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         <PDBx:formula>H2 O</PDBx:formula>
         <PDBx:formula_weight>18.015</PDBx:formula_weight>
         <PDBx:mon_nstd_flag xsi:nil="true" />
         <PDBx:name>WATER</PDBx:name>
         <PDBx:type>non-polymer</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="LEU">
         <PDBx:formula>C6 H13 N O2</PDBx:formula>
         <PDBx:formula_weight>131.173</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>LEUCINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="MET">
         <PDBx:formula>C5 H11 N O2 S</PDBx:formula>
         <PDBx:formula_weight>149.211</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>METHIONINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="SER">
         <PDBx:formula>C3 H7 N O3</PDBx:formula>
         <PDBx:formula_weight>105.093</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>SERINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="TYR">
         <PDBx:formula>C9 H11 N O3</PDBx:formula>
         <PDBx:formula_weight>181.189</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>TYROSINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
      <PDBx:chem_comp id="VAL">
         <PDBx:formula>C5 H11 N O2</PDBx:formula>
         <PDBx:formula_weight>117.146</PDBx:formula_weight>
         <PDBx:mon_nstd_flag>y</PDBx:mon_nstd_flag>
         <PDBx:name>VALINE</PDBx:name>
         <PDBx:type>L-peptide linking</PDBx:type>
      </PDBx:chem_comp>
   </PDBx:chem_compCategory>
   <PDBx:citationCategory>
      <PDBx:citation id="primary">
         <PDBx:country>US</PDBx:country>
         <PDBx:journal_abbrev>J.Biol.Chem.</PDBx:journal_abbrev>
         <PDBx:journal_id_ASTM>JBCHA3</PDBx:journal_id_ASTM>
         <PDBx:journal_id_CSD>0071</PDBx:journal_id_CSD>
         <PDBx:journal_id_ISSN>0021-9258</PDBx:journal_id_ISSN>
         <PDBx:journal_volume>285</PDBx:journal_volume>
         <PDBx:page_first>29671</PDBx:page_first>
         <PDBx:page_last>29675</PDBx:page_last>
         <PDBx:pdbx_database_id_DOI>10.1074/jbc.C110.158303</PDBx:pdbx_database_id_DOI>
         <PDBx:pdbx_database_id_PubMed>20685658</PDBx:pdbx_database_id_PubMed>
         <PDBx:title>Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease.</PDBx:title>
         <PDBx:year>2010</PDBx:year>
      </PDBx:citation>
   </PDBx:citationCategory>
   <PDBx:citation_authorCategory>
      <PDBx:citation_author citation_id="primary" name="Apostol, M.I." ordinal="1"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Sawaya, M.R." ordinal="2"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Cascio, D." ordinal="3"></PDBx:citation_author>
      <PDBx:citation_author citation_id="primary" name="Eisenberg, D." ordinal="4"></PDBx:citation_author>
   </PDBx:citation_authorCategory>
   <PDBx:database_2Category>
      <PDBx:database_2 database_code="3NHD" database_id="PDB"></PDBx:database_2>
      <PDBx:database_2 database_code="RCSB059830" database_id="RCSB"></PDBx:database_2>
      <PDBx:database_2 database_code="D_1000059830" database_id="WWPDB"></PDBx:database_2>
   </PDBx:database_2Category>
   <PDBx:diffrnCategory>
      <PDBx:diffrn id="1">
         <PDBx:ambient_temp>100</PDBx:ambient_temp>
         <PDBx:crystal_id>1</PDBx:crystal_id>
      </PDBx:diffrn>
   </PDBx:diffrnCategory>
   <PDBx:diffrn_detectorCategory>
      <PDBx:diffrn_detector diffrn_id="1">
         <PDBx:detector>CCD</PDBx:detector>
         <PDBx:pdbx_collection_date>2008-01-01</PDBx:pdbx_collection_date>
         <PDBx:type>ADSC QUANTUM 315</PDBx:type>
      </PDBx:diffrn_detector>
   </PDBx:diffrn_detectorCategory>
   <PDBx:diffrn_radiationCategory>
      <PDBx:diffrn_radiation diffrn_id="1">
         <PDBx:pdbx_diffrn_protocol>SINGLE WAVELENGTH</PDBx:pdbx_diffrn_protocol>
         <PDBx:pdbx_monochromatic_or_laue_m_l>M</PDBx:pdbx_monochromatic_or_laue_m_l>
         <PDBx:pdbx_scattering_type>x-ray</PDBx:pdbx_scattering_type>
         <PDBx:wavelength_id>1</PDBx:wavelength_id>
      </PDBx:diffrn_radiation>
   </PDBx:diffrn_radiationCategory>
   <PDBx:diffrn_radiation_wavelengthCategory>
      <PDBx:diffrn_radiation_wavelength id="1">
         <PDBx:wavelength>0.97915</PDBx:wavelength>
         <PDBx:wt>1.0</PDBx:wt>
      </PDBx:diffrn_radiation_wavelength>
   </PDBx:diffrn_radiation_wavelengthCategory>
   <PDBx:diffrn_sourceCategory>
      <PDBx:diffrn_source diffrn_id="1">
         <PDBx:pdbx_synchrotron_beamline>24-ID-E</PDBx:pdbx_synchrotron_beamline>
         <PDBx:pdbx_synchrotron_site>APS</PDBx:pdbx_synchrotron_site>
         <PDBx:pdbx_wavelength_list>0.97915</PDBx:pdbx_wavelength_list>
         <PDBx:source>SYNCHROTRON</PDBx:source>
         <PDBx:type>APS BEAMLINE 24-ID-E</PDBx:type>
      </PDBx:diffrn_source>
   </PDBx:diffrn_sourceCategory>
   <PDBx:entityCategory>
      <PDBx:entity id="1">
         <PDBx:formula_weight>594.659</PDBx:formula_weight>
         <PDBx:pdbx_description>Major prion protein</PDBx:pdbx_description>
         <PDBx:pdbx_fragment>residues 127-132</PDBx:pdbx_fragment>
         <PDBx:pdbx_mutation>M129V</PDBx:pdbx_mutation>
         <PDBx:pdbx_number_of_molecules>2</PDBx:pdbx_number_of_molecules>
         <PDBx:src_method>syn</PDBx:src_method>
         <PDBx:type>polymer</PDBx:type>
      </PDBx:entity>
      <PDBx:entity id="2">
         <PDBx:formula_weight>60.052</PDBx:formula_weight>
         <PDBx:pdbx_description>ACETIC ACID</PDBx:pdbx_description>
         <PDBx:pdbx_number_of_molecules>2</PDBx:pdbx_number_of_molecules>
         <PDBx:src_method>syn</PDBx:src_method>
         <PDBx:type>non-polymer</PDBx:type>
      </PDBx:entity>
      <PDBx:entity id="3">
         <PDBx:formula_weight>18.015</PDBx:formula_weight>
