Release Notes

======================================

Release 90.0, 4th August 2022

New features include:

* The addition of 492 InterPro entries.

* An update to Pfam (35.0).

* Integration of 473 new methods from the CATH-Gene3D (7), CDD (2), PANTHER (4), Pfam (459), SUPERFAMILY (1) databases.

Contents and coverage of InterPro 90.0
InterPro protein matches are now calculated for all UniProtKB and UniParc
proteins. The following statistics are for all UniProtKB proteins.
InterPro release 90.0 contains 40597 entries, representing:
           Active site    132
          Binding site     75
        Conserved site    696
                Domain  11954
                Family  23997
Homologous superfamily   3399
                   Ptm     17
                Repeat    327



Last Entry IPR046937

InterPro cites 53778 publications in PubMed.

Member database information

Signature Database     Version              Signatures*          Integrated Signatures**
       CATH-Gene3D       4.3.0                     6631                             2712
               CDD        3.18                    16212                             3817
             HAMAP     2021_04                     2383                             2379
           PANTHER        15.0                   139691                            10584
             PIRSF        3.10                     3285                             3236
            PRINTS        42.0                     2106                             1944
  PROSITE patterns     2022_01                     1311                             1283
  PROSITE profiles     2022_01                     1336                             1258
              Pfam        35.0                    19632                            19070
              SFLD           4                      303                              158
             SMART         7.1                     1312                             1267
       SUPERFAMILY        1.75                     2019                             1642
          TIGRFAMs        15.0                     4488                             4434



* Some signatures may not have matches to UniProtKB proteins.

** Not all signatures of a member database may be integrated at the time
of an InterPro release.

We use MobiDB-lite, a derivative of the MobiDB database, to provide consensus annotation of long-range intrinsic disorder in protein sequences.
Read more about MobiDB-lite in Bioinformatics, 33(9), 2017, 1402–1404, (doi: 10.1093/bioinformatics/btx015).


   Sequence Database     Version                Count                        Count of proteins matching        
                                                                       any signature      integrated signatures
           UniProtKB     2022_03            227339951                191816900 (84.4%)      186436946 (82.0%)
    UniProtKB/TrEMBL     2022_03            226771949                191265437 (84.3%)      185887710 (82.0%)
UniProtKB/Swiss-Prot     2022_03               568002                   551463 (97.1%)         549236 (96.7%)


Total number of proteins included in InterPro

Canonical sequences: 227339951
Splice variants: 66553
Total proteins: 227406504

InterPro to GO

*         Number of GO terms mapped to InterPro  - 35086


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InterPro - Integrated Resource Of Protein Domains And Functional Sites.
Copyright (C) f"2022" The InterPro Consortium. This manual and the
accompanying database may be copied and redistributed freely, without
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