E, implicated in retinal degradation	true
R-HSA-9918440	Defective visual phototransduction due to RDH12 loss of function	true
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	true
R-HSA-9661070	Defective translocation of RB1 mutants to the nucleus	true
R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	true
R-HSA-9670615	Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	true
R-HSA-9670613	Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	true
R-HSA-9710421	Defective pyroptosis	true
R-HSA-9693928	Defective RIPK1-mediated regulated necrosis	true
R-HSA-9723905	Loss of function of TP53 in cancer due to loss of tetramerization ability	true
R-HSA-9645722	Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	true
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	true
R-HSA-9709570	Impaired BRCA2 binding to RAD51	true
R-HSA-9709603	Impaired BRCA2 binding to PALB2	true
R-HSA-9763198	Impaired BRCA2 binding to SEM1 (DSS1)	true
R-HSA-9709275	Impaired BRCA2 translocation to the nucleus	true
R-HSA-9663199	Defective DNA double strand break response due to BRCA1 loss of function	true
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	true
R-HSA-9699150	Defective DNA double strand break response due to BARD1 loss of function	true
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	true
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	true
R-HSA-5632928	Defective Mismatch Repair Associated With MSH2	true
R-HSA-5632927	Defective Mismatch Repair Associated With MSH3	true
R-HSA-5632968	Defective Mismatch Repair Associated With MSH6	true
R-HSA-5632987	Defective Mismatch Repair Associated With PMS2	true
R-HSA-5545483	Defective Mismatch Repair Associated With MLH1	true
R-HSA-9629232	Defective Base Excision Repair Associated with NEIL3	true
R-HSA-73929	Base-Excision Repair, AP Site Formation	false
R-HSA-73933	Resolution of Abasic Sites (AP sites)	false
R-HSA-9656256	Defective OGG1 Substrate Processing	true
R-HSA-9657050	Defective OGG1 Localization	true
R-HSA-9656255	Defective OGG1 Substrate Binding	true
R-HSA-9608290	Defective MUTYH substrate processing	true
R-HSA-9608287	Defective MUTYH substrate binding	true
R-HSA-9616334	Defective Base Excision Repair Associated with NEIL1	true
R-HSA-9630222	Defective NTHL1 substrate binding	true
R-HSA-9630221	Defective NTHL1 substrate processing	true
R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	true
R-HSA-9022538	Loss of MECP2 binding ability to 5mC-DNA	true
R-HSA-9022535	Loss of phosphorylation of MECP2 at T308	true
R-HSA-9022534	Loss of MECP2 binding ability to 5hmC-DNA	true
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	true
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	false
R-HSA-5682294	Defective ABCA12 causes ARCI4B	true
R-HSA-5678420	Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	true
R-HSA-5679090	Defective ABCG8 causes GBD4 and sitosterolemia	true
R-HSA-5678771	Defective ABCB4 causes PFIC3, ICP3 and GBD1	true
R-HSA-5683678	Defective ABCA3 causes SMDP3	true
R-HSA-5678520	Defective ABCB11 causes PFIC2 and BRIC2	true
R-HSA-5679096	Defective ABCG5 causes sitosterolemia	true
R-HSA-5679001	Defective ABCC2 causes DJS	true
R-HSA-5690338	Defective ABCC6 causes PXE	true
R-HSA-5682113	Defective ABCA1 causes TGD	true
R-HSA-5678895	Defective CFTR causes cystic fibrosis	true
R-HSA-5684045	Defective ABCD1 causes ALD	true
R-HSA-5683371	Defective ABCB6 causes MCOPCB7	true
R-HSA-5683177	Defective ABCC8 can cause hypo- and hyper-glycemias	true
R-HSA-163685	Integration of energy metabolism	false
R-HSA-5659735	Defective SLC6A19 causes Hartnup disorder (HND)	true
R-HSA-5660883	Defective SLC7A9 causes cystinuria (CSNU)	true
R-HSA-5619037	Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)	true
R-HSA-5619036	Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)	true
R-HSA-5619039	Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	true
R-HSA-5619035	Defective SLC17A5 causes Salla disease (SD) and ISSD	true
R-HSA-5619061	Defective SLC33A1 causes spastic paraplegia 42 (SPG42)	true
R-HSA-5619060	Defective CP causes aceruloplasminemia (ACERULOP)	true
R-HSA-5655799	Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	true
R-HSA-5619063	Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)	true
R-HSA-5619062	Defective SLC1A3 causes episodic ataxia 6 (EA6)	true
R-HSA-5619056	Defective HK1 causes hexokinase deficiency (HK deficiency)	true
R-HSA-5619058	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	true
R-HSA-5619068	Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	true
R-HSA-5619071	Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)	true
R-HSA-5619070	Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	true
R-HSA-5619067	Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	true