         <PDBx:pdbx_description>water</PDBx:pdbx_description>
         <PDBx:pdbx_number_of_molecules>2</PDBx:pdbx_number_of_molecules>
         <PDBx:src_method>nat</PDBx:src_method>
         <PDBx:type>water</PDBx:type>
      </PDBx:entity>
   </PDBx:entityCategory>
   <PDBx:entity_name_comCategory>
      <PDBx:entity_name_com entity_id="1">
         <PDBx:name>PrP, PrP27-30, PrP33-35C, ASCR</PDBx:name>
      </PDBx:entity_name_com>
   </PDBx:entity_name_comCategory>
   <PDBx:entity_polyCategory>
      <PDBx:entity_poly entity_id="1">
         <PDBx:nstd_linkage>no</PDBx:nstd_linkage>
         <PDBx:nstd_monomer>no</PDBx:nstd_monomer>
         <PDBx:pdbx_seq_one_letter_code>GYVLGS</PDBx:pdbx_seq_one_letter_code>
         <PDBx:pdbx_seq_one_letter_code_can>GYVLGS</PDBx:pdbx_seq_one_letter_code_can>
         <PDBx:pdbx_strand_id>A,B</PDBx:pdbx_strand_id>
         <PDBx:type>polypeptide(L)</PDBx:type>
      </PDBx:entity_poly>
   </PDBx:entity_polyCategory>
   <PDBx:entity_poly_seqCategory>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLY" num="1">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="TYR" num="2">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="VAL" num="3">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="4">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLY" num="5">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="SER" num="6">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
   </PDBx:entity_poly_seqCategory>
   <PDBx:entryCategory>
      <PDBx:entry id="3NHD"></PDBx:entry>
   </PDBx:entryCategory>
   <PDBx:exptlCategory>
      <PDBx:exptl entry_id="3NHD" method="X-RAY DIFFRACTION">
         <PDBx:crystals_number>1</PDBx:crystals_number>
      </PDBx:exptl>
   </PDBx:exptlCategory>
   <PDBx:exptl_crystalCategory>
      <PDBx:exptl_crystal id="1">
         <PDBx:density_Matthews>1.57</PDBx:density_Matthews>
         <PDBx:density_percent_sol>21.79</PDBx:density_percent_sol>
      </PDBx:exptl_crystal>
   </PDBx:exptl_crystalCategory>
   <PDBx:exptl_crystal_growCategory>
      <PDBx:exptl_crystal_grow crystal_id="1">
         <PDBx:method>VAPOR DIFFUSION, HANGING DROP</PDBx:method>
         <PDBx:pH>5.5</PDBx:pH>
         <PDBx:pdbx_details>0.1M Sodium Acetate pH 5.5, PEG 10,000, vapor diffusion, hanging drop, temperature 298K</PDBx:pdbx_details>
         <PDBx:temp>298</PDBx:temp>
      </PDBx:exptl_crystal_grow>
   </PDBx:exptl_crystal_growCategory>
   <PDBx:pdbx_audit_revision_detailsCategory>
      <PDBx:pdbx_audit_revision_details data_content_type="Structure model" ordinal="1" revision_ordinal="1">
         <PDBx:provider>repository</PDBx:provider>
         <PDBx:type>Initial release</PDBx:type>
      </PDBx:pdbx_audit_revision_details>
   </PDBx:pdbx_audit_revision_detailsCategory>
   <PDBx:pdbx_audit_revision_groupCategory>
      <PDBx:pdbx_audit_revision_group data_content_type="Structure model" ordinal="1" revision_ordinal="2">
         <PDBx:group>Version format compliance</PDBx:group>
      </PDBx:pdbx_audit_revision_group>
   </PDBx:pdbx_audit_revision_groupCategory>
   <PDBx:pdbx_audit_revision_historyCategory>
      <PDBx:pdbx_audit_revision_history data_content_type="Structure model" ordinal="1">
         <PDBx:major_revision>1</PDBx:major_revision>
         <PDBx:minor_revision>0</PDBx:minor_revision>
         <PDBx:revision_date>2010-08-04</PDBx:revision_date>
      </PDBx:pdbx_audit_revision_history>
      <PDBx:pdbx_audit_revision_history data_content_type="Structure model" ordinal="2">
         <PDBx:major_revision>1</PDBx:major_revision>
         <PDBx:minor_revision>1</PDBx:minor_revision>
         <PDBx:revision_date>2011-07-13</PDBx:revision_date>
      </PDBx:pdbx_audit_revision_history>
   </PDBx:pdbx_audit_revision_historyCategory>
   <PDBx:pdbx_database_relatedCategory>
      <PDBx:pdbx_database_related content_type="unspecified" db_id="3NHC" db_name="PDB">
         <PDBx:details xsi:nil="true" />
      </PDBx:pdbx_database_related>
   </PDBx:pdbx_database_relatedCategory>
   <PDBx:pdbx_database_statusCategory>
      <PDBx:pdbx_database_status entry_id="3NHD">
         <PDBx:deposit_site>RCSB</PDBx:deposit_site>
         <PDBx:pdb_format_compatible>Y</PDBx:pdb_format_compatible>
         <PDBx:process_site>RCSB</PDBx:process_site>
         <PDBx:recvd_initial_deposition_date>2010-06-14</PDBx:recvd_initial_deposition_date>
         <PDBx:status_code>REL</PDBx:status_code>
         <PDBx:status_code_sf>REL</PDBx:status_code_sf>
      </PDBx:pdbx_database_status>
   </PDBx:pdbx_database_statusCategory>
   <PDBx:pdbx_entity_nonpolyCategory>
      <PDBx:pdbx_entity_nonpoly entity_id="2">
         <PDBx:comp_id>ACY</PDBx:comp_id>
         <PDBx:name>ACETIC ACID</PDBx:name>
      </PDBx:pdbx_entity_nonpoly>
      <PDBx:pdbx_entity_nonpoly entity_id="3">
         <PDBx:comp_id>HOH</PDBx:comp_id>
         <PDBx:name>water</PDBx:name>
      </PDBx:pdbx_entity_nonpoly>
   </PDBx:pdbx_entity_nonpolyCategory>
   <PDBx:pdbx_entity_src_synCategory>
      <PDBx:pdbx_entity_src_syn entity_id="1" pdbx_src_id="1">
         <PDBx:details>GYVLGS (residues 127-132 with V129) from human prion protein, synthesized</PDBx:details>
         <PDBx:ncbi_taxonomy_id>9606</PDBx:ncbi_taxonomy_id>
         <PDBx:organism_common_name>human</PDBx:organism_common_name>
         <PDBx:organism_scientific>Homo sapiens</PDBx:organism_scientific>
         <PDBx:pdbx_alt_source_flag>sample</PDBx:pdbx_alt_source_flag>
      </PDBx:pdbx_entity_src_syn>
   </PDBx:pdbx_entity_src_synCategory>
   <PDBx:pdbx_nonpoly_schemeCategory>
      <PDBx:pdbx_nonpoly_scheme asym_id="C" ndb_seq_num="1">
