@@ -1,5 +1,5 @@
 <?xml version="1.0" encoding="UTF-8" standalone="yes"?>
-<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" version="1.8; July 1, 2014">
+<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" version="1.9; August 7, 2014">
   <xs:element name="ReleaseSet" type="ReleaseType"/>
   <xs:element name="ClinVarSet" type="PublicSetType">
     <xs:annotation>
@@ -398,6 +398,8 @@
                                 <xs:enumeration value="nucleotide change"/>
                                 <xs:enumeration value="protein change, historical"/>
                                 <xs:enumeration value="transcript variant"/>
+                                <xs:enumeration value="AbsoluteCopyNumber"/>
+                                <xs:enumeration value="CopyNumberTuple"/>
                               </xs:restriction>
                             </xs:simpleType>
                           </xs:attribute>
@@ -650,6 +652,7 @@
               <xs:restriction base="xs:string">
                 <xs:enumeration value="phenocopy"/>
                 <xs:enumeration value="Subphenotype"/>
+                <xs:enumeration value="DrugResponseAndDisease"/>
                 <xs:enumeration value="co-occurring condition"/>
               </xs:restriction>
             </xs:simpleType>
@@ -831,6 +834,7 @@
                           <xs:enumeration value="CompoundHeterozygote"/>
                           <xs:enumeration value="Homozygote"/>
                           <xs:enumeration value="Hemizygote"/>
+                          <xs:enumeration value="NumberMosaic"/>
                           <xs:enumeration value="ObservedUnspecified"/>
                           <xs:enumeration value="AlleleFrequency"/>
                           <xs:enumeration value="GenotypeAndMOIConsistent"/>
@@ -863,8 +867,16 @@
     </xs:sequence>
   </xs:complexType>
   <xs:complexType name="FamilyInfo">
+    <xs:annotation>
+      <xs:documentation>Structure to describe attributes of any family data in an observation. If the details of the number of families and the de-identified pedigree id are not available, use FamilyHistory to describe what type of family data is available. Can also be used to report 'Yes' or 'No' if there are no more details.</xs:documentation>
+    </xs:annotation>
+    <xs:sequence>
+      <xs:element maxOccurs="1" minOccurs="0" name="FamilyHistory" type="xs:string"/>
+    </xs:sequence>
     <xs:attribute name="NumFamilies" type="xs:int" use="optional"/>
-    <xs:attribute name="FamilyHistory" type="xs:string" use="optional"/>
+    <xs:attribute name="NumFamiliesWithVariant" type="xs:int" use="optional"/>
+    <xs:attribute name="NumFamiliesWithSegregationObserved" type="xs:int" use="optional"/>
+    <xs:attribute name="PedigreeID" type="xs:string" use="optional"/>
   </xs:complexType>
   <xs:complexType name="SampleType">
     <xs:sequence>
@@ -883,6 +895,7 @@
             <xs:enumeration value="somatic"/>
             <xs:enumeration value="de novo"/>
             <xs:enumeration value="uncertain"/>
+            <xs:enumeration value="unknown"/>
             <xs:enumeration value="not provided"/>
             <xs:enumeration value="inherited"/>
             <xs:enumeration value="maternal"/>
@@ -977,6 +990,7 @@
         </xs:simpleType>
       </xs:element>
       <xs:element maxOccurs="1" minOccurs="0" name="FamilyData" type="FamilyInfo"/>
+      <xs:element maxOccurs="1" minOccurs="0" name="Proband" type="xs:string"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>