R-HSA-5619066	Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)	true
R-HSA-5619045	Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	true
R-HSA-5658471	Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)	true
R-HSA-5619044	Defective SLC6A19 causes Hartnup disorder (HND)	true
R-HSA-5619047	Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)	true
R-HSA-5619046	Defective SLC26A4 causes Pendred syndrome (PDS)	true
R-HSA-5619041	Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)	true
R-HSA-9036092	Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	true
R-HSA-5619040	Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)	true
R-HSA-5619043	Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	true
R-HSA-5658208	Defective SLC5A2 causes renal glucosuria (GLYS1)	true
R-HSA-5619042	Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)	true
R-HSA-5619053	Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)	true
R-HSA-5619052	Defective SLC9A9 causes autism 16 (AUTS16)	true
R-HSA-5619055	Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)	true
R-HSA-5619054	Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	true
R-HSA-5619049	Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	true
R-HSA-5619048	Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	true
R-HSA-5619050	Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4),  distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	true
R-HSA-5619092	Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)	true
R-HSA-5619095	Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	true
R-HSA-5619094	Variant SLC6A14 may confer susceptibility towards obesity	true
R-HSA-5619089	Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	true
R-HSA-5619088	Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)	true
R-HSA-5619101	Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	true
R-HSA-5619097	Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)	true
R-HSA-5619096	Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)	true
R-HSA-5619099	Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	true
R-HSA-5619098	Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)	true
R-HSA-5619077	Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)	true
R-HSA-5619076	Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)	true
R-HSA-5619078	Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)	true
R-HSA-5619073	Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)	true
R-HSA-5619072	Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)	true
R-HSA-5619085	Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)	true
R-HSA-5660686	Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	true
R-HSA-5619087	Defective SLC12A3 causes Gitelman syndrome (GS)	true
R-HSA-5619081	Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	true
R-HSA-112311	Neurotransmitter clearance	false
R-HSA-5619083	Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)	true
R-HSA-5660724	Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	true
R-HSA-5660862	Defective SLC7A7 causes lysinuric protein intolerance (LPI)	true
R-HSA-5619109	Defective SLC6A2 causes orthostatic intolerance (OI)	true
R-HSA-5619108	Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)	true
R-HSA-5619111	Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	true
R-HSA-5619110	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	true
R-HSA-5619104	Defective SLC12A1 causes Bartter syndrome 1 (BS1)	true
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	true
R-HSA-5663020	Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)	true
R-HSA-5656364	Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)	true
R-HSA-5619113	Defective SLC3A1 causes cystinuria (CSNU)	true
R-HSA-5619114	Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)	true
R-HSA-9646304	Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	true
R-HSA-9632697	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	true
R-HSA-9632700	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	true
R-HSA-9630791	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	true
R-HSA-9630794	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	true
R-HSA-9646303	Evasion of Oncogene Induced Senescence Due to p14ARF Defects	true
R-HSA-5603029	IkBA variant leads to EDA-ID	true
R-HSA-5602566	TICAM1 deficiency - HSE	true
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	true
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	true
R-HSA-5602498	MyD88 deficiency (TLR2/4)	true
R-HSA-5603037	IRAK4 deficiency (TLR5)	true
R-HSA-5602636	IKBKB deficiency causes SCID	true
R-HSA-5602415	UNC93B1 deficiency - HSE	true
R-HSA-5602680	MyD88 deficiency (TLR5)	true