         <PDBx:auth_mon_id>ACY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>ACY</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ACY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>7</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="D" ndb_seq_num="1">
         <PDBx:auth_mon_id>ACY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>ACY</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ACY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>8</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="E" ndb_seq_num="1">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:entity_id>3</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>9</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="E" ndb_seq_num="2">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:entity_id>3</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>10</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
   </PDBx:pdbx_nonpoly_schemeCategory>
   <PDBx:pdbx_phasing_MRCategory>
      <PDBx:pdbx_phasing_MR entry_id="3NHD">
         <PDBx:d_res_high_rotation>1.920</PDBx:d_res_high_rotation>
         <PDBx:d_res_high_translation>1.920</PDBx:d_res_high_translation>
         <PDBx:d_res_low_rotation>20.590</PDBx:d_res_low_rotation>
         <PDBx:d_res_low_translation>20.590</PDBx:d_res_low_translation>
         <PDBx:model_details>Phaser MODE: MR_AUTO</PDBx:model_details>
      </PDBx:pdbx_phasing_MR>
   </PDBx:pdbx_phasing_MRCategory>
   <PDBx:pdbx_poly_seq_schemeCategory>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="1">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>1</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="TYR" seq_id="2">
         <PDBx:auth_mon_id>TYR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TYR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>2</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="3">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>3</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="4">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>4</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>4</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="5">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>5</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>5</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="6">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>6</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>6</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="GLY" seq_id="1">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>1</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="TYR" seq_id="2">
         <PDBx:auth_mon_id>TYR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>TYR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>2</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="VAL" seq_id="3">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>3</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="LEU" seq_id="4">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>4</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>4</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="GLY" seq_id="5">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>5</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>5</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="B" entity_id="1" mon_id="SER" seq_id="6">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>6</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>6</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>B</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
   </PDBx:pdbx_poly_seq_schemeCategory>
   <PDBx:pdbx_struct_assemblyCategory>
      <PDBx:pdbx_struct_assembly id="1">
         <PDBx:details>author_defined_assembly</PDBx:details>
         <PDBx:oligomeric_count>12</PDBx:oligomeric_count>
         <PDBx:oligomeric_details>dodecameric</PDBx:oligomeric_details>
      </PDBx:pdbx_struct_assembly>
   </PDBx:pdbx_struct_assemblyCategory>
   <PDBx:pdbx_struct_assembly_genCategory>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B,C,D,E" oper_expression="1,2,3,4,5,6"></PDBx:pdbx_struct_assembly_gen>
   </PDBx:pdbx_struct_assembly_genCategory>
   <PDBx:pdbx_struct_assembly_propCategory>
      <PDBx:pdbx_struct_assembly_prop biol_id="1" type="ABSA (A^2)">
         <PDBx:value>180</PDBx:value>
      </PDBx:pdbx_struct_assembly_prop>
      <PDBx:pdbx_struct_assembly_prop biol_id="1" type="MORE">
         <PDBx:value>-1</PDBx:value>
      </PDBx:pdbx_struct_assembly_prop>
      <PDBx:pdbx_struct_assembly_prop biol_id="1" type="SSA (A^2)">
         <PDBx:value>1740</PDBx:value>
      </PDBx:pdbx_struct_assembly_prop>
   </PDBx:pdbx_struct_assembly_propCategory>
   <PDBx:pdbx_struct_oper_listCategory>
      <PDBx:pdbx_struct_oper_list id="1">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_555</PDBx:name>
         <PDBx:symmetry_operation>x,y,z</PDBx:symmetry_operation>
         <PDBx:type>identity operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="2">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_556</PDBx:name>
         <PDBx:symmetry_operation>x,y,z+1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>9.5850000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="3">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_554</PDBx:name>
         <PDBx:symmetry_operation>x,y,z-1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>-9.5850000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="4">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>3_455</PDBx:name>
         <PDBx:symmetry_operation>-x-1/2,y+1/2,-z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-20.5865000000</PDBx:vector1>
