@@ -46,6 +46,7 @@
         </xs:annotation>
       </xs:element>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
+      <xs:element maxOccurs="1" minOccurs="0" name="StudyName" type="xs:string"/>
       <xs:element default="public" maxOccurs="1" minOccurs="0" name="ReleaseStatus" type="ReleaseStatusType">
         <xs:annotation>
           <xs:documentation>A release status can be applied the set of submissions, or to each submission. When not provided, the value is set to 'public'. If some assertions need to have a value different from the complete set, the value of ReleaseStatus at the ClinvarSubmission level has precedence.</xs:documentation>
@@ -157,12 +158,13 @@
           <xs:documentation>The number and name of the street or avenue.</xs:documentation>
         </xs:annotation>
       </xs:element>
-      <xs:element maxOccurs="unbounded" minOccurs="1" name="LabContact" type="ContactType">
+      <xs:element maxOccurs="unbounded" minOccurs="0" name="LabContact" type="ContactType">
         <xs:annotation>
           <xs:documentation>Official(not personal) contact for the organization</xs:documentation>
         </xs:annotation>
       </xs:element>
       <xs:element maxOccurs="1" minOccurs="0" name="URL" type="xs:anyURI"/>
+      <xs:element maxOccurs="unbounded" minOccurs="0" name="OrgAttribute" type="AttributeBundleType"/>
     </xs:sequence>
   </xs:complexType>
   <xs:complexType name="AddressType">
@@ -679,6 +681,7 @@
       <xs:element maxOccurs="1" minOccurs="1" name="Attribute" type="AttributeType"/>
       <xs:element maxOccurs="1" minOccurs="0" name="Severity" type="SeverityType"/>
       <xs:element maxOccurs="1" minOccurs="0" name="Zygosity" type="ZygosityType"/>
+      <xs:element maxOccurs="1" minOccurs="0" name="AbsoluteCopyNumber" type="xs:string"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
@@ -752,6 +755,11 @@
           <xs:attribute name="Acc" type="xs:string" use="required"/>
         </xs:complexType>
       </xs:element>
+      <xs:element maxOccurs="unbounded" minOccurs="0" name="ReplacesAccession" type="xs:string">
+        <xs:annotation>
+          <xs:documentation>If this accession replaces another, the other does not need to be submitted explictitly but can be listed here and clinvar will do the merge on the database side.</xs:documentation>
+        </xs:annotation>
+      </xs:element>
       <xs:element maxOccurs="1" minOccurs="1" name="MeasureTrait" type="MeasureTraitType">
         <xs:annotation>
           <xs:documentation>ClinVar uses the term measure to indicate what is measured (sequence variation, expression, protein electrophoretic mobility, etc.) to assess the asserted relationship to the phenotype or condition (trait). Measures of the same type can be grouped into sets; this is useful when, for example, a combination of alleles defines a 'diagnosis' name; or a local haplotype needs to be defined. All measures in a measure-set will have the asserted relationship to all traits in the trait set described here. The measures and traits for this assertion are described below, this element describes only the attributes of the assertion itself.</xs:documentation>
@@ -1193,6 +1201,13 @@
             <xs:enumeration value="de novo"/>
             <xs:enumeration value="uncertain"/>
             <xs:enumeration value="not provided"/>
+            <xs:enumeration value="inherited"/>
+            <xs:enumeration value="maternal"/>
+            <xs:enumeration value="paternal"/>
+            <xs:enumeration value="uniparental"/>
+            <xs:enumeration value="biparental"/>
+            <xs:enumeration value="not-reported"/>
+            <xs:enumeration value="tested-inconclusive"/>
           </xs:restriction>
         </xs:simpleType>
       </xs:element>
@@ -1317,7 +1332,7 @@
         </xs:simpleType>
       </xs:element>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="Description" type="xs:string"/>
-      <xs:element maxOccurs="1" minOccurs="1" name="DateLastEvaluated" type="xs:date"/>
+      <xs:element maxOccurs="1" minOccurs="0" name="DateLastEvaluated" type="xs:date"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
       <xs:element maxOccurs="unbounded" minOccurs="0" name="Comment" type="CommentType"/>
@@ -1568,6 +1583,7 @@
       <xs:enumeration value="in vitro"/>
       <xs:enumeration value="in vivo"/>
       <xs:enumeration value="research"/>
+      <xs:enumeration value="not provided"/>
     </xs:restriction>
   </xs:simpleType>
   <xs:simpleType name="typeObsAttributetype">
@@ -1624,4 +1640,29 @@
       <xs:enumeration value="under review"/>
     </xs:restriction>
   </xs:simpleType>
+  <xs:complexType name="AttributeBundleType">
+    <xs:sequence>
+      <xs:element maxOccurs="1" minOccurs="1" name="AttributeType">
+        <xs:complexType>
+          <xs:simpleContent>
+            <xs:extension base="AttributeTypeType"/>
+          </xs:simpleContent>
+        </xs:complexType>
+      </xs:element>
+      <xs:element maxOccurs="1" minOccurs="1" name="Attribute" type="AttributeType"/>
+      <xs:element maxOccurs="unbounded" minOccurs="0" name="Citation" type="CitationType"/>
+      <xs:element maxOccurs="unbounded" minOccurs="0" name="XRef" type="XrefType"/>
+      <xs:element maxOccurs="1" minOccurs="0" name="Comment" type="CommentType"/>
+    </xs:sequence>
+  </xs:complexType>
+  <xs:simpleType name="typeAttributeType">
+    <xs:union memberTypes="xs:positiveInteger xs:string"/>
+  </xs:simpleType>
+  <xs:complexType name="AttributeTypeType">
+    <xs:simpleContent>
+      <xs:extension base="typeAttributeType">
+        <xs:attribute name="val_type" type="typeIdName" use="required"/>
+      </xs:extension>
+    </xs:simpleContent>
+  </xs:complexType>
 </xs:schema>