R-HSA-9824856	Defective regulation of TLR7 by endogenous ligand	true
R-HSA-5602571	TRAF3 deficiency - HSE	true
R-HSA-5602410	TLR3 deficiency - HSE	true
R-HSA-73893	DNA Damage Bypass	false
R-HSA-73942	DNA Damage Reversal	false
R-HSA-9913635	Strand-asynchronous mitochondrial DNA replication	false
R-HSA-9757110	Prednisone ADME	false
R-HSA-9755088	Ribavirin ADME	false
R-HSA-9753281	Paracetamol ADME	false
R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	false
R-HSA-9749641	Aspirin ADME	false
R-HSA-9754706	Atorvastatin ADME	false
R-HSA-9748787	Azathioprine ADME	false
R-HSA-9793528	Ciprofloxacin ADME	false
R-HSA-3000157	Laminin interactions	false
R-HSA-1474228	Degradation of the extracellular matrix	false
R-HSA-1442490	Collagen degradation	false
R-HSA-1566948	Elastic fibre formation	false
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	false
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	false
R-HSA-8948216	Collagen chain trimerization	false
R-HSA-1566977	Fibronectin matrix formation	false
R-HSA-3000171	Non-integrin membrane-ECM interactions	false
R-HSA-9913351	Formation of the dystrophin-glycoprotein complex (DGC)	false
R-HSA-3000170	Syndecan interactions	false
R-HSA-8941237	Invadopodia formation	false
R-HSA-3000178	ECM proteoglycans	false
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	false
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	false
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	false
R-HSA-5334118	DNA methylation	false
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	false
R-HSA-9842860	Regulation of endogenous retroelements	false
R-HSA-427413	NoRC negatively regulates rRNA expression	false
R-HSA-427359	SIRT1 negatively regulates rRNA expression	false
R-HSA-212300	PRC2 methylates histones and DNA	false
R-HSA-73864	RNA Polymerase I Transcription	false
R-HSA-75944	Transcription from mitochondrial promoters	false
R-HSA-74158	RNA Polymerase III Transcription	false
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	false
R-HSA-983189	Kinesins	false
R-HSA-430116	GP1b-IX-V activation signalling	false
R-HSA-392518	Signal amplification	false
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	false
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	false
R-HSA-76009	Platelet Aggregation (Plug Formation)	false
R-HSA-354192	Integrin signaling	false
R-HSA-114604	GPVI-mediated activation cascade	false
R-HSA-75205	Dissolution of Fibrin Clot	false
R-HSA-418346	Platelet homeostasis	false
R-HSA-9909505	Modulation of host responses by IFN-stimulated genes	false
R-HSA-9674555	Signaling by CSF3 (G-CSF)	false
R-HSA-982772	Growth hormone receptor signaling	false
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	false
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	false
R-HSA-5669034	TNFs bind their physiological receptors	false
R-HSA-1266695	Interleukin-7 signaling	false
R-HSA-8854691	Interleukin-20 family signaling	false
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	false
R-HSA-447115	Interleukin-12 family signaling	false
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	false
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	false
R-HSA-392517	Rap1 signalling	false
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	false
R-HSA-2132295	MHC class II antigen presentation	false
R-HSA-8851680	Butyrophilin (BTN) family interactions	false
R-HSA-1475029	Reversible hydration of carbon dioxide	false
R-HSA-1483249	Inositol phosphate metabolism	false
R-HSA-8979227	Triglyceride metabolism	false
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	false
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	false
R-HSA-8964572	Lipid particle organization	false
R-HSA-74182	Ketone body metabolism	false
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	false
R-HSA-75105	Fatty acyl-CoA biosynthesis	false
R-HSA-2142753	Arachidonate metabolism	false
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	false
R-HSA-200425	Carnitine shuttle	false
R-HSA-1483206	Glycerophospholipid biosynthesis	false
R-HSA-1483255	PI Metabolism	false
R-HSA-8848584	Wax and plasmalogen biosynthesis	false
R-HSA-9018683	Biosynthesis of DPA-derived SPMs	false
R-HSA-2142700	Biosynthesis of Lipoxins (LX)	false
R-HSA-9018677	Biosynthesis of DHA-derived SPMs	false
R-HSA-9027604	Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	false
R-HSA-9018679	Biosynthesis of EPA-derived SPMs	false
R-HSA-8877627	Vitamin E transport	false
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	false
R-HSA-5676934	Protein repair	false
R-HSA-8852135	Protein ubiquitination	false
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	false
R-HSA-9907900	Proteasome assembly	false
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	false
R-HSA-8873719	RAB geranylgeranylation	false