         <PDBx:vector2>9.4795000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="5">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>3_454</PDBx:name>
         <PDBx:symmetry_operation>-x-1/2,y+1/2,-z-1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-20.5865000000</PDBx:vector1>
         <PDBx:vector2>9.4795000000</PDBx:vector2>
         <PDBx:vector3>-9.5850000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="6">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>3_456</PDBx:name>
         <PDBx:symmetry_operation>-x-1/2,y+1/2,-z+1</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-20.5865000000</PDBx:vector1>
         <PDBx:vector2>9.4795000000</PDBx:vector2>
         <PDBx:vector3>9.5850000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
   </PDBx:pdbx_struct_oper_listCategory>
   <PDBx:pdbx_struct_sheet_hbondCategory>
      <PDBx:pdbx_struct_sheet_hbond range_id_1="1" range_id_2="2" sheet_id="A">
         <PDBx:range_1_auth_asym_id>A</PDBx:range_1_auth_asym_id>
         <PDBx:range_1_auth_atom_id>N</PDBx:range_1_auth_atom_id>
         <PDBx:range_1_auth_comp_id>TYR</PDBx:range_1_auth_comp_id>
         <PDBx:range_1_auth_seq_id>2</PDBx:range_1_auth_seq_id>
         <PDBx:range_1_label_asym_id>A</PDBx:range_1_label_asym_id>
         <PDBx:range_1_label_atom_id>N</PDBx:range_1_label_atom_id>
         <PDBx:range_1_label_comp_id>TYR</PDBx:range_1_label_comp_id>
         <PDBx:range_1_label_seq_id>2</PDBx:range_1_label_seq_id>
         <PDBx:range_2_auth_asym_id>B</PDBx:range_2_auth_asym_id>
         <PDBx:range_2_auth_atom_id>O</PDBx:range_2_auth_atom_id>
         <PDBx:range_2_auth_comp_id>GLY</PDBx:range_2_auth_comp_id>
         <PDBx:range_2_auth_seq_id>5</PDBx:range_2_auth_seq_id>
         <PDBx:range_2_label_asym_id>B</PDBx:range_2_label_asym_id>
         <PDBx:range_2_label_atom_id>O</PDBx:range_2_label_atom_id>
         <PDBx:range_2_label_comp_id>GLY</PDBx:range_2_label_comp_id>
         <PDBx:range_2_label_seq_id>5</PDBx:range_2_label_seq_id>
      </PDBx:pdbx_struct_sheet_hbond>
   </PDBx:pdbx_struct_sheet_hbondCategory>
   <PDBx:phasingCategory>
      <PDBx:phasing method="MR"></PDBx:phasing>
   </PDBx:phasingCategory>
   <PDBx:refineCategory>
      <PDBx:refine entry_id="3NHD" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:B_iso_max>40.690</PDBx:B_iso_max>
         <PDBx:B_iso_mean>10.8356</PDBx:B_iso_mean>
         <PDBx:B_iso_min>2.430</PDBx:B_iso_min>
         <PDBx:aniso_B11>-0.5600</PDBx:aniso_B11>
         <PDBx:aniso_B12>0.0000</PDBx:aniso_B12>
         <PDBx:aniso_B13>0.0000</PDBx:aniso_B13>
         <PDBx:aniso_B22>0.9700</PDBx:aniso_B22>
         <PDBx:aniso_B23>0.0000</PDBx:aniso_B23>
         <PDBx:aniso_B33>-0.4200</PDBx:aniso_B33>
         <PDBx:correlation_coeff_Fo_to_Fc>0.9360</PDBx:correlation_coeff_Fo_to_Fc>
         <PDBx:correlation_coeff_Fo_to_Fc_free>0.9410</PDBx:correlation_coeff_Fo_to_Fc_free>
         <PDBx:details>HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS</PDBx:details>
         <PDBx:ls_R_factor_R_free>0.2613</PDBx:ls_R_factor_R_free>
         <PDBx:ls_R_factor_R_work>0.2033</PDBx:ls_R_factor_R_work>
         <PDBx:ls_R_factor_obs>0.2097</PDBx:ls_R_factor_obs>
         <PDBx:ls_d_res_high>1.9200</PDBx:ls_d_res_high>
         <PDBx:ls_d_res_low>20.5800</PDBx:ls_d_res_low>
         <PDBx:ls_number_reflns_R_free>63</PDBx:ls_number_reflns_R_free>
         <PDBx:ls_number_reflns_obs>621</PDBx:ls_number_reflns_obs>
         <PDBx:ls_percent_reflns_R_free>10.1000</PDBx:ls_percent_reflns_R_free>
         <PDBx:ls_percent_reflns_obs>91.5900</PDBx:ls_percent_reflns_obs>
         <PDBx:ls_wR_factor_R_free>0.2942</PDBx:ls_wR_factor_R_free>
         <PDBx:ls_wR_factor_R_work>0.2138</PDBx:ls_wR_factor_R_work>
         <PDBx:occupancy_max>1.000</PDBx:occupancy_max>
         <PDBx:occupancy_min>1.000</PDBx:occupancy_min>
         <PDBx:overall_FOM_work_R_set>0.8950</PDBx:overall_FOM_work_R_set>
         <PDBx:overall_SU_B>2.4530</PDBx:overall_SU_B>
         <PDBx:overall_SU_ML>0.0770</PDBx:overall_SU_ML>
         <PDBx:overall_SU_R_Cruickshank_DPI>0.2994</PDBx:overall_SU_R_Cruickshank_DPI>
         <PDBx:overall_SU_R_free>0.2197</PDBx:overall_SU_R_free>
         <PDBx:pdbx_R_Free_selection_details>RANDOM</PDBx:pdbx_R_Free_selection_details>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_ls_cross_valid_method>THROUGHOUT</PDBx:pdbx_ls_cross_valid_method>
         <PDBx:pdbx_ls_sigma_F>0.000</PDBx:pdbx_ls_sigma_F>
         <PDBx:pdbx_method_to_determine_struct>MOLECULAR REPLACEMENT</PDBx:pdbx_method_to_determine_struct>
         <PDBx:pdbx_overall_ESU_R_Free>0.2200</PDBx:pdbx_overall_ESU_R_Free>
         <PDBx:pdbx_solvent_ion_probe_radii>0.8000</PDBx:pdbx_solvent_ion_probe_radii>
         <PDBx:pdbx_solvent_shrinkage_radii>0.8000</PDBx:pdbx_solvent_shrinkage_radii>
         <PDBx:pdbx_solvent_vdw_probe_radii>1.4000</PDBx:pdbx_solvent_vdw_probe_radii>
         <PDBx:pdbx_stereochemistry_target_values>MAXIMUM LIKELIHOOD</PDBx:pdbx_stereochemistry_target_values>
         <PDBx:solvent_model_details>MASK</PDBx:solvent_model_details>
      </PDBx:refine>
   </PDBx:refineCategory>
   <PDBx:refine_histCategory>
      <PDBx:refine_hist cycle_id="LAST" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:d_res_high>1.9200</PDBx:d_res_high>
         <PDBx:d_res_low>20.5800</PDBx:d_res_low>
         <PDBx:number_atoms_solvent>2</PDBx:number_atoms_solvent>
         <PDBx:number_atoms_total>94</PDBx:number_atoms_total>
         <PDBx:pdbx_number_atoms_ligand>8</PDBx:pdbx_number_atoms_ligand>
         <PDBx:pdbx_number_atoms_nucleic_acid>0</PDBx:pdbx_number_atoms_nucleic_acid>
