This directory contains files supporting special requests for information.
Please let us know if any of these would be of general interest, and we will consider automatic their production.


RCV_meta.txt
File proposed to report meta data for an RCV specific to a VariationID                                  
The columns are:

VariationID            The identifier used to build the URL
RCV                    The RCV accession (without the current version number)
DiseaseNames           If multiple, a semicolon is used as separator
ReviewStatus
ClinicalSignificance  
ConflictSummary        Explanation if there are conflicting interpretations

-------This type of content is now available as ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/submission_summary.txt.gz--------
submitter_overview
This file contains a summary of each submission (SCV) with the following values:

Submitter              Name of the submitter
SubmitterID            How the submitter identified the record
SCV                    The accession assigned to the submission
Definition             How the allele was defined by the submitter
Pref_name              ClinVar's default description
Gene                   Symbol of the gene asserted to be involved
ClinSig                Clinical significance
LastEval               Date last evaluated
AssertionMethod        How the variant was evaluated
Submitted_Condition    The name submitted for the condition
Calc_Condition         ClinVar's preferred name for the condition
Description            Free text describing the interpretation

------This type of content is now available as ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/hgvs4variation.txt.gz-----
HGVS_summary
A tab-delimited file of HGVS transcript expressions based on RefSeqs
The columms are:

NCBI GeneID
HGNC Gene symbol
ClinVar VariationID       What is used to build the URL
ClinVar AlleleID          The identifier for a simple variant
HGVS coding
coding change
HGVS protein
protein change


ACMG_gene_interp_history.tsv
A tab-delimited file of submissions (represented by SCV accessions), for which an interpretation has changed, restricted to genes in scope for ACMG guidelines for reporting of secondary findings (both from 2013 (ACMG2013, PubMed 23788249) or 2016 (ACMG2016, PubMed 27854360).  Sorted by GeneSymbol, then Accession

GeneSymbol
Accession
Intepretation
Date last evaluated
Whether this intepretation is current or previous