R-HSA-8876725	Protein methylation	false
R-HSA-4551638	SUMOylation of chromatin organization proteins	false
R-HSA-4655427	SUMOylation of DNA methylation proteins	false
R-HSA-4570464	SUMOylation of RNA binding proteins	false
R-HSA-3232118	SUMOylation of transcription factors	false
R-HSA-4090294	SUMOylation of intracellular receptors	false
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	false
R-HSA-4615885	SUMOylation of DNA replication proteins	false
R-HSA-3899300	SUMOylation of transcription cofactors	false
R-HSA-3232142	SUMOylation of ubiquitinylation proteins	false
R-HSA-4085377	SUMOylation of SUMOylation proteins	false
R-HSA-9793242	SUMOylation of nuclear envelope proteins	false
R-HSA-3215018	Processing and activation of SUMO	false
R-HSA-8957275	Post-translational protein phosphorylation	false
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	false
R-HSA-8951664	Neddylation	false
R-HSA-5688426	Deubiquitination	false
R-HSA-391251	Protein folding	false
R-HSA-9837999	Mitochondrial protein degradation	false
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	false
R-HSA-209952	Peptide hormone biosynthesis	false
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	false
R-HSA-264876	Insulin processing	false
R-HSA-400508	Incretin synthesis, secretion, and inactivation	false
R-HSA-379724	tRNA Aminoacylation	false
R-HSA-9948299	Ribosome-associated quality control	false
R-HSA-72764	Eukaryotic Translation Termination	false
R-HSA-75072	mRNA Editing	false
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	false
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	false
R-HSA-9937008	Mitochondrial mRNA modification	false
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	false
R-HSA-9836573	Mitochondrial RNA degradation	false
R-HSA-9930044	Nuclear RNA decay	false
R-HSA-6784531	tRNA processing in the nucleus	false
R-HSA-6785470	tRNA processing in the mitochondrion	false
R-HSA-6782315	tRNA modification in the nucleus and cytosol	false
R-HSA-6782861	Synthesis of wybutosine at G37 of tRNA(Phe)	false
R-HSA-6787450	tRNA modification in the mitochondrion	false
R-HSA-72086	mRNA Capping	false
R-HSA-72312	rRNA processing	false
R-HSA-6790901	rRNA modification in the nucleus and cytosol	false
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	false
R-HSA-6793080	rRNA modification in the mitochondrion	false
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	false
R-HSA-445355	Smooth Muscle Contraction	false
R-HSA-5576891	Cardiac conduction	false
R-HSA-390522	Striated Muscle Contraction	false
R-HSA-112307	Transmission across Electrical Synapses 	false
R-HSA-1296071	Potassium Channels	false
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	false
R-HSA-5620924	Intraflagellar transport	false
R-HSA-5620920	Cargo trafficking to the periciliary membrane	false
R-HSA-1592230	Mitochondrial biogenesis	false
R-HSA-8949613	Cristae formation	false
R-HSA-9033241	Peroxisomal protein import	false
R-HSA-9033500	TYSND1 cleaves peroxisomal proteins	false
R-HSA-9609523	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	false
R-HSA-9603798	Class I peroxisomal membrane protein import	false
R-HSA-9827857	Specification of primordial germ cells	false
R-HSA-1187000	Fertilization	false
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	false
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	false
R-HSA-9717189	Sensory perception of taste	false
R-HSA-381753	Olfactory Signaling Pathway	false
R-HSA-9752946	Expression and translocation of olfactory receptors	false
R-HSA-5687128	MAPK6/MAPK4 signaling	false
R-HSA-9706019	RHOBTB3 ATPase cycle	false
R-HSA-5627083	RHO GTPases regulate CFTR trafficking	false
R-HSA-5666185	RHO GTPases Activate Rhotekin and Rhophilins	false
R-HSA-9012999	RHO GTPase cycle	false
R-HSA-9715370	Miro GTPase Cycle	false
R-HSA-1502540	Signaling by Activin	false
R-HSA-9839373	Signaling by TGFBR3	false
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	false
R-HSA-373080	Class B/2 (Secretin family receptors)	false
R-HSA-9006335	Signaling by Erythropoietin	false
R-HSA-8939211	ESR-mediated signaling	false
R-HSA-5362517	Signaling by Retinoic Acid	false
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	false
R-HSA-8852405	Signaling by MST1	false
R-HSA-2586552	Signaling by Leptin	false
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	false
R-HSA-8854214	TBC/RABGAPs	false
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	false
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	false
R-HSA-199992	trans-Golgi Network Vesicle Budding	false
R-HSA-8856828	Clathrin-mediated endocytosis	false
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	false
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	false