         <PDBx:pdbx_number_atoms_protein>84</PDBx:pdbx_number_atoms_protein>
      </PDBx:refine_hist>
   </PDBx:refine_histCategory>
   <PDBx:refine_ls_restrCategory>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_bond_refined_d">
         <PDBx:dev_ideal>0.015</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.022</PDBx:dev_ideal_target>
         <PDBx:number>90</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_bond_other_d">
         <PDBx:dev_ideal>0.001</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>50</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_angle_refined_deg">
         <PDBx:dev_ideal>1.480</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>2.125</PDBx:dev_ideal_target>
         <PDBx:number>118</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_angle_other_deg">
         <PDBx:dev_ideal>0.801</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>3.000</PDBx:dev_ideal_target>
         <PDBx:number>122</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_dihedral_angle_1_deg">
         <PDBx:dev_ideal>6.083</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>5.000</PDBx:dev_ideal_target>
         <PDBx:number>10</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_dihedral_angle_2_deg">
         <PDBx:dev_ideal>5.255</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>20.000</PDBx:dev_ideal_target>
         <PDBx:number>2</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_dihedral_angle_3_deg">
         <PDBx:dev_ideal>15.528</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>15.000</PDBx:dev_ideal_target>
         <PDBx:number>10</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_chiral_restr">
         <PDBx:dev_ideal>0.093</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.200</PDBx:dev_ideal_target>
         <PDBx:number>12</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_gen_planes_refined">
         <PDBx:dev_ideal>0.006</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>102</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_gen_planes_other">
         <PDBx:dev_ideal>0.000</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>18</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_mcbond_it">
         <PDBx:dev_ideal>1.131</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>1.500</PDBx:dev_ideal_target>
         <PDBx:number>62</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_mcbond_other">
         <PDBx:dev_ideal>0.237</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>1.500</PDBx:dev_ideal_target>
         <PDBx:number>26</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_mcangle_it">
         <PDBx:dev_ideal>1.836</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>2.000</PDBx:dev_ideal_target>
         <PDBx:number>88</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_scbond_it">
         <PDBx:dev_ideal>1.997</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>3.000</PDBx:dev_ideal_target>
         <PDBx:number>28</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_scangle_it">
         <PDBx:dev_ideal>2.388</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>4.500</PDBx:dev_ideal_target>
         <PDBx:number>30</PDBx:number>
      </PDBx:refine_ls_restr>
   </PDBx:refine_ls_restrCategory>
   <PDBx:refine_ls_shellCategory>
      <PDBx:refine_ls_shell d_res_high="1.9200" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:R_factor_R_free>0.2680</PDBx:R_factor_R_free>
         <PDBx:R_factor_R_work>0.1480</PDBx:R_factor_R_work>
         <PDBx:d_res_low>2.1440</PDBx:d_res_low>
         <PDBx:number_reflns_R_free>13</PDBx:number_reflns_R_free>
         <PDBx:number_reflns_R_work>116</PDBx:number_reflns_R_work>
         <PDBx:number_reflns_all>129</PDBx:number_reflns_all>
         <PDBx:pdbx_total_number_of_bins_used>5</PDBx:pdbx_total_number_of_bins_used>
         <PDBx:percent_reflns_obs>75.4400</PDBx:percent_reflns_obs>
      </PDBx:refine_ls_shell>
   </PDBx:refine_ls_shellCategory>
   <PDBx:reflnsCategory>
      <PDBx:reflns pdbx_ordinal="1">
         <PDBx:d_resolution_high>1.900</PDBx:d_resolution_high>
         <PDBx:d_resolution_low>90.000</PDBx:d_resolution_low>
         <PDBx:entry_id>3NHD</PDBx:entry_id>
         <PDBx:number_obs>637</PDBx:number_obs>
         <PDBx:pdbx_Rmerge_I_obs>0.193</PDBx:pdbx_Rmerge_I_obs>
         <PDBx:pdbx_chi_squared>1.034</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_netI_over_sigmaI>7.900</PDBx:pdbx_netI_over_sigmaI>
         <PDBx:pdbx_redundancy>5.700</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_obs>91.500</PDBx:percent_possible_obs>
      </PDBx:reflns>
   </PDBx:reflnsCategory>
   <PDBx:reflns_shellCategory>
      <PDBx:reflns_shell pdbx_ordinal="1">
         <PDBx:Rmerge_I_obs>0.223</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.900</PDBx:d_res_high>
         <PDBx:d_res_low>1.970</PDBx:d_res_low>
         <PDBx:number_unique_all>31</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.005</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>3.200</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>56.400</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="2">
         <PDBx:Rmerge_I_obs>0.374</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.970</PDBx:d_res_high>
         <PDBx:d_res_low>2.050</PDBx:d_res_low>
         <PDBx:number_unique_all>53</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.019</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>5.600</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>79.100</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="3">
         <PDBx:Rmerge_I_obs>0.380</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.050</PDBx:d_res_high>
         <PDBx:d_res_low>2.140</PDBx:d_res_low>
         <PDBx:number_unique_all>60</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.156</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>5.900</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>90.900</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="4">
         <PDBx:Rmerge_I_obs>0.389</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.140</PDBx:d_res_high>
         <PDBx:d_res_low>2.250</PDBx:d_res_low>
         <PDBx:number_unique_all>67</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.003</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>6.800</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="5">
         <PDBx:Rmerge_I_obs>0.305</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.250</PDBx:d_res_high>
         <PDBx:d_res_low>2.390</PDBx:d_res_low>
         <PDBx:number_unique_all>65</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.051</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>5.300</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>87.800</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="6">
         <PDBx:Rmerge_I_obs>0.303</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.390</PDBx:d_res_high>
         <PDBx:d_res_low>2.580</PDBx:d_res_low>
         <PDBx:number_unique_all>58</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.028</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>6.400</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="7">
         <PDBx:Rmerge_I_obs>0.266</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.580</PDBx:d_res_high>
         <PDBx:d_res_low>2.840</PDBx:d_res_low>
         <PDBx:number_unique_all>70</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>0.998</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>5.900</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="8">
         <PDBx:Rmerge_I_obs>0.184</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.840</PDBx:d_res_high>
         <PDBx:d_res_low>3.250</PDBx:d_res_low>
         <PDBx:number_unique_all>77</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.063</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>5.400</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>97.500</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="9">
         <PDBx:Rmerge_I_obs>0.160</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>3.250</PDBx:d_res_high>
         <PDBx:d_res_low>4.090</PDBx:d_res_low>
         <PDBx:number_unique_all>68</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.001</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>5.800</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>98.600</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="10">
         <PDBx:Rmerge_I_obs>0.104</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>4.090</PDBx:d_res_high>
         <PDBx:d_res_low>90.000</PDBx:d_res_low>
         <PDBx:number_unique_all>88</PDBx:number_unique_all>
         <PDBx:pdbx_chi_squared>1.013</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_redundancy>5.300</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>96.700</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
   </PDBx:reflns_shellCategory>
   <PDBx:softwareCategory>
      <PDBx:software pdbx_ordinal="1">
         <PDBx:classification>data scaling</PDBx:classification>
         <PDBx:contact_author>Zbyszek Otwinowski</PDBx:contact_author>
         <PDBx:contact_author_email>hkl@hkl-xray.com</PDBx:contact_author_email>
         <PDBx:location>http://www.hkl-xray.com/</PDBx:location>
         <PDBx:name>SCALEPACK</PDBx:name>
         <PDBx:type>program</PDBx:type>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="2">
         <PDBx:classification>phasing</PDBx:classification>
         <PDBx:contact_author>Randy J. Read</PDBx:contact_author>
         <PDBx:contact_author_email>cimr-phaser@lists.cam.ac.uk</PDBx:contact_author_email>
         <PDBx:date>Wed Feb 15 11:59:26 2006</PDBx:date>
         <PDBx:location>http://www-structmed.cimr.cam.ac.uk/phaser/</PDBx:location>
         <PDBx:name>PHASER</PDBx:name>
         <PDBx:type>program</PDBx:type>
         <PDBx:version>1.3.2</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="3">
         <PDBx:classification>refinement</PDBx:classification>
         <PDBx:contact_author>Garib N. Murshudov</PDBx:contact_author>
         <PDBx:contact_author_email>garib@ysbl.york.ac.uk</PDBx:contact_author_email>
         <PDBx:language>Fortran_77</PDBx:language>
         <PDBx:location>http://www.ccp4.ac.uk/dist/html/refmac5.html</PDBx:location>
         <PDBx:name>REFMAC</PDBx:name>
         <PDBx:type>program</PDBx:type>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="4">
         <PDBx:classification>data extraction</PDBx:classification>
         <PDBx:contact_author>PDB</PDBx:contact_author>
         <PDBx:contact_author_email>deposit@deposit.rcsb.org</PDBx:contact_author_email>
         <PDBx:date>June 10, 2010</PDBx:date>
         <PDBx:language>C++</PDBx:language>
         <PDBx:location>http://sw-tools.pdb.org/apps/PDB_EXTRACT/</PDBx:location>
         <PDBx:name>PDB_EXTRACT</PDBx:name>
         <PDBx:type>package</PDBx:type>
         <PDBx:version>3.10</PDBx:version>
      </PDBx:software>
   </PDBx:softwareCategory>
   <PDBx:structCategory>
      <PDBx:struct entry_id="3NHD">
         <PDBx:pdbx_descriptor>Major prion protein</PDBx:pdbx_descriptor>
         <PDBx:title>GYVLGS segment 127-132 from human prion with V129</PDBx:title>
      </PDBx:struct>
   </PDBx:structCategory>
   <PDBx:struct_asymCategory>
      <PDBx:struct_asym id="A">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="B">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="C">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="D">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="E">
         <PDBx:entity_id>3</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
   </PDBx:struct_asymCategory>
   <PDBx:struct_biolCategory>
      <PDBx:struct_biol id="1">
      </PDBx:struct_biol>
   </PDBx:struct_biolCategory>
   <PDBx:struct_keywordsCategory>
      <PDBx:struct_keywords entry_id="3NHD">
         <PDBx:pdbx_keywords>PROTEIN FIBRIL</PDBx:pdbx_keywords>
         <PDBx:text>amyloid-like protofibril, PROTEIN FIBRIL</PDBx:text>
      </PDBx:struct_keywords>
   </PDBx:struct_keywordsCategory>
   <PDBx:struct_refCategory>
      <PDBx:struct_ref id="1">
         <PDBx:db_code>PRIO_HUMAN</PDBx:db_code>
         <PDBx:db_name>UNP</PDBx:db_name>
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_align_begin>127</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>P04156</PDBx:pdbx_db_accession>
         <PDBx:pdbx_seq_one_letter_code>GYMLGS</PDBx:pdbx_seq_one_letter_code>
      </PDBx:struct_ref>
   </PDBx:struct_refCategory>
   <PDBx:struct_ref_seqCategory>
      <PDBx:struct_ref_seq align_id="1">
         <PDBx:db_align_beg>127</PDBx:db_align_beg>
         <PDBx:db_align_end>132</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>3NHD</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>1</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>6</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>P04156</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>6</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
      <PDBx:struct_ref_seq align_id="2">
         <PDBx:db_align_beg>127</PDBx:db_align_beg>
         <PDBx:db_align_end>132</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>3NHD</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>1</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>6</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>P04156</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>B</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>6</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
   </PDBx:struct_ref_seqCategory>
   <PDBx:struct_ref_seq_difCategory>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="1">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:db_mon_id>MET</PDBx:db_mon_id>
         <PDBx:details>Natural variant</PDBx:details>
         <PDBx:mon_id>VAL</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>3</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>3NHD</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P04156</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:pdbx_seq_db_seq_num>129</PDBx:pdbx_seq_db_seq_num>
         <PDBx:seq_num>3</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="2">
         <PDBx:align_id>2</PDBx:align_id>
         <PDBx:db_mon_id>MET</PDBx:db_mon_id>
         <PDBx:details>Natural variant</PDBx:details>
         <PDBx:mon_id>VAL</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>3</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>3NHD</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>B</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P04156</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:pdbx_seq_db_seq_num>129</PDBx:pdbx_seq_db_seq_num>
         <PDBx:seq_num>3</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
   </PDBx:struct_ref_seq_difCategory>
   <PDBx:struct_sheetCategory>
      <PDBx:struct_sheet id="A">
         <PDBx:number_strands>2</PDBx:number_strands>
      </PDBx:struct_sheet>
   </PDBx:struct_sheetCategory>
   <PDBx:struct_sheet_orderCategory>
      <PDBx:struct_sheet_order range_id_1="1" range_id_2="2" sheet_id="A">
         <PDBx:sense>anti-parallel</PDBx:sense>
      </PDBx:struct_sheet_order>
   </PDBx:struct_sheet_orderCategory>
   <PDBx:struct_sheet_rangeCategory>
      <PDBx:struct_sheet_range id="1" sheet_id="A">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>TYR</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>2</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>TYR</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>2</PDBx:beg_label_seq_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>LEU</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>4</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>LEU</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>4</PDBx:end_label_seq_id>
      </PDBx:struct_sheet_range>
      <PDBx:struct_sheet_range id="2" sheet_id="A">
         <PDBx:beg_auth_asym_id>B</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>VAL</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>3</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>B</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>VAL</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>3</PDBx:beg_label_seq_id>
         <PDBx:end_auth_asym_id>B</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>GLY</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>5</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>B</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>GLY</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>5</PDBx:end_label_seq_id>
      </PDBx:struct_sheet_range>
   </PDBx:struct_sheet_rangeCategory>
   <PDBx:struct_siteCategory>
      <PDBx:struct_site id="AC1">
         <PDBx:details>BINDING SITE FOR RESIDUE ACY A 7</PDBx:details>
         <PDBx:pdbx_evidence_code>Software</PDBx:pdbx_evidence_code>
         <PDBx:pdbx_num_residues>6</PDBx:pdbx_num_residues>
      </PDBx:struct_site>
      <PDBx:struct_site id="AC2">
         <PDBx:details>BINDING SITE FOR RESIDUE ACY A 8</PDBx:details>
         <PDBx:pdbx_evidence_code>Software</PDBx:pdbx_evidence_code>
         <PDBx:pdbx_num_residues>6</PDBx:pdbx_num_residues>
      </PDBx:struct_site>
   </PDBx:struct_siteCategory>
   <PDBx:struct_site_genCategory>
      <PDBx:struct_site_gen id="1" site_id="AC1">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>ACY</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>8</PDBx:auth_seq_id>
         <PDBx:label_asym_id>D</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>ACY</PDBx:label_comp_id>
         <PDBx:label_seq_id xsi:nil="true" />
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_554</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="2" site_id="AC1">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>ACY</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>8</PDBx:auth_seq_id>
         <PDBx:label_asym_id>D</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>ACY</PDBx:label_comp_id>
         <PDBx:label_seq_id xsi:nil="true" />
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_555</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="3" site_id="AC1">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>HOH</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>9</PDBx:auth_seq_id>
         <PDBx:label_asym_id>E</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>HOH</PDBx:label_comp_id>
         <PDBx:label_seq_id xsi:nil="true" />
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_555</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="4" site_id="AC1">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>HOH</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>10</PDBx:auth_seq_id>
         <PDBx:label_asym_id>E</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>HOH</PDBx:label_comp_id>
         <PDBx:label_seq_id xsi:nil="true" />
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_555</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="5" site_id="AC1">
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>2</PDBx:auth_seq_id>
         <PDBx:label_asym_id>B</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>TYR</PDBx:label_comp_id>
         <PDBx:label_seq_id>2</PDBx:label_seq_id>
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>2_565</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="6" site_id="AC1">
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>2</PDBx:auth_seq_id>
         <PDBx:label_asym_id>B</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>TYR</PDBx:label_comp_id>
         <PDBx:label_seq_id>2</PDBx:label_seq_id>
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>2_566</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="7" site_id="AC2">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>GLY</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>5</PDBx:auth_seq_id>
         <PDBx:label_asym_id>A</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>GLY</PDBx:label_comp_id>
         <PDBx:label_seq_id>5</PDBx:label_seq_id>
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_555</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="8" site_id="AC2">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>ACY</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>7</PDBx:auth_seq_id>
         <PDBx:label_asym_id>C</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>ACY</PDBx:label_comp_id>
         <PDBx:label_seq_id xsi:nil="true" />
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_556</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="9" site_id="AC2">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>ACY</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>7</PDBx:auth_seq_id>
         <PDBx:label_asym_id>C</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>ACY</PDBx:label_comp_id>
         <PDBx:label_seq_id xsi:nil="true" />
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_555</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="10" site_id="AC2">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>HOH</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>10</PDBx:auth_seq_id>
         <PDBx:label_asym_id>E</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>HOH</PDBx:label_comp_id>
         <PDBx:label_seq_id xsi:nil="true" />
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_556</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="11" site_id="AC2">
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>GLY</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>1</PDBx:auth_seq_id>
         <PDBx:label_asym_id>B</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>GLY</PDBx:label_comp_id>
         <PDBx:label_seq_id>1</PDBx:label_seq_id>
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>1_556</PDBx:symmetry>
      </PDBx:struct_site_gen>
      <PDBx:struct_site_gen id="12" site_id="AC2">
         <PDBx:auth_asym_id>B</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>TYR</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>2</PDBx:auth_seq_id>
         <PDBx:label_asym_id>B</PDBx:label_asym_id>
         <PDBx:label_atom_id xsi:nil="true" />
         <PDBx:label_comp_id>TYR</PDBx:label_comp_id>
         <PDBx:label_seq_id>2</PDBx:label_seq_id>
         <PDBx:pdbx_num_res>6</PDBx:pdbx_num_res>
         <PDBx:symmetry>2_566</PDBx:symmetry>
      </PDBx:struct_site_gen>
   </PDBx:struct_site_genCategory>
   <PDBx:symmetryCategory>
      <PDBx:symmetry entry_id="3NHD">
         <PDBx:Int_Tables_number>18</PDBx:Int_Tables_number>
         <PDBx:space_group_name_H-M>P 21 21 2</PDBx:space_group_name_H-M>
      </PDBx:symmetry>
   </PDBx:symmetryCategory>
</PDBx:datablock>
